Démence : pourquoi les risques diminuent – et ce qui pourrait inverser la tendance

by Chief Editor

The Unexpected Decline in Dementia Rates: What’s Behind the Trend?

As populations age, the expectation is that diagnoses of dementia will rise. However, a surprising trend is emerging: the risk of developing dementia has significantly decreased over the past four decades. This article explores the factors contributing to this decline and what it means for the future of brain health.

A Counterintuitive Shift

Predictions suggested a doubling of dementia cases in Switzerland by 2050, and a tripling globally. Yet, a crucial piece of the puzzle often goes unnoticed – the individual risk of developing dementia is falling. Research from Duke University School of Medicine revealed that, in the United States, the number of dementia cases per age group decreased by two-thirds between 1984, and 2024.

This trend isn’t limited to the US. Similar declines have been observed in Sweden, the Netherlands, the United Kingdom, and France, despite variations in data collection methods.

source: P. J. Eric Stallard et al., JAMA, volume 33 / Graphique: let

The data illustrates a clear pattern: later birth cohorts experience lower dementia prevalence. For example, among 85-89 year olds born between 1895 and 1899 in the US, 30% were affected by dementia. This figure dropped to 13% for those born between 1935 and 1939, and further to 10% for those aged 85-89 in 2024.

What’s Protecting Our Brains?

Researchers have identified two key factors potentially driving this positive trend: a decline in smoking rates and increased educational attainment, particularly among women. Other well-known risk factors, like diabetes, high cholesterol, and hypertension, are also being better managed medically.

Improvements in living conditions also play a role. Earlier generations faced malnutrition and trauma during periods like the Great Depression and the World Wars. Subsequent generations benefited from increased peace and prosperity.

Recent advancements, such as the decline in smoking starting in 1965 with increased awareness of its dangers, the introduction of antidepressants, and improvements in air quality (particularly in Switzerland since the 1980s), have likely contributed to better brain health.

Emerging Protective Measures: The Power of Vaccination

Recent studies suggest that vaccination may offer a surprising layer of protection against dementia. Specifically, the varicella (chickenpox) and herpes zoster (shingles) vaccines have been linked to a reduced risk. Research from Wales and Australia showed a 20% reduction in dementia risk among vaccinated individuals, a finding confirmed by a Canadian study. The newer Shingrix vaccine appears to offer even greater protection, as demonstrated in a 2024 Nature study.

The link between herpes viruses and dementia has long been suspected, and vaccination may help the immune system clear harmful proteins from brain structures. As one expert noted, “If this vaccine were a drug and reduced Alzheimer’s risk by 20%, it would be a major breakthrough.”

New Risks and Uncertainties

While the trend is encouraging, new challenges have emerged. Rising rates of obesity and sedentary lifestyles, along with the increasing prevalence of diabetes, could potentially reverse these gains. The situation in Japan, which hasn’t seen the same positive trends, highlights the importance of lifestyle factors.

Some experts caution against overoptimism. Bogdan Draganski, director of the University Hospital of Bern’s memory clinic, believes the decline in dementia rates may not continue indefinitely, stating, “The post-war generation lived in peace and prosperity. Subsequent generations may face more problems again. But these are just assumptions.”

Bogdan Draganski, professeur spécialisé dans les démences et les maladies neurodégénératives.

Bogdan Draganski, professeur spécialisé dans les démences et les maladies neurodégénératives.Image: dr

The Future of Brain Health

Ongoing research and data collection are crucial to understanding these complex trends. The potential for future breakthroughs, such as vaccines specifically designed to protect against dementia, offers hope. As one researcher emphasized, “At a time when cognitive abilities are more important than ever,” proactive measures to safeguard brain health are essential.

Frequently Asked Questions

  • Is dementia inevitable as we age? No, the risk of developing dementia is decreasing, and lifestyle factors play a significant role.
  • What can I do to protect my brain health? Avoid smoking, maintain a healthy weight, stay physically and mentally active, and consider vaccinations like those for shingles.
  • Are there any new treatments for dementia on the horizon? Research is ongoing, with promising avenues including vaccines and improved management of risk factors.

Pro Tip: Regular physical exercise, even a brisk walk, can significantly improve blood flow to the brain and support cognitive function.

Desire to learn more about brain health and dementia prevention? Explore our other articles on neurological health and healthy aging.

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