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New research from the University of Sheffield has found that switching to a rich diet after following a restricted diet can reduce life expectancy and have adverse health effects.
It has long been known that limiting food intake can extend lifespan, however researchers have now provided new insight into why diets could benefit humans in terms of slowing aging and onset. of age-related diseases.
Experts from the Healthy Lifespan Institute of the University of Sheffield and Brown University in the United States tested the current evolutionary theory that dietary restriction – a reduction in particular or total nutritional intake without causing malnutrition – initiates a strategy of survival in humans and animals. The theory suggests that this is due to the fact that humans and animals invest in maintaining and repairing the body in times of poor food availability, pending moments when food availability increases again.
However, the new findings have challenged this theory. Fruit flies (Drosophilia melanogaster) fed a restricted diet which were then brought back to a rich diet were more likely to die and laid fewer eggs than the flies who spent their life on a rich diet. This shows that instead of waiting for food availability to increase in the future, the flies were essentially waiting to die on a limited diet.
The researchers suggest that instead of limiting the diet by increasing the repair and maintenance mechanisms, it could actually be an escape from the harmful effects of a rich diet. This new interpretation can help us understand why and how diet can have such profound effects on health.
The results also suggest that changing your diet repeatedly or abruptly could be harmful to your health in certain situations.
Ph.D. student Andrew McCracken, of the Department of Animal and Plant Sciences of the University of Sheffield, who led the study, said: “Dietary restriction is an unusual paradox that has attracted great interest in the field of aging. Our results have now directed us towards a more refined explanation of why it occurs and have the potential to completely shift the focus of future research.
“Our most surprising finding was that under certain circumstances, limited diets may also be the origin of particular types of harm to the individual. This better understanding of the sanctions and benefits of certain types of diets will accelerate the search to identify pharmaceutical interventions that mimic dietary restrictions. “
Dr. Mirre Simons, of the Department of Animal and Plant Sciences of the University of Sheffield, said:
The health effects of the diet are enormous, but we understand little about the exact mechanisms. Our work has now discovered a surprising dietary restriction property, as it makes flies poorly prepared for rich diets. This was contrary to our expectations and contrary to current evolutionary theory. In the biology of the aging field, evolutionary biology has been very influential in guiding the interpretation of more mechanistic research. Our work therefore contributes to a wider understanding of dietary restriction and efforts to translate its benefits for humans. “
The research was funded by the National Environment Research Council (NERC), Wellcome, the American Federation of Aging Research and the National Institute on Aging.
The work is part of research by the Healthy Lifespan Institute of the University of Sheffield. The Institute brings together 120 world-class researchers from a wide range of disciplines with the aim of slowing down the aging process and addressing the global multimorbidity epidemic – the presence of two or more chronic conditions – in an attempt to help everyone live healthier, independent lives longer and reduce treatment costs.
Scientists using machine learning algorithms opened new antibiotic compounds that can kill one of the most invulnerable bacteria in the world.
A team of scientists led by Regina Barzalai and James Collins of the Massachusetts Institute of Technology has discovered nine new antibiotics using artificial intelligence. how writes Newsweek, a neural network, scanned a database of chemical compounds and identified a new compound that could effectively destroy the bacterium through the mechanisms of known drugs.
Scientists have noted an open molecule, which in honor of the HAL artificial intelligence system from the movie “2001: Space Odyssey” was called “chalitsin.” This substance was able to destroy the bacteria that cause tuberculosis, pseudomembranous colitis. The experimental mice also managed to get rid of the deadly enterobacteria and Bauman akinetobacteria.
Researchers have not been able to find new classes of antibiotics over the past 30 years. In addition, the existing synthetic and antibacterial agents, of which not so many have appeared in recent years, are only small modifications of antibiotics that were discovered several decades ago. This put the world on the brink of a global catastrophe, scientists say.
British economist Jim O’Neill is confident that by 2050, 10 million people a year will die from infectious diseases in this situation. Now in the USA alone, there are almost 3 million people annually who are infected with pathogens that are completely immune to antibiotics. However, scientists believe that a new antibiotic detected by AI may become the most powerful in the history of the planet.
Face oils are suitable for the needs of different skin types. They care for the skin in a targeted manner and are intended to support the development of a healthy barrier function of the skin against moisture loss and environmental influences. The oils can be used for a short time or can become a permanent part of the care routine. However, oils are considered to be greasy and so there is a rumor that they are not recommended for problematic skin. The opposite is the case, because the right facial oil can even reduce the production of sebum on oily skin or prevent inflammation on blemished skin. Read here which facial oils are suitable for which skin types.
Face oil is versatile
- There is a suitable facial oil for every skin type that cares for it in a targeted manner.
- It is not only suitable for care, but can also gently remove waterproof make-up and dirt residues from the pores.
- Foundation and Co. can be diluted with facial oils and provide valuable moisture.
Different skin types, different oils
Whether a product harmonizes with your skin type depends, among other things, on the level of unsaturated fatty acids. In natural cosmetics, a distinction is therefore made between dry oils and non-drying oils. The so-called iodine number reveals whether an oil dries quickly or slowly.
Is that Iodine number below 100, it is a non-drying oil with more saturated fatty acids. These include, for example, coconut oil, olive oil, avocado oil, almond oil and jojoba oil. These facial oils therefore form a light film on the skin.
A Iodine number between 100 and 170 means the oil is semi-drying. Sunflower oil, wheat germ oil, sesame oil, safflower oil and grape seed oil, for example, belong to this category.
If the Iodine number over 170 is a drying oil with a high proportion of unsaturated fatty acids. These oils are not on the skin and are quickly absorbed. These include, for example, linseed oil and wild rose oil.
Which oil is suitable for oily or blemished skin?
For oily and blemished skin, use an oil that dries quickly. This way, the oil can be absorbed quickly and you avoid gloss formation. Many oils have sebum-regulating ingredients and signal the skin. It then produces less fat because it already gets enough from the outside. At the same time, facial oil can have an antibacterial and anti-inflammatory effect on pimples. The following oils are suitable for oily and impure skin:
- Argan oil
- Rosehip Oil
- castor oil
- Grapeseed oil
- hemp oil
Which facial oils are comedogenic?
The term comedogenic refers to substances that trigger impurities and clog the pores. A composition that does not clog the pores of the skin is called non-comedogenic. Comedogenic facial oils include, for example, coconut oil, wheat germ oil, olive oil and linseed oil. Popular products like almond and castor oil, however, are non-comedogenic and also suitable for blemished skin.
Which face oil is suitable for sensitive and irritated skin?
Sensitive and irritated skin often shows redness and irritation. Use natural oils and avoid ingredients like paraffin. These oils are suitable for sensitive and irritated skin:
- Evening primrose oil
- Borage oil
- Currant Oil
- hemp oil
Which face oil is suitable for dry skin?
Dry skin needs a particularly rich care and so non-drying oils such as almond or jojoba oil are suitable. Especially in winter, many people are affected by dry skin, then care with rich facial oil is particularly worthwhile. This includes:
- Rosehip Oil
- almond oil
- Argan oil
- jojoba oil
- avocado oil
Is facial oil recommended for rosacea?
Rosacea is one of the most common skin diseases in adulthood. The skin is particularly sensitive, appears red, burns or itchy and small poplars can develop. So when it comes to skin care, less is more. A facial oil is less recommended for this sensitive skin, creams that have been specially developed for people with rosacea, such as this one, are more suitable creamthat is supposed to fight redness as well as inflammation.
Which oil is suitable for mature skin?
Nourishing, regenerating and moisturizing facial oils are best suited for mature skin. These include natural oils that are cold-pressed from seeds and nuts of plants and are similar to the skin’s own fat. These could be these oils:
- jojoba oil
- almond oil
- Argan oil
- avocado oil
Which oil is suitable for normal skin?
Normal skin is particularly uncomplicated and can be cared for with various oils. It is best to use a drying oil that is quickly absorbed and does not leave a film on the skin. For example Rosehip Oil his.
Face oil: how to apply it
Thoroughly cleanse your face and remove makeup and dirt from the pores. Then moisten your skin slightly, so that it can absorb the facial oil better. In the evening, the application is most worthwhile, then the facial oil can act overnight. By the way, you only need a few tropics of the facial oil, because the mass is very productive and can be easily spread over the face. Put a few drops of the facial oil in the palms of your hands and warm it up by rubbing it lightly. Then you can spread the oil on the face and massage it into the skin. Ideally, use a practical one Jade Rollerto work the oil into the skin.
How to recognize high quality facial oil
- Make sure that it is cold-pressed or virgin oil that still contains all natural ingredients.
- Especially when it comes to face care, it is worth paying attention to high-quality ingredients, which is why organic oils are well suited.
- Most oils have to be stored protected from light, because this way the nutrients are preserved. The darker the color of the glass bottle, the better the oil is protected.
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The Human papillomavirus It is one of the sexually transmitted diseases which most affects women in the world, and even men, for what they called to prevent it, because can also be transmitted with fingernails or fingers.
Often the Human papillomavirus it is transmitted when there is skin-to-skin contact, and, although in many cases it only causes warts on the skin or mucus in different areas of the body, in more serious cases it can cause Cancer in other places, like the uterus.
In fact, this virus is the leading cause of cervical cancer, and usually appears between 30 and 50 years of age. And although before it was only thought that its transmission had to do only with sexual intercourse or cuts in the skin, to date it has been discovered that it can also be transmitted in other ways.
Natalia Gennaro Della Rossa, specialist in gynecology and obstetrics of the Ruber Juan Bravo clinic in Madrid, confirmed that the Human papillomavirus can also be transmitted through contact with fingernails and fingertips.
“Another recently discovered route of HPV transmission would be genodigital, so that the fingernails and fingertips constitute a reservoir of the virus that would cause infection by this route,” he explained.
Given this, experts recommend both men and women, have regular medical check-ups, protect yourself during sexual intercourse with condoms or with vaccines from adolescence, in order to reduce the chances of developing some type of cancer from this virus.
An inexpensive urine test that simplifies screening for bladder cancer well before the first symptoms appear has been developed, the International Agency for Research on Cancer says. This non-invasive technique highlights biomarkers that can be detected in the urine, including certain genetic mutations.
A simple, non-invasive method of screening for bladder cancer before onset first symptoms has been discovered, presented in a study by the International Cancer Research Center based in Lyon (IARC), the results of which have been published in the EBioMedicine journal.
A test under validation
Scientists say it is enough to do a simple urine test to identify genetic mutations that predict the development of the pathology. The test results of the test “are a promising step towards validating a non-invasive early detection tool,” said lead study author Dr. Florence Le Calvez-Kelm.
The new test is supposed to detect mutations in the reverse transcriptase telomerase gene (TERT), which often precede bladder cancer. Another advantage of this method is its cost-effectiveness and safety, which is suitable for people at risk.
Currently, there is no test that can detect the disease with a high rate of accuracy, cystoscopy remaining an invasive and expensive procedure. To do this, a thin tube with a lens is inserted into the urethra to examine the inner wall of the bladder.
The urine of more than 50,000 Iranians used
To verify the effectiveness of their discovery, CRIC researchers, in collaboration with the University of Medical Sciences and the National Cancer Institute of the United States, used the Golestan Cohort Study giving access to the urine samples from 50,045 Iranians, as well as monitoring their cases over a decade.
The mutations in the TERT gene, considered as biomarkers for future bladder cancer, were studied on the basis of urine samples from 38 individuals who developed bladder cancer 10 years after collection, as well as on a control group comprising 152 healthy people. It should be noted that the tests were carried out at the time when the patients showed no symptoms of the pathology.
Study results show that 46.7% of people who later developed bladder cancer had mutations of the TERT gene. As for the other group, no such mutation was detected.
When a patient arrives in the American emergency room today, he is more likely than ever to see a doctor who is a woman or a black person. And they are also more likely than ever to get a survey after returning home, asking how satisfied they were with their ER care.
But some have worried that a combination of greater doctor diversity, underlying patient bias and greater emphasis on ER satisfaction levels could create problems, especially if hospitals with low ER patient scores face public reporting. or even financial penalties in the future.
A new study by a team from the University of Yale and the University of Michigan could alleviate some of these fears.
Posted in JAMA network open, the study found that patients rated their satisfaction for a simulated ER visit equally if the physician randomly assigned to them was white or African American and male or female. Trust in your doctor also did not vary by doctor’s gender or race.
This was true even after the researchers took into account the variation in the demographic characteristics of the respondents and attitudes such as prejudice and sexism.
Lead author Rachel Solnick, MD, M.Sc. notes that the study does not mean that emergency doctors will never face individual situations in which a patient expresses bias towards them due to race, gender, age or others. factors.
In fact, it was his experience with prejudices as an emergency medicine resident, as well as previous research from others, that led Solnick to do the study.
The fact that ER patients are unable to choose which doctor to see, unlike most other fields of medicine, increases the possibility that biases creep into doctor-patient interaction.
We were really surprised that even after reviewing this data in many different ways, we have not seen evidence of racial or gender bias affecting patient satisfaction or trust. That’s not to say people are free of bias, but it doesn’t seem to fit into their care ratings in the polls. This is good news, with a grain of salt. “
Rachel Solnick, lead author
More information on the study
Solnick, now a national clinical scholar at the U-M Institute for Health Policy and Innovation, sees patients as an emergency medicine doctor at Michigan Medicine, the U-M academic medical center. It is one of about 25% of American ER doctors who are women; 5% of all ER doctors identify themselves as African American.
Working with colleagues from Yale including Kyle Peyton, Ph.D., Gordon Kraft-Todd, Ph.D. (now at Boston College) and Basmah Safdar, MD, M.Sc., the team designed a studio that has attracted his “patients” from two online platforms commonly used in academic research. More than 1,600 were recruited from the Amazon Mechanical Turk interface and another 1,600 were recruited through Lucid using a sample of odds coupled with the census demographics.
Each “patient” received the same scenario: they went to the emergency room for stomach symptoms and received tests, a diagnosis of viral gastroenteritis and a supportive treatment plan from the randomly assigned simulated doctor.
Next to the doctor’s diagnosis there was a contradictory diagnosis from an online symptom checker, which suggested that their symptoms could indicate a much more serious problem: an infected appendix. This contrast was intended to instill doubts about the physician’s competence in providing adequate care.
Evaluating the patient’s propensity towards or against certain types of emergency room physicians is particularly important at this time, adds Solnick.
Federal Centers for Medicare and Medicaid services tested the feasibility of a new investigation tool called the Emergency Department Patient Experiences with Care (EDPEC) that hospitals can use with ER patients who have not been hospitalized.
This tool could be used in the future to impose fines on hospitals with low ER satisfaction levels, just as patient scores already do for other types of care. The new CMS survey tool joins the private ones that hospitals already use internally.
“Patient satisfaction surveys really altered the fabric of the emergency doctor / patient relationship, because in addition to thinking about medical treatment, we are also evaluating how we will be” evaluated “at the end of the meeting,” says Solnick.
This isn’t necessarily a bad thing, he points out. In fact, it made clear communication during an ER visit even more important, although the ERs face crowding and must accept all patients who come to them.
Current research has not studied patient assessments of doctors from other racial and ethnic backgrounds, immigration statuses, ages or national origins. Additionally, the scenario the researchers studied was based in an ER context, and other areas of the healthcare system where patients have a longer term relationship with their doctor or exercise greater discretion in choosing a doctor may reveal results. different. It could be another avenue for follow-up studies.
Although this study did not find that the doctor’s race or gender negatively affects patient satisfaction, on average there is compelling evidence that increasing the diversity of the doctor’s workforce has positive public health benefits. For example, a recent field experiment in Oakland, California found that black men treated by black male doctors reported greater satisfaction and took more preventive health measures than black men treated by white male doctors.
But at the same time, minority doctors and women often experience high rates of exhaustion from work and some report higher rates of work turnover due to discrimination.
Solnick and colleagues believe that these new data point the research spotlight towards other sources of potential discrimination in the workplace – colleagues, superiors and policies – and the need for institutions to identify and evolve in order to support and encourage a diverse workforce. .
Michigan Medicine – University of Michigan
Solnick, R.E., et al. (2020) Effect of the doctor’s gender and race on the assessments and trust of simulated patients in their doctors. JAMA network open. doi.org/10.1001/jamanetworkopen.2019.20511.
GENEVA – The World Health Organization urgently requests $ 40 million to save its operations to end the Ebola epidemic in the eastern part of the Democratic Republic of the Congo.
The Ebola operation in the provinces of northern Kivu and Ituri, in conflict with the Democratic Republic of eastern Congo, is supporting financial life. The World Health Organization reports that its crates will be empty later this month. Encourage donors to step up immediately and contribute the money needed to deal with this virulent disease.
WHO spokesman Tarik Jasarevic says that the failure to support this operation would be tragic as good progress is being made in containing the Ebola virus. Over the past two months, he says that three to 15 Ebola cases have been reported every week. This is compared to 120 reported Ebola cases in April 2019.
“Only one case was reported last week and we only went down to two health zones in the eastern part of the DRC where we have Ebola cases. But once again, if we do not receive this funding, we obviously risk having a greater spread of the virus. So there is this call for more funding, “he said.
WHO reports 3433 Ebola cases, including 2253 deaths, for an overall mortality rate of 66 percent. Jasarevic says the money from the $ 40 million appeal will also be used for preparatory activities in neighboring countries.
It notes a modest WHO investment of $ 18 million in helping Uganda set up screening, monitoring and other systems that managed to prevent Ebola from taking root in that country last year.
He tells VOA that it is crucial that the Ebola operation is not stopped because as long as there is a case of the disease, there will be a risk of further spread.
“So, we really have to go down to zero. We are making progress, but once again, whether you have a case or you have more, the activities you need to do are the same. So, we have to make sure the assets are funded, “said Jasarevic.
Eight confirmed cases of Ebola were recorded by Beni and Mabalako in North Kivu province in the past 21 days. But WHO reports that no new cases have been reported for more than 42 days from the health areas of Butembo and Mambasa.
WHO calls encouraging the reduction in the geographical spread of the Ebola virus and the decreasing number of cases.
To meet the needs of an ever-changing healthcare environment, the board of directors of the American Association of Nurse Anesthetists (AANA) approved the updated “Scope of Nurse Anesthesia Practice”. This document reflects the professional scope of the practice of certified nurse anesthesiologists (CRNA), including the full range of anesthesia services, and describes the professional, educational, clinical and leadership roles of CRNA. The council met before the Assembly of Educational and Clinical Educators which met here from February 19-22.
Health systems across the country are increasingly relying on providers of advanced practices to provide excellent patient care. Anyone in healthcare understands the incredible value offered by nurses registered as CRNA, particularly as healthcare administrators work to expand high-quality care and reduce costs. “
Kate Jansky, MHS, CRNA, APRN, USA, LTC (ret), President of AANA
As anesthesia experts, CRNAs serve a wide range of patients in outpatient surgical centers, hospitals, procedure rooms, emergency rooms and office-based environments such as podiatry and dentistry. As registered advanced practice nurses, the CRNAs are licensed as independent professionals who collaborate with patients and a variety of healthcare professionals in order to provide high quality, holistic, evidence based and economic patient centered care.
The document illustrates the scope of professional practice and the significant role of CRNAs during the perioperative process, in the management of acute and chronic pain and in other clinical services provided by the CRNAs, such as emergency, intensive care and resuscitation services. The document also includes the use by CRNAs of emerging techniques and monitoring modalities such as point-of-care ultrasound. “Scope of Nurse Anesthesia Practice” outlines the education, licensing, certification and accountability of the CRNAs, many of whom have pivotal leadership roles, such as CEOs, administrators, directors, case owners, national and international researchers and more. yet.
“The demand for experienced anesthesia practitioners is increasing and legislators across the country are recognizing the need to access patients to the safe, high-quality care provided by CRNA and other APRNs,” said Jansky. “State legislators are increasingly supporting efforts to remove unnecessary restrictions and to allow CRNAs to exercise their education and training to the fullest extent.”
“As data on safe, high-quality and affordable care demonstrate, the CRNAs will continue to lead in the provision of patient-centered compassionate anesthesia and pain management care,” says the document.
American Association of Nurse Anesthetists