clinical research

Multi-Omic Biomarker Approach Validated for Ovarian Cancer Detection

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A new peer-reviewed study published in the journal Diagnostics validates a multi-omic approach to detecting ovarian cancer, demonstrating that integrating lipidomic, metabolomic, and protein profiles offers higher clinical accuracy than single-modality tests. By analyzing 503 participants, researchers identified that ovarian cancer rewires multiple biological pathways simultaneously, providing the foundation for AOA Dx’s AKRIVIS GD diagnostic … Read more

New Blood Test Predicts Chemotherapy Benefit for Colorectal Cancer

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A personalized blood test measuring circulating tumor DNA (ctDNA) can identify colorectal cancer patients who benefit most from adjuvant chemotherapy after liver metastasis surgery. According to the Phase II GALAXY study presented at the ESMO Gastrointestinal Cancers Congress 2026, patients with detectable ctDNA after surgery saw overall survival rates of 65% with chemotherapy, compared to … Read more

New Blood Test Predicts Alzheimer’s Progression Using Circular RNAs

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A set of 34 specific circular RNAs in the blood can predict the onset of Alzheimer’s disease symptoms, according to a study funded by the National Institutes of Health (NIH). Research indicates these markers can identify the transition to symptomatic Alzheimer’s two to four years before clinical signs appear, potentially improving patient selection for clinical … Read more

New Blood Test Enhances HDL Function Analysis in Heart Disease

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Researchers at the Institute of Science Tokyo have developed a blood-based test that measures cholesterol efflux capacity (CEC), a key indicator of how well high-density lipoprotein (HDL) removes cholesterol from artery walls. Published in the journal Atherosclerosis, the study suggests that low CEC levels correlate with the presence of high-risk, lipid-rich coronary plaques, offering a … Read more

Fred Hutch researchers receive Prostate Cancer Foundation Young Investigator Awards

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The New Frontier of Cancer Care: Why Epigenetics is a Game Changer For decades, the fight against cancer was primarily a battle over genetics—the fixed “blueprint” of our DNA. If a mutation occurred in a specific gene, the result was often a cellular malfunction that led to tumor growth. But a paradigm shift is occurring … Read more

UC trial examines new interventions to treat depression in young people

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Beyond Pills: The Rise of Non-Pharmacological Treatments for Teen Depression For years, selective serotonin reuptake inhibitors (SSRIs) have been a go-to treatment for depression, particularly in adolescents and young adults. However, these medications aren’t without their drawbacks. Side effects can include a worsening of mood, agitation, and, in some cases, even increased suicidal thoughts. This … Read more

Universal HCV Screening in EDs Boosts Detection

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Unlocking the Future of Hepatitis C Screening: Beyond Targeted Approaches As a healthcare journalist, I’ve been following the evolution of hepatitis C virus (HCV) screening for years. The recent study published in JAMA, focusing on nontargeted vs. targeted screening in emergency departments (EDs), is a significant milestone. It underscores a crucial shift in how we … Read more

EMA Review: Tecovirimat for Mpox Effectiveness

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Mpox Treatment Under Scrutiny: What the EMA Review Means for Patients The world of medicine is constantly evolving, and sometimes, a promising treatment doesn’t live up to its initial hype. That’s the situation with Tecovirimat (also known as TPOXX), a medication initially hailed as a potential game-changer in the fight against mpox. Now, the European … Read more

EMA Rejects Elevidys Gene Therapy for Duchenne

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DMD Gene Therapy: Where Do We Go From Here? The recent decision by the European Medicines Agency (EMA) to not grant marketing authorization for delandistrogene moxeparvovec (Elevidys) for Duchenne muscular dystrophy (DMD) treatment highlights the complexities and challenges within gene therapy development. This news, coupled with serious safety concerns, prompts a crucial question: What’s next … Read more

US Health Secretary Kennedy Dismantles Vaccine Committee

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Shifting Sands: The Future of Vaccine Policy in a Politicized Landscape The recent decision by Health Secretary Robert F. Kennedy Jr. to overhaul the U.S. Centers for Disease Control and Prevention’s (CDC) vaccine expert panel has sent ripples through the public health community. This move, replacing all 17 members, signals a potential shift in how … Read more

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