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Coronaviruses like SARS-CoV-2 not only infect the nasopharynx and the airways. In addition to the intestines, kidneys and liver, even the reproductive organs are affected, according to a recent study. Researchers at the German Center for Neurodegenerative Diseases (DZNE) and the US Cornell University have examined cellular factors that could be important for an infection.
Read with BILDplus how the virus affects other organs and how this can affect fertility.
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(27.08.2020) If the body can no longer compensate for the gradual failure of the liver as a result of liver cirrhosis, there is a risk of acute decompensation of the liver cirrhosis. In some patients, this quickly develops into an often fatal acute-on-chronic liver failure, in which other organs such as the kidney or brain fail.
In a study funded by the EF Clif Foundation, an international team of researchers led by Prof. Jonel Trebicka from the Frankfurt University Hospital found out which patients are particularly at risk. The scientists have thus laid the basis for the development of preventive therapies to prevent acute-on-chronic liver failure. (Journal of Hepatology, DOI 10.1016 / j.jhep.2020.06.013)
Our liver has many functions: it stores nutrients and vitamins, produces glucose, clotting factors and hormones, and breaks down toxins, drugs and alcohol. Chronic heavy alcohol consumption, viruses or other diseases can overload the liver and become chronically ill. If left untreated, end-stage chronic liver disease leads to cirrhosis of the liver, in which liver tissue is converted into connective tissue and the liver is less and less able to perform its tasks. The consequences: the blood’s ability to clot is restricted, toxic metabolic products accumulate, the liver is no longer properly supplied with blood and the blood pressure in the portal vein that supplies the liver rises.
The body tries to compensate for the reduced functions of the liver. For example, as a result of the increased portal pressure, bypass circuits develop through the veins of the esophagus, stomach, and intestines, which expand into varicose veins. If such a compensation is no longer possible at some point as the disease progresses – doctors then speak of acute decompensation of the liver cirrhosis – the situation becomes life-threatening: Tissue fluid (ascites) collects in the abdominal cavity, bacterial infections and internal bleeding occur roughly in the esophagus. Difficulty concentrating, mood swings or sleepiness are signs of intoxication of the brain (hepatic encephalopathy), which can lead to hepatic coma.
A Europe-wide clinical study led by Prof. Jonel Trebicka, which was carried out under the umbrella of the European Foundation for the Investigation of Chronic Liver Failure, determined for the first time three clinical course variants of patients who were admitted to hospital with acute decompensation of liver cirrhosis.
The first clinical variant is characterized by high levels of inflammation in the blood, which indicate inflammatory reactions throughout the body. Within three months of being admitted to the hospital, several organs of the body fail: the acute decompensation becomes an “acute-on-chronic liver failure” (ACLF). Therefore, the medical professionals named this variant as pre-ACLF. More than half of the patients die from it, after a year only a third of them are still alive.
The patients of the second clinical course variant do not develop ACLF and have moderate inflammation values, but suffer from a significantly increased portal vein blood pressure. Around 20 percent of them die within the next three months, another 15 percent within the following year. The doctors called this variant “unstable decompensated liver cirrhosis”.
Patients of the third clinical course variant did not show any severe inflammation values or frequent complications. You won’t develop an ACLF in the first three months. However, one in ten of them still dies within a year. The doctors called this variant “stable decompensated liver cirrhosis”.
Study leader Prof. Jonel Trebicka, gastroenterologist and hepatologist at the Medical Clinic I of the University Hospital Frankfurt, explains: “We are now working intensively on developing new diagnostic options, especially for groups of pre-ACLF patients, so that this group can be admitted to hospital identify and initiate countermeasures at an early stage. The development of preventive therapies for the often fatal ACLF is one of our most important research tasks in this context. “
Prof. Dr. Stefan Zeuzem, Dean of the Faculty of Medicine and Director of Medical Clinic I at the University Hospital Frankfurt and co-author of the study, explains: “Liver diseases are one of the main focuses of Medical Clinic I, and we offer numerous special outpatient clinics for patients with acute and chronic liver diseases on. On the one hand, we were able to observe patients for the study. On the other hand, the research results to improve ACLF prevention and therapies very quickly benefit our and all patients. “
The research results are part of the Europe-wide study called PREDICT. The study monitors the clinical course of acute decompensations of liver cirrhosis to find early signs of developing acute-on-chronic liver failure (ACLF). The study is funded by the European Foundation for the Study of Chronic Liver Failure. 136 scientists from 47 centers and institutions in 14 European countries are involved in PREDICT.
Publikation: Jonel Trebicka, Javier Fernandez, Maria Papp, Paolo Caraceni, Wim Laleman, Carmine Gambino, et al.: The PREDICT study uncovers three clinical courses of acutely decompensated cirrhosis that have distinct pathophysiology. Journal of Hepatology, https://doi.org/10.1016/j.jhep.2020.06.013
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– It is difficult to build forecasts, but I believe in the best. I feel sorry for mom, she is very worried, it has been going on for more than a year, – said “KP» 49-year-old math teacher Valery Syropyatov and, with a sigh, he entered the courtroom.
On Monday in the Ordzhonikidze court Perm the teacher was sentenced under the article “Violent acts of a sexual nature”. The sentence is 9 years and 6 months in a maximum security colony.
“The girl begged the three”
This ugly story happened in March last year in a Perm school. According to the teacher, she looked like this:
– In the seventh grade, where the girl studied, I taught mathematics for the first year. In the first quarter, she deceived me, I believed and put the “troika”. But there must be an educational moment. I told her that now she will hand over all the work in the sequence in which they are studied. And until we get to the control for the third quarter, the final mark at her will not be!
On that day, March 27, several students came to the mathematician to take the “tails”.
“Everyone sat at their desks and did the work, and once again she decided to slip away,” the teacher continues. – I began to ask myself, said that her stomach ached, her head … I insisted: “Decide the control, get your” threefold “and you can step on all four sides. If it’s inconvenient for you to study in the classroom – the children are noisy – let’s go to another office. ” We left, she stood at the table and again began to whine. I sit at the table and tell her: “Go, decide!” The man does not leave, I waved. I am sitting, she is standing – where will i get? Here in the belt on the side with the back of the hand and hit. It turned out cotton. I admitted this, and was removed by the director from teaching in this class. I apologized and believed that the incident had been exhausted.
Soon, the information got into law enforcement. First, criminal proceedings were instituted for Art. Art. 135 of the Criminal Code RF “Depraved actions”, and after six months the investigations were re-qualified as more serious, Art. 132 “Violent acts of a sexual nature.”
At each meeting, teachers supported
To the court – at each hearing in the Valery case Syropyatova – a support group gathered: former graduates, colleagues, parents of students … 17 of them acted as witnesses from the defense. They all said that they could not believe the guilt of their beloved teacher. He does not smoke, does sports, organizes excursions around the Perm Territory and cities for children Of Russiaorganizes competitions in rogain, tourist trips, alloys, fees …
Despite all the kind words spoken to the defendant, the state prosecution requested 13 years of imprisonment for him.
Valery Syropyatov on the day the sentence was announced, we met near the courthouse. He was light, without things. As the teacher himself explained, he believed that the court would figure it out and justify it.
“I’ve already checked in, now I’ll take a little walk, breathe in fresh air, mentally tune in and go,” he explained before entering the courtroom.
Despite the fact that the process was closed, the journalists and the support group were allowed to announce the verdict.
It was impossible to understand what the teacher experienced at that moment when the judge said “nine and a half years in a maximum security colony”, the teacher’s face was hidden under a mask. And the former graduates and colleagues who were present at the announcement somehow immediately went down. Someone could not hold back tears.
– Do you understand the verdict and the procedure for appealing against it?
“Yes, your honor,” the convict answered calmly.
At that moment, three escorts entered the courtroom. Knowing the rules of staying in places of deprivation of liberty — the teacher spent three days in a pre-trial detention center while the investigation was under way — the teacher began to unfasten his belt in order to remove it, took money from his pockets, a cell phone and gave it to a relative. The guards locked handcuffs on his hands, and asked all those present to leave the courtroom.
It was impossible to understand what the teacher experienced at that moment when the judge said “nine and a half years in a maximum security colony”, the teacher’s face was hidden under a mask.Photo: Vasily Vakhrin
I closed and he pushed my hands away
– The criminal case was considered in closed court, so we can’t explain the details, you heard the verdict, the evidence that the prosecution presented to the court was enough to plead guilty to a particularly serious crime against the sexual integrity of a minor, therefore the sentence so big – said assistant to the prosecutor of the Ordzhonikidze district of Perm, Dmitry Shishkin. – And that slap, and the version that the defendant himself told everyone about, including in the media, is a way of protection.
As it became known to “Komsomolskaya Pravda” from a source familiar with the materials of the criminal case, one of the evidence presented in court was the correspondence of the seventh grader with his girlfriend in social networks. Late in the evening on the day of math retaking, the schoolgirl wrote to her close friend that she was at school, and the teacher took her to a separate office, put her at her desk, walked up behind and began to touch her bra.
“I sat at the table, he was at the back and was pawing me,” she wrote. – I tried to close my hands, and he pushed his hands and touched me by the chest.
Experts examined the girl for bruises and the only thing found on her body was a small scratch on her finger.
The accusation was also based on the words of the girl, her mother and friend. Investigators also found a video from school surveillance cameras, which shows how one of the schoolgirls told Valery Nikolaevich that she had passed the debt, and he leaned over and began to say in her ear that she was good. This was interpreted later as a kiss.
During the investigation, a forensic medical examination was carried out, the biological traces of the teacher on the things of the victim were not found. The teacher was also tested for a tendency to pedophilia, but the result was negative.
READ ALSO:
“Sex scandal” in Perm: a math teacher shines 13 years for a slap on the priest of the seventh grader
In an interview with Komsomolka, the teacher told his version of events [видео] (More …)
In Perm, 17 graduates spoke at the trial in defense of a mathematics teacher who faces 13 years for a slap on the priest of a seventh grader
Among them were police officers and lawyers [видео] (More …)
“Having heard the verdict, he took off his belt.” In Perm, the teacher received 9 and a half years for a slap on the student’s priest
Valery Syropyatov was handcuffed in the courtroom (More …)
.
– It is difficult to build forecasts, but I believe in the best. I feel sorry for mom, she is very worried, it has been going on for more than a year, – said “KP» 49-year-old math teacher Valery Syropyatov and, with a sigh, he entered the courtroom.
On Monday in the Ordzhonikidze court Perm the teacher was sentenced under the article “Violent acts of a sexual nature”. The sentence is 9 years and 6 months in a maximum security colony.
“The girl begged the three”
This ugly story happened in March last year in a Perm school. According to the teacher, she looked like this:
– In the seventh grade, where the girl studied, I taught mathematics for the first year. In the first quarter, she deceived me, I believed and put the “troika”. But there must be an educational moment. I told her that now she will hand over all the work in the sequence in which they are studied. And until we get to the control for the third quarter, the final mark at her will not be!
On that day, March 27, several students came to the mathematician to take the “tails”.
“Everyone sat at their desks and did the work, and once again she decided to slip away,” the teacher continues. – I began to ask myself, said that her stomach ached, her head … I insisted: “Decide the control, get your” threefold “and you can step on all four sides. If it’s inconvenient for you to study in the classroom – the children are noisy – let’s go to another office. ” We left, she stood at the table and again began to whine. I sit at the table and tell her: “Go, decide!” The man does not leave, I waved. I am sitting, she is standing – where will i get? Here in the belt on the side with the back of the hand and hit. It turned out cotton. I admitted this, and was removed by the director from teaching in this class. I apologized and believed that the incident had been exhausted.
Soon, the information got into law enforcement. First, criminal proceedings were instituted for Art. Art. 135 of the Criminal Code RF “Depraved actions”, and after six months the investigations were re-qualified as more serious, Art. 132 “Violent acts of a sexual nature.”
At each meeting, teachers supported
To the court – at each hearing in the Valery case Syropyatova – a support group gathered: former graduates, colleagues, parents of students … 17 of them acted as witnesses from the defense. They all said that they could not believe the guilt of their beloved teacher. He does not smoke, does sports, organizes excursions around the Perm Territory and cities for children Of Russiaorganizes competitions in rogain, tourist trips, alloys, fees …
Despite all the kind words spoken to the defendant, the state prosecution requested 13 years of imprisonment for him.
Valery Syropyatov on the day the sentence was announced, we met near the courthouse. He was light, without things. As the teacher himself explained, he believed that the court would figure it out and justify it.
“I’ve already checked in, now I’ll take a little walk, breathe in fresh air, mentally tune in and go,” he explained before entering the courtroom.
Despite the fact that the process was closed, the journalists and the support group were allowed to announce the verdict.
It was impossible to understand what the teacher experienced at that moment when the judge said “nine and a half years in a maximum security colony”, the teacher’s face was hidden under a mask. And the former graduates and colleagues who were present at the announcement somehow immediately went down. Someone could not hold back tears.
– Do you understand the verdict and the procedure for appealing against it?
“Yes, your honor,” the convict answered calmly.
At that moment, three escorts entered the courtroom. Knowing the rules of staying in places of deprivation of liberty — the teacher spent three days in a pre-trial detention center while the investigation was under way — the teacher began to unfasten his belt in order to remove it, took money from his pockets, a cell phone and gave it to a relative. The guards locked handcuffs on his hands, and asked all those present to leave the courtroom.
It was impossible to understand what the teacher experienced at that moment when the judge said “nine and a half years in a maximum security colony”, the teacher’s face was hidden under a mask.Photo: Vasily Vakhrin
I closed and he pushed my hands away
– The criminal case was considered in closed court, so we can’t explain the details, you heard the verdict, the evidence that the prosecution presented to the court was enough to plead guilty to a particularly serious crime against the sexual integrity of a minor, therefore the sentence so big – said assistant to the prosecutor of the Ordzhonikidze district of Perm, Dmitry Shishkin. – And that slap, and the version that the defendant himself told everyone about, including in the media, is a way of protection.
As it became known to “Komsomolskaya Pravda” from a source familiar with the materials of the criminal case, one of the evidence presented in court was the correspondence of the seventh grader with his girlfriend in social networks. Late in the evening on the day of math retaking, the schoolgirl wrote to her close friend that she was at school, and the teacher took her to a separate office, put her at her desk, walked up behind and began to touch her bra.
“I sat at the table, he was at the back and was pawing me,” she wrote. – I tried to close my hands, and he pushed his hands and touched me by the chest.
Experts examined the girl for bruises and the only thing found on her body was a small scratch on her finger.
The accusation was also based on the words of the girl, her mother and friend. Investigators also found a video from school surveillance cameras, which shows how one of the schoolgirls told Valery Nikolaevich that she had passed the debt, and he leaned over and began to say in her ear that she was good. This was interpreted later as a kiss.
During the investigation, a forensic medical examination was carried out, the biological traces of the teacher on the things of the victim were not found. The teacher was also tested for a tendency to pedophilia, but the result was negative.
READ ALSO:
“Sex scandal” in Perm: a math teacher shines 13 years for a slap on the priest of the seventh grader
In an interview with Komsomolka, the teacher told his version of events [видео] (More …)
In Perm, 17 graduates spoke at the trial in defense of a mathematics teacher who faces 13 years for a slap on the priest of a seventh grader
Among them were police officers and lawyers [видео] (More …)
“Having heard the verdict, he took off his belt.” In Perm, the teacher received 9 and a half years for a slap on the student’s priest
Valery Syropyatov was handcuffed in the courtroom (More …)
.
– It is difficult to build forecasts, but I believe in the best. I feel sorry for mom, she is very worried, it has been going on for more than a year, – said “KP» 49-year-old math teacher Valery Syropyatov and, with a sigh, he entered the courtroom.
On Monday in the Ordzhonikidze court Perm the teacher was sentenced under the article “Violent acts of a sexual nature”. The sentence is 9 years and 6 months in a maximum security colony.
“The girl begged the three”
This ugly story happened in March last year in a Perm school. According to the teacher, she looked like this:
– In the seventh grade, where the girl studied, I taught mathematics for the first year. In the first quarter, she deceived me, I believed and put the “troika”. But there must be an educational moment. I told her that now she will hand over all the work in the sequence in which they are studied. And until we get to the control for the third quarter, the final mark at her will not be!
On that day, March 27, several students came to the mathematician to take the “tails”.
“Everyone sat at their desks and did the work, and once again she decided to slip away,” the teacher continues. – I began to ask myself, said that her stomach ached, her head … I insisted: “Decide the control, get your” threefold “and you can step on all four sides. If it’s inconvenient for you to study in the classroom – the children are noisy – let’s go to another office. ” We left, she stood at the table and again began to whine. I sit at the table and tell her: “Go, decide!” The man does not leave, I waved. I am sitting, she is standing – where will i get? Here in the belt on the side with the back of the hand and hit. It turned out cotton. I admitted this, and was removed by the director from teaching in this class. I apologized and believed that the incident had been exhausted.
Soon, the information got into law enforcement. First, criminal proceedings were instituted for Art. Art. 135 of the Criminal Code RF “Depraved actions”, and after six months the investigations were re-qualified as more serious, Art. 132 “Violent acts of a sexual nature.”
At each meeting, teachers supported
To the court – at each hearing in the Valery case Syropyatova – a support group gathered: former graduates, colleagues, parents of students … 17 of them acted as witnesses from the defense. They all said that they could not believe the guilt of their beloved teacher. He does not smoke, does sports, organizes excursions around the Perm Territory and cities for children Of Russiaorganizes competitions in rogain, tourist trips, alloys, fees …
Despite all the kind words spoken to the defendant, the state prosecution requested 13 years of imprisonment for him.
Valery Syropyatov on the day the sentence was announced, we met near the courthouse. He was light, without things. As the teacher himself explained, he believed that the court would figure it out and justify it.
“I’ve already checked in, now I’ll take a little walk, breathe in fresh air, mentally tune in and go,” he explained before entering the courtroom.
Despite the fact that the process was closed, the journalists and the support group were allowed to announce the verdict.
It was impossible to understand what the teacher experienced at that moment when the judge said “nine and a half years in a maximum security colony”, the teacher’s face was hidden under a mask. And the former graduates and colleagues who were present at the announcement somehow immediately went down. Someone could not hold back tears.
– Do you understand the verdict and the procedure for appealing against it?
“Yes, your honor,” the convict answered calmly.
At that moment, three escorts entered the courtroom. Knowing the rules of staying in places of deprivation of liberty — the teacher spent three days in a pre-trial detention center while the investigation was under way — the teacher began to unfasten his belt in order to remove it, took money from his pockets, a cell phone and gave it to a relative. The guards locked handcuffs on his hands, and asked all those present to leave the courtroom.
It was impossible to understand what the teacher experienced at that moment when the judge said “nine and a half years in a maximum security colony”, the teacher’s face was hidden under a mask.Photo: Vasily Vakhrin
I closed and he pushed my hands away
– The criminal case was considered in closed court, so we can’t explain the details, you heard the verdict, the evidence that the prosecution presented to the court was enough to plead guilty to a particularly serious crime against the sexual integrity of a minor, therefore the sentence so big – said assistant to the prosecutor of the Ordzhonikidze district of Perm, Dmitry Shishkin. – And that slap, and the version that the defendant himself told everyone about, including in the media, is a way of protection.
As it became known to “Komsomolskaya Pravda” from a source familiar with the materials of the criminal case, one of the evidence presented in court was the correspondence of the seventh grader with his girlfriend in social networks. Late in the evening on the day of math retaking, the schoolgirl wrote to her close friend that she was at school, and the teacher took her to a separate office, put her at her desk, walked up behind and began to touch her bra.
“I sat at the table, he was at the back and was pawing me,” she wrote. – I tried to close my hands, and he pushed his hands and touched me by the chest.
Experts examined the girl for bruises and the only thing found on her body was a small scratch on her finger.
The accusation was also based on the words of the girl, her mother and friend. Investigators also found a video from school surveillance cameras, which shows how one of the schoolgirls told Valery Nikolaevich that she had passed the debt, and he leaned over and began to say in her ear that she was good. This was interpreted later as a kiss.
During the investigation, a forensic medical examination was carried out, the biological traces of the teacher on the things of the victim were not found. The teacher was also tested for a tendency to pedophilia, but the result was negative.
READ ALSO:
“Sex scandal” in Perm: a math teacher shines 13 years for a slap on the priest of the seventh grader
In an interview with Komsomolka, the teacher told his version of events [видео] (More …)
In Perm, 17 graduates spoke at the trial in defense of a mathematics teacher who faces 13 years for a slap on the priest of a seventh grader
Among them were police officers and lawyers [видео] (More …)
“Having heard the verdict, he took off his belt.” In Perm, the teacher received 9 and a half years for a slap on the student’s priest
Valery Syropyatov was handcuffed in the courtroom (More …)
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Friends!
A disgusting event occurred: professional cybercriminals organized a series of powerful DDoS attacks on the server on which the site of the Komsomolskaya Pravda quiz “The Constitution is Me” is located.
It is obvious that the goal of the customers of the attack is to disrupt the quiz, prevent Komsomolskaya Pravda from celebrating its anniversary, stop residents of the Irkutsk region from receiving gifts, and spoil everyone’s mood.
We regard this attack as an attack on freedom of speech and personally on us. And this was started by someone who does not benefit from voting on amendments to the Constitution, someone who really does not want Russia was a social state, someone pursuing the vile goals of the collapse of civil society. Someone who really needs to split the country.
Komsomolskaya Pravda never lost ground. We continue the quiz. We continue to work. And the vote will also continue, no matter what.
Law enforcement agencies are already engaged in solving the crime with an attack on us. We are convinced that the culprits will be found.
We thank everyone who is already participating in the quiz, and those who have shown interest and plan to do this before July 1.
Draws will continue!
Quiz “Constitution is me!” passes every day, from July 25 to July 1. The final will take place on July 8th. The broadcast of the draw itself can be seen on the TV channels “Aist” and “TVC”, or listen to the radio “Komsomolskaya Pravda” (91, 5 fm). And to immediately find out the results and check your number, and, at the same time, and luck, go to irk.kp.ru. They are also published in the newspaper Komsomolskaya Pravda. The winner is determined randomly, a combination of numbers falls in a special program.
By the way, for the convenience of those who did not follow the quiz “The Constitution is Me!” in the Irkutsk region on June 25, 26 and 27, we publish all the winning numbers for these days. Check maybe you are lucky!
On the first day of the draw it was decided who would receive the car, TVs, tablets and immediately a table smartphones. On the second day, another 50 smartphones, 5 tablets, 3 TVs, and finally a car participated in the draw!
On the third day – three televisions, five tablets and 50 smartphones. All of them are looking for their owners.
So, drum roll, we call the ticket numbers of the next winners. If the drawn numbers match your receipt, call to get a prize (phones are listed below).
The quiz “Constitution is me” in the Irkutsk region on June 27, the results:
Congratulations to the winners (look for your numbers)
Five tablets
380228420
380741531
380138024
381162865
380322891
Fifty smartphones
380915100
380882325
380895441
380815963
380726999
380062701
380040460
381058512
380372562
380666521
380181543
380014984
380691028
380906343
380638894
380091914
381101962
380347137
380191308
380626025
380661771
380191313
380415394
380483779
380419023
380692005
380462538
380945855
380539343
380209253
380638861
380652639
380453875
380518317
380701469
380000259
380881572
381121487
380014235
380610211
380224106
380258023
380280186
381011893
380078187
380840459
380904905
380523960
380895244
380864607
Three TVs
380949628
380884252
380680550
The quiz “Constitution is me” in the Irkutsk region on June 26, the results:
Congratulations to the winners (look for your numbers)
Three TVs
381158998
380700525
380716819
Five tablets
381097479
380684952
381014384
380456957
380648004
50 smartphones
380580904
380930732
380189887
381080169
380735729
381148204
380528013
380333136
380054649
380248928
380529958
380806413
380945009
380500435
380333085
380371698
380960057
380840287
380544413
380680777
380554122
380008256
381101511
380645308
380528760
380701967
380388513
380151724
380022132
380258856
380455568
381009448
380405350
380491032
381015517
380807148
380754322
380733113
380544333
381197358
380165429
380256312
380145745
380952013
381012704
380767789
380696022
380116805
381136907
380004144
Constitution quiz is me quiz in Irkutsk Oblast June 25, results
Congratulations to the winners (look for your numbers)
Car:
380347425
TVs:
380544205
380901485
380408476
Tablets
380009943
380809729
380859492
380033763
380549493
Smartphones
380571430
380659143
380016478
380322400
380311556
380027439
380350784
380033724
380799665
380068600
380632952
380609672
380132850
380061141
380281604
380860272
380454777
380005996
380948550
380710341
380339590
380384251
380730143
380008412
380549497
380528012
380748012
380015832
380529731
380016865
380331286
380008461
380350779
380068525
380033767
380444908
380512219
380544407
380528945
380132975
380061576
380592034
380499314
380328761
380066362
380319170
380528807
380145686
380476813
380342935
380473313
380096467
380067061
380291697
380817972
380331478
380425395
380714003
380221996
380009074
380449722
380256161
380032625
380440132
380317985
380815923
380472367
380010689
380132612
380842003
380068597
380452044
380741012
380836444
380452192
380252443
380673101
380012448
380491552
380952004
380400522
380680573
380661719
380041502
380818462
380675062
380780950
380483728
380384625
380408300
380617356
380920037
380829999
380583220
380752506
380351230
380316641
380195246
380066272
380347263
HOW TO WINNERS RECEIVE PRIZES
50 smartphones
Quiz Regulation
.
READ ALSO
Sibiryachka, who won the car in the quiz “The Constitution is me”: “You no longer have to share one car with your husband for two” (Details)
.
The first 10 days after the onset of symptoms of the disease, the 38-year-old American was feeling quite well. He was not at risk; he had no chronic diseases.
– The man was examined, the disease was mild. The patient had a slight cough. Therefore, he was sent home for treatment, ”says the head of the Department of Vascular Surgery at Westchester Medical Center Sean Wengerter.
And then the incredible happened.
One morning, a man woke up with icy and numb legs. The body was constrained by terrible weakness; there was not even the strength to get out of bed.
The examination showed that the patient had aortic occlusion – a large blood clot formed in the main artery at the place where the artery diverged in two directions – to the right and left leg. Because of this clot, blood enriched with oxygen did not enter the iliac arteries.
“This is extremely dangerous.” From this can die from 20% to 50% of patients, – notes Vangerter. – But such things are not typical for 38-year-olds.
An emergency operation to remove a blood clot could save the patient’s life. But doctors working with patients with COVID-19 are everywhere faced with rather strange and frightening phenomena in infected patients. For example, the formation of blood clots (actually blood clots) of various sizes throughout the body, renal failure, inflammation of the heart muscle and malfunctions of the immune system.
“Coronavirus occurs in each patient in its own way,” notes Scott Brackenridge, associate professor of emergency surgery at the College of Medicine at the University of Florida. – In some cases, the patient has a problem with breathing, in others, the internal organs begin to fail. In children, the immune system as a whole begins to rebel.
Coronavirus is not just a respiratory diseasePhoto: Ivan MAKEEV
MYSTERIOUS STROKES
A new type of coronavirus is considered to be a respiratory virus, although it is already becoming obvious – the infection affects the entire human body. The most common symptoms are fever, pneumonia, and acute respiratory distress syndrome.
In this case, the virus attacks some organs directly. First of all, the mucous membrane of blood vessels, which entails unnatural coagulation of blood.
– COVID-19 provokes a local inflammatory reaction that leads to the formation of blood clots, – explains Wengerter. – This is due to the direct effect of the virus on the arteries.
A number of doctors recorded strokes in young patients with coronavirus, as well as the formation of blood clots in the lungs. Blood clots were found even in the smallest vessels.
“Since each organ feeds on blood vessels, and the virus attacks them first and foremost, we end up with damage to internal organs,” adds Dr. Scott Brackenridge.
Another serious symptom that is observed in some patients who become ill with the new coronavirus is the “co-fingers.” The infected toes swell, becoming red or purple. It is possible that the reason for this is blockage of blood vessels. But doctors say that usually this does not have serious consequences.
Kawasaki Syndrome
One of the most alarming reactions to COVID-19 is observed in children. It has already been named as a children’s multisystem inflammatory syndrome. In newYork Doctors have identified more than 100 cases.
This syndrome is characterized by a rather long fever, inflammatory process, malfunction of one or more internal organs, as well as the general condition, which is usually observed with shock. Pediatricians also compare these symptoms with the syndrome. Kawasaki.
Kawasaki syndrome is a rare disease that affects children aged 3 to 10 years. It is characterized by damage to the medium and small arteries, thrombosis, the formation of aneurysms and rupture of the vascular wall. Cases of infection are rare. However, recently, doctors have noted an increase in the number of patients with this syndrome.
Both childhood multisystem inflammatory syndrome and Kawasaki syndrome lead to an overly aggressive immune system response to coronavirus. This may be accompanied by inflammation of the blood vessels and heart muscle.
KILLER CELLS
However, scientists note that coronavirus is not able to cause a strong immune response, but, on the contrary, suppress the entire immune system. And this can allow the infection to freely attack the internal organs.
Partly this theory was confirmed by Chinese experts, led by Dr. Zhang Zhang. Scientists analyzed samples of immune cells taken from the lungs of 9 patients infected with coronavirus. The results of the study showed an abnormally high level of leukocytes – macrophages and neutrophils responsible for the destruction of harmful pathogen – in severe patients. At the same time, these patients had a rather low level of CD8 T cells, which are called killer cells. They are responsible for killing virus-infected cells.
But doctors are reassuring, noting that they have drugs that can thin the blood, and also help the work of white blood cells that resist infection.
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On April 16, 2024, a Te Deum must resound under the vault of Notre-Dame de Paris. On that day, the cathedral will in principle open again for worship, five years after the fire that ravaged it. “This Te Deum will have the same symbolic significance as the Magnificat interpreted in August 1944. It will mark in a festive and solemn way a liberation”, underlines Henri Chalet, choirmaster of the master’s degree at Notre-Dame de Paris.
Liturgical singers, organists, clerics and laity, faithful and tourists, all are impatient to return to Notre-Dame and hear again singing its stones or resounding its silences. But will the acoustics so particular of this imposing building ever be the same?
Scientifically define the sound environment of Notre-Dame and formulate recommendations to find this lost world as best as possible, such is the mission entrusted to Brian Katz, acoustician, CNRS research director, and to Mylène Pardoen, archaeologist of the sound landscape, who lead the “acoustic” expertise group for catering.
→ MAINTENANCE. Notre-Dame, “The liturgy makes the stones resonate”
Brian Katz, who has measurements made on site in 2013, performs digital capture and acoustic simulation of the cathedral. Mylène Pardoen feeds it with history, creating an audio mix guided by the archives. But to account for a moving and intangible sensory reality comes up against a great difficulty. “Words are too poor to describe the soundscape”, she regrets.
For “Provide recontextualized sound facts in an acoustic environment”, their small team of six experts works “To reconstruct the everyday sound environments by layers of noise” relying on “Sound recordings, in order to recover the waves and thus create an acoustic volume”.
” Our work, summarizes Mylène Pardoen, is like building a virtual ship that takes you back in time. We imagine the sounds of the past: in the Middle Ages, they were different because of another interior arrangement – a rood screen, tapestries… We project those of the future, for example if we added a partition of plexiglass here or there to protect a artwork. “
→ LONG FORMAT. Notre-Dame de Paris: duels at the foot of the towers
It’s about gathering information from all possible sources, “Nature, geography, wind, human noise, the sounds of the forecourt, traffic flows …”, and confront them with the sounds of the cathedral, “Masses, concerts and less dense atmospheres, not monks, or rumor of visitors”. Brian Katz models these acoustic volumes with the absorption coefficients of the different materials, integrating sound and its reverberation in this place of life, worship and tourism, prayer and music.
The masters of Notre-Dame, the cathedral’s singing school and choir, as well as the organists, Olivier Latry, Philippe Lefebvre and Vincent Dubois with the grand organ, Yves Castagnet with the choir organ, daily accompanist of the liturgy, acquired them also a great science of the sounds of the building. “I’m trying to tame the acoustics of this very populated place that you have to learn to master”, says Henri Chalet. In this ship, you have to find “Places that sound good for each repertoire”.
With an immense privilege of which the singers and musicians of Notre-Dame keep a poignant nostalgia, “To be alone every night to rehearse”. A unique opportunity to try different placements: facing the audience to project the sound, in front of the altar to better disperse it, scattered on the sides to give listeners the feeling of being surrounded …, each time the resonances are different.
The 160 master singers adapt their vocal technique and their tone to the cathedral, “In order to radiate without forcing their voices”, serving a thousand services a year and 60 concerts. Sacred music, written for places of this magnitude, unfolds there. Henri Chalet remembers a Te Deum by the Estonian composer Arvo Pärt repeated in the modern Philharmonie de Paris before being performed in the cathedral. “The resonance of Notre-Dame made evident this slow music which plays a lot over time. The work took on its full meaning in a magical moment! “
The bells, “Brass voice singing in 300-foot stone flutes “, According to Victor Hugo; the emergency sirens of the Quai des Orfèvres or the Hôtel-Dieu; the riverboats revolving around the Ile de la Cité with a serious, very slow sound, “Sixty seconds during which the singers freeze before resuming”, says Henri Chalet; a whole symphony is played at Notre-Dame.
→ VIDEO. At Notre-Dame, in the body of the organ
The soloist is the great organ, the instrumental jewel of the cathedral. “We can thank Viollet-le-Duc and his whims, smiles the organist Olivier Latry. As he imposed his architectural choices on the organ builder Cavaillé-Coll, he gave him free rein to harmonize it. “
Cavaillé-Coll has endowed his masterpiece with a wide symphonic palette and a harmonic pyramid creating a feeling of power and mystery. Its low notes, of which you only feel the vibration, bring out the purity of the treble. “The large organ allows a lot of variety in colors and harmonics, and to explore all playing families; anywhere in the cathedral you can hear him enveloping you as if he were creeping into every pore of the stone “, said Olivier Latry.
Covered with dust and lead, the instrument will be dismantled, decontaminated, each of its many delicate parameters will be checked … Three years of work! “We will have to restore the sound to a coherent whole, concludes Mylène Pardoen. Notre-Dame is still there, we must keep its uniqueness. “
According to her, in the event of reconstruction with identical materials of all that was destroyed below the vault, “Minor differences would be visible in our models but not audible to the ear. The sound found would not be so different from that which we remember ”. The “acoustic” group is working to restore it, exploring the sound environments of the past to better prepare those of tomorrow.
Notre Dame de Paris measures 127 m long and 48 m wide, giving an indoor area of 4,800 m2, total of 6,000 m2. Its spire culminates at 96 m, its towers rise to 69 m, and its height under the arch is 33 m.
To listen : “Notre-Dame, Cathedral of emotions” recordings of the mastery of Notre Dame, Warner, available in streaming, in CD on May 15 (€ 1 per CD paid to the Notre Dame Foundation).
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“Marcel Moreau [mort à Bobigny le 4 avril, des suites du coronavirus, ndlr] would not have liked to be said of him that he was a Belgian writer, he was born in the Borinage, in Belgium, but he was a French writer, it was very important for him. He was born in 1933 to a working class family. Her mother, who was a simple woman, had a perfect spelling. His father, who worked on the roofs, fell, he died and Marcel Moreau found himself head of the family at 15 years old. He arrived in Paris in 1968. Straight, his first novel (1963) was immediately praised by Simone de Beauvoir. He was recognized by Dubuffet, by Henry Miller, Anaïs Nin. His writing is lyrical, incandescent, of great beauty, and very classical, there is a purity, a baroque intoxication. It is a very demanding, new, held, very robust and noble proletarian literature.
“He was a possessed, a speleologist who wrote “In the bowels” (see his book visceral arts) who advocated the “Chaonaissance”, knowledge through chaos. Marcel Moreau is a companion in my life as a bookseller that I can never forget. He had written a Twisted Egobiography that I love. He had the art of titles, Mongolian thought, Love to die of it, the song of paroxysms… At Bourgois, Lettres vives. He had won the Wepler Prize in 2003 for Corpus Scripti, published by Denoël where Olivier Rubinstein reissued four of his books in one volume. He got up at 4 am to work, he was a proofreader in the press, wore his tongue like knowledge. He was a character, a big colossus, excessive, meat eater, passionate, very generous, very apart, wild, one of the last great wild authors, a “Filthy”, not a narcissist who refused meetings. I had organized an evening in Saint-Eustache around him with the organist Jean Guillou, and Denis Lavant was reading his texts, there I realized his aura.
“I read a lot during this confinement. I had passed byGospel of the lost from Georgina Tacou, to the Surveyor. I loved Girl by Camille Laurens (to be published by Gallimard). I was dazzled by a great Brazilian Lacanian, Betty Milan, who publishes with Erès From you to me, his responses to correspondence from the heart of a journal; by a conference by Delphine Horvilleur, Understanding the world (Bayard) and by Michael Edwards’ subversive essay on the Bible, For an untimely Christianity (Fallois).
Marie-Rose Guarniérie runs the Abbesses bookstore: 30, rue Yvonne-Le-Tac 75018.
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After returning home from Iraq, Army veteran Kellen Leech, who has been deployed three times over the course of 14 years, has struggled with his mental health: PTSD, survivors’ fault and depression – until he has read a Facebook post on Ellery Payton.
Payton’s previous kidney transplant failed and in 2012 he needed another; Leech, a resident of Prince George County, Maryland, decided he wanted to donate his.
After discovering that his kidney was paired, Leech’s mind was focused on the surgical procedure in search of mutual healing, but to “sustain” would have cost savings in terms of deployment. He had to delay his two-month donation while “scraping money” from his church and local veteran organizations.
House Bill 944 would ease the financial burdens of living donors by increasing the donor income tax reduction to $ 10,000, starting at $ 7,500, according to state legislative analysis.
If the invoice is approved, the higher credit would be applied to 2020 income taxes, which are due to expire on April 15 of next year.
“This is exactly the type of utility bill that donors need to eliminate financial stress,” Leech told Capital News Service.
Side by side, donor and recipient testified to the legislators of the House Ways and Means Committee in favor of the bill on February 25, and each claimed that the other saved his life.
The current $ 7,500 tax credit for living donors was created two years ago, brought into legislature by former House president Michael Busch, D-Anne Arundel, who received a transplant before his death in 2019 liver from his sister.
Karen Young Delegate, D-Frederick, is sponsoring House 944 and told Capital News Service that “need-related donors” are missing and, “I am a champion of greater access to health care and greater health coverage. relief. I feel this bill is in line with that, “Young said.
Senator Ronald Young, D-Frederick, sponsors an identical bill, the Senate 651 bill.
Nationally, around 8,000 people awaiting a transplant die because they have not received a life-saving organ, according to Donate Life America, an organ donation defense group.
In Maryland and other states, waiting lists for organ transplants have grown, according to legislative analysis.
There are 3,168 candidates on the waiting list for organ transplants in Maryland, most, 2,341, are waiting for kidney transplants; nationwide 112,114 candidates are on the organ transplant waiting list with over three quarters listed for the kidneys, according to the United States Department of Health and Human Services.
Kidney transplants from living donors tend to last longer than those from deceased donors, according to the American Kidney Fund.
Living organ donor transplants have had a downward trend in Maryland since 2000, which has seen a peak of 265. 2019 saw only 147, according to the United States Department of Health and Human Services.
Karen Kennedy, director of the Living Legacy Foundation of Maryland Education, whose group works with deceased organ donation logistics, educates hospitals and the public and works closely with living donor organizations, told Capital News Service that a Sometimes “the intention and the will” to be a live donor is there, but “practical reasons prevent people from donating” because they cannot get a work permit, they are not financially capable or for other reasons.
Payton, a single father from Charles County, Maryland, said he received his first kidney transplant in 1993 from a cousin, but was unsuccessful, and had to undergo dialysis in 2011 until he received one. of kidneys donated by Leech in 2012.
In Payton’s testimony, he said he would go through peritoneal dialysis while his son, who was 12 years old at the time, was on the soccer field, adding “I don’t want the two months to wait for a kidney on anyone.”
The bill is expected to reduce state revenues by a relatively small amount, $ 10,000 per year, and local revenue is estimated to decrease by approximately $ 6,500 per year, according to legislative analysis.
At the hearing, Payton said, “A new kidney gives you a new lease on life, and it is only through the kindness and love that Kellen has had for me and my son that allows me to do it.”
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This article was provided to The Associated Press by the University of Maryland Capital News Service.
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