Gene

Non-Endocytic Transmembrane Delivery for Precision Medicine

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Non-endocytic transmembrane delivery strategies are emerging to bypass canonical cellular uptake routes, directly addressing the low endosomal escape efficiency that has long hindered the clinical translation of therapeutic biomacromolecules like mRNA and gene-editing tools. According to a review published in Biomedical Analysis, these advanced platforms offer a direct path to the cytosol, potentially reshaping the … Read more

Genome Folding Linked to Alzheimer’s Brain Organization

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Researchers at Carnegie Mellon University, the University of Pittsburgh, and the University of Washington have mapped how 3D genome architecture differs in brain cells affected by Alzheimer’s disease. According to a study published in Science, the research team linked genome folding to gene activity and brain tissue organization using single-cell technology, spatial mapping, and a … Read more

How DNA Enhancer Hubs Drive Prostate Cancer Genes

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Researchers at the Keck School of Medicine of USC have identified a 3D hierarchy of DNA “enhancers” that function as master switches for prostate cancer development. According to a study published in Genome Biology, these interconnected networks control gene expression, revealing potential new targets for precision cancer therapies that could move beyond current gene-specific treatments. … Read more

5 Epigenetic Clocks: Shared and Distinct Aging Signals

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Epigenetic clocks—tools designed to measure biological age through DNA methylation—capture distinct, non-overlapping biological processes rather than a single universal aging mechanism. According to a study published in npj Aging, researchers have developed Transcriptomic Aging Gene Scores (TAGS) to better interpret these clocks, showing that gene expression patterns often predict health outcomes like mortality and frailty … Read more

Tailored Gene Therapy Significantly Reduces Childhood Epilepsy Seizures

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Researchers at the University of California San Diego and the Rady Children’s Institute for Genomic Medicine have successfully treated two children with SCN2A-related developmental epileptic encephalopathy (DEE) using personalized, allele-selective antisense oligonucleotides (ASOs). According to a study published July 21, 2026, in Nature Medicine, the therapy reduced seizure frequency by up to 90%, improved developmental … Read more

New Portable Strip Test Rapidly Detects Mosquito-Borne Viruses

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Researchers at China Pharmaceutical University have developed a multisite bridging-mediated lateral flow immunoassay (mbLFIA) that detects mosquito-borne viruses like Chikungunya (CHIKV) with high sensitivity without the need for specialized laboratory equipment. According to a study published in Targetome on April 30, 2026, the method achieves a visual detection limit of 2 pmol·L−1, offering a portable … Read more

New Immune Receptor Identified as Key Driver of Organ Aging

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Stanford Medicine researchers have identified a primary driver of biological aging: the failure of tissue-resident macrophages to clear senescent, or “zombie,” neutrophils from the body. According to a study published July 16 in Science, blocking a specific pro-inflammatory receptor, EP2, on these immune cells rejuvenated organ function and reduced age-related frailty in mice. This discovery … Read more

Optimizing Liver Cancer Treatment via Gene Signatures and Multi-Omics

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Hepatocellular carcinoma (HCC) is currently the third leading cause of cancer death, with patient outcomes hindered by late diagnosis and scarce early biomarkers. According to a 2026 review in the journal Gene Expression, advancements in multi-omics and liquid biopsy are shifting the clinical landscape by enabling more precise prognostic tracking and personalized immunotherapy selection, though … Read more

New Genetic Reference Map Accelerates Stem Cell Research

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Bioengineers at the University of California San Diego have created the first genome-scale reference map detailing how individual genes influence the behavior and identity of human induced pluripotent stem cells (iPSCs). Published in Nature Biotechnology, the study utilized CRISPR technology to systematically switch off 11,692 genes, providing a reference atlas for researchers to predict how … Read more

Early Detection of Congenital Ventriculomegaly: Preventing Developmental Disabilities

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New research published in Science Translational Medicine indicates that congenital cerebral ventriculomegaly (CCV)—a condition marked by fluid-filled brain ventricle swelling—is frequently linked to rare, damaging gene mutations. According to investigators at the Mass General Brigham Neuroscience Institute, these genetic findings suggest that CCV is often a marker of underlying neurodevelopmental disorders, including autism spectrum disorder, … Read more

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