Hidden features within the spleen detected on abdominal imaging scans can signal a person’s risk of developing coronary artery disease, according to a new study published in Science Translational Medicine. Led by investigators from Mass General Brigham, the research leverages artificial intelligence and genomic analyses to uncover how blood-forming and immune functions in the spleen … Read more
Neurogenesis in the adult brain hippocampus stalls in patients with major depressive disorder, according to a study published by researchers at Columbia University Vagelos College of Physicians and Surgeons. While previous medical models linked depression primarily to neurotransmitter deficiencies like serotonin, the new findings indicate that the condition stems from broader issues affecting neuronal adaptability … Read more
Broken String Biosciences has launched BaseMap ABE, a new platform designed to identify unintended off-target editing events in adenine base editing (ABE) applications. According to the company and reporting from OneNucleus, the tool uses INDUCE-seq technology to generate genome-wide data directly from biologically relevant cells rather than relying on prediction-based models. How BaseMap ABE Tracks … Read more
Modern humans with non-African ancestry carry a Neanderthal growth hormone receptor variant that increases muscle mass and alters bone structure, according to a study published in Current Biology. Led by the Max Planck Institute for Evolutionary Anthropology, researchers found this genetic legacy persists in roughly 20% of some South and East Asian populations. Neanderthal DNA … Read more
A new study published in Nature Genetics reveals how the three-dimensional organization of DNA in rare immune cells helps explain the genetic risk for Crohn’s disease and other autoimmune conditions, according to research co-led by Prof. Valeriya Malysheva, group leader at the VIB-UAntwerp Center for Molecular Neurology. Rather than viewing the genome as a simple … Read more
Cellular instructions for activating genes have remained nearly unchanged across two billion years of evolution, while the mechanisms used to switch genes off vary widely across branches of life, according to a study published in Nature Genetics by the Centre for Genomic Regulation (CRG) in Barcelona. Researchers used a new profiling method called iChIP2 to … Read more
According to new research published July 30, 2026, in the journal Science, modern human genomes contain genetic traces from two previously unknown archaic hominin lineages: a “ghost” lineage in Africa that mixed with Homo sapiens more than 50,000 years ago, and a “super-archaic” lineage dating back over 1.7 million years that left its footprint via … Read more
Researchers at Carnegie Mellon University, the University of Pittsburgh, and the University of Washington have mapped how 3D genome architecture differs in brain cells affected by Alzheimer’s disease. According to a study published in Science, the research team linked genome folding to gene activity and brain tissue organization using single-cell technology, spatial mapping, and a … Read more
Rapidly developing antibiotic resistance during severe lung infections can occur when patients acquire circular pieces of DNA called plasmids from transient environmental bacteria, according to researchers at the University of Washington School of Medicine. Publishing their findings in Nature Microbiology, the team reported that this gene transfer can cause pathogen resistance to jump more than … Read more
Researchers at the Keck School of Medicine of USC have identified a 3D hierarchy of DNA “enhancers” that function as master switches for prostate cancer development. According to a study published in Genome Biology, these interconnected networks control gene expression, revealing potential new targets for precision cancer therapies that could move beyond current gene-specific treatments. … Read more