very cheap and long-known drugs help save the lungs with coronavirus

Cloving hospital on the basis of the Medical Scientific and Educational Center (ISSC) Moscow State University named after M.V.Lomonosov took the first patients on April 21 and completed his work on June 13. It turned out that it was possible to achieve the best treatment results for COVID-19 in Moscow. Over the entire period, 4 patients died, and among severe patients who got mechanical ventilation, the mortality rate was less than 14% (for comparison, the average for the city and the world was up to 70 – 80%). Eighteen doctors out of 220 employees of the hospital were infected with coronavirus, there were no deaths among the medical staff.

What approaches were used at the University Hospital of Moscow State University to achieve such results? We continue the conversation with the head. Department of Therapy, Faculty of Fundamental Medicine, Moscow State University, Head of the Department of Age-Associated Diseases, Medical Scientific and Educational Center, Doctor of Medical Sciences, Cardiologist Yana Orlova.

MEDICINE FOR COUGH FOR 80 RUBLES

– Most of those who are ill or are afraid to get sick are worried about fibrotic changes in their lungs. They say that you have developed special therapy that can reduce the risk of developing fibrosis. Is it possible?!

– Yes, we launched an appropriate clinical study. There are no final results yet, but we have developed clinical practice.

“What did you do to save the lungs?”

– We used a combination of bromhexine and spironolactone (both are long-known very cheap drugs. – Ed.). Bromhexine is an expectorant that has been prescribed to patients with pneumonia and cough for many years. At the same time, experimental data showed that this drug can block a specific enzyme and impede the penetration of coronavirus into cells. True, it was on this effect that we counted to a lesser extent in inpatients, since such an effect is important mainly in the early stages of the disease. But the expectorant effect of bromhexine really helps patients with COVID. I heard that our colleagues in Peter launched a study of bromhexine for prophylactic purposes. We will wait for the results.

Coronavirus infected 18 doctors from 220 employees of the hospital, there were no deaths among the medical staffPhoto: Ivan MAKEEV

FIBROSIS OBSTACLE

– The second drug – spironolactone – is traditionally widely used in cardiology for the treatment of heart failure, severe hypertension. It has a small diuretic, magnesium and potassium-preserving effect, continues Yana. Orlova. – It has several mechanisms through which it can be useful in coronavirus infection.

Firstly, a mechanism that prevents the development of fibrosis in general in the body. There are works that, in particular, show that spironolactone reduces fibrosis in the heart. At the same time, it is known that the tendency to fibrosis is not local, but systemic – where there is more inflammation, there will certainly be fibrosis. And we see, of course, fibrotic changes in the “covide” in our patients. Therefore, we prescribed spironolactone as a drug for the prevention of this process.

Secondly, this drug blocks sex hormone receptors, in particular testosterone. Some published studies suggest that “high-testosterone” men suffer from “covid” more often and develop more severe fibrotic changes. Therefore, blocking these receptors for several weeks during COVID treatment may be useful in reducing the severity of complications. We are not talking about a longer intake, since male patients are unlikely to agree with a decrease in testosterone levels in the long term.

And perhaps the most important point. In almost all of our patients, we observed hypokalemia (a decrease in potassium levels. – Ed.). With coronavirus infection, potassium is intensely excreted from the body, and scientific articles even suggest that hypokalemia serves as the trigger for a cytokine storm. So spironolactone has a real chance to reduce the risk of this dangerous complication. But the main thing, in my opinion, is that lowering the level of potassium in the body is extremely harmful to the heart and triggers life-threatening rhythm disturbances, increasing the risk of sudden death. We, like all others, replenished potassium with droppers, but it was more effective to retain it in the body with the help of spironolactone.


Men certainly get worse than women;  the elderly are heavier than the young;  overweight people are heavier than patients without excess weight Photo: Ivan MAKEEV

Men certainly get worse than women; the elderly are heavier than the young; overweight people are heavier than overweight patientsPhoto: Ivan MAKEEV

WHEN PRESCRIBED PATIENTS

– Yana Arturovna, how many patients did you have on average?

– About 10 – 14 days. But someone and 50 days.

– Have you noticed signs by which it can be assumed that the disease in the person brought is likely to go the hard way?

– Such studies were carried out in the world, our clinical practice confirmed them. Men certainly get worse than women; the elderly are heavier than the young; overweight people are heavier than overweight patients. Men with a classic male type of baldness, a lot of facial hair, we can say brutal men get sick harder.

– Under what conditions did you discharge patients?

– We acted as close as possible to the recommendations Ministry of Health: so that the temperature for three days was not higher than 37.5 degrees; so that C-reactive protein (an indicator of inflammation) is lower than 10 mg / l, and saturation, that is, the level of oxygen in the blood, is higher than 96%.

“HEAD OF EPIDEMIOLOGY DEPARTMENT OF ITSELF WORKED AT SANPROPUSNIK”

– How often do you get sick doctors and nurses?

– In the first month no one got sick at all. We have a very powerful epidemiological service. The head of the sanitary-epidemiological department, a senior researcher, correctly organized the whole process, and for the first two weeks she personally worked in the sanitary inspection room at the exit from the “red zone” and helped doctors and nurses who were exhausted after the shift safely remove protective clothing.

Then both people’s fatigue and viral load accumulated. By the middle of the second month, sick people began to appear. There were no seriously ill patients. We treated part of the staff in our observation, part of it was treated at home. In total, 18 people were infected from the medical staff (less than 10%).

– Doctors take something for prevention? Vitamins C, D, Zinc?

– I saw the recommendations of American nutritionists, they speak out positively about taking zinc, melatonin and vitamin C. There were somewhat conflicting data on vitamin D. But we did not give any such recommendations to our employees. We have all the prevention was associated with minimizing contacts and other measures of epidemiological safety.

Physicians are the heroes of our time.“If you think that you are special and that a pandemic will not affect you, you are deeply mistaken,” listen to what the doctors who are fighting with coronavirus say

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Prince William and Kate Middleton called Prince Harry a puppet Meghan Markle

When at the end of March, Prince Harry heard his father’s alarmed voice in the telephone, he immediately realized that something was wrong.

The 35-year-old Duke of Sussex, who escaped with his wife Meghan Markle from Britain first in To Canadaand then in USAheard the terrible news. Prince Charles, 71, said his coronavirus test was positive.

“Harry at that moment realized that Charles and the Queen would not be around forever. Harry’s biggest fear is not to be in Of England the moment his grandmother Elizabeth II dies. ”

On the last day of June, another book dedicated to the British royal family – War in the Royal Family: the story of the shocking breakup between Harry and Megan with the Windsor House – is being published. This time, her heroes were Prince Harry and Meghan Markle and Prince William and Kate Middleton. Authors Andy Tillett and Dylan Howard are trying to get to the bottom of the truth – which caused the Dukes of Sussex to refuse the rank of members of the British royal family.

Once in the USA and sitting in a luxury mansion in LosAngelesPrince Harry sank into depression. He is trying to find his salvation in yoga classes. But being eight thousand kilometers from the royal family, Harry feels guilty before his family for his flight to the States, especially now, when the threat of the coronavirus epidemic still hangs over the world.

“Megan assures Harry that when everything settles down, he will like their new life in Los Angeles. She plans a joint trip, tells him about the local polo club and how Harry will love surfing, ”the authors write, referring to a source surrounded by the Dukes of Sussex.

The refusal of Harry and Megan from the title of members of the royal family, which became known in January, not only upset Queen Elizabeth II, but also aggravated the already difficult relationship between the families of the two brothers. Prince William and Kate Middleton were indignant at learning about the decision of Harry and Megan, because of this they had doubled the “social burden” – attending official events.

“They consider it unfair that Harry and Megan can enjoy being part of the royal family without any effort,” the book says. – Kate is in a panic, not understanding how she will combine the additional burden with family chores.

At the same time, William and Kate immediately understood who Harry had contacted: 38-year-old Meghan Markle will skillfully manipulate her husband, who is known as far from the smartest man.

“They are sure that Megan treats Harry like a puppet,” says another person close to the royal family. “They accepted that Harry was lost for their family soon.”

Close friends Meghan Markle said that the American actress never planned to stay in Buckingham Palace. At her originally there was a plan – to return to the USA.

“Megan has always dreamed of her own brand – to be recognizable. But I don’t think that she married Harry only because of his surname and image, although this, of course, was a decisive factor, ”say close actresses.

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Ukrainian mayor burned the flag of Russia in front of the embassy in Kiev

The politician called the Russian Federation “the occupying country”

The Ukrainian mayor burned the flag of Russia in front of the embassy in Kiev. Photo: frame from the video from Artyom Semenikhin’s Facebook page

Resize text:

Head of the Ukrainian city Konotop, which is located on the border with Russian territory in the Sumy region, Artem Semenikhin burned the flag Of Russia in front of the diplomatic mission in Kiev. The politician posted a video with this misconduct on his page on the social network Facebook.

– I stand under the embassy of the “occupying country.” I do this in response to the Ukrainian blogger Tolik Shary, who recently released a video about me, in which he allegedly exposes me in something. I watched this video and realized that my greatest sin is that I once burned the flag of Russia when I was in the ATO (military operation in Donbass“, – commented on the actions of the video Artyom Semenikhin.

After that, the Ukrainian mayor, to the sounds of the anthem of his country, burned the Russian flag. Semenikhin arranged his “action”, being across the street from the Russian embassy. Moreover: in a commentary on the published video, the head of Konotop wrote threats against the Russian president. Representatives of the Russian embassy have not yet commented on this situation.

The Ukrainian mayor and before that distinguished himself with several anti-Russian actions. At the beginning of this year, the head of the city of IvanoFrankivsk Ruslan Martsinkiv said that he had consulted with a Konotop colleague, and they decided to install a statue near the Russian border in honor of the leader of the Organization of Ukrainian Nationalists * Stepan Bandera.

Earlier, the site kp.ru wrote that the Ukrainian journalist Ostap Drozdov confessed his hatred of Ukraine. He said that the only goal of his state is to be the antipode of Russia, “there is no other purpose for the existence of independent Ukraine”

* prohibited in the territory of the Russian Federation

SOURCE KP.RU

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Doctors compared mortality of COVID and other infections

On the page of the doctor and TV presenter Alexander Myasnikov interesting information about the situation with infectious diseases in the world was published on the social network. And in particular that rotavirus infection causes hundreds of thousands of deaths per year in the world. Is the familiar and familiar rotavirus more dangerous than the coronavirus? “KP»Understands together with the immunologist, expert in public health and international health care, candidate of medical sciences Nikolay Kryuchkov.

– Of course, in addition to COVID-19, there are many other dangerous diseases in the world and these are not necessarily infectious diseases. Let me remind you that mortality from cardiovascular diseases is in the first place, also high mortality is associated with oncological diseases, in particular, lung cancer, and, of course, infectious diseases are also often the cause of death. However, the threat of rotavirus infection today is greatly exaggerated, said Nikolai Kryuchkov.

How many people die from rotavirus?

According to pessimistic estimates provided by the World Health Organization, around the world in 2013, 215 thousand children under the age of five died from rotavirus infection. According to other data obtained in international studies, this is 122 thousand deaths in 2013.

– The situation since 2013 in terms of mortality from rotavirus infection has not changed much. I think here we can talk about 200 thousand deaths per year among children under five years of age. Half of the world’s deaths occur in five countries: India, Pakistan, Nigeria, Angola and Congo– emphasizes the immunologist Nikolai Kryuchkov. – In the media you can often find information that up to a third of deaths of children under five are caused by rotavirus. This is not true! The fact is that among all deaths of children under five years of age in the world, mortality from diarrhea accounts for about 8%, but among these 8% of deaths from diarrhea – from 25% to 30% are attributable to rotavirus. That is, it turns out about 200 thousand deaths of children under five years of age per year in the world, while more than 6 million children under five die in the world per year.

On the page of the doctor and TV presenter Alexander Myasnikov on the social network, interesting information was published on the situation with infectious diseasesPhoto: Ivan PROKHOROV

Is rotavirus disease relevant for Russia?

If you consider Europeyy region to which Russia, then the figures for mortality from diarrhea are lower than in developing countries. Mortality from diarrhea among children under five in Europe is 4% – 5% of all childhood deaths. About a quarter of them are rotavirus.

In Russia, according to WHO estimates, in 2013, 52 children under the age of five died from rotavirus infection, which is 0.3% of all other deaths of children under five years of age. Rotavirus infection is not the most common cause of death among children, and even more so among adults (the latter rarely die from rotavirus, so all statistics are data on the death of children – approx. Ed.).

– Rotavirus is a problem primarily in poor countries with a warm climate. For Russia, this is also a problem, but to a much lesser extent, ”said Nikolai Kryuchkov, a doctor. – It is important to emphasize that effective and safe rotavirus vaccines exist.

The incidence of rotavirus infection after the introduction of vaccination has decreased many times. In Russia, universal vaccination against rotavirus is not carried out, but, despite this, mortality is low, given that it is clear how to help such patients. The main thing here is replenishment of lost fluid and symptomatic therapy. Given these two factors — the availability of a vaccine and the development of affordable treatment — mortality from rotavirus is very low even among children from zero to five years old, not to mention adults. Among adults, these are isolated cases.

Who is worse: rotavirus or coronavirus?

According to epidemiologists, mortality (taking into account the number of deaths from the number of episodes of the disease) of rotavirus infection in the world is from 0.05% to 0.09%. This is comparable to mortality from seasonal flu. Yes, in the poorest countries it can reach up to 2%. However, in this case, only moderate to severe episodes are taken into account, and not all cases of rotavirus infection.

“With coronavirus infection, according to my most optimistic forecasts, the mortality rate in the world will be 2%,” says Nikolay Kryuchkov. – Let me remind you that now the mortality rate from COVID-19 in Russia is about 4%. AT Germany – 3.5%, and this is one of the best examples in Europe. Of course, a lot depends on how the data are kept and analyzed, but even though there are probably unaccounted cases, the mortality from coronavirus infection is much higher than the mortality from rotavirus. And the epidemic of coronavirus infection is still far from over.

“It is also important to understand that we are having a coronavirus pandemic, and the situation with rotavirus is under control.” The number of deaths from coronavirus is now growing, due to the fact that there is an increase in cases of infection. The daily increase in new cases of coronavirus infection in the world is more than 5%, and in Russia today it is more than 8%. Therefore, it is obvious that the situation with rotavirus is stable, and the coronavirus pandemic for us is not known how it will end. The coronavirus infection pandemic continues to grow, it is important to understand this, ”Nikolay Kryuchkov emphasized in a conversation with“ KP ”. – When we talk about the number of deaths from rotavirus, 200 thousand people a year around the world among children under five years of age are deaths that happened in a year! As we know, the coronavirus epidemic lasts about four months. This is significantly less than a year.


The daily increase in new cases of coronavirus infection in the world is more than 5%, and in Russia today it is more than 8% Photo: Ivan MAKEEV

The daily increase in new cases of coronavirus infection in the world is more than 5%, and in Russia today it is more than 8%Photo: Ivan MAKEEV

How many deaths from coronavirus infection will be in a year (given that, according to the data of May 3, 243,922 people died in the world – approx. Ed.)? Yes, there are other dangerous infections in the world, but many of them can be protected. This is Hepatitis B, and pneumococcal infection, tetanus, and so on. And Dr. Myasnikov rightly points out the need for widespread vaccination against the most dangerous and common infections. Unfortunately, there are no vaccines from COVID-19 yet, they will be ready by the spring of next year at best.

Also, an important difference between the course of rotavirus infection and coronavirus infection: hospitalization with rotavirus disease in developed countries is very rare. All necessary treatment conditions can be provided at home. With coronavirus, the patient often needs active therapy, which can only be provided in a specialized medical institution.

SPECIFICALLY

Dr. Myasnikov gives such statistics on mortality from infections (in the world for a year)

Measles (there is a vaccine) – 140 thousand deaths per year

Pneumococcus (there is a vaccine) – 2 -2.5 million deaths per year

Hepatitis B (there is a vaccine) – 650 thousand deaths per year

Tetanus (there is a vaccine) – 89 thousand deaths per year

Cervical cancer (there is a vaccine) – 250 thousand deaths per year

Tuberculosis (there is a vaccine) – 1.5 million deaths per year

Influenza (there is a vaccine) – 650 thousand-1 million deaths per year

Coronavirus (no vaccine) – 244 thousand deaths from the beginning of the spread

Coronavirus: myths and reality.The farther the coronavirus, the more truth and speculation around it. We tried to deal with the main myths about the Covid-19 pandemic

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roommate-tyrant for three years beat the star of the “Factory of stars” Julia Parshutu

Singer Julia Parshuta made a very personal and frank confession. The scandal prompted the star of the Star Factory to take this step, which erupted after two interviews with Regina Todorenko. Fans decided that the TV presenter considers women guilty of men raising their hands on them. Parshuta said that for three years she lived with a home tyrant and was afraid to leave her roommate because he threatened her and her relatives.

In 2010 Julia Parshuta fell madly in love with a handsome handsome man. As it seemed to her, the chosen one was the smartest, most caring and attentive. “He was an energetic scholar – a man who is always interesting and fun with. I fell in love without memory. This was the first time with me. He was wonderful. The first few months,” she said.

And then real hell began. The first time he beat her, Julia persuaded herself to forgive him. The tyrant roommate was kneeling and begging forgiveness. “My family never had physical abuse. Therefore, I did not know that it was not treated with a wise word and a meek look. That it should not be forgiven,” the girl said.

She suffered beatings for three years. “In March 2013, a week after an appendectomy, on Nizhnyaya Syromyatnicheskaya street I got hit in the stomach with my fist, “decorated” with the stitches of the operation. A stab in the stomach from his man. Another blow, and only God knows which is the bill for our life together, “Julia Parshuta began her confession.

After that, the man took her phone, bag and car keys. But the girl still ran away from him to her friend. “Having come in, I asked her for water and said that my bag was stolen from me. And with all my strength I showed that everything was fine with me. The third year of our relationship was on. In fact, the third year in a box of fear and despair. Without the ability to search and find protection and exit, “writes the 32-year-old artist.

She also explained why before that she did not dare to leave Tirana. “He was strong. Very. It was the third year of “I-guilty-in-everything”, the third year of “I-worthless”, the third “I-not-for-nothing-capable” year. Because it was the third year I was intimidated to the bone. The third year, as the veil of hopelessness grew stronger from his threats. Because threats are not just me. The threat “I will cut your family” and “to you … if you go to the police”, ”the Star Factory participant shocked with revelation.

Parshuta stressed that for a long time she could not find the strength to admit that she was a victim of domestic violence. The actress urges women not to be silent about the beatings and are not afraid of conviction. “Talking about violence should not be embarrassing,” she summed up.

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