After the success of the Oxford vaccine on monkeys … an Indian institute produces 60,000 doses within months to counter Corona

A major candidate for the Covid-19 Corona virus vaccine, developed by the University of Oxford, has shown promising results in animal experiments and is expected to see massive production in India within months.

According to global reports, it is likely that the Serum Institute of India, the world’s largest vaccination institute in India this year, can produce up to 60 million doses.

The Serum Institute of India, according to the Chinese website “SCMP”, the world’s largest vaccine producer by volume, said this year it plans to produce up to 60 million doses of a possible vaccine developed by Oxford University, which is now undergoing human clinical trials in Britain.


The trend of the largest institute for sera to produce the vaccine krona virus

Adar Poonawala, CEO of Serum at Serology Institute, said that although the vaccine candidate, named “ChAdOx1 nCoV-19”, has not yet been proven to work against Covid-19, Serum decided to start its manufacture because it showed success in animal experiments and progressed To human tests, 6 macaques with a vaccine filter were injected into the Rocky Mountain Laboratory at the National Institutes of Health in Montana last month, according to the New York Times.

The newspaper reported, quoting researcher Vincent Munster, who conducted the test, that the animals were then exposed to large quantities of the new coronavirus, but all six remained healthy after more than 28 days.

“They are a group of highly qualified and great scholars (at Oxford) … so we said we would go with this and that is why we are confident,” Poonawala told Reuters in a telephone interview.

Macaques
Macaques

“Being a private limited company, not accountable to public investors or bankers, I can take on some risks and ignore some of the products and other commercial projects that I have planned at my current facility,” Poonawala said.

Poonawala said he hopes the Oxford vaccine trials, which are due to be completed around September, will succeed, while Oxford University scientists said last week that the primary focus of the initial tests is to ensure not only the success of the vaccine, but rather that it causes good immune responses and has no unacceptable side effects .

Serum, owned by Indian billionaire Cyrus Poonawala, is planning to manufacture the vaccine at its two factories in the western city of Pune, with the goal of producing up to 400 million doses next year if all goes well.

“The majority of the vaccine, at least initially, should go to our citizens before traveling abroad,” he said, adding that he would leave it up to the Indian government to decide which countries will receive the amount of the vaccine and when, adding that over the next five months, a serum will be spent between ($ 4.4M to $ 5.9M) making about 3-5 million doses per month.

The recipient of the Oxford vaccine denies the news of her death
The first recipient of the Oxford vaccine

Serum has partnered with American biotechnology company Codagenix and Austrian company Themis on other candidates for the Covid-19 vaccine, and plans to announce a fourth alliance within two weeks.

Poonawala said that the Serum board of directors had also agreed last week to invest approximately ($ 8.8 billion) in establishing a new manufacturing unit to produce only Corona virus vaccines.

Other vaccines worldwide

There are currently up to 100 potential Covid-19 vaccines currently under development by biotechnology and research teams around the world, at least 5 of which are in initial testing in people in so-called first stage clinical trials.

So far more than 3 million people have been infected worldwide, and more than 210,000 people have died from Covid-19, a respiratory disease caused by coronaviruses.

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Djokovic opposes Covid-19 vaccine

MADRID.

Serbian tennis player Novak Djokovic, number one in the ATP ranking, expressed his opposition to the vaccines, given the possibility that one against Covid-19 will be discovered and become mandatory, and recognized that he would not like anyone to “force” him to put them on “in order to travel”, he also explained that if that becomes an indispensable condition he will have to make “a decision”.

Personally, I am against vaccination and I do not want someone to force me to be vaccinated in order to travel. But if it becomes mandatory, what will happen? I will have to make a decision, “he said in a chat on the social network Facebook with other Serbian athletes.

So, the Balkan would face an ethical dilemma between his ideas and his work, if the future coronavirus vaccine becomes a requirement to be able to travel. “I have my own opinions on the matter, and if they will change at some point, I don’t know.”Djokovic pointed out.

All tennis competitions are suspended until at least July 13, although the Balkan believes that this break will continue. “Hypothetically, if the season were to resume in July, August or September, although it is unlikely, I understand that the vaccine will become a requirement immediately after we get out of strict quarantine. And there is no vaccine yet,” he explained.

elf

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Newly discovered corona vaccine: agent kills pathogens in 48 hours

Researchers have successfully tested a drug in the laboratory that can kill the deadly Corvid-19 pathogen in a few hours.

Researchers have discovered a drug that can kill the causative agent of Covid-19 in just 48 hours. Previous laboratory tests have proven exactly that, now tests on humans are pending to determine the effect of the potential Coronavirus vaccine to prove.

Coronavirus vaccine: Not the only one in the works

There are currently over 20 coronavirus vaccines in development worldwide. One of these antidotes for Covid-19 has even progressed so far that the first volunteers are using the new drug in test series. Nevertheless, it can still take months before a finished product can be passed on to the population.

A potential coronavirus vaccine newly identified by Australian researchers could give rise to particularly great hope. The active ingredient “ivermectin” has not yet been administered to a Covid 19 patient, but laboratory analyzes have shown that the agent can eliminate any traces of the coronavirus in just two days.

New coronavirus vaccine thanks to old anti-parasite agent

“Ivermectin” is not a completely new drug. In fact, it is an active ingredient that was originally developed against parasites in the 1970s. Today, the potential coronavirus vaccine is a widely used and safe drug that is used, among other things, against HIV infections, dengue fever and the Zika virus, such as BGR reported.



“We found that even a simple dose can remove virtually any viral RNA within 48 hours, and that there is a significant reduction even after 24 hours.” explained Dr. Kylie Wagstaff from the Biomedicine Discovery Institute (BDI) at Monash University.

Now it is necessary to find out whether the dosage of the possible coronavirus vaccine that humans can tolerate is also effective. When and whether tests on humans are approved for “ivermectin” is still unclear. By the way: You can help find a suitable coronavirus vaccine.

Latest videos on futurezone.de

Latest videos on futurezone.de

show description

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Coronavirus vaccine: new discovery kills pathogens in 48 hours

Researchers have successfully tested a drug in the laboratory that can kill the deadly Corvid-19 pathogen in a few hours.

Researchers have discovered a drug that can kill the causative agent of Covid-19 in just 48 hours. Previous laboratory tests have proven exactly that, now tests on humans are pending to determine the effect of the potential Coronavirus vaccine to prove.

Coronavirus vaccine: Not the only one in the works

There are currently over 20 coronavirus vaccines in development worldwide. One of these antidotes for Covid-19 has even progressed so far that the first volunteers are using the new drug in test series. Nevertheless, it can still take months before a finished product can be passed on to the population.

A potential coronavirus vaccine newly identified by Australian researchers could give rise to particularly great hope. The active ingredient “ivermectin” has not yet been administered to a Covid 19 patient, but laboratory analyzes have shown that the agent can eliminate any traces of the coronavirus in just two days.

New coronavirus vaccine thanks to old anti-parasite agent

“Ivermectin” is not a completely new drug. In fact, it is an active ingredient that was originally developed against parasites in the 1970s. Today, the potential coronavirus vaccine is a widely used and safe drug that is used, among other things, against HIV infections, dengue fever and the Zika virus, such as BGR reported.



“We found that even a simple dose can remove virtually any viral RNA within 48 hours, and that there is a significant reduction even after 24 hours.” explained Dr. Kylie Wagstaff from the Biomedicine Discovery Institute (BDI) at Monash University.

Now it is necessary to find out whether the dosage of the possible coronavirus vaccine that humans can tolerate is also effective. When and whether tests on humans are approved for “ivermectin” is still unclear. By the way: You can help find a suitable coronavirus vaccine.

Latest videos on futurezone.de

Latest videos on futurezone.de

show description

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“Our vaccine could be injected to caregivers in the fall”

INTERVIEW – Moderna Therapeutics is the most advanced company in the production of a possible vaccine. His boss is a Frenchman, Stéphane Bancel. It details Figaro progress made and schedule followed.

Stéphane Bancel, head of Moderna Therapeutics.
Stéphane Bancel, head of Moderna Therapeutics. Businessinsider.fr

LE FIGARO. – Where is Moderna Therapeutics in the development of a vaccine against the coronavirus?

Stéphane BANCEL. – We launched on March 16 with the National Institutes of Health (NIH), the American counterparts of Inserm, a phase 1 clinical study with 45 people in Seattle. We are testing three different doses given in two injections three weeks apart. The second injection of this vaccine called mRNA-1273 will take place this week. Phase 1 trials assess the safety and tolerability of the vaccine. They also make it possible to check whether the antibody against the virus is now present in the blood of the people tested, who obviously were not previously infected. We then measure the concentration of the antibody and its ability to neutralize the virus. It’s an important step. If the response to this test is positive, there is a good chance that the vaccine will work.

In April or early May, we will have the results on toxicity and tolerance. The

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US CDC Admits to Misdiagnosing Coronavirus Patients

The Center for Disease Control and Prevention (CDC) has admitted to misdiagnosing some patients with # COVID_19, this according to a tweet from Lijian Zhao, a Chinese politician and current deputy director of the Information Department at the Ministry of Foreign Affairs. .

According to Zhao, several people were diagnosed with the flu instead of COVID-19 during the 2019 flu season.

Given this, Zhao encouraged the authorities to get patient 0 since the COVID-19 virus has been around since September of last year.

According to CDC statisticsBetween October 2019 and February 2020, the flu affected some 34 million people, of whom an estimated 12,000 died. On the other hand, the coronavirus has infected more than 300,000 and a total of 14,611 people have died. The World Health Organization (WHO) It has identified more than 150 with cases of coronavirus.

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CORONAVIRUS CASES IN INDIA | LATEST CORONAVIRUS UPDATES | CORONAVIRUS KANIKA KAPOOR CORONAVIRUS KASHI VISHWANATH PURI JAGANNATH CORONAVIRUS LIVE NEWS

coronavirus in india, coronavirus india, kanika kapoor, corona virus india, janata curfew corona, covid 19 india, coronavirus india update, corona cases in india, italy, india coronavirus, coronavirus cases in india, janata curfew, corona in india, coronavirus italy , corona india, corona update india, coronavirus news india, corona virus cases in india, coronavirus cases india, coronavirus india update, kanika, coronavirus italy, china, latest news india, coronavirus in india update, corona virus update india, total coronavirus cases in india, jagannath puri temple, puri mandir, varanasi news, tirupati temple, jagannath mandir temple Kashi Vishwanath, coronavirus symptoms, coronavirus vaccine, coronavirus treatment, coronavirus janata curfewCoronavirus in India: Prime Minister Narendra Modi, in his speech to the nation, on Thursday had called on citizens to carry out a self-imposed Janta curfew to bring about a change in attitude towards the Covid-19 pandemic.

Coronavirus News: Coronavirus cases in India exceeded 300 on Saturday, with several people testing positive for the infection. In Kerala, 12 new cases have been reported bringing the state numbers to 49, while in Punjab it has reached 13. The death toll from a highly contagious disease remains four 22 patients healed so far. Central and state governments are struggling to stop the transmission of the community as they move to close all places where a possible meeting could take place. Prime Minister Modi, in a series of tweets, urged migrants not to go to their cities, warning them that this move could spread the highly contagious infection further. Meanwhile, the Rajasthani government has announced the blockade in the state from March 21 to 31. The Gujarat government has decided to block four cities: Ahmedabad, Surat, Rajkot and Vadodara until March 25th. CM Arvind Kejriwal of Delhi said that a similar step deemed necessary in the coming days could be taken. Kejriwal has ordered the closure of all stores, malls and other places that are prone to contagion with exceptions given to pharmacies and grocery stores. Delhi Metro services will not be available on Monday 23 March from 10 to 16. Maharashtra CM Uddhav Thackeray has also requested similar measures and a virtual blockade has been called in Mumbai, Pune, Nagpur and Pimpri-Chinchwad.

The Indian railways have announced that no passenger trains will depart from their home station from midnight to 10pm on March 22 during Janata’s curfew. Airlines also announced their reduced or complete interruption of their operations during Janata’s curfew. Indigo said it will only operate on 60% of its routes, while Vistara and GoAir have also announced the reduction of their service to help the government control the spread of highly contagious coronavirus.

Financial Express Online offers you the latest news and updates on Coronavirus cases in India, LIVE. Stay tuned:

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the dangers of a hastily developed vaccine

Faced with the emergency, scientists are calling for speeding up testing procedures and doing without the usual animal tests. A laudable strategy, but one that could prove counter-productive at best, and at worst cause death.

While the epidemic is an increase in an endemic disease or the appearance of a large number of patients where the disease was … “data-url =” https://news.google.com/ health / definitions / vie-epidemie-3837 / “data-more =” Read more “>epidemic of Covid-19 continues to gain ground, scientists around the world have embarked on a speed race at vaccine. More than 20 possible candidates are under development, including one from the Institut Pasteur which started testing on mice on March 11. The most advanced is that of Start-ups, digital and biotechnologies
The … “data-image =” https://cdn.futura-sciences.com/buildsv6/images/midioriginal/d/6/e/d6eab33032_90352_shutterstock-stock-rocket.jpg “data-url =” https: / /news.google.com/tech/definitions/tech-start-up-15740/ “data-more =” Read more “>start-up Moderna, organized jointly with the NIH (National Institute of Health, American equivalent of Inserm), which started phase 1 trials with volunteers on March 16. A trial started in record time, just a few weeks after the availability of the genome of Sars-Cov-2.

15 to 20 years to develop a vaccine

Normally, get a effective vaccine, non-toxic and usable takes between 15 and 20 years. We must first develop a formula with the chemical and pharmaceutical prerequisites, conduct studies of the factors that influence immunogenicity
The more the response will be strong and induced … “data-image =” https://cdn.futura-sciences.com/buildsv6/images/midioriginal/3/d/c/3dc6039c28_50084159_vaccin4jpg.jpg “data-url =” https : //news.google.com/sante/definitions/medecine-immunogenicite-13234/ “data-more =” Read more “>immunogenicity In animals, assess the This toxicity also depends on the dose of xenobiotic necessary for … “data-image =” https://cdn.futura-sciences.com/buildsv6/images/midioriginal/a/c/9 /ac93ff44a1_50035323_symbole-toxique-yves-guillo-domaine-public.jpg “data-url =” https://news.google.com/sante/definitions/medecine-toxicite-6517/ “data-more =” Read more ” >toxicity of the vaccine in animals, then in humans, and finally, testing its effectiveness on a large scale. But, faced with the emergency, the pressure governments and health authorities, some call for speeding up procedures. European Commission President Ursula von der Leyen said Tuesday she hoped for a vaccine against new coronavirus before’autumn. More reasonably, Moderna promises that its vaccine will be ready at best by mid-2021.

When the vaccine facilitates viral infection

But is it a good idea to skip the steps? A vaccine is not harmless: it is most often a The infection function allows the virus to be introduced into program files, into files … “data-url =” https: //news.google.com/tech/definitions/informatique-virus-informatique-2434/ “data-more =” Read more “>virus disabled or weakened, and can in some cases worsen the disease it is supposed to prevent. Peter Hotez, Dean of the National School of Tropical Medicine Baylor College of Medicine and who worked on the SARS epidemic in 2003, found that some vaccinated animals developed examples of symptoms
Symptoms can affect different organs:
muscle, joint pain, headache, digestive problems, vision problems, rashes … “data-image =” https://cdn.futura-sciences.com/buildsv6/images/midioriginal/e/8/8 /e882bacd5b_96032_symptome-femme-mal-tete.jpg “data-url =” https://news.google.com/sante/definitions/medecine-symptome-834/ “data-more =” Read more “>symptoms even more severe when exposed to the virus due to a weakened immune system. This is called a “facilitation of infection by the structure of an antibody.
An antibody is a protein complex. If every organism with an immune system codes for billions of different antibodies, they all have the same global characteristics. These are … “data-image =” https://cdn.futura-sciences.com/buildsv6/images/midioriginal/a/5/4/a543c37e56_50034150_ Antibody-yohan-gfld.jpg “data-url =” https: //news.google.com/sante/definitions/medecine-anticorps-93/ “data-more =” Read more “>antibody “(Antibody-dependent enhancement or ADE in English).

Conventionally, the virus initiates the cycle of infection by fixing Roles of proteins
Proteins can perform a wide variety of functions within the cell or organism.
They can have:
a structural role (like actin or tubulin which … “data-image =” https://cdn.futura-sciences.com/buildsv6/images/midioriginal/4/6/e/46e94f9da7_50034188_actine-thomas-splettstoesser -cc.jpg “data-url =” https://news.google.com/sante/definitions/biologie-proteine-237/ “data-more =” Read more “>protein spike-like viral surfaces to target cell receptors. In doing so, these proteins induce an immune response where surface antibodies will inhibit certain elements of the cell necessary for the virus such as the receptor binding site or the. We speak of dipeptides, tripeptides when … “data-url =” https://news.google.com/sante/definitions/biologie-peptide-292/ “data-more =” Read more “>peptide of The melting point of water, in other words the temperature at which the ice … “data-image =” https://cdn.futura-sciences.com/buildsv6/images/midioriginal/7 /d/0/7d0df59f3c_82086_fusion.jpg “data-url =” https://news.google.com/sciences/definitions/physique-fusion-15305/ “data-more =” Read more “>fusion. However, in certain circumstances, these antibodies will on the contrary bind with the tips of the virus and facilitate their entry into the cell, or cause a replication and increased infection.

The best known example is that of a vaccine against respiratory syncytial virus (RSV, against Bronchiolitis, a childhood respiratory infection
Bronchiolitis … “data-image =” https://cdn.futura-sciences.com/buildsv6/images/midioriginal/6/4/d/64df840b26_53924_bronchiolite.jpg “data-url =” https: // news. google.com/sante/definitions/medecine-bronchiolite-14333/ “data-more =” Read more “>bronchiolitis) developed by Pfizer in the 1960s, which led to several serious cases pneumonia in children, resulting in the deaths of two of them. The same phenomenon has been reported with a dengue vaccine from Sanofi or the West Nile virus. It is also seen in animals for the Flu Agent
The infectious agent is a virus from the Orthomyxoviridae family, the genome of which consists of eight RNA segments. These RNAs are grouped in the same viral particle, … “data-image =” https://cdn.futura-sciences.com/buildsv6/images/midioriginal/8/f/5/8f5a87906d_117966_grippe-fievre.jpg “data -url = “https://news.google.com/sante/definitions/medecine-grippe-3442/” data-more = “Read more”>influenza, Zika virus… and the coronavirus like the Sars.

Reliable animal models too long to develop

The exact mechanisms of these side effects and why some people are affected and others are not yet known. ” But the best way to insure against this risk is to test the vaccine on animals “, Assures Peter Hotez to the agency Reuters. And this is where the second problem arises. Because to have tests that can be extrapolated to humans, you must first obtain mouse lines that have been genetically engineered to match their immune response to that of humans.

A process which takes a lot of time and which Moderna did without. The company points out that its vaccine poses a lower risk of facilitating infection by antibodies, because it only uses proteins from viral surfaces, and not a whole virus deactivated. However, neither Moderna nor a good number of start-ups in the race have never produced a vaccine, which leaves a doubt on their ability to grasp the phenomenon.

There is no reason to put people at risk in a study for an ineffective vaccine

Speed ​​versus security, an assumed choice

There is no reason to put people at risk in a study for a vaccine ineffective “Warns Karen Maschke, researcher at the Hastings Center, a non-partisan think tank, on the site STAT. ” If, against all odds, this hasty project works, then society will have to be even more attentive in monitoring and tracking the people who benefit from it. “Adds Arthur Caplan, head of medical ethics at Grossman School of Medicine from New York University. Arguments that do not seem to outweigh the panic triggered by the Covid-19 epidemic.

In a closed meeting, officials from the World Health Organization (Health: what is WHO?
As stated in its constitution, WHO aims to bring all people to the highest level of health … “data-image =” https://cdn.futura-sciences.com/buildsv6/ images / midioriginal / c / 0/3 / c0318e9153_101519_oms-logo.jpg “data-url =” https://news.google.com/sante/definitions/medecine-oms-4321/ “data-more =” Read more “>WHO) have agreed to allow testing on humans before results on animals are known, reports a Reuters participant. The institutions are said to be ready to assume the risk of a few serious cases in exchange for a quick vaccine that will, at best, not be available until the peak of the epidemic.

What you must remember

  • Laboratories around the world have embarked on a speed race for the Covid-19 vaccine, even without the usual tests in animals.
  • These vaccines can then, in some cases, facilitate infection with the virus and lead to worsening of symptoms.
  • Companies also lack reliable animal models for testing their vaccines.
  • The urgency and the pressure are such that these risks are no match.

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Rajasthan: Italian couple who received COVID-negative anti-HIV drugs

Written by Hamza Khan
, Abantika Ghosh
| Jaipur, New Delhi |

Published: March 16, 2020, 4:33:55





coronavirus, coronavirus in India, coronavirus cases in India, coronavirus infection, coronavirus death toll, COVID-19, coronavirus treatment, coronavirus vaccine Union Health Minister Dr Harsh Vardhan told Indian Express that India had for the first time used the Lopinavir / Ritonavir combination in the treatment of the two Italian patients.

TWO Italian tourists – a 69-year-old man and his 70-year-old wife – who were given the Lopinavir / Ritonavir combination, usually a second-line HIV drug, after testing positive for COVID-19 in Jaipur earlier this month, they have now turned negative.

“They tested the coronavirus-negative twice, which means they are coronavirus-free,” said Rohit Kumar Singh, assistant secretary in charge of Rajasthan. He said that another patient, an 85-year-old man who returned from Dubai on February 28 and tested positive on March 11, now has negative results.

Earlier, said Health Minister Harsh Vardhan The Indian Express that India, for the first time, had used the Lopinavir / Ritonavir combination in the treatment of the two Italian patients. Public health officials said Sunday that antiviral drugs were also given to the 85-year-old.

The decision was made after their conditions worsened, also taking into account the increased mortality risks associated with the elderly, officials said. The necessary procedure was followed, including obtaining patient consent.

The Indian Council of Medical Research (ICMR) had previously obtained authorization for a “limited use” of the combination of drugs in the event of a “public health emergency” related to COVID in the country. China is also conducting a trial of 199 subjects on the effectiveness of drugs.

Senior ICMR officials have warned that the results in Rajasthan cannot be interpreted as evidence of the effectiveness of the drugs. “We will wait for the results of the largest trial in China,” said R R Gangakhedhar, head of epidemiology and communicable diseases.

While 10 others have healed and discharged from hospitals across the country so far, none of them have received antiviral drugs.

The Italian man had tested positive on March 3, while his wife had tested positive the following day. Both were quarantined at the Hospital for Infectious Diseases, under the government-run Sawai Man Singh (SMS) hospital here. “I want to greet my colleagues, doctors, anesthesiologists, paramedics, resident and nursing staff who have been an integral part of this result,” said the director of the SMS Sudhir Bhandari hospital.

“Happy to share, 3 crown patients including 2 seniors with comorbidity problems at the SMS hospital have been successfully treated and their test reports are now negative. My most sincere congratulations to the doctors and SMS staff for their commendable and dedicated service in the treatment of crown patients, “tweeted Prime Minister Ashok Gehlot.

With this, Rajasthan now only has one positive patient for COVID: a 24 year old with travel history in Spain.

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