RDIF announced the start of the third phase of the coronavirus vaccine trial :: Society :: RBC

Photo: press service of the RF Ministry of Defense / RIA Novosti

Post-registration clinical trials of a coronavirus vaccine are starting in Moscow, 40 thousand people will take part in the study. This is stated in the message of the Russian Direct Investment Fund (RDIF), received by RBC.

Russian Direct Investment Fund, Sovereign Fund of the Russian Federation, Moscow Government and National Research Center for Epidemiology and Microbiology named after N.F. The Gamaleis announce the start of a post-registration clinical trial, ”the message says.


Gamaleya Center eliminated the need to take tests before vaccination



With the support of RDIF, tests will be carried out in five more countries.

Russians over 18 years old with a Moscow compulsory medical insurance policy can participate in the study. In addition, candidates should not be sick with SARS, not have contact with those infected with coronavirus at least two weeks before the start of vaccination, and also not be sick with COVID-19.

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Coronavirus pandemic. Most relevant for August 18 :: Society :: RBC

An outbreak of the disease in the Mariinsky, doctors will begin to vaccinate until the vaccine research is completed, the President of Mexico decided to test the Russian vaccine on himself, the main thing is in the RBC review

Coronavirus

Russia Moscow World

0 (per day)

Recovered

0

0 (per day)

Got infected

0

0 (per day)

Died

0 (per day)

Recovered

0

0 (per day)

Got infected

0

0 (per day)

Died

0 (per day)

Recovered

0

0 (per day)

Got infected

0

0 (per day)

Died

Source: JHU,
federal and regional
virus control headquarters

Source: JHU, Federal and Regional Anti-Virus Headquarters

Situation in Russia

The number of confirmed cases of coronavirus infection exceeded 932 thousand (plus 4748 per day). In total, 15,872 people died from COVID-19 in the country (plus 55 per day). More than 742 thousand people have recovered since the beginning of the epidemic.

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Coronavirus pandemic. Most relevant for August 18 :: Society :: RBC

An outbreak of the disease in the Mariinsky, doctors will begin to vaccinate until the vaccine research is completed, the President of Mexico decided to test the Russian vaccine on himself, the main thing is in the RBC review

Coronavirus

Russia Moscow World

0 (per day)

Recovered

0

0 (per day)

Got infected

0

0 (per day)

Died

0 (per day)

Recovered

0

0 (per day)

Got infected

0

0 (per day)

Died

0 (per day)

Recovered

0

0 (per day)

Got infected

0

0 (per day)

Died

Source: JHU,
federal and regional
virus control headquarters

Source: JHU, Federal and Regional Anti-Virus Headquarters

Situation in Russia

The number of confirmed cases of coronavirus infection exceeded 927 thousand (plus 4892 per day). In total, 15,740 people died from COVID-19 in the country (plus 55 per day). More than 736 thousand people have recovered since the beginning of the epidemic.

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In Moscow, another 1,045 people recovered from coronavirus :: Society :: RBC

Photo: Sofia Sandurskaya / AGN “Moscow”

Another 1,045 patients with coronavirus have recovered in Moscow, said Anastasia Rakova, deputy mayor of the capital for social development, her words leads operational headquarters for infection control.

Since the beginning of the epidemic, the number of patients who have recovered from COVID-19 has reached 197,143.

In Moscow, during the epidemic, more than 251 thousand cases of coronavirus infection were detected, over 4.6 thousand died.


Sobyanin announced the start of influenza vaccination from September 1

August 11 President Vladimir Putin statedthat the first vaccine against COVID-19 was registered in Russia. He noted that this vaccine creates robust immunity to coronavirus and does not cause serious side effects. She was introduced by one of the daughters of the head of state.

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Coronavirus pandemic. Most relevant as of August 16 :: Society :: RBC

When the mass vaccination against COVID-19 begins in Russia, 21.5 million people have become infected with the coronavirus in the world; the main thing is in the RBC review

Coronavirus

Russia Moscow World

0 (per day)

Recovered

0

0 (per day)

Got infected

0

0 (per day)

Died

0 (per day)

Recovered

0

0 (per day)

Got infected

0

0 (per day)

Died

0 (per day)

Recovered

0

0 (per day)

Got infected

0

0 (per day)

Died

Source: JHU,
federal and regional
virus control headquarters

Source: JHU, federal and regional virus headquarters

Situation in Russia

The number of confirmed cases of coronavirus infection exceeded 922 thousand (plus 4969 per day). In total, 15 685 people died from COVID-19 in the country (plus 68 per day). More than 732 thousand people have recovered since the beginning of the epidemic.

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In Russia, 5057 new cases of coronavirus were detected per day :: Society :: RBC

The total number of infected people exceeded 907 thousand. Over the past 24 hours, no COVID-19 cases were found in two Russian regions – the Nenets and Chukotka Autonomous Districts

Photo: Valery Matytsin / TASS

Over the past day, 5,057 new cases of coronavirus infection COVID-19 have been identified in Russia, according to the operational headquarters to combat the disease.

The total number of infected people as of August 13 was 907,758.

According to the headquarters, over the past 24 hours, cases were registered in 83 regions of the country. At the same time, 1.3 thousand people (26.3%) do not have clinical manifestations of the disease.


In Russia, 124 people died from COVID-19 per day


Photo: Elena Afonina / TASS

In Moscow, 692 cases of infection were detected, in total, since the beginning of the COVID-19 pandemic, 250.3 thousand people have been confirmed. In second place in terms of the number of infected per day is the Sverdlovsk region (162 people, 22.9 thousand in total), in third – St. Petersburg (160, 33.5 thousand in total).

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very cheap and long-known drugs help save the lungs with coronavirus

Cloving hospital on the basis of the Medical Scientific and Educational Center (ISSC) Moscow State University named after M.V.Lomonosov took the first patients on April 21 and completed his work on June 13. It turned out that it was possible to achieve the best treatment results for COVID-19 in Moscow. Over the entire period, 4 patients died, and among severe patients who got mechanical ventilation, the mortality rate was less than 14% (for comparison, the average for the city and the world was up to 70 – 80%). Eighteen doctors out of 220 employees of the hospital were infected with coronavirus, there were no deaths among the medical staff.

What approaches were used at the University Hospital of Moscow State University to achieve such results? We continue the conversation with the head. Department of Therapy, Faculty of Fundamental Medicine, Moscow State University, Head of the Department of Age-Associated Diseases, Medical Scientific and Educational Center, Doctor of Medical Sciences, Cardiologist Yana Orlova.

MEDICINE FOR COUGH FOR 80 RUBLES

– Most of those who are ill or are afraid to get sick are worried about fibrotic changes in their lungs. They say that you have developed special therapy that can reduce the risk of developing fibrosis. Is it possible?!

– Yes, we launched an appropriate clinical study. There are no final results yet, but we have developed clinical practice.

“What did you do to save the lungs?”

– We used a combination of bromhexine and spironolactone (both are long-known very cheap drugs. – Ed.). Bromhexine is an expectorant that has been prescribed to patients with pneumonia and cough for many years. At the same time, experimental data showed that this drug can block a specific enzyme and impede the penetration of coronavirus into cells. True, it was on this effect that we counted to a lesser extent in inpatients, since such an effect is important mainly in the early stages of the disease. But the expectorant effect of bromhexine really helps patients with COVID. I heard that our colleagues in Peter launched a study of bromhexine for prophylactic purposes. We will wait for the results.

Coronavirus infected 18 doctors from 220 employees of the hospital, there were no deaths among the medical staffPhoto: Ivan MAKEEV

FIBROSIS OBSTACLE

– The second drug – spironolactone – is traditionally widely used in cardiology for the treatment of heart failure, severe hypertension. It has a small diuretic, magnesium and potassium-preserving effect, continues Yana. Orlova. – It has several mechanisms through which it can be useful in coronavirus infection.

Firstly, a mechanism that prevents the development of fibrosis in general in the body. There are works that, in particular, show that spironolactone reduces fibrosis in the heart. At the same time, it is known that the tendency to fibrosis is not local, but systemic – where there is more inflammation, there will certainly be fibrosis. And we see, of course, fibrotic changes in the “covide” in our patients. Therefore, we prescribed spironolactone as a drug for the prevention of this process.

Secondly, this drug blocks sex hormone receptors, in particular testosterone. Some published studies suggest that “high-testosterone” men suffer from “covid” more often and develop more severe fibrotic changes. Therefore, blocking these receptors for several weeks during COVID treatment may be useful in reducing the severity of complications. We are not talking about a longer intake, since male patients are unlikely to agree with a decrease in testosterone levels in the long term.

And perhaps the most important point. In almost all of our patients, we observed hypokalemia (a decrease in potassium levels. – Ed.). With coronavirus infection, potassium is intensely excreted from the body, and scientific articles even suggest that hypokalemia serves as the trigger for a cytokine storm. So spironolactone has a real chance to reduce the risk of this dangerous complication. But the main thing, in my opinion, is that lowering the level of potassium in the body is extremely harmful to the heart and triggers life-threatening rhythm disturbances, increasing the risk of sudden death. We, like all others, replenished potassium with droppers, but it was more effective to retain it in the body with the help of spironolactone.


Men certainly get worse than women;  the elderly are heavier than the young;  overweight people are heavier than patients without excess weight Photo: Ivan MAKEEV

Men certainly get worse than women; the elderly are heavier than the young; overweight people are heavier than overweight patientsPhoto: Ivan MAKEEV

WHEN PRESCRIBED PATIENTS

– Yana Arturovna, how many patients did you have on average?

– About 10 – 14 days. But someone and 50 days.

– Have you noticed signs by which it can be assumed that the disease in the person brought is likely to go the hard way?

– Such studies were carried out in the world, our clinical practice confirmed them. Men certainly get worse than women; the elderly are heavier than the young; overweight people are heavier than overweight patients. Men with a classic male type of baldness, a lot of facial hair, we can say brutal men get sick harder.

– Under what conditions did you discharge patients?

– We acted as close as possible to the recommendations Ministry of Health: so that the temperature for three days was not higher than 37.5 degrees; so that C-reactive protein (an indicator of inflammation) is lower than 10 mg / l, and saturation, that is, the level of oxygen in the blood, is higher than 96%.

“HEAD OF EPIDEMIOLOGY DEPARTMENT OF ITSELF WORKED AT SANPROPUSNIK”

– How often do you get sick doctors and nurses?

– In the first month no one got sick at all. We have a very powerful epidemiological service. The head of the sanitary-epidemiological department, a senior researcher, correctly organized the whole process, and for the first two weeks she personally worked in the sanitary inspection room at the exit from the “red zone” and helped doctors and nurses who were exhausted after the shift safely remove protective clothing.

Then both people’s fatigue and viral load accumulated. By the middle of the second month, sick people began to appear. There were no seriously ill patients. We treated part of the staff in our observation, part of it was treated at home. In total, 18 people were infected from the medical staff (less than 10%).

– Doctors take something for prevention? Vitamins C, D, Zinc?

– I saw the recommendations of American nutritionists, they speak out positively about taking zinc, melatonin and vitamin C. There were somewhat conflicting data on vitamin D. But we did not give any such recommendations to our employees. We have all the prevention was associated with minimizing contacts and other measures of epidemiological safety.

Physicians are the heroes of our time.“If you think that you are special and that a pandemic will not affect you, you are deeply mistaken,” listen to what the doctors who are fighting with coronavirus say

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The number of patients recovered from coronavirus in Moscow exceeded 148 thousand. :: Society :: RBC

Photo: Sofya Sandurskaya / AGN “Moscow”

Over the past day, 1007 patients with coronavirus infection recovered in the capital. This was stated by Vice Mayor Anastasia Rakova, reports the operational headquarters of Moscow.

“Over the past day after undergoing treatment, another 1007 patients recovered. In total, the number of people cured of the infection increased to 148 102, ”said the vice mayor.

Doctors report coronavirus vaccine testers

Photo: Igor Ivanko / AGN “Moscow”

According to the latest data, since the beginning of the epidemic in Moscow, more than 220 thousand patients have been identified. Of these, 3,761 patients died. In total, 634,437 infected were registered in Russia, 9,073 people were cured.

On the eve of the doctor anesthetist-resuscitator of the branch of the military hospital named after N.N. Burdenko Oleg Chikhlyaev said that volunteers who are testing the coronavirus vaccine have not yet revealed negative health effects. At the stage of clinical trials is a drug developed jointly with the Ministry of Defense, they began on June 18.

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The number of patients recovered from coronavirus in Moscow exceeded 148 thousand. :: Society :: RBC

Photo: Sofya Sandurskaya / AGN “Moscow”

Over the past day, 1007 patients with coronavirus infection recovered in the capital. This was stated by Vice Mayor Anastasia Rakova, reports the operational headquarters of Moscow.

“Over the past day after undergoing treatment, another 1007 patients recovered. In total, the number of people cured of the infection increased to 148 102, ”said the vice mayor.

Doctors report coronavirus vaccine testers

Photo: Igor Ivanko / AGN “Moscow”

According to the latest data, since the beginning of the epidemic in Moscow, more than 220 thousand patients have been identified. Of these, 3,761 patients died. In total, 634,437 infected were registered in Russia, 9,073 people were cured.

On the eve of the doctor anesthetist-resuscitator of the branch of the military hospital named after N.N. Burdenko Oleg Chikhlyaev said that volunteers who are testing the coronavirus vaccine have not yet revealed negative health effects. At the stage of clinical trials is a drug developed jointly with the Ministry of Defense, they began on June 18.

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Doctors reported well-being of vaccine testers against coronavirus :: Society :: RBC

Volunteers participating in the clinical trials of the coronavirus vaccine have not yet identified any negative health effects. This was stated by the doctor anesthetist-resuscitator of the branch of the main military clinical hospital named after N.N. Burdenko Oleg Chikhlyaev, reports “Red Star”.

According to him, doctors regularly examine the test participants who received a test injection against COVID-19. “Their health is good, they have no active complaints. Temperature, blood pressure, pulse, respiration rate are within normal limits, ”said Chikhlyaev.

Volunteers after the introduction of the vaccine are quarantined. Hospital specialists several times a day check the pressure, temperature and examine the injection site. No adverse reactions to the drug were observed in the military.

Volunteers reported well-being after vaccination with COVID-19

Tests of the Russian coronavirus vaccine vaccine began on June 18, when doctors introduced one component of the drug to nine volunteers, and nine more to the other.

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