Oct 22, 2020
Experts at the University of California at San Francisco said that four adenovirus vaccines against the new type of coronavirus contain components that increase the risk of contracting HIV infection through direct contact with the body fluids of an infected person. All drugs are currently undergoing clinical trials.
The key reason for the activation of the human immunodeficiency virus is the presence of the recombinant adenovirus Ad5. It plays the role of a “supplier” of coronavirus protein to the body. It is an S-protein that binds to the ACE2 receptor and penetrates into healthy cells.
Adenoviruses by themselves are capable of causing a common cold, and adenoviral vectors do not pose a danger to humans in principle.
However, the Ad5 vector has previously been used in the art to create an HIV vaccine. Even then, tests showed that such a campaign was useless, since the drug has the exact opposite effect, increasing the likelihood of infection. The mechanism of action of this vector is still unclear. Scientists speculate that this is due to increased activation of the immune system, which provides HIV with more cells to infect.
The vaccine developers assured that they were aware of this risk, but stressed that abandoning the Ad5 vector may not be the best solution in the fight against a pandemic, since it can provide a good immune response against coronavirus infection. At the moment, researchers are trying to identify all possible side effect mechanisms.
Previously, LIVE24 reported for which groups of people the vaccine against COVID-19 could be useless… The body of each person is so individual that in some cases it will be difficult to predict how the drug will behave within a specific immune system.