Blood Lipid Changes at Age 8 in Children with Genetic Unity

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BARCELONA – metabolic symptoms of type 2 diabetes are detectable in some children are as young as 8 years of age, according to the results of major epidemiological studies presented here at the 2019 Annual Meeting of the European Society for the Study of Diabetes (EASD).

"It is great to see signs of adult diabetes in the blood from such a young age – this is about 50 years before it is commonly diagnosed," said chief investigator Joshua Bell, PhD, MRC Integrated Epidemiology Unit, University of Bristol, UK.

Bell and his colleagues used data from the Avon Longitudinal Study of Parents and Children (ALSPAC) to look at the early aspects of type 2 diabetes in children aged 8 years and older.

The research assessed the genetic liability of the children using adult-related variants and calculated a genetic risk score, which was cross-referenced with metabolic markers in the blood measured at four points of time. The children grew up to the age of the children. 25. The full article is also available online.

"This is a way of trying together what the disease looks like when it is developing," he said Medscape Medical News.

Specifically, high density lipoprotein cholesterol (HDL-C) metabolism or "good" cholesterol was one of the earliest aspects of blood change. Low levels of this marker appeared to correlate with higher genetic probability that type 2 diabetes developed when they were adult, Bell explained.

These changes occurred before any change in low-density lipoprotein cholesterol (LDL-C) or on "bad" cholesterol.

The moderator of the session, Naveed Sattar, MD, from the Institute of Cardiovascular & Medical Sciences at the University of Glasgow, UK, welcomed the work but said that it is unlikely that this information would be used clinically, at least at present.

"He adds a bit of new information about what pathways for diabetes are – so there is only research interest – not for the clinic for many years, if any," he said.

"We already have good risk scores based on simple weight or waist questions and measurements … which help to communicate those at high risk (diabetes) and should consider testing it," he said. it.

What are the earliest Features of Diabetes Type 2? How are they targeted?

Bell explained that the development of type 2 diabetes takes many years and, based on adult data, it has been proven that disease-related changes can occur in the decade or two until diagnosis.

"What we do not know is how a short start of the disease is seen," he explained.

Using the ALSPAC data (also known as the 90s study cohort), Bell and colleagues genotyped 4765 children for 162 genetic versions of adult type 2 diabetes and also examined lipid measures – including triglycerides as well as some amino acids and fatty acids – in blood samples taken at ages 8, 15, 18 and 25 years.

"We wanted to find out how this genetic susceptibility would affect blood students. How early in life do we see the start of the disease activity? And how does it start?" He told him Medscape Medical News.

He admitted that the results are "more prejudiced than clinical," but he stressed that they give an early view of "the aspects that could be directed to progress to prevent clinical disease."

Elizabeth Robertson, PhD, research director at Diabetes UK, said the results could be useful in the years ahead.

"In the future, such insights could be that we can find out who is at higher risk and – more importantly – find ways to intervene to reduce this risk far. earlier in a person's life than we do today and … that would prevent more cases of type 2 diabetes being developed at all, ”she said.

"While we cannot do anything about our genetic risk, there are things you can do to reduce the risk of developing the condition including maintaining a healthy weight, eating well, and moving more. , "she said.

EASD Annual Meeting 2019. Presented 19 September, 2019. Summary 81.

Bell did not report any relevant financial relationships.

For more diabetes and perchology news, we continued Twitter and Facebook.

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