very cheap and long-known drugs help save the lungs with coronavirus

Cloving hospital on the basis of the Medical Scientific and Educational Center (ISSC) Moscow State University named after M.V.Lomonosov took the first patients on April 21 and completed his work on June 13. It turned out that it was possible to achieve the best treatment results for COVID-19 in Moscow. Over the entire period, 4 patients died, and among severe patients who got mechanical ventilation, the mortality rate was less than 14% (for comparison, the average for the city and the world was up to 70 – 80%). Eighteen doctors out of 220 employees of the hospital were infected with coronavirus, there were no deaths among the medical staff.

What approaches were used at the University Hospital of Moscow State University to achieve such results? We continue the conversation with the head. Department of Therapy, Faculty of Fundamental Medicine, Moscow State University, Head of the Department of Age-Associated Diseases, Medical Scientific and Educational Center, Doctor of Medical Sciences, Cardiologist Yana Orlova.

MEDICINE FOR COUGH FOR 80 RUBLES

– Most of those who are ill or are afraid to get sick are worried about fibrotic changes in their lungs. They say that you have developed special therapy that can reduce the risk of developing fibrosis. Is it possible?!

– Yes, we launched an appropriate clinical study. There are no final results yet, but we have developed clinical practice.

“What did you do to save the lungs?”

– We used a combination of bromhexine and spironolactone (both are long-known very cheap drugs. – Ed.). Bromhexine is an expectorant that has been prescribed to patients with pneumonia and cough for many years. At the same time, experimental data showed that this drug can block a specific enzyme and impede the penetration of coronavirus into cells. True, it was on this effect that we counted to a lesser extent in inpatients, since such an effect is important mainly in the early stages of the disease. But the expectorant effect of bromhexine really helps patients with COVID. I heard that our colleagues in Peter launched a study of bromhexine for prophylactic purposes. We will wait for the results.

Coronavirus infected 18 doctors from 220 employees of the hospital, there were no deaths among the medical staffPhoto: Ivan MAKEEV

FIBROSIS OBSTACLE

– The second drug – spironolactone – is traditionally widely used in cardiology for the treatment of heart failure, severe hypertension. It has a small diuretic, magnesium and potassium-preserving effect, continues Yana. Orlova. – It has several mechanisms through which it can be useful in coronavirus infection.

Firstly, a mechanism that prevents the development of fibrosis in general in the body. There are works that, in particular, show that spironolactone reduces fibrosis in the heart. At the same time, it is known that the tendency to fibrosis is not local, but systemic – where there is more inflammation, there will certainly be fibrosis. And we see, of course, fibrotic changes in the “covide” in our patients. Therefore, we prescribed spironolactone as a drug for the prevention of this process.

Secondly, this drug blocks sex hormone receptors, in particular testosterone. Some published studies suggest that “high-testosterone” men suffer from “covid” more often and develop more severe fibrotic changes. Therefore, blocking these receptors for several weeks during COVID treatment may be useful in reducing the severity of complications. We are not talking about a longer intake, since male patients are unlikely to agree with a decrease in testosterone levels in the long term.

And perhaps the most important point. In almost all of our patients, we observed hypokalemia (a decrease in potassium levels. – Ed.). With coronavirus infection, potassium is intensely excreted from the body, and scientific articles even suggest that hypokalemia serves as the trigger for a cytokine storm. So spironolactone has a real chance to reduce the risk of this dangerous complication. But the main thing, in my opinion, is that lowering the level of potassium in the body is extremely harmful to the heart and triggers life-threatening rhythm disturbances, increasing the risk of sudden death. We, like all others, replenished potassium with droppers, but it was more effective to retain it in the body with the help of spironolactone.


Men certainly get worse than women;  the elderly are heavier than the young;  overweight people are heavier than patients without excess weight Photo: Ivan MAKEEV

Men certainly get worse than women; the elderly are heavier than the young; overweight people are heavier than overweight patientsPhoto: Ivan MAKEEV

WHEN PRESCRIBED PATIENTS

– Yana Arturovna, how many patients did you have on average?

– About 10 – 14 days. But someone and 50 days.

– Have you noticed signs by which it can be assumed that the disease in the person brought is likely to go the hard way?

– Such studies were carried out in the world, our clinical practice confirmed them. Men certainly get worse than women; the elderly are heavier than the young; overweight people are heavier than overweight patients. Men with a classic male type of baldness, a lot of facial hair, we can say brutal men get sick harder.

– Under what conditions did you discharge patients?

– We acted as close as possible to the recommendations Ministry of Health: so that the temperature for three days was not higher than 37.5 degrees; so that C-reactive protein (an indicator of inflammation) is lower than 10 mg / l, and saturation, that is, the level of oxygen in the blood, is higher than 96%.

“HEAD OF EPIDEMIOLOGY DEPARTMENT OF ITSELF WORKED AT SANPROPUSNIK”

– How often do you get sick doctors and nurses?

– In the first month no one got sick at all. We have a very powerful epidemiological service. The head of the sanitary-epidemiological department, a senior researcher, correctly organized the whole process, and for the first two weeks she personally worked in the sanitary inspection room at the exit from the “red zone” and helped doctors and nurses who were exhausted after the shift safely remove protective clothing.

Then both people’s fatigue and viral load accumulated. By the middle of the second month, sick people began to appear. There were no seriously ill patients. We treated part of the staff in our observation, part of it was treated at home. In total, 18 people were infected from the medical staff (less than 10%).

– Doctors take something for prevention? Vitamins C, D, Zinc?

– I saw the recommendations of American nutritionists, they speak out positively about taking zinc, melatonin and vitamin C. There were somewhat conflicting data on vitamin D. But we did not give any such recommendations to our employees. We have all the prevention was associated with minimizing contacts and other measures of epidemiological safety.

Physicians are the heroes of our time.“If you think that you are special and that a pandemic will not affect you, you are deeply mistaken,” listen to what the doctors who are fighting with coronavirus say

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Banks have limited the ability to go negative by debit cards :: Finance :: RBC

Banks announced a reduction in interest rates on deposits and loans after the Central Bank

“Equifax” in statistics takes into account only debit cards to which the overdraft option is connected. Banks of “not the first echelon” usually offer such a product, explained Oleg Lagutkin, General Director of Equity Bank.

The combined credit bureau (the only BKI that has data from Sberbank) includes in its statistics on overdrafts debts not only on debit cards, but also on installment cards, if banks define debt as an overdraft, explained his representative. According to the OKB, in May the average overdraft limit amounted to 42 thousand rubles, and compared with March, the indicator decreased by only 7.3%. He, like issuing overdraft cards, recovered after a sharp decline in April.

The National Bureau of Credit Histories (NBCH), which is also included in the top 3 Russian credit indexes, does not keep such statistics, a representative of the bureau said.

Why banks have changed overdrafts

A decrease in the number and volume of open overdrafts on cards is a direct consequence of bank policies in a pandemic, Lagutkin said. “By changing their lending policies after the start of the self-isolation regime, lenders extended most of the measures not only to popular consumer loans,” adds the General Director of Equifax Investment Company.

Banks reduced overdraft limits due to a general decrease in real incomes of the population, says Mikhail Doronkin, head of the bank ratings department of the NKR agency. According to him, this may be due to the peculiarities of the methodology for calculating such limits.

“If, when opening a credit card, banks can request information on income from customers to assess their reliability and set a limit, then in the case of a debit card, overdraft limits are often set automatically and do not take account transactions into account,” the analyst explains. In the pre-crisis period, providing customers with an overdraft allowed banks to earn money on those who “went into the red” or did not suspect an overdraft. “Under current conditions, the presence of such an option, on the contrary, could increase the risk of non-return,” he adds.

“Issuance of overdraft cards, including installment cards, declined significantly during quarantine, as did issuance in other lending segments. Moreover, the reduction was not so strong compared to that which we observe in the segment of credit cards, ”noted Artur Design Bureau General Director. This could be due to a lower available limit on these cards than on credit cards, which means less risk for banks, he added.

In a crisis, banks could cut low-demand products in order to reduce credit risk, agrees Sergey Grishunin, head of the rating service of the National Rating Agency (NRA). He draws attention to the fact that banks, as a rule, require customers to repay the overdraft in a short time, and the interest rate on such loans is higher than on classic credit cards. “Based on all this, it is simply unprofitable for banks to keep a product that most likely a“ good ”borrower will not use (they have a credit card, often with bonuses). A “bad” bank is not profitable, ”the expert concludes.

Bank customers began to complain about a reduction in credit card limits

Фото: Simon Dawson / Bloomberg

Which banks give customers an overdraft

According to Frank RG, there are now special cards with overdraft in the lines of five organizations: Absolut Bank, Asia Pacific Bank, Uralsib, Center-Invest Bank and Transcapitalbank. The representative of Uralsib told RBC that the bank does not offer such a product, the remaining banks did not respond to inquiries.

Which banks offer overdraft on their debit cards as an option, Frank RG does not track. Most of the large organizations surveyed said they did not provide such a service. Among them are Sberbank, Gazprombank, Otkrytie, Alfa Bank, Promsvyazbank, Sovcombank, UniCredit Bank, Home Credit, Zenit, Ak Bars, Renaissance Credit and MTS Bank. However, on the banki.ru profile forum, there are many reviews of customers of large banks about connecting an overdraft without notice, technical overdraft and other problems associated with this product.

The only bank that has confirmed the availability of the overdraft option for debit cards is VTB. Such a service is offered to salary clients, a bank representative said. “In March-May, the bank did not change the terms of connection and the average size of limits for this product. “We do not notice any changes in client preferences for disabling or activating overdraft services,” he added.

Will banks become more loyal to using overdraft

“There is a version that it’s precisely by such actions that banks are preparing for the end of exemptions regarding the accrual of reserves. We believe that overdrafts in the event of a crisis may even disappear or remain only with premium customers of banks, ”says Grishunin. On Friday, June 26, the Bank of Russia announced a partial curtailment of support measures for banks introduced at the onset of the crisis. But softened reserve requirements will continue until September 30.

The Central Bank will prohibit paying with expired cards

Photo: Artem Geodakyan / TASS

Banks must form reserves not only for loans actually issued, but also for unused limits, taking into account demand ratios. Overdraft is included in this category, said the director of bank ratings of Expert RA, Ivan Uklein. According to him, banks are so far “reinsured”, and after lifting sanitary restrictions and stabilizing the situation on the labor market, the policy of creditors regarding opening overdrafts will become softer.

In June, the retail lending market experienced a recovery, says Lagutkin from Equifax. According to him, this may in the future have an impact, including on the overdraft segment.

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What happened during the night. Breaking news RBC :: Society :: RBC

Germany is preparing a response to possible US sanctions, how many people participated in online voting on the amendments, banks began to buy gold, Unilever will be removed from the packaging the word “white”; main news — a review of RBC

The media learned about the plans of Germany in case of sanctions against the “Nord stream-2”

The administration of German Chancellor Angela Merkel is preparing retaliatory measures in case of imposition of us sanctions against the gas pipeline “Nord stream-2”, found out by Bloomberg.

  • In particular, the German authorities are considering a coordinated response of the European Union in relation to possible sanctions. What exactly are these actions has not yet been disclosed.
  • Last week the Chairman of the Commission of the German Bundestag for economy and energy, Klaus Ernst, has suggested several possible measures in response to sanctions: a call to the American Ambassador in Germany, personal limitations against the initiators of the sanctions, the imposition of duties on American LNG.
  • On new sanctions against the pipeline, which was prepared by the U.S. Senate, became known in early June. According to the Ministry of economy of Germany, these restrictions may affect German and European companies, banks and government agencies.

Venediktov said the number of voters on the Constitution online

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British drug 70% decreased the growth of aggressive tumors

Bertoneri in combination with chemotherapy affects the DNA of cancer cells, not allowing her to recover.

Photo: depositphotos.com

Specialists from the Institute of cancer research UK are looking for new ways to fight cancer. British scientists have focused on the ability of cancer cells to restore DNA. In the course of studies has identified the ATR protein, which is responsible for the repair of cells, which were exposed to the drug personaltab. Scientists did not expect so much positive effect, because the British drug in combination with chemotherapy 70% decreased the growth of aggressive tumors. Experts believe that made a breakthrough in the treatment of severe forms of cancer, because patients with such diagnoses have experienced a new drug.

The success of the operation personeria is that chemotherapy also affects the DNA of tumors makes them more sensitive to the ingredients of the new drug. To date, the side effects of the drug are mild and do not go to any comparison with the benefit from personaltime. Scientists are going to continue to create tools that act on the DNA of cancer tumors.

Kartashov Timur

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A third of the population of Ukraine with regret spoke about the collapse of the Soviet Union : Society :: RBC

The most nostalgic was among those who in modern Ukraine not enough money even for food

Photo: Gleb Garanich / Reuters

The collapse of the USSR regrets just over a third (33.5 per cent) of residents of Ukraine, according to the report, Kiev international Institute of sociology (KIIS). Conducted by KIIS survey showed that the proportion of those who grieve the collapse of the Soviet Union, the highest in the East (of 49.3%) and South (48.1 percent) of Ukraine, while in the Western regions of the country, it is only 15.3 percent.

To KIIS note that in the first place about the collapse of the Soviet Union regret elderly — from 44.1% among those 50 to 59 years, to 50.1% among those older than 70 years. Young people aged 18 to 29 years of the Soviet Union regret is rare (14.3 per cent). Among the young, which in the USSR was never alive, most frequently (32.2 per cent) are those who answer the question about regrets nothing. The majority of young (53,5%) on the collapse of the Soviet Union does not regret.

The proportion of bored for the Soviet Union is highest among those who define their nationality as Russian (66,9 vs 30.5%, and among those who consider themselves Ukrainians) and communicates at home in Russian (44,2 compared to 25.8% of those who normally speaks Ukrainian at home).

From the KIIS report also suggests that:

  • women regret the Soviet collapse more often than men — 36.3 vs. 30,1%;
  • people in small towns are nostalgic for the Union most of the inhabitants of the large — 37,8 against 32.5%;
  • received only secondary education miss the USSR more than holders of high school diploma (vs 41,6 23,4%), and the workers — and more entrepreneurs (of 42.3, as compared to 19.4%).

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The white house said about preparing for the second wave of coronavirus :: Society :: RBC

Adviser to trump, said it could erupt soon, and laid at China be responsible for the emergence and spread COVID-19. “Whether they did it on purpose, it is an open question,” he said

Photo: Cindy Ord / Getty Images

The white house is preparing for the second wave of the spread of coronavirus COVID-19, which could happen next fall. In an interview with CNN, said Advisor to the President of the United States on trade issues Peter Navarro.

Answering a question from host Jake Tapper, are the American government for a second wave COVID-19, Navarro said, “of Course.” “We are preparing, preparing for what is [это] can happen. I’m not saying that this will happen, but of course, you have to prepare for it,” he said.

The adviser also added that “China has created this pandemic.” “They created this virus. And they sent hundreds of thousands of Chinese citizens to spread it worldwide,” said Navarro.

Advisor trump has accused China of spreading COVID-19 through tourists

Photo: Alex Brandon / AP

On specifying question of the leader, whether China was behind the creation of this infection, Navarro suggested instead of the word “created” to use the word “spawned”. “Whether they did it on purpose, it is an open question. But it’s a fact,” he said.

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The centre-right, if invited by the Count, we’ll all go together – Policy

“When will come the invitation for the comparison of Palazzo Chigi, Forza Italia will reply in the affirmative. We are going to present our proposals for a united states, together with the League and Brothers of Italy, as we have always done so far.” Sources of Forza Italy, with regard to the invitation to make a comparison announced by the Count.

“For charity,when I was called in I have always been; but will not decide the Count as we go and we go together, we are a coalition and let’s go together”. He said the leader of Fdi Giorgia Meloni on Channel 5 about the request of the premier, Count to meet the parties of the centre-right separately. “Even Mattarella is to review the composition of the delegations. If the Count wants us to receive to receive us all together,” he added.

“The count announces the intention to invite the head separately? The centre-right is united, and we must not lose time. The government enlists the help of the coalition. If the intentions of the Count will be finally series, the centre-right will come along as has happened in the past.” Explain the sources of the Alloy.

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