Arbutus honey inhibits cell proliferation in colon cancer lines, according to a study promoted by scientists from the Universities of Vigo, Granada and the Polytechnic delle Marche (Italy) who have analyzed the potential of this Mediterranean product for the first time. most frequent cancer in Spain.
The honey that is extracted from the flowers of the strawberry tree (Arbutus unedo) is appreciated in the beekeeping sector for its organoleptic characteristics, especially for its strong bitter taste and dark color.
The results of the study show that madrono honey is able to inhibit the proliferation of tumor cells grown in laboratory dishes. Specifically, those of a line of human colon adenocarcinoma (HCT-116) and another with metastatic characteristics (LoVo) widely used to investigate this type of tumor, as reported by the University of Granada.
The researchers explain that "treatment with honey stops the cycle of tumor cells by regulating some genes, inhibits cell migration, reduces the capacity of colonies and induces apoptosis or programmed cell death through the modulation of other key genes. and various apoptotic factors ».
It also suppresses the epidermal growth factor receptor called EGFR / HER2 and its signaling pathways, which could be an attractive target in cancer therapies due to its important function in the processes of cell survival and proliferation, as well as in those of apoptosis. and metastasis.
The cytotoxicity and antitumor effects of strawberry tree honey against colon cancer lines increased with the amount and time the treatment was applied.
This led to other relevant results, such as a reduction of transcription factors, the activity of certain enzymes, mitochondrial respiration and glycolysis of tumor cells.
"None of these effects was observed when honey was applied to healthy cell lines," the authors note, pointing to the anticancer potential of this natural product, but insisting on the need to perform new studies on in vivo models of colon cancer. to confirm its chemopreventive effects. (tagsToTranslate) honey (t) madrono (t) cancer (t) colon