a study by researchers at the University of Waterloo in Canada showed that mixing ibuprofen with hypertension and diuretics can be life-threatening. According to scientists, the combination of these three drugs would cause severe dehydration and affect the functioning of the kidneys.
Medications indicated for the treatment of high blood pressure are usually prescribed in association with diuretics, because urine often helps reduce high blood pressure. However, if the patient does not drink enough water, the drug can lead to dehydration. Ibuprofen, in turn, would intensify the dehydration, which could cause irreparable damage to the kidneys, warns the research.
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The study was conducted using computer-simulated models, and was published in the scientific journal Mathematical Biosciences. Scientists have found that in people with high blood pressure, the combination can cause acute kidney injury, which in some cases can be permanent. In the case of hypertensive patients, it is recommended that patients talk to their doctor to decide which medications to use in case of pain or fever.
Anita Layton, a professor of mathematics at Waterloo and a researcher in mathematics and medicine at the same institution, said: But research shows enough of a problem to be cautious.
Computer simulation drug testing can quickly produce time-consuming results in human clinical trials. Layton and his team use math and computer science to give doctors an insight into issues such as drug side effects.
“Diuretics are a family of drugs that make the body retain less water,” Layton explains. – “Getting dehydrated is a major factor in acute kidney injuries and then the high blood pressure medication and ibuprofen hit the kidney and this intestine. If you are taking medication for these high blood pressure and you need a pain reliever, consider using acetaminophen.