Corona virus Passive antibody therapy may be considered for patients in serious condition at the resort start of the outbreak in Turkey is served.
With the support of various universities, especially the Red Crescent and Hacettepe Faculty of Medicine, under the coordination of the Ministry of Health, plasma will be removed from the blood, which will be taken from voluntary donors who have passed their health and have had negative results, and transferred to patients in severe condition.
In the Covid-19 epidemic, the sign that the plasma transplant, which is on the agenda of the world, will also be initiated in our country, is the first head of the Turkish Red Crescent. Kerem Kınık gave from his social media account and said, “We have worked on an important project today and we have reached a promising point for our patients.
Hacettepe University is one of the most important supporters of the implementation of this treatment of Turkey Faculty of Medicine, Department of Hematology Faculty and Hacettepe Hospital Blood Center and Apheresis Unit Director Prof. Dr. Osman Özcebe explained all the details of the process.
Professor Dr. Osman Özcebe
KIZILAY WILL BE DONE IN THE COORDINATION OF THE MINISTRY OF HEALTH
Professor Dr. Özcebe said, “With the contribution of our Red Crescent and health institutions, this organization can easily be held in our country. As in the rest of the world, our Ministry of Health is aware of this business and we now have patients who are recovering. So, after a week or 10 more days, plasma collection will start from these people, I think. In this project, Kızılay, the biggest lead player of the blood supply, will be the primary supporters of the Ministry of Health, and our universities will reveal all kinds of information and “Know How” for the establishment of this system, including Hacettepe University, of which I am a member. The Ministry of Health and administrative and health units affiliated to the ministry will also be in this organization. This is done in all European countries. This treatment is not an organization that can be carried out alone in small-scale laboratories. ”
” PLASMS CAN BE USED IN THE SECOND OUTBACK WAVE ”
Emphasizing that when the system is started to be applied, if the collected plasma is supplied more than necessary, it can be used in a possible second wave corona virus epidemic. Dr. Özcebe said, “If these plasmas can be stored under suitable conditions, they can be melted and reused in the future. In addition, it is possible to concentrate these plasma by converting them into ready-made commercial preparations in factories that produce pharmaceutical products and blood products. “If the virus, by the way, is not obvious mutation-proof and still remains sensitive to the antibodies we have, that is, if it remains on the target board, it could have such an advantage.”
” PATIENTS CAN BE LOST despite ALL THERAPY TREATMENTS ”
Defining antibodies developed by the body’s own immune system or created by vaccination from childhood, as “magic bullets that instantly destroy them by recognizing them when microbes enter our bodies”. Dr. Özcebe gave the following information: “We can call them targeted weapons. When you have an infection, it’s usually these antibodies that help keep your immunity permanent. When you create antibodies with the vaccine, you will protect against possible factors. When we obtain these antibodies from the blood of the healed person and give it to another patient who fights the infection and suffers the disease because his immune system is weak, he contributes significantly to the recovery process of the patient. We call it passive immunization (immunity). ”
“IT IS WRONG TO PROVIDE AS A NEW METHOD”
Underlining that it is not correct to present this method as a new method, Professor. Dr. Özcebe said, “This method was used in many infections that have previously been in the form of pandemics (global epidemics) and endemias (regional epidemics). Typical examples of this are the 2009 influenza (H1N1) endemia, Ebola in 2014 and MERS in 2015, this antibody transfer, ie passive immunization, was used during all these outbreaks. Why did it come up again in the Covid-19 outbreak? Because in a 5 percent patient, the disease is severe; we also lose about 1 percent of patients. This is part of the 5% of patients, needs respiratory support in intensive care units. In other words, despite all tried and partially effected treatment approaches, there is no definitive solution. That’s why we lose some of our patients. With a suitable organization, it is not a difficult procedure to perform, but it is actually a passive antibody treatment with plasma transplantation. In Turkey, under the leadership of the Ministry of Health that treatment can be done, “he said.
” WE HAVE A BLOOD BANKING SYSTEM IN EUROPEAN STANDARDS ”
Turkey’s infrastructure is ready for the job, and stressed that a strong blood banking system with European standards Prof. Dr. Osman Özcebe said, “We have a blood banking system, which is fully trained and equipped with adequate technical infrastructure, fully compliant with European Union directives. Kızılay already controls and operates this system. Thus, in Turkey there is no reason not to apply this method. The patient groups to be effective have been identified: Patients who need supportive care in intensive care. In addition, we have strict rules so that the blood product we receive from the person we transfer blood does not harm. Donors should also meet universal blood banking donor criteria. Both the swab from the throat and the blood sample taken must have been negative in the PCR tests at least 2 weeks after the symptoms have passed. How to process the serum to be taken from the donor, what tests to do, all of these are defined. “There is not much risk of this plasma transplant,” he said.
DONOR CALLS STARTED IN THE WORLD
Reminding that passive antibody treatment was first attempted in Corona virus epidemic by colleagues in China with small-scale studies. Dr. Özcebe ended his words as follows:
“In a study of 5 diseases in the Western world, later, passive antibody transfer has been shown to increase the chances of heavy patients to get rid of intensive care, respiratory support and discharge. Therefore, WHO (World Health Organization) and the American Food and Drug Administration FDA, one of the world’s leading healthcare institutions, have officially announced that this method can be used in this outbreak by 24th of this month, and the public, especially in the USA, has been advertised and passed Covid-19. people were called to donate plasma. ”
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