Researchers at the Memorial Sloan Kettering Cancer Center have identified a single protein called ZFP36L2 that acts as a molecular switch linking the gut’s damage-sensing system to cellular identity shifts, according to a study published August 5 in Nature. According to physician-scientist Karuna Ganesh, senior author of the study, the protein controls how cells detect … Read more
A non-invasive fecal immunochemical test done entirely at home can cut colorectal cancer deaths by 50% among adults aged 50 to 69, according to a 21-year study from Spain examining data from 2.2 million people. Colorectal cancer is the second most common cause of cancer deaths in men and women, with screening rates climbing among … Read more
Researchers at the University of Copenhagen have identified the protein NDRG1 as a potential therapeutic target for cancer, utilizing the antimalarial drug quinacrine to exploit specific cellular vulnerabilities. According to a study published in Science Signaling, high levels of NDRG1 correlate with poor patient survival, and inhibiting this protein creates a synthetic lethal interaction that … Read more
Patient-derived tumor organoids are emerging as high-fidelity preclinical models for precision oncology, offering a way to test cancer treatments on three-dimensional cell clusters that mirror a patient’s specific disease. Recent research led by investigators at Weill Cornell Medicine demonstrates that these “avatars” can reliably predict treatment sensitivity, potentially expanding the pool of patients eligible for … Read more
A personalized blood test measuring circulating tumor DNA (ctDNA) can identify colorectal cancer patients who benefit most from adjuvant chemotherapy after liver metastasis surgery. According to the Phase II GALAXY study presented at the ESMO Gastrointestinal Cancers Congress 2026, patients with detectable ctDNA after surgery saw overall survival rates of 65% with chemotherapy, compared to … Read more
A comprehensive review of over 1.5 million cancer cases, published in Nature Metabolism, has identified a link between obesity and an increased risk of 19 different types of cancer. The study provides evidence that excess body fat acts as an active biological driver for malignancies, including leukaemia, non-Hodgkin lymphoma, bladder cancer, and glioma. Dr. Saneya … Read more
A blood test detecting circulating tumour DNA (ctDNA) after surgery can identify colorectal cancer patients most likely to benefit from adjuvant chemotherapy, according to research presented at the 2026 ESMO Gastrointestinal Cancers Congress. The Phase II GALAXY study, led by researchers from Hyogo Medical University and collaborators including the University of Oxford, found that patients … Read more
Many older adults dismiss cancer warning signs as normal aging, according to Dr. Jad Chahoud, an oncologist at the Orlando Health Cancer Institute. Symptoms such as persistent fatigue, unexplained weight loss, and bowel changes are often misattributed to stress or the natural aging process, delaying life-saving medical intervention. Medical experts emphasize that rapid declines in … Read more
Early-onset colorectal cancer—defined as a diagnosis before age 50—is increasingly linked to demographic and birth-related factors, including sex, ethnicity, and paternal age. A population-based study published in the journal Cancer by researchers at the Yale School of Public Health found that men face a 34% higher risk of early diagnosis than women, while Hispanic ethnicity … Read more
The loss of the transcription factor GATA6 acts as a biological switch that reprograms colorectal cancer cells to metastasize to the liver, according to research published June 22 in Cell Stem Cell. By silencing this “identity keeper,” cancer cells adopt a flexible, fetal-like state that allows them to travel through the bloodstream and colonize distant … Read more