very cheap and long-known drugs help save the lungs with coronavirus

Cloving hospital on the basis of the Medical Scientific and Educational Center (ISSC) Moscow State University named after M.V.Lomonosov took the first patients on April 21 and completed his work on June 13. It turned out that it was possible to achieve the best treatment results for COVID-19 in Moscow. Over the entire period, 4 patients died, and among severe patients who got mechanical ventilation, the mortality rate was less than 14% (for comparison, the average for the city and the world was up to 70 – 80%). Eighteen doctors out of 220 employees of the hospital were infected with coronavirus, there were no deaths among the medical staff.

What approaches were used at the University Hospital of Moscow State University to achieve such results? We continue the conversation with the head. Department of Therapy, Faculty of Fundamental Medicine, Moscow State University, Head of the Department of Age-Associated Diseases, Medical Scientific and Educational Center, Doctor of Medical Sciences, Cardiologist Yana Orlova.

MEDICINE FOR COUGH FOR 80 RUBLES

– Most of those who are ill or are afraid to get sick are worried about fibrotic changes in their lungs. They say that you have developed special therapy that can reduce the risk of developing fibrosis. Is it possible?!

– Yes, we launched an appropriate clinical study. There are no final results yet, but we have developed clinical practice.

“What did you do to save the lungs?”

– We used a combination of bromhexine and spironolactone (both are long-known very cheap drugs. – Ed.). Bromhexine is an expectorant that has been prescribed to patients with pneumonia and cough for many years. At the same time, experimental data showed that this drug can block a specific enzyme and impede the penetration of coronavirus into cells. True, it was on this effect that we counted to a lesser extent in inpatients, since such an effect is important mainly in the early stages of the disease. But the expectorant effect of bromhexine really helps patients with COVID. I heard that our colleagues in Peter launched a study of bromhexine for prophylactic purposes. We will wait for the results.

Coronavirus infected 18 doctors from 220 employees of the hospital, there were no deaths among the medical staffPhoto: Ivan MAKEEV

FIBROSIS OBSTACLE

– The second drug – spironolactone – is traditionally widely used in cardiology for the treatment of heart failure, severe hypertension. It has a small diuretic, magnesium and potassium-preserving effect, continues Yana. Orlova. – It has several mechanisms through which it can be useful in coronavirus infection.

Firstly, a mechanism that prevents the development of fibrosis in general in the body. There are works that, in particular, show that spironolactone reduces fibrosis in the heart. At the same time, it is known that the tendency to fibrosis is not local, but systemic – where there is more inflammation, there will certainly be fibrosis. And we see, of course, fibrotic changes in the “covide” in our patients. Therefore, we prescribed spironolactone as a drug for the prevention of this process.

Secondly, this drug blocks sex hormone receptors, in particular testosterone. Some published studies suggest that “high-testosterone” men suffer from “covid” more often and develop more severe fibrotic changes. Therefore, blocking these receptors for several weeks during COVID treatment may be useful in reducing the severity of complications. We are not talking about a longer intake, since male patients are unlikely to agree with a decrease in testosterone levels in the long term.

And perhaps the most important point. In almost all of our patients, we observed hypokalemia (a decrease in potassium levels. – Ed.). With coronavirus infection, potassium is intensely excreted from the body, and scientific articles even suggest that hypokalemia serves as the trigger for a cytokine storm. So spironolactone has a real chance to reduce the risk of this dangerous complication. But the main thing, in my opinion, is that lowering the level of potassium in the body is extremely harmful to the heart and triggers life-threatening rhythm disturbances, increasing the risk of sudden death. We, like all others, replenished potassium with droppers, but it was more effective to retain it in the body with the help of spironolactone.


Men certainly get worse than women;  the elderly are heavier than the young;  overweight people are heavier than patients without excess weight Photo: Ivan MAKEEV

Men certainly get worse than women; the elderly are heavier than the young; overweight people are heavier than overweight patientsPhoto: Ivan MAKEEV

WHEN PRESCRIBED PATIENTS

– Yana Arturovna, how many patients did you have on average?

– About 10 – 14 days. But someone and 50 days.

– Have you noticed signs by which it can be assumed that the disease in the person brought is likely to go the hard way?

– Such studies were carried out in the world, our clinical practice confirmed them. Men certainly get worse than women; the elderly are heavier than the young; overweight people are heavier than overweight patients. Men with a classic male type of baldness, a lot of facial hair, we can say brutal men get sick harder.

– Under what conditions did you discharge patients?

– We acted as close as possible to the recommendations Ministry of Health: so that the temperature for three days was not higher than 37.5 degrees; so that C-reactive protein (an indicator of inflammation) is lower than 10 mg / l, and saturation, that is, the level of oxygen in the blood, is higher than 96%.

“HEAD OF EPIDEMIOLOGY DEPARTMENT OF ITSELF WORKED AT SANPROPUSNIK”

– How often do you get sick doctors and nurses?

– In the first month no one got sick at all. We have a very powerful epidemiological service. The head of the sanitary-epidemiological department, a senior researcher, correctly organized the whole process, and for the first two weeks she personally worked in the sanitary inspection room at the exit from the “red zone” and helped doctors and nurses who were exhausted after the shift safely remove protective clothing.

Then both people’s fatigue and viral load accumulated. By the middle of the second month, sick people began to appear. There were no seriously ill patients. We treated part of the staff in our observation, part of it was treated at home. In total, 18 people were infected from the medical staff (less than 10%).

– Doctors take something for prevention? Vitamins C, D, Zinc?

– I saw the recommendations of American nutritionists, they speak out positively about taking zinc, melatonin and vitamin C. There were somewhat conflicting data on vitamin D. But we did not give any such recommendations to our employees. We have all the prevention was associated with minimizing contacts and other measures of epidemiological safety.

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experts explain why obesity “helps” coronavirus

– Has long been known that overweight people have lowered immunity, says head of the Department of endocrinology of the medical faculty Russian national research medical University. N. And. Pirogov Tatiana Demidova. Research and practice show that in these patients increases the risk of atherosclerosis sharply increases the risk of heart attacks, strokes and heart failure. Increased risk of endocrinological, oncological diseases, joint diseases, psychological disorders.

Epidemic COVID has added another item to the list of high threats to people who are overweight. It turned out that when infected with coronavirus patients with obesity more often require hospitalization, fall into the ICU, on the ventilator (artificial lung ventilation). Alas, is growing and the risk of death.

– If the original messages from China on the most severe cases COVID it was mainly about the older people with severe chronic diseases, according to the latest data from Europe and USA the risk group includes people with obesity – says Tatiana Demidova.

FACTS AND FIGURES

In what diseases most often develop complications due to coronavirus

90% of patients admitted with severe COVID-19 US hospitals, were the following comorbidities:

– hypertension — 49.7%,and

– obesity or 48.3%,

– chronic lung disease — 34,6%,

– diabetes type 2 diabetes was 28.3%,

– cardiovascular disease — 27,8%.

Thus, obesity is second among the States in which CouId be severe.

CORONAVIRUS, INFLUENZA, AND HIV, “LIKE” ADIPOSE TISSUE

Visceral adipose tissue, that is, one that is in the abdomen, is, in fact, highly individual body, experts explain. This body affects the immune, endocrine system and metabolism in the body as a whole.

– People who are overweight fat cells are much larger. So, is synthesized in much more of various hormones and inflammatory cells. Among them, including interleukin-6, interleukin-1, tumor necrosis factor, and others, – says Tatiana Demidova. Often in the body, there is a creeping inflammation.

At the same time observed that many viral infections and especially COVID-19 amplify the effects cytokines and lead to the extension of the generalization of inflammation. “It was proved that adipose tissue serves as a reservoir for some viruses, such as influenza, HIV and cytomegalovirus. Also, according to the latest data, it can be activated and coronavirus,” adds Demidov.

INSULATION NEEDS TO BE LONGER?

Studies have shown one more feature of coronavirus. As it turned out, he is able to spread rapidly in adipose tissue surrounding internal organs – lungs, liver, kidneys, heart, etc. because Of this, developing severe damage to these vital organs and people with excess weight, excess amount of adipose tissue increases the risk of death from multiple organ failure.

There is evidence that such patients are also unable to stay longer carriers of the virus, require longer hospital stay and isolation, said Tatyana Demidova.

AFTER INFECTION — DIABETES

There is evidence and that not less than one-third of patients hospitalized with COVID-19 in China, European countries and the United States, the infection resulted in damage of the pancreas. This was confirmed by elevated enzymes amylase and lipase, and glucose levels in the blood plasma.

– This is a very disturbing circumstance. Since we talking about high risk of developing diabetes type 2 diabetes in people with the original obesity after recovery from infection, says Dr. Demidov.

It is not excluded that after the break the pace of the epidemic COVID, we will see a worldwide surge in the incidence of diabetes, experts say.

So now, when the opportunity walks, sports, seasonal ripe fruits and vegetables rich in fiber, doctors suggest the obese individuals to exert their maximum effort for getting rid of really dangerous extra pounds.

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Soloist Little Big Sophia Tayurskaya shocked with pictures before losing weight

Looking at the soloist of the popular Little Big group Sofya Tayurskaya, it is hard to imagine that this miniature brown-haired woman could have problems with being overweight. However, the 28-year-old singer decided to show how she looked before losing weight.

Sophia Tayurskaya loves to experiment with her appearance. It appears in provocative outfits, demonstrating mouth-watering forms. Fans are often interested in how their pet keeps fit. The other day, the singer made a live broadcast with her followers. The audience once again asked whether the Little Big vocalist has always been such a beauty.

Sophia did not hide and showed bold pictures before losing weight. In a girl in a red ball gown, it is almost impossible to recognize Sophia.

Tayurskaya did not say how much she weighed before losing weight. However, judging by the pictures, she had to lose about 30 kgPhoto: Personal archive

Tayurskaya was born in Irkutsk, from childhood, was engaged in music. In the family, she was the youngest, third child. Her childhood passed in the Arkhangelsk region in a small town Novodvinsk. After school, the girl moved to St.Petersburg.

During her studies, she worked part time, speaking in a cafe and karaoke. In college, the girl was overweight. She could not get rid of extra pounds for a long time. I followed a diet and went in for sports. Gradually, all efforts brought results.


Fans were shocked by what they saw Photo: Personal archive

Fans were shocked by what they sawPhoto: Personal archive

Now the singer’s height is -164 cm, she weighs 54 kg. At the same time, Tayurskaya did not say how much she weighed before losing weight. However, judging by the pictures, she had to lose about 30 kg.

Fans were shocked by what they saw. Many do not hide their admiration for such a sharp transformation of the idol. Moreover, the public noticed that at the beginning of her career, the girl’s head was decorated with a thick long scythe. Now Tayurskaya most often loosens her hair. The singer is a real decoration of the St. Petersburg team.

LITTLE BIG SKIBIDI (official music video)..

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Asymptomatic carriers, scientists called the “coronavirus vaccine”

Collective immunization takes place at the expense of these people.

Up to 50 percent of infected people carry the virus without symptomsUp to 50 percent of infected people carry the virus without symptomsPhoto: REUTERS

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Asymptomatic coronavirus carriers do what the vaccine should do. So says the Head of the department of interferons and the laboratory of interferonogenesis at the National Research Center for Epidemiology and Microbiology named after Gamalei, academician of RAS Felix Ershov

A vaccine that scientists around the world are working on should lead to collective immunity from the disease. As in the case of the flu. The more people vaccinated, that is, not susceptible to the virus, the less the spread of the disease. There is no vaccine from coronavirus, then collective immunization can take place at the expense of asymptomatic people:

– These are mainly young people, children. They spread the virus and, in fact, do what the vaccine should do: collective immunization is underway. When it reaches 70%, the growth of the disease will end. This process is well known among viral infections, ”the scientist said on the air. NSN.

But the danger is that this process is uncontrolled, asymptomatic carriers can infect people at risk: the elderly, people with chronic diseases. For this category of patients, infection can be deadly.

– It is necessary to maintain strict control measures. They have already allowed to reduce the incidence – it is not explosive, ”advises Felix Ershov. – People need to wash their hands more often. Patients must wear masks. Healthy, not necessarily, rather it is necessary for complacency.

SOURCE KP.RU

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