Marina Simian: Trajectory, Cancer Research & Entrepreneurship | Exclusive Interview

Argentina’s Marina Simian: Pioneering Early Cancer Detection and Inspiring a New Generation of Scientists

Marina Simian, a 54-year-classic Argentinian scientist, is making waves in the fight against cancer with her innovative approach to early detection. Her journey, marked by dedication and perseverance, highlights both the challenges and rewards of a career in scientific research. Simian’s story, particularly resonant on International Women’s Day, underscores the importance of supporting women in STEM fields.

From Early Passion to Groundbreaking Research

Simian’s interest in science blossomed early. She received a scholarship to study marine biology in the United States during high school, an uncommon opportunity at the time. This early exposure fueled her passion, leading her to the Faculty of Exact and Natural Sciences at the University of Buenos Aires, where she was captivated by the teachings of biologist Alberto Kornblihtt. His influence sparked a deep fascination with molecular and cellular biology.

Her academic path continued with a doctorate at the Lawrence Berkeley National Laboratory (University of California) and a postdoctoral fellowship at the Ángel H. Roffo Oncology Institute in Buenos Aires. After over 20 years as a researcher at CONICET (National Council for Scientific Research), Simian embarked on a new chapter, co-founding Oncoliq, a biotechnology company focused on early cancer detection.

The Rise of Oncoliq: A New Approach to Cancer Screening

Driven by the alarming statistic that approximately 50% of adults will develop cancer in their lifetime, and that 80% of those diagnosed late-stage will die within five years, Simian and her team are developing a blood test to detect cancer earlier. The test analyzes microRNAs, molecules not currently assessed in standard clinical exams, aiming to integrate this technology into routine blood screenings.

Oncoliq’s initial focus is on breast cancer, with a product launch anticipated mid-2026. The company is also expanding its research to include lung cancer and collaborating on an HPV screening program in the Argentinian province of Chubut to detect cervical cancer early.

The Demands and Rewards of a Research Career

Simian emphasizes the lengthy and demanding path to becoming a researcher, comparable to medical school – a bachelor’s degree (approximately six and a half years), followed by a doctorate (five years), and a postdoctoral fellowship (two years). She notes the importance of continuous learning, connecting ideas, and developing conclusions, alongside practical laboratory skills.

She also observes a growing trend among younger students: a lower tolerance for frustration and difficulties with scientific writing and organization. However, she stresses the crucial role of mentors, recalling the significant influence of her doctoral advisor, Mina J. Bissell.

Balancing Science and Family Life

Simian’s career has also involved navigating the challenges of balancing professional ambitions with family life. She had her first two children whereas pursuing her doctorate in the United States, benefiting from the supportive environment fostered by her advisor. She maintained unconventional work hours for many years, dedicating long stretches of time to her research.

Advice for Aspiring Scientists and Entrepreneurs

For young scientists considering entrepreneurship, Simian advises completing their academic training first, particularly earning a doctorate to build a strong scientific foundation. She acknowledges that starting a biotech company presents unique challenges, but emphasizes that perseverance is key. Her final piece of advice: “Locate a huge and real problem—and prepare very well to solve it.”

Frequently Asked Questions

• What is Oncoliq’s primary goal? To reduce mortality associated with late cancer diagnoses.
• What makes Oncoliq’s cancer detection test unique? It analyzes microRNAs, molecules not typically assessed in standard clinical exams.
• How long does it take to turn into a researcher? Approximately 13-14 years, including bachelor’s, doctoral, and postdoctoral studies.
• What skills are essential for a research career? Continuous learning, analytical thinking, laboratory skills, and perseverance.

Pro Tip: Networking with established researchers and seeking mentorship can significantly accelerate your career in science.

Did you know? Marina Simian was the first Latin American researcher to receive a grant from the Susan G. Komen Foundation in 2006.

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