Detection of dementia is more effective in winter and in the spring because it is when strong proteins appear, new research is suggested. In a large-scale study of seniors in the U.S. U., France and Canada, researchers found cognitive ability over 70 years overall is much sharper in summer and autumn. The brain and healthy subjects seemed, on average, 4.8 younger years during these months than they did between November and May. Those with Alzheimer's disease also experienced "flooding" in the winter, due to "seasonal rhythms" in certain proteins, which seemed to make genes related to dementia more expressed in the brain. The results suggest that assessing people for neurodegenerative disease in the last months of the year can be the most effective way to detect the disease, for which there is not yet a definitive test.
People with dementia experience '& # 39; dips & # 39; In winter due to "seasonal rhythms" in Alzheimer's-related proteins, what seems to be more demented genes expressed in the brain. According to the lead author of Dr. Andrew Lim, assistant professor of neurology at the University of Toronto, discoveries are an important step in improving diagnosis and treatment of Alzheimer's. "This association was independent of mood, sleep, physical activity and thyroid status," he explained. "It was clinically significant, as it is reflected in almost 30 percent higher probabilities of meeting criteria for mild cognitive impairment or dementia in winter and spring compared to summer and autumn, and persisted in cases with pathologically confirmed Alzheimer's disease" . He adds: "There may be a value in increasing clinical resources related to dementia in the winter and early spring when the symptoms are likely to be more pronounced." After clarifying the underlying mechanisms for seasonal improvement in knowledge in the summer and early autumn, these discoveries also open the door to new pathways for Alzheimer's disease treatment. "Some studies that suggested the season can be associated with cognitive function in some younger adult populations. But studies about the seasonal impact on older adults are lacking and few are known about the underlying mechanisms. Only 3,353 adults over the age of 70 were recruited. Without Alzheimer's disease in three cohort studies in the United States, Canada and France, they tested their thinking and concentration and measured the proteins related to Alzheimer's disease in their spinal fluid, on which the brain was killed and performed. The average cognitive functioning was greater In summer and in the fall, in winter and spring, the cognitive effect equivalent to 4.8 years difference in age-related decline. Likewise, the probabilities of fulfilling the diagnostic criteria for mild cognitive insufficiency or dementia were higher in Winter and spring that in summer or fall. There are several theories about what could be the cause of these piq Ues and cachos. First, explains Dr. Lim, there are environmental factors such as lighter and warmer temperatures that can increase general cognition in summer and autumn. It's true, then interventions such as phototherapy or temperature change can be effective in maintaining this peak throughout the year, "he says. Second, in summer, we tend to be more active, with a better diet and better sleeping habits." In this study, the association between the season and cognition was independent of sleep and physical activity, although studies that incorporate objective markers of these and other behaviors may reveal a more important role for behavioral factors. "Three, there is a seasonal season Depressive disorder, which affects so many in the winter months. These seasonal rhythms in a psychological state, according to him, can also boost the association between the season and cognition. "In this study, the seasonality of cognition was independent of depression; However, others Psychological factors, such as the negative affect associated with mild cognitive insufficiency and dementia, may be important. "In short, there is something s that occur within the body. All these factors – environmental, lifestyle and psychological – affect our levels of hormones and vitamins. "In our study to adjust serum levels of the thyroid stimulating hormone, there has not been a significant reduction in the estimates of the association between season and cognition," explains Dr. Lim "However, the additional metabolic factors that can bind cognition season are vitamin D, sex hormones such as testosterone and melatonin." The study, published today in PLOS Medicine magazine, had a clear limitation, among others: participants were only evaluated once per season and only included information on individuals from temperate regions of the northern hemisphere and not from the southern hemisphere or from equatorial regions. However, Dr Lim urges that they are something. "The persistence of a robust peak of learning in summer / autumn suggests that even in pathologically confirmed Alzheimer's disease, there is still a substantial cognitive plasticity. Focusing the drivers or mediators of this effect may allow this plasticity to be used to improve cognition throughout the year" . A Dra. Rosa Sancho, Research Chief of Alzheimer's Research UK, attends. The study is just one piece of the puzzle but sheds light on a little-discussed element about the lives of patients with dementia. "For the majority of people with dementia, the symptoms are getting worse over the course of several years but there are things that can also affect the memory and thinking ability in the short term. We know that factors such as the quality of the dream and the mood can affect the Cognitive performance, whether someone has dementia, and this study suggests that the time of the year can also influence these abilities, "he said. "In this research, scientists analyzed the data collected in three major cognitive health studies in older people, finding that participants who had their memory and thinking skills evaluated in summer and in autumn tended to have better scores than those assessed in the winter And in the spring, seasons can affect our lifestyle and health in several ways, and while the study does not tell us what this seasonal variation in cognitive abilities could be, the effect was found in people with or without dementia. " Interestingly, in addition to the seasonal variation in cognitive abilities, the researchers found similar fluctuations in the biological markers of Alzheimer's in the vertebral column fluid of the participants. "The study suggests that researchers may have to take into account the time of year to measure how Alzheimer's disease develops over time and there may be a need for additional assistance and assistance during the winter months but we need to see More work to be sure of these findings. "Aunt is complex, caused by age mix, genetics and lifestyle factors, and the results of this study do not mean that we should all rush to reserve Sun breaks during the winter months Although there is no safe way to avoid dementia, the research highlighted the things we can do to reduce the risk of the disease. The best current tips to keep our brain healthy as we grow older is to exercise regularly, eat a balanced diet, maintain a healthy weight, not smoke and keep blood pressure and cholesterol under control ».