CHLA’s Jesse Levine Studies Immune Mechanisms in Rare Pediatric Diseases

CHLA's Jesse Levine Studies Immune Mechanisms in Rare Pediatric Diseases

Childhood Pacemaker Implant A two-year-old child received a pacemaker implant that ultimately directed Jesse M. Levine toward a career in medical research. “I had a pacemaker implanted when I was two years old,” Dr. Levine said. “As a kid, I thought it was so cool that someone had an interesting idea and they were able … Read more

Study Identifies Liver-Derived Proteins Entering the Brain in Mice

Study Identifies Liver-Derived Proteins Entering the Brain in Mice

Ninety-two circulating proteins cross the blood-brain barrier and enter the brain parenchyma, according to a study published in the journal Cell. Protein Transport Pathways Researchers characterized blood-to-brain protein transport and identified alterations in Alzheimer’s disease models. The study was carried out by investigators at the Gladstone Institutes, the University of California, San Francisco, the Buck … Read more

Personality Shifts Signal Frontotemporal Dementia Decline

Personality Shifts Signal Frontotemporal Dementia Decline

Conscientiousness linked to daily functioning in frontotemporal dementia Lower levels of conscientiousness are associated with greater difficulty in managing daily tasks for people with frontotemporal dementia, according to a study published November 10, 2026, in Neurology®, the medical journal of the American Academy of Neurology. Researchers found that personality traits accounted for approximately 40% of … Read more

Uppsala University Researchers Develop Method to Track Glioblastoma Spread

Uppsala University Researchers Develop Method to Track Glioblastoma Spread

Researchers at Uppsala University developed a new method combining artificial intelligence and live brain tissue imaging to track how individual glioblastoma cells spread. Glioblastoma stands out as one of the most aggressive brain cancers. Tumor cells routinely migrate past the surgical margin into healthy tissue, triggering recurrence after treatment. To capture this movement, scientists published … Read more

Unstable Repeat DNA May Explain Missing Heritability in Mental Illness

Unstable Repeat DNA May Explain Missing Heritability in Mental Illness

Schizophrenia and bipolar disorder run in families with an 81 percent heritability rate in twin studies, yet standard genome-wide surveys have only uncovered about a quarter of that genetic risk. Researchers in Pune, India, propose that short, stuttering stretches of DNA largely overlooked by standard methods account for the missing inheritance, News-Medical reported. These repetitive … Read more

45 Days of Yoga: Brain Scans Reveal Surprising Changes

Study: Common yoga protocol improves cognitive functions and neural connectivity

Adults practicing a standardized daily yoga routine for 45 days reported positive affect scores about 4 points higher and negative affect scores about 3.5 points lower than a control group, according to research published in Scientific Reports. The randomized controlled trial, conducted between October 2023 and January 2025 at a university in Pune, India, examined … Read more

Christopher Sepúlveda is seizure-free after DEE-SWAS diagnosis

Christopher Sepúlveda is seizure-free after DEE-SWAS diagnosis

Christopher Sepúlveda was 2 years old when involuntary mouth and movement episodes began, along with freezing spells lasting nearly two minutes. Parents seek additional opinions after multiple medications fail A local pediatrician initially diagnosed the symptoms as a potential tic disorder. However, Christopher’s parents sought out additional opinions after trying multiple medications that failed to … Read more

Graded Exercise Proposed as Formal Psychiatric Treatment

Graded Exercise Proposed as Formal Psychiatric Treatment

Prescribing Movement as Clinical Treatment A team of psychiatric researchers is arguing that physical exercise should move from informal lifestyle advice to a formal clinical treatment. A new Viewpoint published in the journal Brain Health argues that exercise should be prescribed with the same precision as medication, specifying dosage, frequency, and intensity to target cognitive … Read more

Longer reproductive lifespan may link to better brain vascular health

Longer reproductive lifespan may link to better brain vascular health

Brain Vascular Health Linked to Reproductive History Researchers found that women with a longer window of estrogen exposure—defined as the years between their first period and menopause or ovary removal—exhibited fewer markers of cerebral small vessel disease later in life. The study, which followed 352 women in Sweden starting at age 70, assessed participants for … Read more

Study links psychedelics to persisting perceptual abnormalities

Study links psychedelics to persisting perceptual abnormalities

Visual Disturbances After Psychedelic Use “It’s truly unclear whether this guy is at greater risk for psychosis,” Max Greenwald says, describing a 25-year-old man who contacted him after seeing a huge, unblinking eye in his ceiling every night as he fell asleep. The man had taken psychedelics in the past, prompting concerns about developing psychosis … Read more