A preliminary study followed by doctors and scientists from Wuhan, China -the epicenter of the pandemic– indicates that the coronavirus It could impact male sex hormones, hampering your reproductive system. While the results “they are not conclusive“And they will need”future research“The report raised concern among local authorities. Based on small-scale research, the pathogen could affect androgen levels.
The researchers of the Zhongnan Hospital of Wuhan University and the Hubei Clinical Research Center for Prenatal Diagnosis and Birth HealthThey reported in their investigation that they analyzed blood samples from 81 men aged 20 to 54 who tested positive for the coronavirus and were hospitalized in January, when the outbreak was already out of control.
“In this study, we compared sex-related hormones between 81 men of reproductive age with SARS-CoV-2 infection and 100 healthy men of the same age, and found that serum luteinizing hormone (LH) increased significantly, but the proportion Testosterone (T) to LH and the ratio of follicle-stimulating hormone (FSH) to LH decreased dramatically in males with COVID-19. This study provides the first direct evidence on the influence of COVID-19’s medical condition on male sex hormones, alerting assessment of gonadal function among patients recovered from SARSCoV-2 infection, especially men of reproductive age.“Indicates the study to which he had access Infobae.
The report, which is signed by doctors and researchers Ling Ma, Wen Xie, Danyang Li, Lei Shi, Yanhong Mao, Yao Xiong, Yuanzhen Zhang Y Ming Zhang, adds that “Except for respiratory symptoms such as cough, fever, and even acute respiratory failure, there is evidence of a SARS-CoV-2 attack on multiple organs such as the digestive, cardiovascular, and urinary systems.”
According to the description of the universe analyzed by the professionals – those who were ruled out and repressed by the regime when they wanted to alert about the outbreak – the average age of the participants was 38 years with an important addition: 90 percent of them only had mild symptoms and the samples were collected in the last days of their hospital stayl.
“The virus can be planted in the male reproductive tract because the barrier of the blood testes is not perfect enough to completely isolate the virus. A large number of viruses have been found, such as Zika, Ebola, Marburg, etc. in testicles and semen. Virus-induced damage to the testicles can damage gonadal hormone, secretion, and spermatogenesis, as seen in HIV or mumps-induced orchitis.“Adds the paper.
“There is evidence that the male reproductive systems are vulnerable to viral infection. Unlike bacterial infections that generally invade the accessory glands and the epididymis, the virus that circulates in the blood primarily attacks the testicles. It is known that a wide range of virus families, including human immunodeficiency virus (HIV), mumps virus, influenza, Zika virus, CoxsacKie virus, can induce orchitis and even cause infertility in males. Also, many viruses such as Ebola, HIV, Zika, and Hepatitis B / C can spread to semen and cause sexual transmission.“Alarms the document published in MedRxiv the database founded by Cold Spring Harbor Laboratory (CSHL), a non-profit educational and research institution, the Yale University, Y BMJ, a global provider of healthcare knowledge.
The researchers who participated in the study announced that they planned to launch a long-term analysis, which could include the collection and analysis of sperm samples. Previous studies have reported that the new coronavirus could bind to ACE2, a receptor protein cell, a large number of which is concentrated in the testes.. Li Yufeng, of the Tongji Hospital in Wuhan, had already warned that the testicles could become an important target of the attack of the COVID-19, according to an article published on the site South China Morning Post.
Men more vulnerable?
The first fatality of the coronavirus was a 60-year-old man with health problems. Age and medical history were not random.
Around the 80% of the more than 2,000 people who have died since the outbreak began are people age 60 and older, and 75% had previous illnesseslike diabetes, according to a report by the Chinese National Health Commission (NHC). The death rate is 2.1%, a much lower figure than the almost 10% of SARS that emerged in 2002-2003 and killed 800 people worldwide.
A new study revealed that the sex of the first victim was not accidental either. This week, the Chinese Center for Disease Control and Prevention revealed that although men and women have been infected in nearly equal numbers, the mortality rate among men is 2.8%, compared to 1.7% of women.
Men were also disproportionately affected during the SARS and MERS outbreaks. More women than men were infected with SARS in Hong Kong in 2003, but the death rate among men was 50% higher, according to a study published in the magazine Annals of Internal Medicine.
As for the MERS, about 32% of men who got it ended up dying, compared to 25.8% of women. And it’s not a trait of 21st-century disease, since young male adults also died in a much higher proportion than young women during the 1918 flu epidemic. Why do women tend to resist this type of disease better than men? virus? Scientists claim that there are different factors that can act against one sex and in favor of another.
There is a biological pattern: men’s bodies tend to generate a weaker immune response against infections. “This is a pattern that we have seen in many viral respiratory tract infections: men may have worse results, “said Sabra Klein, a scientist at the Johns Hopkins University Bloomberg School of Public Health, consulted by The New York Times. “We have seen this with other viruses. Women fight them better ”he added.
Women also produce stronger immune responses after vaccines. In addition, they have better immune memory, which protects them from the pathogens to which they were exposed when they were girls. “There is something in the immune system of women that is more exuberant”said Janine Clayton, director of the Office of Women’s Health Research at the National Institutes of Health, also consulted by the American newspaper.
The negative for the female sex is that this greater protection has a side effect. Women are much more susceptible to autoimmune diseases, such as rheumatoid arthritis and lupus, in which the immune system starts up and attacks the body’s own organs and tissues. Almost 80% of people with autoimmune diseases are women.
In any case, the deep causes why women have stronger immune responses are not entirely clear, and the investigation is still in an initial stage. There are biological factors that seem to have an important role. The female sex hormone, estrogen, supports immunity. Added to that is the fact that women carry two X chromosomes, which also contain genes related to immunity.