very cheap and long-known drugs help save the lungs with coronavirus

Cloving hospital on the basis of the Medical Scientific and Educational Center (ISSC) Moscow State University named after M.V.Lomonosov took the first patients on April 21 and completed his work on June 13. It turned out that it was possible to achieve the best treatment results for COVID-19 in Moscow. Over the entire period, 4 patients died, and among severe patients who got mechanical ventilation, the mortality rate was less than 14% (for comparison, the average for the city and the world was up to 70 – 80%). Eighteen doctors out of 220 employees of the hospital were infected with coronavirus, there were no deaths among the medical staff.

What approaches were used at the University Hospital of Moscow State University to achieve such results? We continue the conversation with the head. Department of Therapy, Faculty of Fundamental Medicine, Moscow State University, Head of the Department of Age-Associated Diseases, Medical Scientific and Educational Center, Doctor of Medical Sciences, Cardiologist Yana Orlova.

MEDICINE FOR COUGH FOR 80 RUBLES

– Most of those who are ill or are afraid to get sick are worried about fibrotic changes in their lungs. They say that you have developed special therapy that can reduce the risk of developing fibrosis. Is it possible?!

– Yes, we launched an appropriate clinical study. There are no final results yet, but we have developed clinical practice.

“What did you do to save the lungs?”

– We used a combination of bromhexine and spironolactone (both are long-known very cheap drugs. – Ed.). Bromhexine is an expectorant that has been prescribed to patients with pneumonia and cough for many years. At the same time, experimental data showed that this drug can block a specific enzyme and impede the penetration of coronavirus into cells. True, it was on this effect that we counted to a lesser extent in inpatients, since such an effect is important mainly in the early stages of the disease. But the expectorant effect of bromhexine really helps patients with COVID. I heard that our colleagues in Peter launched a study of bromhexine for prophylactic purposes. We will wait for the results.

Coronavirus infected 18 doctors from 220 employees of the hospital, there were no deaths among the medical staffPhoto: Ivan MAKEEV

FIBROSIS OBSTACLE

– The second drug – spironolactone – is traditionally widely used in cardiology for the treatment of heart failure, severe hypertension. It has a small diuretic, magnesium and potassium-preserving effect, continues Yana. Orlova. – It has several mechanisms through which it can be useful in coronavirus infection.

Firstly, a mechanism that prevents the development of fibrosis in general in the body. There are works that, in particular, show that spironolactone reduces fibrosis in the heart. At the same time, it is known that the tendency to fibrosis is not local, but systemic – where there is more inflammation, there will certainly be fibrosis. And we see, of course, fibrotic changes in the “covide” in our patients. Therefore, we prescribed spironolactone as a drug for the prevention of this process.

Secondly, this drug blocks sex hormone receptors, in particular testosterone. Some published studies suggest that “high-testosterone” men suffer from “covid” more often and develop more severe fibrotic changes. Therefore, blocking these receptors for several weeks during COVID treatment may be useful in reducing the severity of complications. We are not talking about a longer intake, since male patients are unlikely to agree with a decrease in testosterone levels in the long term.

And perhaps the most important point. In almost all of our patients, we observed hypokalemia (a decrease in potassium levels. – Ed.). With coronavirus infection, potassium is intensely excreted from the body, and scientific articles even suggest that hypokalemia serves as the trigger for a cytokine storm. So spironolactone has a real chance to reduce the risk of this dangerous complication. But the main thing, in my opinion, is that lowering the level of potassium in the body is extremely harmful to the heart and triggers life-threatening rhythm disturbances, increasing the risk of sudden death. We, like all others, replenished potassium with droppers, but it was more effective to retain it in the body with the help of spironolactone.


Men certainly get worse than women;  the elderly are heavier than the young;  overweight people are heavier than patients without excess weight Photo: Ivan MAKEEV

Men certainly get worse than women; the elderly are heavier than the young; overweight people are heavier than overweight patientsPhoto: Ivan MAKEEV

WHEN PRESCRIBED PATIENTS

– Yana Arturovna, how many patients did you have on average?

– About 10 – 14 days. But someone and 50 days.

– Have you noticed signs by which it can be assumed that the disease in the person brought is likely to go the hard way?

– Such studies were carried out in the world, our clinical practice confirmed them. Men certainly get worse than women; the elderly are heavier than the young; overweight people are heavier than overweight patients. Men with a classic male type of baldness, a lot of facial hair, we can say brutal men get sick harder.

– Under what conditions did you discharge patients?

– We acted as close as possible to the recommendations Ministry of Health: so that the temperature for three days was not higher than 37.5 degrees; so that C-reactive protein (an indicator of inflammation) is lower than 10 mg / l, and saturation, that is, the level of oxygen in the blood, is higher than 96%.

“HEAD OF EPIDEMIOLOGY DEPARTMENT OF ITSELF WORKED AT SANPROPUSNIK”

– How often do you get sick doctors and nurses?

– In the first month no one got sick at all. We have a very powerful epidemiological service. The head of the sanitary-epidemiological department, a senior researcher, correctly organized the whole process, and for the first two weeks she personally worked in the sanitary inspection room at the exit from the “red zone” and helped doctors and nurses who were exhausted after the shift safely remove protective clothing.

Then both people’s fatigue and viral load accumulated. By the middle of the second month, sick people began to appear. There were no seriously ill patients. We treated part of the staff in our observation, part of it was treated at home. In total, 18 people were infected from the medical staff (less than 10%).

– Doctors take something for prevention? Vitamins C, D, Zinc?

– I saw the recommendations of American nutritionists, they speak out positively about taking zinc, melatonin and vitamin C. There were somewhat conflicting data on vitamin D. But we did not give any such recommendations to our employees. We have all the prevention was associated with minimizing contacts and other measures of epidemiological safety.

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salute from the cable-stayed bridge, hovering above the water Assol and space suits

The brightest evening of the country’s graduates ended, which the guys were looking forward to this year. So, as always, the Scarlet Sails Festival 2020 became a beautiful chord of the All-Russian holiday. This year it was both traditional and completely unusual at the same time. We tell you what the Scarlet Sails 2020 surprised.

The main innovation of this year is the change of locationPhoto: Oleg GOLD

Well, firstly, the main innovation is the change of location. For several years in a row, a snow-white brig passes through the water area Not you along the Peter and Paul Fortress, the Hermitage and right under the Palace Bridge. This year, another, no less picturesque place was chosen, with very recognizable sights. Petersburg – stadium “Gazprom-Arena “, Lakhta-center and cable-stayed bridge ZSD.


Access to all locations was closed due to the difficult epidemic situation both in the city and throughout the country. Photo: Artem KILKIN

Access to all locations was closed due to the difficult epidemic situation both in the city and throughout the country.Photo: Artem KILKIN

The second innovation: live Petersburgers and visitors could not see all this beauty. And all because this year there are special requirements: because of the pandemic, access to the park is closed, it was also impossible to see from the water, since part of the Neva and the Gulf of Finland were blocked. GIMS boats and various services went around the water area and made sure that no one violated the ban. Law enforcement officers were also on duty on land: if they met people in a territory where there should not be anyone, they politely asked to leave the place and go home.


Everyone was politely asked to leave the coast Photo: Artyom KILKIN

Everyone was politely asked to leave the coast.Photo: Artem KILKIN

And at home, by the way, everyone would have considered it in the best possible way: there was a live broadcast of a concert and a pyrotechnic show on the Internet and on TV. By the way, on the screen you can see what on the shore would definitely not be accessible to the eye. And all because along the Neva and the Gulf of Finland there were several scenes at once and on each of them there was an action.

The main stage was next to the Gazprom Arena stadium, it was also very unusual – as if soaring in the air, and with it the stars acting on it. Leading the holiday were Ivan Urgant and Daria Александрова.


The hosts of the holiday were Ivan Urgant and Daria Alexandrova Photo: Oleg GOLD

Leading the holiday were Ivan Urgant and Daria AlexandrovaPhoto: Oleg GOLD

Timur Rodriguez, Vera performed their hits Brezhnev, RASA group, Dima Bilan and Surganova. And there were surprises in the form of a show of pirates and drummers, yes, it is worth noting separately what costumes the artists had – just space ones. Be sure to watch Bilan’s performance if you missed. And also a salute, well, the passage itself of a sailboat!


The cable-stayed bridge of the WHSD was both a platform for light and a launch site for fireworks. Photo: Oleg ZOLOTO

The cable-stayed bridge of the WHSD was both a platform for light and a launch site for fireworksPhoto: Oleg GOLD

By the way, the pyrotechnic show lasted almost half an hour, hundreds of volleys were launched into the sky, the first cable-stayed bridge of the WHSD was used. It was both a platform for light, and for launching a salute.


But the highlight, of course, was the passage of a snow-white brig with Scarlet Sails along the Gulf of Finland Photo: Oleg ZOLOTO

But the highlight, of course, was the passage of a snow-white brig with Scarlet Sails along the Gulf of FinlandPhoto: Oleg GOLD

And at the end of the extravaganza, the romantic Assol soared above the water to meet her dream. By the way, this year the holiday was dedicated to the author of the fairy tale about Scarlet Sails Alexander Green – marks 140 years since his birthday.

If you missed the broadcast live, there is an opportunity to watch the best moments of the show.

Graduation Scarlet Sails in St. Petersburg ended with a grandiose salute.Alena CHICHIGINA

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Photo of Nadezhda Kadysheva without Photoshop shocked fans

The star of the folk song theater “Golden Ring” Nadezhda Kadysheva invariably delighted admirers of her talent with a well-groomed appearance. Intricate hairstyles, vibrant outfits, catchy makeup – at 60, the singer carefully monitors her stage image. Hope appears from time to time on the covers of glossy magazines, and on the posters of the Golden Ring theater she invariably shines with youth and beauty. What was the surprise of Instagram users when they saw fresh pictures of the artist without photoshop. In the photographs, Kadysheva looks very tired and sharply aged.

Dark circles under the eyes and an extinct look shocked the fans of the Russian folk song and made them worry. On the Web they discuss: is everything all right with the health of Hope, and does it hide some kind of illness? However, perhaps the artist in recent months has overworked – before Russia the pandemic seized, and all concerts were canceled, Kadysheva had a very busy tour schedule. Fans wish her health and hope that the artist will take advantage of the period of self-isolation in order to properly relax.

New photos of Nadezhda Kadysheva surprised her fans.

Instagram users compare Nadezhda Kadysheva with her colleague, singer Nadezhda Babkina. Nadezhda Georgievna is 10 years older than Kadysheva, but she looks much younger. Probably the whole thing is plastic surgery: Babkina does not hide the fact that the surgeon’s scalpel helped wipe her face for several years and extended her youth. She made a circular facelift and blepharoplasty, lifting her eyelids and removing wrinkles around her eyes.

With her husband and colleague in the ensemble “Golden Ring” Alexander Kostyuk Nadezhda Kadysheva has been living for 37 years – they got married in 1983. This is a rare example of family longevity in show business. At couples have an adult son.

The singer looks tired. Perhaps the reason for this is a busy tour schedule.

Doctors more than once saved the singer and literally pulled her out of the next world. At 30 years old her found a breast tumor, for two years she lived between life and death – Hope was sure that she would die from oncology. But during the operation, the diagnosis was not confirmed. The next time doctors saved the artist when she was 49 years old: he almost died of acute tachycardia. Doctors miraculously prevented a heart attack.

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A curtain! Member “Let’s get married” opened the “ins and outs” show

Apparently, there is no smell of any search for love there.

For more than 10 years, the program “Let’s get married!” Has been broadcast on Channel One. But if at the first stages the script of the show really resembled a search for love, then recently the situation is more like a farce. About a year ago, Garik Kharlamov began to show suspicious interest in the project, the public wondered for a long time what caused such close attention of the comedian. But the other day the picture became clear: the participant in the program revealed the “ins and outs” of what is happening.

The guest of the program, one of the contenders for the main character’s hand, bluntly stated that his surprise was “not standard”. Moreover, under this definition, the man clearly had in mind the “circus” performance, not typical of the show, in the form of dances with a tambourine and the like. Also, the participant seemed to have let it slip: “I would not want to go to the blog with Garik Kharlamov.” The comedian himself, of course, instantly reacted and posted the edited video on his Instagram, which once again confirms his amazing awareness of what is happening on the project.

There is reason to believe that the guest really wanted to try their luck on a date. However, he was apparently explained backstage that the essence of the program was a spectacle amid staged performances. In this case, the role of the Bulldog in the scheme becomes absolutely clear – the promotion of this “circus” for a certain fee. In other words, a curtain! Around only the struggle for ratings and the desire to please the mass audience. But before in such programs really people found their soul mate. By the way, it is possible that the “agreement” between Kharlamov and Channel One extends to the program “Live healthy!”.

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roommate-tyrant for three years beat the star of the “Factory of stars” Julia Parshutu

Singer Julia Parshuta made a very personal and frank confession. The scandal prompted the star of the Star Factory to take this step, which erupted after two interviews with Regina Todorenko. Fans decided that the TV presenter considers women guilty of men raising their hands on them. Parshuta said that for three years she lived with a home tyrant and was afraid to leave her roommate because he threatened her and her relatives.

In 2010 Julia Parshuta fell madly in love with a handsome handsome man. As it seemed to her, the chosen one was the smartest, most caring and attentive. “He was an energetic scholar – a man who is always interesting and fun with. I fell in love without memory. This was the first time with me. He was wonderful. The first few months,” she said.

And then real hell began. The first time he beat her, Julia persuaded herself to forgive him. The tyrant roommate was kneeling and begging forgiveness. “My family never had physical abuse. Therefore, I did not know that it was not treated with a wise word and a meek look. That it should not be forgiven,” the girl said.

She suffered beatings for three years. “In March 2013, a week after an appendectomy, on Nizhnyaya Syromyatnicheskaya street I got hit in the stomach with my fist, “decorated” with the stitches of the operation. A stab in the stomach from his man. Another blow, and only God knows which is the bill for our life together, “Julia Parshuta began her confession.

After that, the man took her phone, bag and car keys. But the girl still ran away from him to her friend. “Having come in, I asked her for water and said that my bag was stolen from me. And with all my strength I showed that everything was fine with me. The third year of our relationship was on. In fact, the third year in a box of fear and despair. Without the ability to search and find protection and exit, “writes the 32-year-old artist.

She also explained why before that she did not dare to leave Tirana. “He was strong. Very. It was the third year of “I-guilty-in-everything”, the third year of “I-worthless”, the third “I-not-for-nothing-capable” year. Because it was the third year I was intimidated to the bone. The third year, as the veil of hopelessness grew stronger from his threats. Because threats are not just me. The threat “I will cut your family” and “to you … if you go to the police”, ”the Star Factory participant shocked with revelation.

Parshuta stressed that for a long time she could not find the strength to admit that she was a victim of domestic violence. The actress urges women not to be silent about the beatings and are not afraid of conviction. “Talking about violence should not be embarrassing,” she summed up.

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In Italy, announced the softening of measures and the launch of the second phase of the fight against the virus :: Society :: RBC

Also from May 4 will open access to public parks and gardens. There, citizens will have to observe the required distance. In addition, the ban on attending funeral ceremonies will be lifted. At the same time, the ban on mass events and crowds will be preserved.

Italian scientists called the real mortality rate from coronavirus

According to Conte, the government decided to make an indulgence for playing sports. It will be possible to deal with them at a distance of two meters from each other. Professional athletes in certain disciplines will be able to return to training “behind closed doors.”

From May 4, bars and restaurants will start operating in Italy. The owners of the establishments will be allowed to engage in catering, and visitors will be able to place take-away orders, but so far they can only use the food they buy at home.

In his address, Conte said that from May 18, museums and the main attractions of Italy will be opened. Full opening of bars, restaurants, hairdressers and beauty salons will occur on June 1. All schools will be closed until the end of the school year.

Italy was among the countries that suffered the most from COVID-19. According to the latest data, 26 644 people died due to the virus (the second result after the USA), more than 197 thousand were infected (third place in the world), almost 65 thousand patients managed to recover.

Coronavirus

Russia Moscow Peace

0 (per day)

Recovered

0

0 (per day)

Infected

0

0 (per day)

Died

0 (per day)

Recovered

0

0 (per day)

Infected

0

0 (per day)

Died

0 (per day)

Recovered

0

0 (per day)

Infected

0

0 (per day)

Died

Source: JHU, JHU,
federal and regional
anti-virus operations

Source: JHU, federal and regional anti-virus operations

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the doctor said why there are few coronavirus cases in Samara

The number of patients with coronavirus in the Samara region since the beginning of April has grown by three people. It’s really a bit, but the situation around is more like preparing for combat action. New infectious beds are constantly being prepared in the region, doctors are being trained, hospitals are being re-equipped. Residents perplexed: “More patients? They don’t tell any information? ” In fact, there is no need to look for a dirty trick: citizens are honestly told about how the situation is developing. But what comes next is difficult to predict. Associate Professor of the Department of Infectious Diseases of Samara State Medical University, Chief Specialist of the Ministry of Health of the Samara Region on the Problems of Diagnosis and Treatment of HIV Infection, Infectious Disease Doctor with 30 Years of Experience Elena Strebkova now helps to organize an infectious diseases hospital at the hospital named after Midpoint “There are no patients here, but who knows if they will appear tomorrow.” She told in an exclusive interview to a journalist “KPSamara”, Why the whole branch of medicine is working so hard today, although the numbers of cases and the inhabitants seem low, are Samara residents at risk of picking up a coronavirus and why is COVID-19 more dangerous than“ ordinary flu ”.

– Elena Alekseevna, why is such mass training, reprofiling of hospitals necessary?

– The measures taken by the government of the country and the region, and now allow us to prevent a surge in incidence. If not for them, we would be faced with a situation that is now happening around the world. Thanks to the measures taken for isolation and sanitation, a large number of cases of infection do not appear. This is done so that all our medical organizations have time to prepare. We see that new cases of infection and new cases appear daily, and we must be prepared to provide highly qualified medical assistance to the residents of the region. Like all my colleagues, we will be happy if we do not have to. But we must be prepared.

– How are hospitals preparing to receive coronavirus patients, what is the peculiarity of interacting with such patients?

– Infectious diseases that we usually deal with in the Samara Region are caused by microorganisms that do not require special preparation from a doctor. And COVID-19 is a particularly dangerous infection. Therefore, all protective measures in hospitals converted to infectious hospitals, for example, in SOKB named after V.D. Seredavina, taken for this class of pathogenicity. For this, doctors put on protective suits, masks, goggles – a person must be fully protected, because even small aerosol drops that remain in the air after coughing or sneezing can get on it and then lead to infection.

– How are doctors trained to resist the coronavirus?

– Doctors at hospitals that are converting to infectious hospitals are currently undergoing training. First of all, they are taught to wear and take off protective clothing correctly. Because the physician must first protect himself from infection, otherwise there will be no one to help people.

In addition, doctors are told how the virus is transmitted and how to protect themselves; they explain all the rules for disinfection. Of course, we study the clinical forms of the disease, how it manifests itself, what supporting signs of coronavirus infection, what indicators you need to pay attention to in order to make a diagnosis and assess the severity of the patient.

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– And as for lung ventilation, for example? Is she taught to do it?

– Naturally, such a huge number of resuscitators, infectious disease specialists, pulmonologists, which may be needed in case of a surge in incidence, is not in the healthcare system. Therefore, if necessary, infectious disease specialists and pulmonologists will work as consultants. One infectious disease specialist and pulmonologist per 100 patients – this will be quite hard work.

Under their guidance, doctors of all other specialties, after training, will be able to work with such patients. But the main burden will fall on resuscitators. Here, one resuscitator with two nurses will work for six people. Although basic training in mechanical ventilation and resuscitation will still pass all the doctors. For example, the staff of Seredavin Hospital is almost completing such training.

– How large, in your opinion, is an infectious disease specialist with 30 years of experience in the likelihood of a scenario when 100 coronavirus patients fall on one pulmonologist?

– We all want to hope that this probability is low, but we should always be prepared for this. It’s impossible to deploy an infectious diseases hospital in a hospital that was not intended for this; deploying such a huge number of resuscitation beds is impossible. The preparations that are currently underway will allow us to avoid the so-called “Italian scenario” – the very help that is needed will be immediately provided to the patients. IN Italy such a difficult situation was due to the large number of patients at the same time. Quarantine was announced late in the country; the healthcare system was not ready for such an arrival of patients who need ventilation support. In our country, the health system managed to prepare.

– Explain why we have so few patients and how relevant is self-isolation in this situation?

– These are the rules for the development of the epidemic. Why in Moscow so many sick? Not only because there are more people. But also because people from different countries flocked there and only then were distributed among the regions. Therefore, a huge number of sources of infection fell precisely in the capital. Naturally, there is the largest percentage of cases. But people from Moscow came here, and now the virus is spreading here. And now it doesn’t have to be contact with a person who came from abroad. This may be contact with a person who has not left the territory of the Samara region, who himself does not suspect that he is a source of infection.

The virus already exists in the urban environment, and it was for this reason that self-isolation measures were taken to protect people from each other. The closer we are to each other, the greater the likelihood of becoming infected, and the biggest danger is that this will happen at the same time, giving a greater burden on the health system.

“How can the virus spread if we all sit at home?”

– Let’s really look at things. You are not sitting at home. Anyway, you go to the store, to the pharmacy, where to whatever. The main distribution path is through door handles, through the buttons of elevators, in contact with trolleys in stores. These are transmission routes that no one has canceled. And with close contact at a distance of less than two meters, infection from person to person is also possible.

– They say that coronavirus is less dangerous than ordinary flu, it has less mortality, there is no reason for panic?

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– Mortality from influenza was also quite high until the moment of mass vaccination. Now vaccination saves us from a large number of deaths with the flu. And we expect the appearance of a coronavirus vaccine only by the end of the year. Therefore, people are not protected. And since the virus is new, it first appeared this year, we have no immunity. And since no one has immunity, there is no layer that would restrain the explosive nature of the epidemic. Explosive is when several thousand cases appear at one moment. According to some experts, the main surge in the incidence may occur next week. The medical system must be prepared for this.

– In social networks, KP-Samara asked readers why, in their opinion, in the Samara region such a low incidence of coronavirus. It turned out that most are sure: we just have little testing for coronavirus. How do you rate coronavirus testing in the region? Are they enough?

– We test as much as necessary, except Rospotrebnadzor A laboratory has been deployed at the AIDS Center. They test those who came from abroad and are in quarantine, all patients with pneumonia, with severe forms of acute respiratory infections, pregnant women – volumes are large.

“And the main question that worries everyone is when will it all end?”

– So far, the measures taken are designed for the next three months. But we will all be happy if everything ends earlier.

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Asmus “revealed” why Kharlamov is mocking Guzeeva

As it turned out, the host of “Let’s Get Married” guilty of the comedian’s family.

For several months, the network has been actively discussing the conflict between Garik Kharlamov and Larisa Guzeeva. The comedian quite often posts on Instagram, where he exposes the leading “Let’s get married” uncultured habalka. But was there really a conflict between them? And why Guzeeva appears on Instagram Garik more often than his young wife Christina Asmus.

As it turned out, Kharlamov’s “love” for the host “Let’s get married!” not so baseless. The other day, Christina Asmus “revealed” why Kharlamov is mocking Guzeeva. The fact may be that Larisa several years ago greatly offended the sentimental Christina Asmus. In her interview, the actress said that when she was 8 months pregnant, she had to participate in one event, where, strictly speaking, the harsh host of Channel One took part.
Kristina was a little late, for good reason, and when she went into the room she immediately saw the bitchy look of Larisa Guzeeva. He was so piercing and unhappy that a pregnant girl remembered him for life. It is possible that this look brought the impressionable Christina to tears, and she shared this incident with Kharlamov.

In turn, Garik began to avenge the tears of his pregnant wife, exposing the lead in an unsightly light. However, he drew a big plus from this, subscribers are madly in love when jokes with the participation of Larisa reappear on Kharlamov’s page.

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