Regional Outbreak Severity: North Macedonia Leads in Fatalities
North Macedonia remains the hardest hit by the seasonal vector-borne disease. Authorities in Skopje declared an epidemic in several city districts earlier in the month as patient numbers continued to rise.
According to health officials, Serbia has identified 11 West Nile virus infections since early June. The affected patients in Serbia have an average age of 66, with cases documented in Belgrade, multiple Vojvodina districts, and central Serbia. Out of those 10 cases, the infection affected the nervous system.
Transmission Dynamics and Clinical Symptoms
Health experts emphasize that quarantine measures are unnecessary because the West Nile virus does not spread from person to person. According to medical specialists, mosquitoes act as the sole vector for transmission. Approximately 80 percent of infected individuals remain entirely asymptomatic, while severe neuroinvasive disease develops in only a small fraction of cases.
Mild manifestations of the illness include fever, headaches, muscle and joint pain, as well as gastrointestinal discomfort. In severe cases, patients can develop meningitis, encephalitis, or other neurological complications. Elderly individuals and those with compromised immune systems face the highest risk of severe illness.
Cross-Border Spread: Cases in Croatia
Croatia has also confirmed three West Nile virus infections detected across July and August, according to health reports. One of the Croatian patients currently requires intensive care and mechanical ventilation.
Did you know?
Mosquitoes transmit the West Nile virus primarily through bites after feeding on infected birds. Because human-to-human transmission does not occur, public health interventions focus on vector control and personal protection against mosquito bites rather than isolation or quarantine.
Frequently Asked Questions
How does the West Nile virus spread between humans?
It does not. According to health experts, the virus is transmitted exclusively through mosquito bites, meaning quarantine or isolation of patients is unnecessary.
What are the common symptoms of West Nile fever?
Mild cases involve fever, headaches, muscle and joint aches, and digestive issues. Severe cases can progress to meningitis or encephalitis, particularly in elderly or immunocompromised patients.

Which country is most affected in the region?
According to health authorities, North Macedonia has the most severe outbreak, with 43 recorded infections and five deaths.
Where have cases been detected in Serbia?
Authorities report 11 cases in Belgrade, central Serbia, and several districts across Vojvodina, with an average patient age of 66.
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