Lifestyle factors like an unhealthy diet can worsen the effects of genetic causes of male infertility, according to a proof-of-concept study published in Human Reproduction. Led by Dr Jessica Dunleavy and Professor Moira O’Bryan from the University of Melbourne’s School of BioSciences, the research used a mouse model carrying defects in the M1AP gene to … Read more
Texas A&M University researchers are investigating the paternal role in early pregnancy loss, shifting focus to sperm epigenetics and male fertility factors that affect over 50% of human conceptions and roughly half of cattle pregnancies. According to Lacey Luense, Ph.D., an assistant professor in the Texas A&M College of Agriculture and Life Sciences Department of … Read more
Researchers at Ludwig Princeton have discovered that tumors can manipulate distant organs to evade the immune system, according to a study published in Cell Metabolism. Led by Yibin Kang and Yong Tang, the research demonstrates how cancer cells send signals across the body to alter fat metabolism in the liver and immune responses in CD8⁺ … Read more
According to a study published in the journal Nature Medicine, age-related cognitive decline in humans is linked to the dysfunction of oligodendrocytes, the brain cells responsible for forming myelin. Researchers from the University of Edinburgh and the UK Dementia Research Institute analyzed brain tissue from participants in the Lothian Birth Cohort 1936 to track how … Read more
According to researchers at the Institute for Basic Science (IBS), a misplaced molecular switch called ERBB4 acts as an early driver of multiple Alzheimer’s disease pathologies in mouse models, triggering neuronal hyperactivity, synapse loss, reactive gliosis, amyloid accumulation, and cognitive impairment when it turns on in excitatory neurons instead of inhibitory neurons. How Misplaced ERBB4 … Read more
The findings demonstrate that mature astrocytes control thalamic neural activity through GABA signaling pathways, offering potential implications for epilepsy, Alzheimer’s disease and other disorders associated with memory problems. How Astrocytes Shape Memory Consolidation During Sleep Research has shown that a good night’s sleep has many benefits, including memory consolidation. Dr. Benjamin Deneen, corresponding author, professor … Read more
According to research published in the Chinese Medical Journal, a mitochondrial matrix protein known as RTN4IP1 drives the progression and metastasis of triple-negative breast cancer by disrupting cellular energy metabolism. Triple-negative breast cancer accounts for roughly 15% of all breast cases and lacks estrogen, progesterone, and HER2 receptors, leaving patients with high risks of recurrence … Read more
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Folic acid prevents serious neural tube birth defects by interacting with an enzyme called ALDH1L1 to produce retinoic acid, according to a study published in the Proceedings of the National Academy of Sciences (PNAS). Researchers from the Hebrew University of Jerusalem and NOVA Medical School discovered that without this specific enzyme pathway, vitamin B9 loses … Read more
New research published in the journal Neuron identifies a biological mechanism linking childhood adversity to lifelong stress hypersensitivity. By studying mouse models, scientists discovered that early-life stress (ELS) triggers epigenetic changes—specifically the enrichment of the H3K4me1 histone mark and the enzyme SETD7—within the brain’s ventral tegmental area (VTA), effectively priming dopamine neurons to overreact to … Read more
Broken String Biosciences has launched BaseMap ABE, a new platform designed to identify unintended off-target editing events in adenine base editing (ABE) applications. According to the company and reporting from OneNucleus, the tool uses INDUCE-seq technology to generate genome-wide data directly from biologically relevant cells rather than relying on prediction-based models. How BaseMap ABE Tracks … Read more