biotechnology

Broken String Biosciences Launches BaseMap ABE for Base Editing Off-Target Analysis

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Broken String Biosciences has launched BaseMap ABE, a new platform designed to identify unintended off-target editing events in adenine base editing (ABE) applications. According to the company and reporting from OneNucleus, the tool uses INDUCE-seq technology to generate genome-wide data directly from biologically relevant cells rather than relying on prediction-based models. How BaseMap ABE Tracks … Read more

AI-Powered Target Discovery for Rare Sinonasal Cancer by Insilico Medicine

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Insilico Medicine published a collaborative study in the journal npj Precision Oncology, detailing how artificial intelligence and multi-omic analysis identified therapeutic targets in inverted papilloma-associated sinonasal squamous cell carcinoma (IP-SNSCC), a rare head and neck cancer. Conducted with researchers from the University of Chicago and Johns Hopkins University, the peer-reviewed paper offers the first comprehensive … Read more

Eli Lilly Expands Retatrutide Access Beyond Single Patient

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Eli Lilly Expands Early Access to Retatrutide Following Patient Advocacy Eli Lilly has confirmed it will allow a broader range of patients to apply for early access to its unapproved obesity drug, retatrutide. The decision follows a report by STAT regarding a 79-year-old patient who previously received special access to the medication. The pharmaceutical company … Read more

Directed Enzyme Evolution: Methods and Applications

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Directed evolution, a method for engineering enzymes by mimicking the natural process of selection, is shifting from a niche lab technique to a primary engine for industrial chemistry. According to Caltech’s Frances Arnold, who received the 2018 Nobel Prize in Chemistry for this work, the future of the field lies in integrating machine learning with … Read more

New Genetic Reference Map Accelerates Stem Cell Research

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Bioengineers at the University of California San Diego have created the first genome-scale reference map detailing how individual genes influence the behavior and identity of human induced pluripotent stem cells (iPSCs). Published in Nature Biotechnology, the study utilized CRISPR technology to systematically switch off 11,692 genes, providing a reference atlas for researchers to predict how … Read more

Space Travel and Aging: How Liver Changes Unlock New Clues

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Exposure to space radiation and microgravity triggers rapid genetic changes in the liver that mirror the human aging process, according to research published in the journal GeroScience. How does space travel accelerate the aging process? Space environments force the human body to endure conditions that trigger premature biological decline. Michal Masternak, a professor of medicine … Read more

New Hybrid Lens Design Slashes 3D Microscopy Costs

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Columbia University researchers have developed a new optical framework, HySIL (Hybrid Solid–Liquid Optics), that enables high-resolution 3D tissue imaging at a fraction of the cost and complexity of traditional systems. By using immersion liquid as an active optical component, the design allows affordable air-based microscope lenses to capture deep-tissue images, according to a study published … Read more

New Geroscience Initiative to Accelerate Anti-Aging Therapies

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The Albert Einstein College of Medicine has launched the Batia and Idan Ofer program for Validation of Interventions Targeting Aging and Longevity (BIO-VITAL), a specialized initiative designed to accelerate the development of pharmaceutical therapies that address the biological mechanisms of aging. By providing biotechnology firms access to proprietary research models and human longevity data, the … Read more

Human-AI Co-Design for Clinical Prediction Models

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HACHI is an iterative human-in-the-loop framework that utilizes AI agents to accelerate the development of fully interpretable clinical prediction models (CPMs) from unstructured clinical notes. By alternating between AI-driven statistical exploration and expert human feedback, the system optimizes for transparency and steerability, demonstrably outperforming traditional modeling approaches in tasks like acute kidney injury and traumatic … Read more

Ractigen Therapeutics Unveils saRNA Breakthrough for Obesity at ADA 2026

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Beyond Appetite Suppression: The New Frontier of Metabolic Engineering For years, the gold standard for weight management has been the “incretin” revolution. Drugs like semaglutide have dominated the conversation by curbing appetite, but they have brought a troubling side effect: the loss of lean muscle mass. As the medical community looks toward the next generation … Read more

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