very cheap and long-known drugs help save the lungs with coronavirus

Cloving hospital on the basis of the Medical Scientific and Educational Center (ISSC) Moscow State University named after M.V.Lomonosov took the first patients on April 21 and completed his work on June 13. It turned out that it was possible to achieve the best treatment results for COVID-19 in Moscow. Over the entire period, 4 patients died, and among severe patients who got mechanical ventilation, the mortality rate was less than 14% (for comparison, the average for the city and the world was up to 70 – 80%). Eighteen doctors out of 220 employees of the hospital were infected with coronavirus, there were no deaths among the medical staff.

What approaches were used at the University Hospital of Moscow State University to achieve such results? We continue the conversation with the head. Department of Therapy, Faculty of Fundamental Medicine, Moscow State University, Head of the Department of Age-Associated Diseases, Medical Scientific and Educational Center, Doctor of Medical Sciences, Cardiologist Yana Orlova.

MEDICINE FOR COUGH FOR 80 RUBLES

– Most of those who are ill or are afraid to get sick are worried about fibrotic changes in their lungs. They say that you have developed special therapy that can reduce the risk of developing fibrosis. Is it possible?!

– Yes, we launched an appropriate clinical study. There are no final results yet, but we have developed clinical practice.

“What did you do to save the lungs?”

– We used a combination of bromhexine and spironolactone (both are long-known very cheap drugs. – Ed.). Bromhexine is an expectorant that has been prescribed to patients with pneumonia and cough for many years. At the same time, experimental data showed that this drug can block a specific enzyme and impede the penetration of coronavirus into cells. True, it was on this effect that we counted to a lesser extent in inpatients, since such an effect is important mainly in the early stages of the disease. But the expectorant effect of bromhexine really helps patients with COVID. I heard that our colleagues in Peter launched a study of bromhexine for prophylactic purposes. We will wait for the results.

Coronavirus infected 18 doctors from 220 employees of the hospital, there were no deaths among the medical staffPhoto: Ivan MAKEEV

FIBROSIS OBSTACLE

– The second drug – spironolactone – is traditionally widely used in cardiology for the treatment of heart failure, severe hypertension. It has a small diuretic, magnesium and potassium-preserving effect, continues Yana. Orlova. – It has several mechanisms through which it can be useful in coronavirus infection.

Firstly, a mechanism that prevents the development of fibrosis in general in the body. There are works that, in particular, show that spironolactone reduces fibrosis in the heart. At the same time, it is known that the tendency to fibrosis is not local, but systemic – where there is more inflammation, there will certainly be fibrosis. And we see, of course, fibrotic changes in the “covide” in our patients. Therefore, we prescribed spironolactone as a drug for the prevention of this process.

Secondly, this drug blocks sex hormone receptors, in particular testosterone. Some published studies suggest that “high-testosterone” men suffer from “covid” more often and develop more severe fibrotic changes. Therefore, blocking these receptors for several weeks during COVID treatment may be useful in reducing the severity of complications. We are not talking about a longer intake, since male patients are unlikely to agree with a decrease in testosterone levels in the long term.

And perhaps the most important point. In almost all of our patients, we observed hypokalemia (a decrease in potassium levels. – Ed.). With coronavirus infection, potassium is intensely excreted from the body, and scientific articles even suggest that hypokalemia serves as the trigger for a cytokine storm. So spironolactone has a real chance to reduce the risk of this dangerous complication. But the main thing, in my opinion, is that lowering the level of potassium in the body is extremely harmful to the heart and triggers life-threatening rhythm disturbances, increasing the risk of sudden death. We, like all others, replenished potassium with droppers, but it was more effective to retain it in the body with the help of spironolactone.


Men certainly get worse than women;  the elderly are heavier than the young;  overweight people are heavier than patients without excess weight Photo: Ivan MAKEEV

Men certainly get worse than women; the elderly are heavier than the young; overweight people are heavier than overweight patientsPhoto: Ivan MAKEEV

WHEN PRESCRIBED PATIENTS

– Yana Arturovna, how many patients did you have on average?

– About 10 – 14 days. But someone and 50 days.

– Have you noticed signs by which it can be assumed that the disease in the person brought is likely to go the hard way?

– Such studies were carried out in the world, our clinical practice confirmed them. Men certainly get worse than women; the elderly are heavier than the young; overweight people are heavier than overweight patients. Men with a classic male type of baldness, a lot of facial hair, we can say brutal men get sick harder.

– Under what conditions did you discharge patients?

– We acted as close as possible to the recommendations Ministry of Health: so that the temperature for three days was not higher than 37.5 degrees; so that C-reactive protein (an indicator of inflammation) is lower than 10 mg / l, and saturation, that is, the level of oxygen in the blood, is higher than 96%.

“HEAD OF EPIDEMIOLOGY DEPARTMENT OF ITSELF WORKED AT SANPROPUSNIK”

– How often do you get sick doctors and nurses?

– In the first month no one got sick at all. We have a very powerful epidemiological service. The head of the sanitary-epidemiological department, a senior researcher, correctly organized the whole process, and for the first two weeks she personally worked in the sanitary inspection room at the exit from the “red zone” and helped doctors and nurses who were exhausted after the shift safely remove protective clothing.

Then both people’s fatigue and viral load accumulated. By the middle of the second month, sick people began to appear. There were no seriously ill patients. We treated part of the staff in our observation, part of it was treated at home. In total, 18 people were infected from the medical staff (less than 10%).

– Doctors take something for prevention? Vitamins C, D, Zinc?

– I saw the recommendations of American nutritionists, they speak out positively about taking zinc, melatonin and vitamin C. There were somewhat conflicting data on vitamin D. But we did not give any such recommendations to our employees. We have all the prevention was associated with minimizing contacts and other measures of epidemiological safety.

Physicians are the heroes of our time.“If you think that you are special and that a pandemic will not affect you, you are deeply mistaken,” listen to what the doctors who are fighting with coronavirus say

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Revenge of the offended stepdaughter, or why Guzeeva still can not forgive the strict stepfather

The attitude of the leading “Let’s get married” to the elderly was clearly affected by childhood.

Larisa Guzeeva expressed her negative attitude towards the elderly, who ruined the lives of their children. The reason for such words, most likely, was the fact that the presenter still can not forgive the strict stepfather for a difficult childhood.

The heroine of one of the recent episodes of the television show “Let’s Get Married” was a girl named “deprived of her childhood”. The host of the program, Larisa, was imbued with the story of a participant whose parents suffered from alcoholism. The news that after all that happened the children again adopted their father in the family, Larisa was outraged. She quipped that she did not consider it necessary to respect people of mature age only for their old age. In her opinion, a person is not worthy of this, if he did all his life that he spoiled the life of his family. Such a reaction seems strange, and you involuntarily wonder: why did Guzeeva so dislike the heroine’s father?

The case, apparently, is in the difficult childhood of the TV presenter herself. Guzeeva never saw her father and was brought up by her stepfather. According to her, he was quite strict, so he did not allow her to dress and dress as she wanted. She did not like it, so the future TV star did everything exactly the opposite.

A difficult childhood undoubtedly influenced the views of the host and such words about the elderly, most likely, became the revenge of the offended stepdaughter. But to say something concrete without Larisa’s comments on this subject is probably not worth it yet. In any case, the 60-year-old Guzeeva has already seen a lot, and such an experience influenced her attitude to old age.

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Asymptomatic carriers, scientists called the “coronavirus vaccine”

Collective immunization takes place at the expense of these people.

Up to 50 percent of infected people carry the virus without symptomsUp to 50 percent of infected people carry the virus without symptomsPhoto: REUTERS

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Asymptomatic coronavirus carriers do what the vaccine should do. So says the Head of the department of interferons and the laboratory of interferonogenesis at the National Research Center for Epidemiology and Microbiology named after Gamalei, academician of RAS Felix Ershov

A vaccine that scientists around the world are working on should lead to collective immunity from the disease. As in the case of the flu. The more people vaccinated, that is, not susceptible to the virus, the less the spread of the disease. There is no vaccine from coronavirus, then collective immunization can take place at the expense of asymptomatic people:

– These are mainly young people, children. They spread the virus and, in fact, do what the vaccine should do: collective immunization is underway. When it reaches 70%, the growth of the disease will end. This process is well known among viral infections, ”the scientist said on the air. NSN.

But the danger is that this process is uncontrolled, asymptomatic carriers can infect people at risk: the elderly, people with chronic diseases. For this category of patients, infection can be deadly.

– It is necessary to maintain strict control measures. They have already allowed to reduce the incidence – it is not explosive, ”advises Felix Ershov. – People need to wash their hands more often. Patients must wear masks. Healthy, not necessarily, rather it is necessary for complacency.

SOURCE KP.RU

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Health Several tips for elderly patients to protect from corona infection

The Ministry of Health and Population revealed a set of advice to protect the elderly from infection with the Corona virus, as part of plans to combat the epidemic and prevent an outbreak among citizens.

In a leaflet, the Ministry of Health and Population said, addressing the elderly and people with complete illnesses: Keep routine activities and schedules as much as possible, or make sure to do new activities in a new environment such as exercising, cleaning, singing, daily tasks and drawing.

The Ministry of Health and Population announced that the Ministry cooperated with the “Twitter” website to launch an awareness initiative to provide reliable health information about the Coronavirus “Covid-19” by activating the hashtag # Questions_Covid19.

A statement clarified that through this initiative, citizens will be able to post a tweet on Twitter to inquire about any information about the virus by posting it with the hashtag # Questions_Covid19, and the ministry will respond to questions on Tuesday of each week in via its account on the site ” Twitter. “

He added that the Ministry of Health and Population created an account on Twitter last January, with the aim of creating new communication platforms with citizens about the latest services provided by the ministry.

The statement pointed out that the laws of “Twitter” include obliging people to remove the tweets that are inconsistent with the recommendations of the authorities and governments responsible for health, in order to reduce the possibility of a person affecting people in any matter or taking preventive measures related to the virus that may be unacceptable and contrary to the recommended instructions, adding The site also obliges people to remove any tweets that are not based on scientific facts about the transmission of the virus during the incubation period, or on the instructions of health authorities in general and other tweets that violate the platform’s policies.

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Mayweather has time to knock Habib in 10 rounds

Nurmagomedov underestimates the strength of his “elderly” opponent.

The conflict between Floyd Mayweather and Khabib Nurmagomedov flared up in 2018. And only now began to approach its climax.

The parties were not going to give in to each other and offered a duel-duel, each according to its own rules. Habib, of course, longed for a fight in the octagon, and Floyd advocated for a boxing match.

At the moment, favorable conditions have developed for Floyd, as Nurmagomedov proposed a compromise of 10 three-minute rounds of boxing and 1 five-minute rounds in the octagon.

Of course, it may seem that these are just guesses, but quite a few concrete facts indicate that Mayweather will have time to knock Khabib out in 10 rounds. Only Nurmagomedov himself tries to prove the opposite with words.

This fight is important for the Dagestan to win the love of the American public and forever “disown” from a rematch with Conor, whom, by the way, Floyd defeated by TKO, precisely in the 10th round. The Irishman, as you know, is more prepared for contact confrontation than Habib. This could just be seen during their battle in 2018.

Recently, Nurmagomedov often began to joke about Floyd’s age, intentionally or accidentally, but the years cannot be considered a clear flaw. For his 43 years, Mayweiser won 50 victories and not a single defeat, and the Dagestan only 28. Overweight on the face. Nurmagomedov clearly underestimates the strength of his “elderly” opponent.

A similar picture was already in the world of battles, when the whole world shouted that Mike Tyson would tear Evander Holyfield with a coefficient of 22 to 1, but experience won.

Plus, do not forget that even according to the rules of MMA, if Khabib survives the 11th five-minute round, no one can forbid Mayweather to use his fists in the cage.

Although Nurmagomedov can apply the well-known tactics just before the battle – “no battle, no defeat”. However, running forever in any case will not work.

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