- Regular sessions of hyperbarism would reverse the aging process of blood cells.
- There are two aspects to high pressure oxygen therapy: lengthening the telomeres, which are the protective regions located at the two ends of each chromosome, and reducing the accumulation of senescent cells.
But so far, no treatment has been able to reverse, or even to stop the biological aging process human cells.
New study from Tel Aviv University (TAU) and Shamir Medical Center in Israel published in the journal Aging however, highlights the spectacular effects on cellular aging of treatments with hyperbar oxygen (OHB). According to its authors, the latter would be able to rejuvenate the blood cells of aging adults.
Reverse the cellular aging process
“For many years, our team has been engaged in research and hyperbaric therapy – treatments based on protocols of exposure to high pressure oxygen at different concentrations inside a pressure chamber, details the Professor Shai Efrati. Some of our accomplishments over the years have included improving brain functions damaged by age, stroke or brain damage. “
The clinical trial wanted “to examine the impact of HBOT on healthy and independent aging adults, and to find out whether such treatments can slow, stop or even reverse the normal aging process at the cellular level”, continues the researcher.
To do this, the researchers recruited 35 healthy people aged 64 or older who were exposed to 60 sessions of hyperbarism over a 90-day period. They also provided blood samples before, during and at the end of the treatments, as well as some time after the end of the series of treatments. The researchers then analyzed various immune cells in the blood and compared the results.
A significant lengthening of telomeres
The results indicated that the treatments reversed the aging process in two of its main aspects: it made it possible to lengthen telomeres by 20 to 38%, that is to say the protective regions located at the two ends of each chromosome. , but also to prevent the accumulation of senescent cells, the old and failing cells of the body, responsible in particular for the appearance of metabolic disorders linked to aging. According to the researchers, the percentage of senescent cells in the overall cell population was reduced from 11 to 37% depending on the cell type.
Today, telomere shortening is considered the “Holy Grail of the Biology of Aging”, says Professor Efrati. “Researchers around the world are trying to develop pharmacological and environmental interventions that allow telomere lengthening. Our HBOT protocol was able to achieve this, proving that the aging process can in fact be reversed at the basic cellular-molecular level. . “
“So far, interventions such as lifestyle modification and strenuous exercise have been shown to have some inhibitory effect on telomere shortening., adds Dr Amir Hadanny, co-author of the study. But in our study, only three months of HBOT lengthened telomeres at rates far greater than any currently available intervention or lifestyle modification. With this pioneering study, we have paved the way for further research into the cellular impact of HBOT and its potential to reverse the aging process. “