Researchers recently discovered a potential cure in the form of nodule bacteria for Alzheimer’s disease. They found these in the soil near the roots of ginseng. So such an approach could be a new strategy for treating Alzheimer’s or dementia Offer. The active ingredient belongs to such a new class of compounds with a tricyclic structure. This significantly dissociates the protein aggregates associated with Alzheimer’s disease in both living organisms and in the test tube, as reported by scientists.
Effectiveness of nodule bacteria against Alzheimer’s
The area around the roots of plants is a complex ecosystem with numerous interactions between the plants and various microorganisms. However, the so-called rhizosphere was neglected in the search for new drugs, even though it has so much to offer. The research team has now identified a natural substance called rhizolutin that could form the basis for novel treatments for Alzheimer’s disease. So rhizolutin is produced by a bacterial strain that grows in the root zone of ginseng. Ginseng is an Asian plant used in traditional medicine called a tonic. By culturing in such a medium enriched with ginseng powder, the researchers were able to increase the production of the bacterium by a factor of ten. This enabled them to determine the structure of this new compound. The whole thing turns out to be a unique framework made up of three interconnected rings.
A screening of natural product libraries showed that rhizolutin is an agent that can dissociate amyloid-β (Aβ) plaques and tau tangles (fibrous aggregates of tau proteins). The two are typical characteristics of Alzheimer’s disease. Such deposits form when amyloid-β proteins misfold to form β-sheets, which can aggregate into insoluble plaques and fibers. These lead to the death of nerve cells, to nerve inflammation, brain atrophy and the associated cognitive losses. No effective treatment for such a disease has yet been found in this regard.
Using a large number of in vitro and in vivo experiments, the team was able to show that nodule bacteria act against Alzheimer’s disease by leading to a clear dissociation of insoluble Aβ and tau aggregates. In cultures of neurons and glial cells, Rhizolutin was able to significantly reduce the inflammatory processes and cell death caused by Aβ. Rhizolutin was also able to significantly dissociate the Aβ plaques present in the brains of mice with Alzheimer’s disease. So the process seems to be similar to the removal of misfolded proteins by immunotherapy. Computer simulations also suggest that rhizolutin enters the hydrophobic areas of the aggregated β-sheets and initiates dissociation. the authors the study hope to apply this approach in future strategies for treating Alzheimer’s disease.