very cheap and long-known drugs help save the lungs with coronavirus

Cloving hospital on the basis of the Medical Scientific and Educational Center (ISSC) Moscow State University named after M.V.Lomonosov took the first patients on April 21 and completed his work on June 13. It turned out that it was possible to achieve the best treatment results for COVID-19 in Moscow. Over the entire period, 4 patients died, and among severe patients who got mechanical ventilation, the mortality rate was less than 14% (for comparison, the average for the city and the world was up to 70 – 80%). Eighteen doctors out of 220 employees of the hospital were infected with coronavirus, there were no deaths among the medical staff.

What approaches were used at the University Hospital of Moscow State University to achieve such results? We continue the conversation with the head. Department of Therapy, Faculty of Fundamental Medicine, Moscow State University, Head of the Department of Age-Associated Diseases, Medical Scientific and Educational Center, Doctor of Medical Sciences, Cardiologist Yana Orlova.

MEDICINE FOR COUGH FOR 80 RUBLES

– Most of those who are ill or are afraid to get sick are worried about fibrotic changes in their lungs. They say that you have developed special therapy that can reduce the risk of developing fibrosis. Is it possible?!

– Yes, we launched an appropriate clinical study. There are no final results yet, but we have developed clinical practice.

“What did you do to save the lungs?”

– We used a combination of bromhexine and spironolactone (both are long-known very cheap drugs. – Ed.). Bromhexine is an expectorant that has been prescribed to patients with pneumonia and cough for many years. At the same time, experimental data showed that this drug can block a specific enzyme and impede the penetration of coronavirus into cells. True, it was on this effect that we counted to a lesser extent in inpatients, since such an effect is important mainly in the early stages of the disease. But the expectorant effect of bromhexine really helps patients with COVID. I heard that our colleagues in Peter launched a study of bromhexine for prophylactic purposes. We will wait for the results.

Coronavirus infected 18 doctors from 220 employees of the hospital, there were no deaths among the medical staffPhoto: Ivan MAKEEV

FIBROSIS OBSTACLE

– The second drug – spironolactone – is traditionally widely used in cardiology for the treatment of heart failure, severe hypertension. It has a small diuretic, magnesium and potassium-preserving effect, continues Yana. Orlova. – It has several mechanisms through which it can be useful in coronavirus infection.

Firstly, a mechanism that prevents the development of fibrosis in general in the body. There are works that, in particular, show that spironolactone reduces fibrosis in the heart. At the same time, it is known that the tendency to fibrosis is not local, but systemic – where there is more inflammation, there will certainly be fibrosis. And we see, of course, fibrotic changes in the “covide” in our patients. Therefore, we prescribed spironolactone as a drug for the prevention of this process.

Secondly, this drug blocks sex hormone receptors, in particular testosterone. Some published studies suggest that “high-testosterone” men suffer from “covid” more often and develop more severe fibrotic changes. Therefore, blocking these receptors for several weeks during COVID treatment may be useful in reducing the severity of complications. We are not talking about a longer intake, since male patients are unlikely to agree with a decrease in testosterone levels in the long term.

And perhaps the most important point. In almost all of our patients, we observed hypokalemia (a decrease in potassium levels. – Ed.). With coronavirus infection, potassium is intensely excreted from the body, and scientific articles even suggest that hypokalemia serves as the trigger for a cytokine storm. So spironolactone has a real chance to reduce the risk of this dangerous complication. But the main thing, in my opinion, is that lowering the level of potassium in the body is extremely harmful to the heart and triggers life-threatening rhythm disturbances, increasing the risk of sudden death. We, like all others, replenished potassium with droppers, but it was more effective to retain it in the body with the help of spironolactone.


Men certainly get worse than women;  the elderly are heavier than the young;  overweight people are heavier than patients without excess weight Photo: Ivan MAKEEV

Men certainly get worse than women; the elderly are heavier than the young; overweight people are heavier than overweight patientsPhoto: Ivan MAKEEV

WHEN PRESCRIBED PATIENTS

– Yana Arturovna, how many patients did you have on average?

– About 10 – 14 days. But someone and 50 days.

– Have you noticed signs by which it can be assumed that the disease in the person brought is likely to go the hard way?

– Such studies were carried out in the world, our clinical practice confirmed them. Men certainly get worse than women; the elderly are heavier than the young; overweight people are heavier than overweight patients. Men with a classic male type of baldness, a lot of facial hair, we can say brutal men get sick harder.

– Under what conditions did you discharge patients?

– We acted as close as possible to the recommendations Ministry of Health: so that the temperature for three days was not higher than 37.5 degrees; so that C-reactive protein (an indicator of inflammation) is lower than 10 mg / l, and saturation, that is, the level of oxygen in the blood, is higher than 96%.

“HEAD OF EPIDEMIOLOGY DEPARTMENT OF ITSELF WORKED AT SANPROPUSNIK”

– How often do you get sick doctors and nurses?

– In the first month no one got sick at all. We have a very powerful epidemiological service. The head of the sanitary-epidemiological department, a senior researcher, correctly organized the whole process, and for the first two weeks she personally worked in the sanitary inspection room at the exit from the “red zone” and helped doctors and nurses who were exhausted after the shift safely remove protective clothing.

Then both people’s fatigue and viral load accumulated. By the middle of the second month, sick people began to appear. There were no seriously ill patients. We treated part of the staff in our observation, part of it was treated at home. In total, 18 people were infected from the medical staff (less than 10%).

– Doctors take something for prevention? Vitamins C, D, Zinc?

– I saw the recommendations of American nutritionists, they speak out positively about taking zinc, melatonin and vitamin C. There were somewhat conflicting data on vitamin D. But we did not give any such recommendations to our employees. We have all the prevention was associated with minimizing contacts and other measures of epidemiological safety.

Physicians are the heroes of our time.“If you think that you are special and that a pandemic will not affect you, you are deeply mistaken,” listen to what the doctors who are fighting with coronavirus say

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Trump ridiculed Biden for the assumption of his betrayal in favor of Russia

US President Donald Trump criticized his Democratic rival in the upcoming Democratic head of state, Joe Biden, who accused the White House owner of betraying the US military.

Earlier, the newspaper The New York Times (NYT) wrote about an investigation of US intelligence: they allegedly learned that Russia secretly offered rewards to the Taliban supporters (banned in the Russian Federation) for the killing of the US military in Afghanistan. Mr. Biden said that if the article on Russian intelligence contacts with the Taliban is true, then Donald Trump, knowing this, betrayed the US military. Mr. Trump himself called the publication in NYT a fake. The Russian Foreign Ministry also called the information fake.

“It’s ridiculous to watch the venal Joe Biden read out a statement about Russia, clearly written by his curators. Russia furnished him and Barack Obama when they were in power so badly that Obama wanted to remove them from the G8. The USA was weak in everything, and especially with Russia! ” Mr Trump tweeted.

According to NYT interlocutors, Russia’s actions relate to 2019. In 2019, 20 US troops died in Afghanistan, but it is not known which sources were killed to reward Russia, sources add. US intelligence concluded that Russia was involved in these killings, in particular, based on interrogations of captured terrorists and criminals, the newspaper writes, without giving details.

Earlier, the White House announced the “inaccuracies” of the published material and reported that the presidential administration was not aware of intelligence from the US intelligence agencies. Journalists claimed in a publication that the actions of Russia in Afghanistan were reported to the Donald Trump administration several months ago.

The Taliban also denied the information presented in the newspaper. The Russian Embassy in Washington announced unfounded and anonymous allegations that led to threats against Russian diplomats.

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Does not wash the dishes. Things are not erased. Tatyana Plaksina went to terrorize her father?

Assumption daughter flew to the USA, where she behaves disgustingly

As soon as Tatyana Plaksina flew to her father, everything in her life changed dramatically, as did Ouspensky. Tatyana while she lived with her mother spoke a lot about the famous mother throughout the country, and after that, she began to apologize to her for all that was said. Subscribers suspected that the girl made Uspenskaya apologize, since Plaksina read everything from a sheet of paper and, as they say, she read it without a soul. Due to the fact that Love makes her do what she does not like, Tatyana ran away to her father in the USA 2 months ago. Everything would be fine, but at one point the girl, communicating with subscribers, forgot to turn off the live broadcast. And everyone heard how the father was trying to negotiate with his daughter, he asked if the cleaning lady would be able to clean the room.

Tatyana only hysterically shouted that she did not want to talk to him and her jaw hurt. And also, if she does not play her music, she will die. Alexander Plaksin patiently reassures his daughter, but to no avail. The girl doesn’t wash things, doesn’t wash dishes, she doesn’t even allow her to enter her room. Alexander referred to the fact that guests would come, and Tatyana began to twist and ask questions that the navel of land would come. Apparently, the father is still suffering with a nervous and not obedient daughter. Ouspenskaya feels very badly, despite the fact that she tried to forget herself through work, she does not succeed. We can conclude that Tatyana brought her mother to white heat, and went to terrorize her father.

Vlad Usacheva

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Massachusetts has planned a pandemic for years. Here is what is expected. – NBC Boston

Flatten the curve.

You have probably heard public health officials repeat this phrase as they announce major cancellations and closures related to the new coronavirus pandemic.

So what exactly does that mean? And what can you do to help?

The “curve” refers to exponential growth in new cases that could occur if the virus can spread uncontrollably in the community.

A sharp spike in COVID-19, the disease caused by the virus, could bring a stream of new patients, many of whom would need intensive care. Experts say the scenario would have overwhelmed the health system, making it more difficult to make life-saving treatments for all sick people.

The director of the National Institute for Allergies and Infectious Diseases, dr. Anthony Fauci explains social distancing and how it can help slow the spread of coronavirus in elderly and immunocompromised patients.

That’s why it’s imperative to stop the transmission of the virus and slow it down in the coming weeks, said Dr. Davidson Hamer, an infectious disease specialist at the University of Boston School of Public Health.

Even if the same number of people contract the virus, doctors and nurses will have a greater chance of saving lives if the cases spread over a longer period of time.

“If there is a big wave all at once, then hospitals could run out of beds, run out of negative pressure rooms,” he said. “You know, if there are many patients on fans, potentially even running out of fans.”

State leaders have yet to indicate what could be a spike in COVID-19 cases in Massachusetts. In a press conference last week, Health and Human Services Secretary Marylou Sudders said the state is now busy planning scenarios for “what could happen in Massachusetts.”

Governor Charlie Baker has announced that Massachusetts has established a command center for coronavirus response. Recognizing the empty shelves seen around Commonwealth food stores, he told people that there is no need to accumulate food.

The Massachusetts Hospital Association has forwarded NBC10 Boston’s questions to the Department of Public Health, which has not yet responded to requests for information on the state’s hospital capacity.

But previous state projections shed light on how serious a public health emergency in the Bay State can be.

In a 2006 flu pandemic preparedness plan, Massachusetts public health officials predicted that as many as 2 million people would fall ill following the emergence of a new respiratory disease.

Using the modeling developed by the U.S. Centers for Disease Control and Prevention, the state predicted that over 1 million people would have to be treated on an outpatient basis, based on the most likely scenario of how the pandemic would spread across the globe. state. The model predicted that over 80,000 people would have to be treated in a hospital and up to 20,000 could die, in part because the hospital system would be overwhelmed by a flood of cases.

As part of the preparation planning, public health officials in Massachusetts asked hospitals across the state to negotiate agreements to use other large facilities in their region, such as high schools and arsenals, such as so-called “alternative care sites”. The state plans to touch those facilities to treat patients with less severe cases of theoretical disease, allowing hospitals to focus only on the sickest patients.

Importantly, the new coronavirus that now plagues people around the world may not follow the same trajectory as that shown in the state’s projections. These numbers were based on the assumption that 30 percent of the population would contract the virus. This figure may be higher or lower as researchers collect more data on the virus causing COVID-19.

The president and vice president told the public that anyone who wants a test can get one, but dozens of people have contacted NBC10 Boston investigators to say it wasn’t their experience, including a chemotherapy patient.

Massachusetts’ population has also increased since the state made its forecasts, going from about 6.4 million in 2006 to about 6.9 million today.

Emergency measures put in place by Governor Charlie Baker and others could also mitigate the spike in the epidemic, Hamer said, drastically reducing the number of patients who need treatment simultaneously and potentially saving lives.

“If social distancing and personal hygiene and work at home and all these types of strategies don’t work and we have a very large number of cases in a short period of time, I think it could overwhelm the health care system,” he said.

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Fight between inmates so that Ronaldinho chooses which team he plays on

Paraguay entered the phase of anticipated fear of the coronavirus. In supermarkets, consumers dispute hygiene products as if the end of the world is coming. The Police Specialized Group is, meanwhile, the scene of another controversy in Asunción. The inmates dispute to Ronaldinho on their soccer teams. Villa Real, Pira Guasu, Halcones, Chacarita, Sport Espada, Sport Pitufo and Negro Cumbiero, made up of inmates and even uniformed personnel, want to have the presence of the former Barcelona star. What is at stake is more than honor: a 16 kilos pig to share among the players. “Dinho” could help them reach the delightful trophy and take a consecratory Olympic lap in the perimeters of the penitentiary.

The youngest claim their presence and leadership, albeit briefly, because they know that the Brazilian’s team of lawyers is seeking the Supreme Court to grant him the house arrest to wait in a mansion asunceña the trial for having entered the country with fake passport along with his brother. The largest inmates adhere to the internal regulations of the Special Unit and, according to the Paraguayan press, maintain that, in case of participating in futsal matches, Ronaldinho will only be able to do so with the over 35 years, like him, who is close to reaching four decades.

Beyond each other’s fantasies, Commissioner Blas Vera, in charge of the Specialized Association, estimates that the star prisoner will prefer to stay in his VIP cell, with television and an air conditioning that mitigates heat and humidity. “I don’t think he participates because right now it is not very good emotionally, “said the officer.

In this context, it was learned that the people who processed the adulterated documents of Ronaldinho, his brother Roberto de Assis Moreira and the Brazilian businessman Wilmondes Sousa Lira, paid $ 6,000 to materialize each lie. Meanwhile, the new director of Migrations, Ángeles Arriola, denied that the former world champion tried at some point to obtain residence in Paraguay, as the defense alleged, when requesting house arrest.

The Prosecutor’s Office raided this Friday the mansion of the businesswoman Dalia López, who was linked to the scandal. López, with fluid contacts with the Paraguayan political world, is a fugitive from justice. The police went to look for his luxurious property. Among the “evidences & rdquor; they took are between 4,000 and 6,000 balls with the smiling face of Ronaldinho Gaúcho.

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Ronaldinho, tenant of the Quadrilateral, dungeon of drug traffickers and politicians

Ronaldinho’s smile darkened behind bars. The former star of Barcelona was left without the possibility of fulfilling the pretrial detention in a mansion from the Paraguayan capital. Judge Gustavo Amarilla rejected the request for outpatient freedom or house arrest requested by the seven defenders of the former soccer player and his brother Roberto Assis Moreira. The lawyers had offered an 11-hectare house valued at more than 900,000 euros as the place of temporary detention while their case is being processed.

“The prosecution expressed its opposition. The amount is not enough of the property that he offered to the defender, attending the economic solvency of the exfutbolistto. Also a week ago the investigation began and the cause has a great magnitude for the complicity of public officials, businessmen. “According to Amarilla,” we are faced with an expectation of deprivation of liberty of up to five years“.

The magistrate also considered that if Ronaldinho left the cell of the Specialized Police Group there was a danger that he would flee the country. Everything seems to indicate that the 2002 world champion with Brazil will have to get used to the limits imposed by “the Quadrilateral”, as the sector located on the top floor of the building where they are also enclosed is known drug traffickers, police and politicians accused of corrupt acts.

A movie leak

The Paraguayan prisons are under strong suspicion since the cinematographic escape in January of the Pedro Juan Caballero prison in Paraguay. Seventy-six inmates, some of them belonging to the Brazilian criminal group First Capital Command (PCC), they left the prison through a tunnel while others left through the same door.

In a prison universe crossed by the underworld, Ronaldinho spends his nights. “Seeing an idol like that hurts“said President Mario Abdo Benítez. The case shakes the right-wing government. Benítez said during an interview that he ordered a thorough investigation to the questioned Interior Minister, Euclides Acevedo. “We have to know the truth“complained the president.

The truth can bring problems. Prosecutor Federico Delfino confirmed the arrest of four officials of the National Directorate of Civil Aviation and Migration. The new director of that unit, Ángeles Arriola, said she wants to know if there was a “order from above” which facilitated the entry into Paraguay of Ronaldinho and his brother with forged passports. “I would love to know why they acted that way. Could it be that they got scared?” He asked about the attitude of the officials.

Dalia López, the businesswoman who hired the former player, is reluctant to appear before the judge. It is suspected that López, with close contacts with the Paraguayan political world, played an important role in the preparation of false documents. “The authorities are stuck in this until the neck“said his lawyer Marcos Estigarribia.

Business without clarification

Ronaldinho landed in Asunción on March 4. He claimed to have been invited only for one Charity event and to participate in the launch of a casino. “However, witnesses confirmed that he wanted do business in Paraguay and so they were managing their documents, “the newspaper ‘ABC’ published.” There are still open questions in this grotesque affair who has already gone around the world, to the derision of honest Paraguayans, “he said in his editorial on Tuesday.” It is hard to believe such folly, even though lawyer Adolfo Marín has qualified as “dumb” to his defendant Ronaldinho“.

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