Jurgen Klopp hopes that Fabinho will be able to adapt to other Liverpool midfielder facilities.
The Brazilian was recalled on Sunday for the Merseyside derby against Everton.
Fabinho started alongside Georginio Wijnaldum for the Reds, with Roberto Firmino in front of them in a No. 10 role.
Liverpool often used a different 4-3-3 system he had played last season and Klopp admits that the changes were made to make the most of Monaco's summer signing.
"Until now, for Fabinho, he feels very familiar with another number 6 in the center," said Klopp before the shock with Burnley.
"But of course, he has to [play in other systems] and he will do it.
"The difference is not so great. We adapt to our defensive players as a unit and to our attacking players as a unit with slight skill-based adjustments.
"It's like that, if you have fast half-centers you can defend higher.
"So the ball behind is not a problem, that's what we need to do in these situations."
James Milner and Naby Keita hope to be involved in Turf Moor while skipper Jordan Henderson is available again after serving a ban.
Klopp is also concerned about Sadio Mane and Andy Robertson after the spectacular success of this derby.