Endocrine

FOXA2’s Role in Glucose Regulation: New Review Highlights

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FOXA2 serves as a master transcription factor that coordinates pancreatic development, maintains islet cell identity, and regulates systemic glucose homeostasis, according to a review published in the journal Genes & Diseases (DOI: 10.1016/j.gendis.2025.101972). By orchestrating gene networks from early organogenesis into adulthood, FOXA2 ensures the functional integrity of insulin-producing β-cells and glucagon-secreting α-cells, providing a … Read more

Fitness Influencer Exposes Teen Testosterone Use on Hannity Podcast

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Fitness influencer Braden Eric Peters, known online as Clavicular, recently disclosed on the “Hang Out with Sean Hannity” podcast that he began using testosterone at age 14 to accelerate muscle growth. Peters, who gained notoriety for his “looksmaxxing” content, characterized traditional, natural weightlifting as a “complete waste of time” compared to the efficiency of performance-enhancing … Read more

Chronotype and Liver Health: No Significant Link Found

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A recent cross-sectional study published in the journal Nutrients found no statistically significant link between an individual’s chronotype—their natural preference for morning or evening activity—and the presence of liver fat or fibrosis in adults with overweight or obesity. Researchers at the National Institute of Gastroenterology in Italy assessed 119 medication-naïve participants using the Morningness–Eveningness Questionnaire … Read more

New Prolactinoma Management Guidelines: Updated Clinical Consensus

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A multidisciplinary panel of 60 specialists has released the 2025 edition of the Chinese consensus on the diagnosis and treatment of prolactinomas, published in the Chinese Neurosurgical Journal on June 8, 2026. This evidence-based framework standardizes care across endocrinology, neurosurgery, and radiology to improve early detection and patient outcomes for the most common hormone-secreting pituitary … Read more

Gut Microbes Linked to Estrogen-Driven Cancers

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Scientists are increasingly viewing gut microbes as active participants in hormone-driven cancers, moving beyond the traditional “estrobolome” model to define a bidirectional endocrine-microbiome axis. According to a review published in the journal npj Biofilms and Microbiomes, researchers are investigating how these microbial communities influence the metabolism of estrogen and contribute to the development of breast … Read more

Why Cutting Sugar Could Damage Your Gut Health

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Eliminating sucrose from a low-fat diet may disrupt gut health and trigger metabolic dysfunction, according to research presented at the Endocrine Society’s annual meeting, ENDO 2026. While high-sugar consumption is linked to health risks, a 16-week study by the Dasman Diabetes Institute indicates that a total absence of dietary sugar can lead to gut bacteria … Read more

GLP-1 Drugs: Study Highlights Frequent Stop-and-Start Patterns

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Nearly 4 in 10 patients with type 2 diabetes stop their GLP-1 medication within the first year of treatment, according to research presented at the Endocrine Society’s annual meeting, ENDO 2026. While discontinuation rates climb to nearly 6 in 10 by the end of two years, the data reveals a high frequency of patients restarting … Read more

Common Plasticizer Linked to Lifelong Anxiety Risks

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Early-life exposure to the common plasticizer di-(2-ethylhexyl) phthalate (DEHP) is linked to increased anxiety-like behavior in adulthood, according to research presented at the Endocrine Society’s annual meeting, ENDO 2026. Scientists from the University of Buenos Aires School of Medicine found that prenatal and postnatal exposure to the chemical in rats caused lasting behavioral changes, including … Read more

Diabetes Increases Mortality Risk Following Solid-Organ Transplantation

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Solid-organ transplant recipients face a significantly higher risk of mortality if they develop diabetes, according to a comprehensive analysis presented at ENDO 2026, the Endocrine Society’s annual meeting. Researchers analyzed data from over 800,000 U.S. patients who underwent transplants between 2003 and 2021, finding that both pre-existing and post-surgery diabetes consistently reduced long-term survival rates … Read more

New Guidelines: Personalized Care for Precocious Puberty

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New Clinical Guidelines Aim to Reduce Unnecessary Testing for Precocious Puberty The Endocrine Society has released updated clinical practice guidelines for managing central precocious puberty, emphasizing that not all children showing early signs of development require medical intervention. According to the guidelines, published in The Journal of Clinical Endocrinology & Metabolism, clinicians should prioritize observation … Read more

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