D + A: Australia will change the coronavirus test criteria, says medical agent Paul Kelly, while dr. Norman Swan slams the slow response

Posted

March 24, 2020 2:45:15 AM

Australian Deputy Chief Medical Officer Paul Kelly announced on Q + A that new protocols that determine who can be tested for COVID-19 will be announced in the coming days.

Key points:

  • The test criteria will shift from those who have recently traveled to others with symptoms
  • Authorities urged to consider smartphone apps and open data to track the spread of coronavirus
  • The deputy medical director denies that the main ICUs will soon be able to at the current rate of spread

Monday’s Q + A episode was dedicated to the discussion of the coronavirus crisis and featured ABC’s Dr. Norman Swan, Australian deputy chief medical officer, Professor Paul Kelly, and the leading infectious disease expert, Professor Sharon Lewin. As in the past few weeks, the episode was shot without a studio audience.

The government’s response to the coronavirus epidemic was put under a microscope when Senator Rex Patrick, the fourth Australian politician to have a confirmed case, appeared via video link.

The South Australian senator, quarantined over the past eight days, said that he was most likely infected by liberal Senator Andrew Bragg during an investigation into the Senate, in which Senator Bragg was showing flu-like symptoms.

Senator Patrick asked Professor Kelly why Senator Bragg could not have been tested earlier; the current testing regime limits the tests to those who have traveled abroad within 14 days of the onset of symptoms or come into contact with that person.

“He had flu-like symptoms but did not qualify for a COVID-19 test because he had not been in contact with anyone who was a known COVID-19 courier,” said Senator Patrick.

“A week later he realized others who had gone to a wedding he had been contracted with coronavirus, and at that point had qualified for a test.

“If he had been tested when he had symptoms for the first time, I would not have spent eight days working in the country of South Australia.

“Why are the test criteria so strict? Can you see how 10 minutes two weeks ago could have saved so much time and significantly reduced someone’s risk of infection?”

Professor Kelly initially rejected the application, saying that the marriage in question was a “super-spread” event and that the virus is more contagious than the flu.

But when host Hamish Macdonald pushed Professor Kelly to be more direct, his host announced that changes to the test protocol were imminent.

“We will remove the traveler component, but we are currently working on it,” said Kelly.

“There will be announcements about it in the coming days.”

Professor Kelly indicated that the authorities were investigating many measures in terms of how to respond to the current crisis.

Australia must “overcome the fear of data”

The show opened with Professor Kelly saying that health authorities in Australia “have been preparing for a pandemic like this for many years.”

It was a comment that soon returned to bite him.

After a spectator called to condemn what he considered lax control measures at Australian international airports, Singapore’s response was discussed.

There, the government is monitoring the movement of potential cases using a smartphone app with Bluetooth functionality.

Macdonald asked Professor Kelly: “Why aren’t monitoring and apps something you already have at your disposal?”

Professor Kelly said that apps were a tool available to the government, but were cut by dr. Swan.

“I’m sorry, do you already have that technology at your disposal?” Asked Dr. Swan.

“Well, we all have cell phones and location services are on cell phones – these are difficult decisions to make in terms of people’s privacy,” said Professor Kelly.

Dr. Swan was far less than satisfied.

“Paul, you didn’t introduce these technologies. Singapore has,” said Dr. Swan.

“You have had weeks to introduce these technologies and they have not yet been implemented.

“We should test every single person who comes out of one of these plans, because asymptomatic diffusion is what we have to worry about and at least you have a basis.

“You know if they get off the plane and are positive or not.

“The symptoms we have seen with Diamond Princess and South Korea are not a good sign of people who could spread the virus.

“Everyone who gets off an airplane or boat must be tested regardless of whether or not they have symptoms.”

Professor Kelly defended the trial measures and claimed to have done the job, especially when the Australians were returning from China because very few had proved positive.

It has been mentioned that in Taiwan they are also using smartphone apps to track data, including where people have been, and dr. Swan suggested that Australia forget about privacy issues and do the same.

“Taiwan’s big message is that they are shameless and embarrassed about the use of data, the linking of data and actually rather personal data for the public good,” he said.

“We are too nervous in Australia to connect, we connect some data but now we could take advantage of this opportunity to connect data on a large scale and be able to do something similar in Taiwan so we know what’s going on and we can actually measure things.

“We really have to overcome our fear of data.”

‘We are not in Italy’

Another key issue discussed was whether schools should be closed.

Prime Minister Scott Morrison has been against taking this step in recent days, despite having closed pubs, clubs and most of the places where people gather.

Professor Kelly said that if schools closed it would be “at least for the next six months, probably for the entire school year.”

Dr Swan said that modeling at Imperial College London shows that closing schools would help “flatten the curve”.

“Imperial College London Group found that closing schools … actually had the greatest effect,” said Dr. Swan.

The potential for “curve flattening” to relieve stress in Australia’s public health sector was another point of disagreement.

Dr. Swan said if the “hockey stick [trend line] it doesn’t change much … we will be out of ICU beds in New South Wales, Victoria will be behind us by April 10 “.

“And in that case, ICU doctors will face some very difficult decisions,” he said.

Asked if the prediction was accurate, Professor Kelly sifted through and said that ICUs could potentially triple their capacity.

He pointed out that Australia had no comparison with Italy, which had more COVID-19 deaths than anywhere else, with 5,476.

“We also have strategies to reduce pressure on the hospital system in a broad sense, not just for intensive care units,” said Professor Kelly.

“We are not in Italy. I have seen some people say when they look at the curves of what Norman refers to, the epidemiological curve that we are two weeks behind Italy.

“We are not two weeks behind Italy.

“We have tested and found many other mild cases.

“Italy has mainly tested the top of the pyramid, the very serious cases that have entered the hospital. This is what their first 1,000 were.

“Our first 1,000 were primarily community cases. Mainly involved with travel from abroad. We have had only 20 people during this entire period who have been in intensive care.”

What about a vaccine?

Professor Lewin, who is a leading expert in infectious diseases and committed to working on vaccines, said that a COVID-19 vaccine could arrive in “12-18 months”, but hoped more that treatments could be developed sooner. .

“We haven’t talked much about the treatments in public and I think they can play a very important role while we wait for a vaccine,” said Professor Lewin.

“We don’t have a specific treatment for the virus.

“People improve on their own or improve because they receive supportive care in the hospital.

“If we had a treatment, an antiviral drug that blocked virus replication could potentially do two things: it could potentially improve the outcome – people don’t get sick and don’t die – or even reduce the transmission because most of the transmission of virus is related to the amount of virus present on board.

“Just recently, we learned about one drug in particular.

“It is an arthritis drug. A very small but widely tested study that shows that the drug has reduced the amount of virus that we could measure in someone’s swab.

“We can actually measure the quantity accurately, and it certainly has decreased with this particular arthritis drug.

“One thing we might see in the not-so-distant future is a great understanding of the drugs that block replication and which could have implications for both the clinical outcome and how contagious you are.

“I’m a little optimistic about it.”

The health department clarifies the comments

At the end of the episode, the Department of Health released a statement explaining Professor Kelly’s comments on the test protocols.

“As we learn more about the virus, we have continued to review the test criteria,” said a spokesman.

“In light of our stronger travel restrictions, attention logically shifts to the community with COVID-19 symptoms, in addition to returning travelers and close contacts in the cases.

“Professor Kelly has reported that the CDNA will change the testing guidelines for public health units in the near future.”

Themes:

Health,

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breathing problems,

Australia

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Coronavirus: Australian hospitals running out of masks

  • 15 million Australians could catch the virus in a few months
  • Shock therapy of angry teachers in the fight against viruses in schools

The multi-billion dollar Coronavirus economic response package received the final tick of approval in the House of Representatives around 11pm Monday evening.

Treasurer Josh Frydenberg said that the economic measures, described as the most significant since wartime, were designed to build a bridge to recovery from the other side of the virus.

“We know that the economic situation has deteriorated over the days,” he said at a late night press conference in Parliament.

“The Australian people can be sure that their parliament has reached political division tonight.

“We face an enemy who has no flag and has no face.

“We must deploy every weapon in our arsenal to defeat it.”

The treasurer said he expected around one million Australians to receive the coronavirus supplement.

DENIED FACE MASKS OF AUXILIARY HOSPITALS FROM STOCKPILE

Eighty Catholic hospitals that supply 10% of the nation’s public hospital beds are running out of masks, gloves, clothing and other protective equipment, while COVID-19 extends the system.

Catholic Health Australia calls on the Morrison government to urgently release stocks of personal protective equipment (PPE) to hospital staff – some of whom have a supply of less than a week – as the stocks in its network reach extremely low levels.

People lined up for coronavirus tests at Royal Melbourne Hospital. Image: Tim Carrafa
media_cameraPeople lined up for coronavirus tests at Royal Melbourne Hospital. Image: Tim Carrafa

The Catholic network employs tens of thousands of nurses and clinical staff.

“Requests from Catholic hospitals to access stocks of clothing, masks and gloves have been met with confusion, the passage of dollars between states and the Commonwealth and even a diktat that supplies supplies will only be released to publicly owned hospitals” Pat Patcia, CEO of Catholic Health Australia said.

The COVID -19 clinic at St Vincent's Hospital in Sydney, Australia. Image: Getty Images
media_cameraThe COVID -19 clinic at St Vincent’s Hospital in Sydney, Australia. Image: Getty Images

Nearly one in ten public hospital beds are in Catholic hospitals, but because they are not directly owned by the state, they are denied access to supplies, he said.

In some cases, stocks of personal protective equipment in Catholic hospitals would run out in less than a week, prompting Mr. Garcia to write to state, territorial and federal health ministers warning of the impending shortage.

“We can’t have a situation where thousands of doctors and nurses treat unprotected people – it’s a shocking situation for patients, staff and the community in general. We need every weapon in our arsenal to fight coronavirus and masks, clothes and gloves are the bases. It would be like sending our fireworks to fight fires without trucks. “

Garcia said that Catholic hospitals are conducting clinical trials, treating COVID-19 patients and increasing the capacity in their emergency departments and departments to relieve pressure on public hospitals.

“We are working with all members of the wider healthcare network to combat this virus. All we ask for is the same access to the public network and a clear and efficient way for our staff to obtain supplies of PPE (personal protective equipment) in a timely manner. ) “.

People are seen in a long line outside a Centrelink office in Melbourne's Abbotsford. Image: AAP
media_cameraPeople are seen in a long line outside a Centrelink office in Melbourne’s Abbotsford. Image: AAP

The general manager of the group of San Giovanni di Dio, dr. Shane Kelly, who runs 17 hospitals in Western Australia, Victoria and New South Wales, said time is running out.

“Starting today, if I can’t get more PPE titles, some of my hospitals will end in a week. To protect nurses, doctors and other health care workers and help reduce infections, we need sufficient supplies of gloves, clothes and masks to continue operating and we are not getting the right information on how we can access the inventory.

“We have tried to do everything we can to manage supplies, but we cannot and will not compromise the safety of our staff and ultimately of our patients,” he said.

GYMS CLOSED: CAN I RESET MY REGISTRATION RATES?

Two of Australia’s leading gyms will freeze member payments after the federal government has expanded its blockade.

Prime Minister Scott Morrison announced on Sunday that non-essential services, including hospitality venues, places of worship, cinemas and gyms, would be closed in an attempt to stop the spread of the deadly coronavirus.

In a Facebook statement, Goodlife Health Clubs said that its gyms would be “temporarily closed” nationwide and that an “automatic block” had been placed on members. He said it would provide members with “a whole range of online training content”.

Fitness First also used social media to warn that customer signups had been blocked, adding that it would provide members with home training materials.

News Corp asked Fitness First, Goodlife Health Clubs, Jetts Fitness Australia, Anytime Fitness, Zap Fitness, Virgin Active and F45 directly about whether members will have the option to cancel their contracts in advance, if a refund will be offered to members. who paid in advance and whether clubs will face permanent closure if the ban lasts at least six months.

Mount Waverley's Muscle City gym is seen empty after the gyms are forced to close. Image: Getty
media_cameraMount Waverley’s Muscle City gym is seen empty after the gyms are forced to close. Image: Getty

Fitness Australia is seeking clarifications on the time of the closings, which will remain in effect until midnight on April 13th, but may be extended.

Fitness Australia is seeking clarifications on the time of the closings, which will remain in effect until midnight on April 13th, but may be extended.

Simon Thompson, an executive officer of the collective wellness group that is responsible for the Anytime Fitness franchises, told News Corp that he was working with clubs to find a solution.

“Yesterday, the government announced a temporary shutdown of non-essential services, including gyms, starting at noon today, Monday 23 March 2020, which subsequently led to the temporary shutdown of all Anytime Fitness Australia clubs,” said Thompson. in a note.

In light of this, we are working closely with our individually owned and managed partners to find the best solution for our 560,000 members. At this stage, our priority is to inform our members directly and we hope to confirm the next steps as soon as possible. “

Earlier, the CEO of Fitness Australia, Barrie Elvish, said in a statement: “It is not yet clear whether the services offered in the fitness sector can continue to function.

“For example, can a PT (personal trainer) continue to train a client indoors in a 1: 1 environment provided that all social distance measures are in place? Or can these services only be offered outdoors? “

The sector body is also looking for clarifications on the closure deadline, which will remain in force until midnight on April 13th, but could be extended.

It was vital that people continue to remain active during social distancing, he said.

“Staying active during a period of isolation and uncertainty is extremely important for our mental health and as an industry, it is our mission to ensure that people can continue to exercise safely,” he said.

HUNTING FOR CRUISE PASSENGERS

The hunt for potentially infected passengers aboard Princess Ruby was handed over to the military with Defense personnel sent to COVID-19 civilian coordination centers across the country.

The cruise ship Ruby Princess obtained permission to dock and disembark in Sydney last Thursday, despite the results of ongoing tests on those showing coronavirus symptoms.

Passengers were allowed to disperse nationally and it has since been confirmed that there were 2,700 infected people on board; it is one of the five cruise ships that docked in Australia with the crates they could land on board.

Defense confirmed that staff from the reconnaissance and planning support teams have been incorporated into COVID-19 civilian coordination centers in New South Wales, Victoria, Queensland, Northern Territory and Western Australia.

They are tracking passengers on those ships in each state with additional staff waiting for a call.

Cruise ship passengers disembarked from Princess Cruises' Ruby Princess at Circular Quay on Thursday. Image: AAP
media_cameraCruise ship passengers disembarked from Princess Cruises’ Ruby Princess at Circular Quay on Thursday. Image: AAP

The deployment adds to the dozens of staff who provide clinical and epidemiological support to national health operations and even to the production of facial masks and hand sanitizers.

Defense Minister Linda Reynolds said the teams are contributing to the “overall strength and resilience of the Australian health system in this difficult time”.

“These ADF teams will provide logistical, transportation, healthcare and general planning assistance as the workload of civilian medical teams continues to increase as more Australians are diagnosed or affected by COVID-19,” he said. Senator Reynolds.

“The defense continues to follow the advice of the Australian health authorities in prioritizing its support arrangements.

Nine Defense staff members have been diagnosed with COVID-19 including six in New South Wales.

The death toll rises in Europe

Spain extended its blockade until after Easter as the country’s death toll rises, with health workers representing 12% of the total coronavirus cases.

The Spanish government warned that the worst was “yet to come”, as nurses and doctors are bearing the brunt of the outbreak there, which has reported nearly 30,000 infections.

Further tests were expected to increase that number again, with Spain becoming the new epicenter as it followed Italy’s deadly path.

A conference center in Madrid was being set up as a makeshift military hospital, with images showing structures similar to some of the hospitals used during the Spanish flu in 1918.

A man wearing a protective mask collapses in Rome. Image: Getty
media_cameraA man wearing a protective mask collapses in Rome. Image: Getty
Medical staff assists man. Image: Getty
media_cameraMedical staff assists man. Image: Getty

Spanish Prime Minister Pedro Sanchez said: “Unfortunately the number of diagnosed cases will increase in the coming days.

“The worst is yet to come and is pushing our capabilities to the limit.”

The death toll in Italy rose yesterday with 651 more deaths, bringing the total to 5476, while the country desperately tries to extend its blockade to prevent further outbreaks.

Health workers facing the coronavirus crisis cheer in exchange for police cheers outside Bellvitge hospital near Barcelona. Image: AFP
media_cameraHealth workers facing the coronavirus crisis cheer in exchange for police cheers outside Bellvitge hospital near Barcelona. Image: AFP

The death toll announced on Monday in Australia (Sunday local time) was less than nearly 1000 dead on Saturday local time, but it was too early to tell if the virus had peaked.

The head of the Italian civil protection service Angelo Borrelli, who manages the country’s response, was cautious that the blockade in progress since March 8 was starting to work.

“The figures announced today are lower than yesterday’s,” he said.

“I hope and we all hope that these figures can be confirmed in the coming days. But don’t let your guard down. “

The UK will appeal to the army to deliver parcels of food to up to 1.5 million people while asking sick, vulnerable and elderly people to stay home for 12 weeks.

The UK was sending letters to people over 70 and others considered at risk asking them to stay home.

Passengers stop on an underground Central Line train at Stratford station, East London, despite guidelines for social distance. Image: AFP
media_cameraPassengers stop on an underground Central Line train at Stratford station, East London, despite guidelines for social distance. Image: AFP

He will also be offered help with army-coordinated food and medicine spills if they don’t have a support network to keep them going.

British Prime Minister Boris Johnson said the UK must step up its measures, but stops at a complete blockade with police patrolling the streets.

French army soldiers set up tents while building a military hospital in Mulhouse, eastern France. Image: AA)
media_cameraFrench army soldiers set up tents while building a military hospital in Mulhouse, eastern France. Image: AA)

In France, the first doctor died when the toll hit 674, with nearly 16,018 cases in which the terrible toll rose 112 in one day.

The country has ordered 250 million masks as it tries to slow the epidemic.

There were 1,746 coronavirus patients in intensive care, with 35% of those under the age of 65, who had broken theories that it was a disease that only affected the elderly.

Germany has banned meetings of more than two people, with the exception of families, since her chancellor Angela Merkel entered quarantine after being treated by a doctor who has the coronavirus.

Passengers at a subway station in Shanghai. Image: AFP
media_cameraPassengers at a subway station in Shanghai. Image: AFP

Merkel was told of her doctor’s positive test after holding a press conference, raising concerns that she might have spread the virus if she had also been infected. Hairdressers in Germany will also close now, with new penalties in place for at least two weeks. Germany has almost 24,000 cases but a mortality rate of only 0.3 percent.

India has 396 cases, but it is feared that up to 300 million will contract the disease if it manages to take over the second most populous country in the world.

In Pakistan, telephone companies exchanged ringtones when people called for warning messages on COVID-19, while doctors and nurses posted images of bruises on their faces from protective equipment during patient treatment.

Pakistan has 730 cases so far, but there were concerns about a higher death toll due to the country’s already struggling health system compared to western hospitals.

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Coronavirus: no “indiscriminate test”, chain breaking is the key, says Govt | India news

NEW DELHI: After extending its testing policy to all hospitalized patients with pneumonia or severe flu symptoms, the government said that its strategy remained adequate and “indiscriminate testing” was not necessary since isolation and rupture of the transmission chain were the key to contain the spread of Covid-19 in India.
India’s approach to testing will remain largely focused on symptomatic cases with travel history or on those who have come in contact with positive cases. Travel history and home or institutional quarantine lists are, however, fairly large, although all international arrivals have been suspended until March 31, when the situation will be reviewed.
During a briefing on Sunday, the ministry of health and the Indian Council of Medical Research (ICMR) argued that there was no need for panic since government laboratories had the ability to test 50,00070,000 samples per week, apart from l further increase in capacity in private diagnostic laboratories. About 60 private laboratories have applied for authorization, which is granted. “Indiscriminate tests don’t have to be done. Isolation, isolation, isolation is the key to controlling spread, “said ICMR director general Balram Bhargava. India has so far tested over 17,000 samples, including 360 positive until Sunday. It is currently testing around 5,000 samples at week and the number is expected to increase with the involvement of private laboratories and wider test criteria.
Compared to India, other countries are testing more samples and most of them have not yet stopped transmission. According to Balram Bhargava, the United States was testing 26,000 samples per week, while France did 10,000 and the United Kingdom tested 16,000 each week. Only Indian government laboratories could make around 10,000 samples each day, said Bhargava. Bhargava said that those who were in isolation and showing symptoms should be tested.
The possibility remains that in many cases, up to 80% of the symptoms do not proceed beyond mild manifestations. Currently, 111 public labs are testing Covid-19 suspects, while 60 private labs have applied for ICMR for approval. The board has already started to register these labs, which will significantly expand the network of labs and collection centers. The government also set the maximum price for Covid-19 tests at Rs 4500 for private laboratories, urging them to do so for free or at reduced rates.
So far India has adopted a conservative approach to testing, arguing that unnecessary testing will not help, but will only spread panic and wasteful resources. In response to a question, Lav Agarwal, joint secretary of the ministry of health, said 1,200 fans had been ordained.
He also said that the rules on personal protective equipment were in force and had recently been revised. According to the current test protocol, all those with international travel history in the past 14 days should be quarantined and tested only when they are symptomatic of fever, cough or breathlessness. In addition, all direct and high-risk contacts, including those living in the same family and healthcare professionals who have come into direct contact with a confirmed case, should be tested once between day 5 and day 14 of making contact with a positive case.

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Explained: How far are we from COVID-19 drugs, from the vaccine?

Written by Abantika Ghosh
| New Delhi |

Updated: March 21, 2020 9:26:16 AM





coronavirus india, coronavirus treatment, coronavirus medicines, coronavirus vaccines, coronavirus The World Health Organization has announced SOLIDARITY, a multi-arm and multi-country clinical trial to seek the best treatment against COVID-19.

As the world defends itself against the new coronavirus, scientists are working around the world on the development of vaccines and therapies.

When can a drug or vaccine be expected?

The vaccine is still months away. In a recent interview with The Indian Express, the WHO chief scientist, dr. Soumya Swaminathan said: “if all goes really well, we would probably have a vaccine in the next 12-18 months, but even after that there would be the question of the availability of sufficient doses. We are probably looking at an 18-24 month window for this. “

The development of drugs and vaccines is an elaborate process. Resetting to a candidate drug or vaccine can take years. Once a new drug has passed animal tests, clinical trials begin. In three stages, safety and efficacy must be tested according to protocols. A fourth phase involves the collection and analysis of post-marketing data.

However, the coronavirus novel comes from a family where work has already been done around the world after SARS and MERS. “Many of the existing vaccine development efforts may be slightly modified, so we’re not exactly starting from scratch … However, at least six months could pass on vaccines before the first data starts to come – there’s always a chance that don’t make it successful too. On the treatment side, there may be some news on the ritonavir-lopinavir combination (both are anti-HIV drugs) at any time. The idea is to wait for data on the effectiveness of existing antivirals and see how much better we make them, “said dr. Anurag Agarwal, director of the Institute of genomics and integrative biology of the CSIR.

coronavirus india, coronavirus treatment, coronavirus medicines, coronavirus vaccines, coronavirus Some shops in Delhi remained open on Friday. (Express photo / Amit Mehra)

Where are we on the hunt for a drug?

The World Health Organization (WHO) has announced SOLIDARITY, a multi-arm, multi-country clinical trial to seek the best treatment against COVID-19. Will test the remdesivir of the antiviral drug; a combination of HIV drugs lopinavir and ritonavir; lopinavir and ritonavir plus interferon beta; and the antimalarial chloroquine drug. So far Argentina, Bahrain, Canada, France, Iran, Norway, South Africa, Spain, Switzerland and Thailand have joined.

REMDESIVIR: According to dr. Swaminathan, the most promising trial is that on remdesivir under the auspices of the United States National Institutes of Health (NIH). Tests have started on adult patients with COVID-19 admitted to the University of Nebraska Medical Center. “The first participant in the trial is an American who was repatriated after being quarantined on the Diamond Princess cruise ship that docked in Yokohama, Japan, and volunteered to participate in the study,” said NIH. Remdesivir, developed by Gilead Sciences Inc, has previously been tested on humans with Ebola virus disease and has also shown promising results against MERS and SARS.

coronavirus india, coronavirus treatment, coronavirus medicines, coronavirus vaccines, coronavirus Over 200 coronavirus cases have been reported to date in India. (Photo Express / Kamleshwar Singh)

LOPINAVIR + RITONAVIR: India has had its own experience with a combination of these second-line HIV drugs – 12 people recovered without antivirals (one died later; this is not officially considered a COVID-19 death). Trials are underway worldwide. In an article in the New England Journal of Medicine, Chinese researchers reported 22% mortality in seriously ill patients who received the lopinavir-ritonavir combination, higher than the 11% to 14.5% mortality reported in the studies. initial descriptive. The researchers concluded: “No benefit has been observed with lopinavir-ritonavir treatment beyond standard care.”

CHLOROQUINE: In a document awaiting peer review, researchers at Chinese Sun Yat-sen University reported on an ongoing study using the lopinavir-ritonavir combination with chloroquine. The drugs are administered to eligible patients between February 12 and May 31. “Previous studies have shown that chloroquine can inhibit coronavirus replication through multiple mechanisms. Our previous use of chloroquine to treat patients with pneumonia infected with SARS-CoV-2 (novel coronavirus) has a higher negative rate of acid. nucleic in throat swabs within 5 days of administration compared to that with lopinavir / ritonavir, “the researchers said.

coronavirus india, coronavirus treatment, coronavirus medicines, coronavirus vaccines, coronavirus On Friday, Connaught Place in New Delhi almost left a blank stare. (Express photo / Amit Mehra)

FAVIPIRAVI: This is a drug used in Japan to treat new flu strains. The media cited the Chinese scientific and technological authorities saying that the drug, developed by a subsidiary of Fujifilm, appears to be effective in coronavirus patients. Patients who received the medicine were reported to have turned negative after a median of four days, compared to a median of 11 days for those who were not given the drug.

NEW POSSIBILITIES: There are also efforts to develop a drug from scratch. At the Quantitative Biosciences Institute of the University of California, San Francisco, researchers are identifying the proteins inside the cell that the virus uses to roll its replication machinery. Now they are exploring whether targeting any of these proteins would stop the virus from marching.

coronavirus india, coronavirus treatment, coronavirus medicines, coronavirus vaccines, coronavirus Most public places have been closed between fears over the spread of the coronavirus. (Express photo / Amit Mehra)

How far has work on a vaccine progressed?

WE: A phase 1 clinical trial started in Seattle, funded by the National Institute of Allergy and Infectious Diseases (NIAID). “The open-air trial will enroll 45 healthy adult volunteers aged 18 to 55 for about 6 weeks. The first participant received the experimental vaccine today,” said the NIH in a statement. The vaccine, mRNA-1273, was developed by NIAID scientists and collaborators from the modern biotechnology company.

CHINA: Researchers from the Academy of Military Medical Sciences, affiliated with China’s People’s Liberation Army, have received approval for vaccine routes, which will recruit 108 people between March and December. It will be joined by the CanSino Biologics company listed in Hong Kong. According to a People’s Daily article, scientists are exploring options such as using the virus minus its potent elements or using other attenuated (rendered harmless) vaccines to introduce the virus into the body to generate a natural immune response against a real infection.

coronavirus india, coronavirus treatment, coronavirus medicines, coronavirus vaccines, coronavirus A senior official from the Ministry of Health confirmed that “the test protocol has been changed today”. (Express photo / Amit Mehra)

What was the experience of India?

Last week, doctors from the SMS hospital were Jaipur who were given the lopinavir-ritonavir combination on an Italian couple, 70 and 69 years old, after they were put on ventilation. Both were discharged after being tested twice for the virus, according to the established protocol. The man died on Friday. Answering a question, Lav Agarwal, joint secretary of the Ministry of Health, said: “The Italian tourist who died in Jaipur was a 70-year-old smoker; had twice tested negative for coronavirus. He died of cardiac arrest while receiving treatment for other ailments in another hospital. How can it be counted as a COVID-19 case? “

The government revised the clinical management guidelines for COVID-19: “The use of Lopinavir / Ritonavir in PEP regimens for HIV (4 weeks) is also associated with significant adverse events that sometimes lead to discontinuation of therapy. . In the light of the foregoing, Lopinavir / Ritonavir should ONLY be used with the express and informed consent, case by case, for serious cases, within the framework mentioned below, together with the support treatment as needed. “The combination should be used in patients with hypoxia, hypotension, dysfunction of a new organ (one or more) and also in some” high risk groups “.

Here is a short guide to coronavirus to stay up to date: who should be tested for Covid-19 and when? | How are you supposed to quarantine yourself? | How often (and how) should you clean your home? | What is the Janata curfew announced by PM Modi? | Who is forbidden to come to India and since when? | How long can the virus live on surfaces or in the air around you? | More questions and answers about the Coronavirus Here the news has been explained

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Coronavirus in Minnesota: COVID-19 home tests soon available from the pair of Eagan – WCCO

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Coronavirus Australia live updates: NRL 2020; AFL 2020; Covid-19 news, restrictions, round 1, round 2, Scott Morrison

Fans must be stuck for at least six months since Prime Minister Scott Morrison has announced severe new restrictions to combat the growing coronavirus crisis.

Speaking to the media on Wednesday, Morrison said that all non-essential internal meetings of at least 100 people will be banned in Australia.

Morrison said it is now up to the NRL and AFL to decide whether the comeptition would go ahead under the restrictions, which should be in place for “at least six months.”

“Whether it’s the AFL, the NRL or any other, it’s a decision they have to make in accordance with the established rules,” he said.

Turn 2

“No gatherings of over 500. No internal gatherings of 100 or more – and there will be others. So they have to make their own decisions on how to handle it.

“We will focus on our responsibilities as prime ministers, prime ministers and prime ministers. And the CEOs of AFL and NRL can make decisions about what’s best for their game.

“But they obviously have to comply with all established health rules and guidelines.”

Outdoor gatherings of 500 or more people have been banned over the weekend as the federal government tries to curb the spread of the disease.

Australian Prime Minister Scott Morrison said it was up to the NRL and AFL to decide whether to continue with their seasons.
Australian Prime Minister Scott Morrison said it was up to the NRL and AFL to decide whether to continue with their seasons.Source: AAP

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The Prime Minister’s comments would appear to mean that blockades of the NRL and AFL crowds will remain the norm, while the new ban on over 100 indoor matches could throw clubs, pubs and sports facilities into disarray.

The NRL and AFL were forced to respond to Morrison’s comments last Friday when he prefigured indefinite restrictions on non-essential meetings of 500 or more people.

Both leagues announced that all matches for the foreseeable future would be played in empty stadiums. Indeed, this week’s AFL opener between Richmond and Carlton will be forced to block up to 100,000 fans for the annual MCG blockbuster.

While the main Australian football codes remain open, administrators have faced a number of challenges and the situation changes hour by hour.

The NRL is considering a number of options after a biosafety expert has recommended players and teams to isolate themselves as much as possible, while the Warriors are in limbo as they face the prospect of staying indefinitely on Australian soil.

A small town in Queensland has emerged as a potential savior for the NRL if further restrictions restrict player movements.

The central city of Calliope, Queensland, has taken a step at the NRL to host all 16 clubs if they decide to move the competition north. And the NRL is seriously considering it.

AFL is ready to make a call on whether to play or delay Round 1 by the end of Wednesday. Paul Marsh, CEO of the AFL Players Association, said that the union is pushing AFL to reconsider its decision to reduce the season to 17 weeks, compared to 22.

Perceiving part of the motivation of the players behind the push was to make sure they didn’t lose 20% of their wages, Bulldogs legend Bob Murphy said it was a worrying sign.

“I am baffled by this. Staggered. It completely disagrees with the way the rest of the world is trending,” Murphy told Bob and Andy of SEN.

Meanwhile, Collingwood president Eddie McGuire has revealed that he has recently been tested for coronavirus and received a negative reading.

McGuire revealed Wednesday morning that he had been tested as a precaution last week after being exposed to many people through his footy and media roles.

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PolitiFact slaps Biden with a “mostly false” rating for claiming that the United States “refused” WHO coronavirus tests

PolitiFact left-handed fact-checking website elected Democratic presidential candidate and former vice-president Joe Biden with a “mostly false” assessment of a recent claim that the United States “refused” to accept the coronaviruses offered by the World Health Organization.

Biden made the request during Sunday evening’s primary presidential democratic debate against Senator Bernie Sanders (I-Vt.) In response to a question about President Donald Trump’s management of the current coronavirus outbreak.

“President Trump says he takes no responsibility for problems with coronavirus tests, in part because he claims to have inherited so many rules, regulations and bureaucracy,” debate moderator Jake Tapper told the former vice president. according to a Rev transcription. “Has bureaucratic bureaucracy somehow obstructed this response?”

“No; look, the World Health Organization offered, offered the test kits they have available and to give it to us right away,” Biden replied.

“We refused them. We didn’t want to buy them. We didn’t want to take them from them. We wanted to make sure we have ours,” Biden continued. “I think [Trump] said something like, “We have the best scientists in America” ​​or something like that. “

When PolitiFact reached the Biden campaign on the request, the fact checker states that the campaign indicated a story published earlier this month to the Politician that the United States was not among the 60 countries in which the WHO had sent end of February test:

Why the United States refused to use the WHO test, even temporarily as a bridge until the Centers for Disease Control and Prevention could produce their own test, remains a staggering question and the key to the inability of the Trump administration to provide sufficient tests to identify coronavirus infections before they can be transmitted, according to POLITICAL interviews with dozens of viral disease experts, former officials and some officials of the administration’s health agencies.

However, PolitiFact wrote in a post Monday that WHO-assisted countries were the ones lacking the same type of virological laboratory capacity as the United States, and cited the work done by the Pan American Health Organization as an example:

The group is the WHO arm in the Americas. He has conducted training courses and sent materials to conduct tests to 29 nations. The list included Paraguay, Bolivia, Argentina, Chile, Belize, Costa Rica, El Salvador, Honduras, Nicaragua and many others.

The group said it focused most of its efforts on “countries with weaker health systems”.

“There has been no discussion between the WHO and the CDC on WHO that has provided COVID-19 tests to the United States,” said WHO spokeswoman Margaret Harris. “This is consistent with experience since the United States usually does not rely on WHO for reagents or diagnostic tests because of sufficient domestic capacity.”

The post goes on to explain that Biden’s comments leave out the context on how different countries have chosen the type of test to use, based on multiple different models. Even if the United States had adopted the same test model preferred by the World Health Organization, which it did not do, the country would not have needed the WHO to send supplies.

While the United States has not tried to use the WHO test model, “Biden’s emphasis on WHO offering kits is simply wrong,” concludes PolitiFact. “We consider this claim mostly false.”

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For the Sick, an agonizing wait for tests in Massachusetts – NBC Boston

Danni Aubain has cancer, so when she started feeling lousy late last month, she was particularly worried.

Aubain said the disease hit her like a ton of bricks. He had a 103-degree fever and a horrible, dry cough.

“I really couldn’t breathe,” he said, “and that’s scary for anyone undergoing chemotherapy.”

When seeking medical attention, Aubain said that both her oncologist and a Massachusetts General Hospital emergency room doctor pushed for her to be tested for COVID19, the new coronavirus disease that spreads worldwide.

But despite their recommendations, the response they got from state epidemiologists was that Aubain did not meet the test criteria.

“They called the Public Health Department and I was told that if I couldn’t name a person I knew had a positive test and that I hadn’t traveled outside the country, I couldn’t have been tested,” he said.

In response to NBC10 Boston’s questions, Mass. General said he cannot discuss the treatment of any patient.

But Aubain’s story is like so many others streamed to NBC10 Boston investigators in the past week by spectators across the state who have not been able to take a test. Many said they experienced symptoms of the disease, such as fever and shortness of breath. Like Aubain, some have also been seen by doctors who were convinced they need to be screened.

But with a shortage of test kits available in the state until the end of last week and with restrictive guidelines in place by the federal government, many said they were frustrated, scared and confused as to what to do next.

Federal officials are rapidly increasing the nation’s infrastructure to test COVID-19 this week after a series of missteps hampered the country’s ability to control the virus as it migrated from its epicenter in China to destinations around the world. As of Monday, there have been over 4,000 disease cases reported in the United States, which have so far seen over 70 deaths.

On Monday, health officials in Massachusetts announced that around 1,300 people were tested for the disease and 197 tested positive.

The state’s ability to test patients has increased significantly in the past few days when federal officials have granted Massachusetts clearance to begin testing the samples at the state’s public health laboratory, rather than sending them to a centralized, managed location. by the US Centers for Disease Control and Prevention.

Federal officials also expanded their testing guidelines, offering doctors more discretion to order a test for the virus, and last week they shipped around 5,000 additional test kits to Massachusetts, easing local supply.

The CDC has also published new guidelines that allow doctors and nurses to subject a single nasal swab to tests, rather than a nasal swab and another sample from the patient’s throat. The change is expected to allow Massachusetts to double its testing capacity, bringing the number of tests conducted every day from 200 to 400, public health commissioner Monica Bharel said at a press conference on Sunday.

The Food and Drug Administration, which must approve the test sites, also granted permission at the end of last week to a couple of private companies – Quest Diagnostics and LabCorp – to begin testing samples collected from patients in Massachusetts. Massachusetts hospital labs are expected to launch their testing programs shortly.

“With more and more clinical labs in Massachusetts working to gain FDA approval, more online capabilities will also be available soon,” said Bharel on Sunday.

Federal officials say the United States is now on track to test thousands of patients a day for the virus after falling far behind other countries in its efforts to detect the virus.

Independent research cited by the CDC indicates that the United States had completed approximately 20,000 tests as of March 13. That number pales in comparison to the aggressive testing effort in South Korea, which has a much smaller population, but has tested around 15,000 people per day.

While the United States is ready to learn more about the extent of the pandemic soon, many in the Bay State who fear having contracted the disease say they believe the government has missed an important opportunity to help curb its spread.

“I have a couple of friends in my social circle who are experiencing flu-like symptoms and are just writing it as flu,” said Rita Czernewski, a Cantonese resident who had an unexplained illness a few weeks ago and was frustrated by her inability to get tested for the new coronavirus.

“We are just a little stuck,” he said. “The only thing we can do is just be careful.”

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Coronavirus Test Lab: Accredited private labs can test Covid-19 | India news

NEW DELHI: in line with the request for further tests, the Center has decided to allow accredited private laboratories to test Covid-19. Dr Balram Bhargava, director general of the Indian Council of Medical Research – the country’s top organ for health research – confirmed this to the TOI on Monday.
There are 50 to 60 private laboratories, accredited by the National Accreditation Board for Laboratories, that can take the test, said Bhargava.
At the moment, only government laboratories can perform the test. Although their capacity is around 5,000 samples per day, only 60 to 70 samples are processed per day. This is because the current guidelines allow tests to be carried out only for symptomatic subjects with a history of travel in the affected countries or in direct contact with an infected individual.
More on Covid-19

Asked if others who are symptomatic but do not fit the current criteria could also be tested, Bhargava said: “All those who require tests will be tested.” This signals a possible change in policy to loosen the verification criteria.
DG ICMR said that the allegations for Covid-19 tests in private laboratories and the modalities for reporting positive cases were processed.

The ICMR has a network of 106 virus research and diagnostics (VRDL) laboratories across the country. These laboratories regularly obtain samples of flu-like diseases (ILI) and severe acute respiratory infections (SARI).
Scientists said 13 of these labs had periodically tested 20 random samples for Covid-19 since February to see if the new coronavirus had spread to the community. Experts claimed that all samples so far have tested negative.
On Monday, random tests of ILI and SARI specimens – those with the same symptoms as Covid-19 – were extended to 51 laboratories to more aggressively search for community transmission of the new coronavirus. This would justify testing people outside the current protocol, i.e. those who may not have a travel history in an affected country or who may not have come into contact with an infected individual. Community transmission is a phase in which the disease begins to spread to the community in general.
DG ICMR said that random tests have clearly shown that India has not yet reached the transmission stage of the community. “However, we must be ready. That’s why we are constantly working to add more testing labs, “said Dr. Bhargava.
He added that nine additional government-run VRDL laboratories will be operational to test Covid-19 from Tuesday, compared to 63 existing laboratories. New additions include VRDL at Lady Hardinge Medical College and New Delhi Military Hospital and that at Pune’s Armed Forces Medical College.
Bhargava said that another 70 government laboratories – including medical colleges across the country and laboratories managed by the Organization for Defense Research and Development (DRDO) and the Council for Scientific and Industrial Research (CSIR) – were ready to conduct Covid-19 tests.
Testing for Covid-19 involves two key chemicals, the primer and the probe. Primer can be prepared locally while ICMR must purchase the probes. Recently, the ICMR ordered two lakh probes from a German company to increase its testing capability.
In addition, sources said, some of the best companies in the world such as the Swiss multinational Roche and South Korea Seegene presented their Covid-19 test kits to the ICMR for validation. “Once the ICMR has validated the kits of one of these companies and has given the green light to the private laboratories to be tested, we can certainly join together,” said Dr. Arvind Lal, president and CEO of Lal Pathlabs.
He added that they have been involved in talks with government authorities on Covid-19 tests, but there is still no final word. “We have two important laboratories in Delhi and Calcutta where tests can be performed. Specimen collection can be done in over 100 centers across the country. We already did this earlier when the swine flu epidemic occurred in 2009, “he said. Dr. Navin Dang, owner of Dr Dang’s laboratory in Delhi, also said he could start testing the day in which the government will give permission for.
Covid-19 tests in government labs are free for the public. However, it costs around Rs 6,000 to Rs 6,500 for the government. In private laboratories, the cost of tests could be much higher. Therefore, industry experts said the government may have to decide whether to allow private operators to charge according to their costing model or to subsidize tariffs.

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The stock market suffers the biggest loss in 33 years

The Australian stock market collapsed to the biggest one-day drop in 33 years, bleeding billions of dollars in its 9.7 percent path.

Investors were startled when negotiations began this morning with increasingly tight travel restrictions that have held back a paralyzed economy that is already stalling.

The ASX200 dropped to 5002 after the Federal Reserve cut interest rates in the United States to zero and the Reserve Bank of Australia reported a cut out emergency session for Thursday.

“As much as you want to watch it, it has been very bad on the market today,” CMC Markets chief strategist Michael McCarthy told News.com.au.

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The veteran analyst said that higher percentages occurred during the horrifying 1987 crash sessions, but he doubts there has been a day in history that has lost more value.

The market crashed outdoors this morning and fluctuated its losses during the session until a few minutes died, which McCarthy says is a disturbing sign.

“The market was absolutely destroyed in the match-out (when all negotiations are settled),” he said.

“This type of finish indicates that many sellers have been unsatisfied today, which means they are likely to return to pressure tomorrow.”

Julia Lee, Burman Invest’s Chief Investment Officer, said that the emergency package for the United States, which includes quantitative easing plans, only served to raise hysteria.

“We are panicking the market now,” he told news.com.au.

“If the Federal Reserve releases a bazooka as it did and has no effect on sentiment and, if anything, we have seen a downward spiral, then it is not a good sign for politicians.

“And it shows that at the heart of this, there is a health crisis and secondary are economic considerations.”

The decision to reduce rates to zero in the United States means that global banks will be under pressure and, as a result, the local financial sector is struggling soon.

“Given the global environment, not only with interest rates but also with recessionary conditions, banks are falling,” said Lee.

The main lenders were particularly affected by the ANZ and the NAB which both lost 10.3%, Westpac closed down 9.4% and the Commonwealth Bank lost 7.9%.

Analysts say global stocks will continue to be at the mercy of the deadly disease this week as the number of cases increases and Prime Minister Scott Morrison has announced that all international travelers would be forced to isolate themselves from this morning.

“The situation in global markets is currently totally wild,” market analyst IG Kyle Rodda said in a statement this morning.

“The main problem is coronavirus, obviously. But in the current phase the crisis is underway, for markets, everything revolves around which place in the world is stopping and what emergency measures are being taken by politicians to support economies through the turmoil.

“The signs of stress on the financial system remain as evident as they have been with the GFC. And by extension, volatility remains very high.”

Rodda said that the increase in volatility would lead to both rising and falling irregular movements, as illustrated in Friday’s session.

Traders were blown away when the ASX closed more than 4% more on the last day of the week after falling 8% during the day – a swing of more than 12%.

“From a fundamental economic point of view, the main concern right now is a recession in the United States,” said Rodda.

“Markets seem to welcome the Trump administration’s new package to combat this risk.

“He declared the coronavirus epidemic a national emergency and promised a number of measures, including freezing interest on student debt and providing free coronavirus tests,” he said.

The market lost $ 529 billion from its all-time high reached just three weeks ago on February 20.

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Both the central banks of the United States and New Zealand aggressively cut interest rates to zero and 0.25 percent as part of a global trend to prepare for the financial crisis caused by the pandemic.

The Australian dollar fluctuates in a 2% range based on the levers pulled by politicians across the planet.

It weakened when the RBNZ cut its rates and strengthened when the Federal Reserve did the same. The Australian dollar was buying 61.69 US cents at closing, down from 62.98 US cents as the market closed on Friday.

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