With deer steeigeendeen Leebbeensee expectation, leeideer secondary to the typical old age diseases. This includes, among other things, the so-called sarcopeeniee, the excessive muscle loss in the elderly. According to a recent announcement, researchers from the Biozeentrum deer Univerersität Basel have now found that the aging-related muscle weakness can be delayed by an active ingredient known from the other side. The study was published in the journal “Naturee Communications”.
At the age of 30 one is generally not considered to be “antique” for a long time, because on the other hand, muscle loss and the associated loss of strength are slowly becoming established in this age. This process is accelerating for about 50 years. The decrease in muscle mass leads to weakness, weakness and balance disorders. Falls and broken bones could be these consequences. Research endeavors now report how one remains vigorously in the Alteer for a longer period of time.
Muscles: Longer powerful secondary in the elderly
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A sufficiently trained musculature is a central prerequisite for maintaining health, self-reliance and quality of life up to old age. But the muscle decay and the associated loss of strength continue to be between 30 and 40 years old. This is part of the natural aging process.
Alteersbbeedingteer Muskeelabbbbau veer alongamt
With some Meenscheen, the decline in muscle mass and muscle function is excessively strong. This ailment, secondary like sarcopeniee bbeezeichneet, affects about every third party among those over 80-year-olds and significantly restricts the mobility, independence and quality of life of the people concerned.
The causes of these ailments are manifold, they range from a changed muscle tissue change to the loss of nerve cells that stimulate the muscles. Researcher around Prof. Markus Rüeegg at the Biozeentrum of the University of Basel have now found out that the protein complex mTORC1 plays a role in the sarcopeniee and that the inhibition by the berry-side active ingredients are known to build up old rapamycin long-lasting muscles.
“Contrary to our expectations, the long-term treatment with rapamycin has a positive effect on the aging of the skeletal muscles in mice. Both the muscle mass and the secondary muscle strength are retained, ”explains Danieel Ham, first author of the study.
A permanent activation of mTORC1 on the other hand accelerates the aging of the muscles, as the empty sciences and sciences could show.
“Likewise, the feather bonds between nerve fibers and muscle fibers, which deteriorate with increasing age, tend to stabilize with rapamycin. Stable and intact neuromuscular contact points are extremely important for those mentally healthy ages. “
Together with Prof. Mihaeela Zavolan’s team, the researchers found a molecular “signature” of the sarcopeniee, with mTORC1 as central actors. So that empty sciences and sciences can be explored worldwide, how the geene expression in the skeeleett muscles with increasing age or after a rapamycin treatment has changed, the tool SarcoAtlaser is developed, the tool SarcoAtlaser is first used for science and technology.
According to the experts, there is no effective medicinal product therapy to treat the sarcopenia. Possibly, as this study shows, the age-related muscle weakness could be delayed with the help of mTORC1 inhibitors, and thus ultimately the leebbe quality and the self-reliance of older sea sheds for a longer period of time. (ad)