Recognize periodontitis in good time and treat it correctly

What to do with periodontitis

Periodontitis is a chronic bacterial inflammation of the tooth bed. The common disease periodontitis is widespread – around eleven million people suffer from it in Germany alone. The success of a periodontal treatment does not depend solely on the dentists treating you. Those affected must also take action, which is why education about this disease is particularly important.

The German Society for Dentistry, Oral and Maxillofacial Medicine eV (DGZMK) and the German Dental Association (BZÄK) recently updated the information for patients about periodontitis. In-depth scientific information on the diagnosis and treatment of periodontal disease was presented in a brief Overview summarized.

Periodontal disease can have serious consequences

In the course of the disease, the jawbone usually becomes inflamed, which slowly breaks down bone mass. As a result, deep gum pockets develop and the teeth increasingly lose their hold. This slowly progressing process is largely painless, which is why many people do not treat periodontitis until late.

After the age of 45, such chronic inflammation is the most common cause of tooth loss. The effects do not only affect the oral cavity. The constant bacterial load is considered a risk factor for Heart disease and type 2Diabetes.

Risk factors for the development of periodontal disease

In addition to poor oral hygiene, there are a number of risk factors for the development of periodontal disease, according to DGZMK and BZÄK. These include above all smoking, being overweight and Stress as well as a family disposition.

Warning signs of the presence of periodontal disease

Since periodontitis is mostly painless, the disease is often recognized late. The following symptoms indicate the presence of periodontitis:

How is periodontal disease diagnosed?

During dental check-ups, suspected periodontal disease can be examined using the so-called Periodontal Screening Index (PSI). To do this, the dentist drives a special probe over the gums to check the state of health. The costs for this measure are covered by the statutory health insurance every two years. If the PSI is abnormal, further examinations may be necessary, such as a systematic analysis of the gingival pocket depth and an x-ray of the jaw.

How is periodontal disease treated?

Periodontitis is not completely curable. However, the progression can be stopped or massively slowed down. The aim of periodontal treatment is to stop the inflammation in the tissue around the tooth root in order to prevent further breakdown of the jawbone. In addition to prophylaxis sessions with professional cleaning of the teeth, detailed oral hygiene instructions are also provided for daily oral hygiene. In this way, the superficial degree of inflammation of the gums is usually significantly reduced.

Treatment of moderate cases

Depending on the severity, careful cleaning of the recessed gum pockets under local anesthesia is carried out in further sessions. In some cases this treatment step is supported by the administration of antibiotics. In moderately severe cases, this can achieve freedom from inflammation.

Treatment of severe periodontal disease

If the above methods do not show the desired effect, further measures may be necessary. In a small operation, the gum pockets are then opened and treated precisely. Biofilms and tartar as well as inflamed tissue are removed from the pockets. In this context, bone defects can also be treated with special tissue engineering methods.

Prevent a return

Since periodontitis is a chronic disease, controls and personal initiative must ensure that the inflammation does not spread again. In addition to dental floss or interdental toothbrushes, regular checks in the dental practice with two to four appointments per year are required. (vb)

Author and source information

This text complies with the requirements of specialist medical literature, medical guidelines and current studies and has been checked by medical professionals.

Author:

Diploma-Editor (FH) Volker Blasek

Swell:

  • German Medical Association: Patient information periodontal treatment (as of August 2020), bzaek.de

Important NOTE:
This article is for general guidance only and should not be used for self-diagnosis or self-treatment. He can not substitute a visit at the doctor.

.

Tymoshenko recovered from COVID-19 :: Politics :: RBC

Former Prime Minister of Ukraine suffered from coronavirus infection, but the latest test showed that she recovered, although some symptoms persist

Yulia Timoshenko

(Photo: Evgen Kotenko / Ukrinform / ZUMA Wire / TASS)

The leader of the Ukrainian Batkivshchyna party Yulia Tymoshenko passed a negative test for coronavirus. About this on your Facebook reported press secretary of the politician Marina Soroka.

“The coronavirus has been overcome. She felt much better. So far, the pneumonia remains, but the treatment is successful, and soon she will return to normal life and work, ”she wrote.

That Tymoshenko got infected coronavirus, it became known earlier on August 23. RBC Ukraine, citing sources, reported that the daughter of the Batkivshchyna leader Yevgeny and her husband Artur Chechetkin were also infected. The doctors assessed her condition as serious, the temperature rose to 39 degrees.

September 2 Tymoshenko for the first time after the break published an entry on his Facebook, writing that “almost two weeks of fighting a serious illness change the feeling of reality.” She thanked everyone who supported her during her illness.

Facebook post of user YuliaTymoshenko


Ukraine because of the pandemic has banned the entry of transit passengers into the country


Photo: RIA Novosti




Video

Read on RBC Pro

According to Johns Hopkins University, 152.2 thousand cases of coronavirus infection were recorded in Ukraine, of which more than 16 thousand were in Kiev. 3132 people died. The number of newly diagnosed cases in the country began to rise again after the decline in July. If on August 10, a little more than 1,000 new cases per day were detected in the country, then on September 10 there were already 2,600. Hopkins University also includes statistics on the self-proclaimed DPR and LPR in statistics for Ukraine.

The spread of the coronavirus Covid-19 in the world

Number of confirmed cases of infection

Source: JHU

World data i


Georgy Tadtaev

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These conditions can be behind itchy feet

When itching on their feet, many think first of athlete’s foot. But the stubborn fungal infection is not always to blame if you have to scratch your foot all the time. Sometimes the soles just need a little maintenance. Allergies, overload and circulatory disorders can also be to blame for the nasty itching.

Dry and sore skin are one of the most common causes of itchy feet. The skin becomes sensitive, tiny cracks and inflammation may have formed. If the feet sweat, the skin is also attacked by the excreted salts.

Dry skin often makes feet itchy

The nerve fibers then react irritated. Various messenger substances on the skin, including histamine, increase this effect. The body produces these messenger substances among other things in the course of the immune defense. So itching is always an indication that the body is on alert. Neurodermatitis and eczema also form dry areas of the skin that itch uncomfortably.

Urea and panthenol care for dry skin areas

Nourishing creams, for example with urea and panthenol, supply the skin with moisture, support the skin’s ability to bind water and promote healing. An ointment containing cortisone can also help with acute itching. Natural oils ensure the supply of fat and keep the skin supple. If the itching persists despite intensive foot care, one should continue researching the cause.

If your feet are itchy, also think about an allergy

Allergies can lead to itching of the feet. This is often triggered by certain ingredients in a foot cream, such as preservatives or fragrances. A new detergent, fabric softener, foot deodorant or shower gel can also promote the skin reaction. Food and medication are also possible. An allergy test at a dermatologist can provide clarity.Chicory pollen: it can also be an allergy. (Source: Ian Cuming / imago images)

Itchy feet due to metabolic disorders

Metabolic disorders such as gout and diabetes mellitus are also factors that cause itching. Many diabetics know the problem: a high blood sugar level promotes dry skin. In addition, diabetics generally have an increased risk of infections in their feet. In addition, nerve damage can occur in the course of the disease.

Many feet react to mechanical stimuli with itching

Many athletes are also familiar with itchy feet. The nerves on the feet often react irritably to the friction from socks and shoes as well as to the high temperatures and sweating in the sports shoes. In addition, calluses and dry areas of skin easily form when the feet are subjected to heavy loads, which also make itching easier. Cooling foot baths with essential oils such as peppermint or tea tree oil provide relief. Then put some lotion on your feet and let them “breathe”, so don’t put on your socks and shoes again.

Suspected athlete’s foot? Look at the spaces between the toesWalk well - taking care of your skin and nails prevents discomfort.  (Source: imago images)Walk well – taking care of your skin and nails prevents discomfort. (Source: imago images)

Anyone who suffers from itchy feet should take a closer look at the spaces between the toes. Athlete’s foot often shows itself first in the area of ​​the little toe as redness and flaking. Many people mistakenly think of dry skin. Sometimes small blisters also show up. A smear at the dermatologist shows whether a fungal infection is behind the itching.

Sick liver can cause itching

Other possible causes of the itching include liver, gallbladder, and kidney diseases. Then the symptoms often increase in the evening hours. Hormonal changes and stress, but also iron and zinc deficiencies as well as neurological diseases also often make the skin itchy. Also Thyroid disorders are a possible trigger. If the symptoms do not subside, you should always consult a doctor in order to rule out serious illnesses or to be able to identify them as early as possible.

Important NOTE: Under no circumstances does the information replace professional advice or treatment by trained and recognized doctors. The content of t-online.de cannot and must not be used to make independent diagnoses or to start treatments.

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Support healing processes through nutrition – naturopathy & naturopathic specialist portal

Dietary interventions for the healing of inflammation

Our bodies use inflammation to respond to damage. However, persistent inflammation can be the cause of chronic diseases and accelerate the aging process. A research team has now shown that a certain type of diet can fight inflammation in the body.

Researchers at the Inflammation Research Foundation documented how dietary interventions affect the inflammation in the body that develops as a result of injuries. A low-calorie diet rich in omega-3 fatty acids and polyphenols therefore helps to resolve inflammatory processes in the body more quickly. The results were published in the medical journal “Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry“Published.

Cure inflammation through proper diet

Our body reacts to injuries with an inflammatory process in order to bring the damage under control. As the inflammation resolves, healing is usually associated with it. However, this process is still not fully characterized. Current research suggests that the nutrients from the food we ingest are involved in inflammatory processes and their breakdown to a large extent. The researchers also propose a nutritional approach that has a positive effect on the healing of inflammatory damage.

Inflammation is a common cause of disease

The researchers point out that unresolved inflammation is associated with the development of numerous diseases, including metabolic disorders, Diabetes, Autoimmune diseases, neurogenerative diseases as well Krebs.

Which hormones and genetic factors are involved in inflammation?

As the research team reports, successful resolution of injury-related inflammation requires a continuous balance of hormonal and genetic factors. The hormones eicosanoids and resolvins are primarily involved in the inflammation. In addition, the inflammation is controlled by the gene transcription factor NF-κB.

Omega-3 fatty acids against inflammation

The results of the study show that hormones from the group of resolvins can balance the hormones from the group of eicosanoids, which has a positive effect on the resolution of the inflammatory process. The formation of resolvins is promoted by omega-3 fatty acids. Many omega-3 fatty acids are found in fish, vegetable oils, vegetables, nuts, seeds and soy, for example.

AMPK – the main switch of metabolism

Furthermore, according to the study, the gene transcription factor NF-κB has to be balanced by the activation of AMPK. AMPK is an enzyme that plays an important role in the regulation of biosynthetic processes and acts as a kind of genetic master switch for metabolism. AMPK and NF-κB contribute significantly to the repair of damaged tissue.

In their study, the researchers describe that the uptake of polyphenols has a beneficial effect on the activation of AMPK, which accelerates the healing process. Many polyphenols are found in cloves, peppermint, star anise, real cocoa powder, berries, plums, cherries, grapes, apples, nuts, artichokes and chicory.

Systems-based approach to inflammation

“The balancing act between the initiation of the inflammation and its final resolution, which leads to healing, is a system-based approach,” explains Dr. Barry Sears, President of the Inflammation Research Foundation. Every step of the process can either be reinforced or inhibited by diet. The interactions between NF-κB, AMPK, eicosanoids and resolvins are decisive. (vb)

Also read: Ingredients in food that cause inflammation.

Author and source information

This text complies with the requirements of specialist medical literature, medical guidelines and current studies and has been checked by medical professionals.

Author:

Diploma-Editor (FH) Volker Blasek

Swell:

  • Barry Sears, Mary Perry, Asish K. Saha: Dietary Technologies to Optimize Healing from Injury-Induced Inflammation; in: Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 2020, eurekaselect.com
  • Inflammation Research Foundation: Dietary control of the healing of injury-induced inflammation (veröffentlicht: 10.08.2020), eurekalert.org

Important NOTE:
This article is for general guidance only and should not be used for self-diagnosis or self-treatment. He can not substitute a visit at the doctor.

.

Supporting healing processes through nutrition – naturopathy & naturopathic specialist portal

Dietary interventions for the healing of inflammation

Our bodies use inflammation to respond to damage. However, persistent inflammation can be the cause of chronic diseases and accelerate the aging process. A research team has now shown that a certain type of diet can fight inflammation in the body.

Researchers at the Inflammation Research Foundation documented how dietary interventions affect the inflammation in the body that develops as a result of injuries. A low-calorie diet that is rich in omega-3 fatty acids and polyphenols therefore helps to resolve inflammatory processes in the body more quickly. The results were published in the medical journal “Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry“Published.

Cure inflammation through proper nutrition

Our body reacts to injuries with an inflammatory process to bring the damage under control. As the inflammation resolves, healing is usually associated with it. However, this process is still not fully characterized. The current research indicates that the nutrients from the food that we ingest are involved to a large extent in inflammatory processes and their breakdown. The researchers also propose a nutritional approach that has a positive effect on the healing of inflammatory damage.

Inflammation is a common cause of disease

The researchers point out that unresolved inflammation is associated with the development of numerous diseases, including metabolic disorders, Diabetes, Autoimmune diseases, neurogenerative diseases as well Krebs.

Which hormones and genetic factors are involved in inflammation?

As the research team reports, successful resolution of injury-related inflammation requires a continuous balance of hormonal and genetic factors. The hormones eicosanoids and resolvins are primarily involved in the inflammation. In addition, the inflammation is controlled by the gene transcription factor NF-κB.

Omega-3 fatty acids against inflammation

The results of the study show that hormones from the group of resolvins can balance the hormones from the group of eicosanoids, which has a positive effect on the resolution of the inflammatory process. The formation of resolvins is promoted by omega-3 fatty acids. Many omega-3 fatty acids are found in fish, vegetable oils, vegetables, nuts, seeds and soy, for example.

AMPK – the main switch of metabolism

Furthermore, according to the study, the gene transcription factor NF-κB must be balanced by the activation of AMPK. AMPK is an enzyme that plays an important role in the regulation of biosynthetic processes and acts as a kind of genetic master switch for metabolism. AMPK and NF-κB make a significant contribution to the repair of damaged tissue.

In their study, the researchers describe that the uptake of polyphenols has a beneficial effect on the activation of AMPK, which accelerates the healing process. Many polyphenols are found in cloves, peppermint, star anise, real cocoa powder, berries, plums, cherries, grapes, apples, nuts, artichokes and chicory.

Systems-based approach to inflammation

“The balancing act between the initiation of the inflammation and its final resolution, which leads to healing, is a system-based approach,” explains Dr. Barry Sears, President of the Inflammation Research Foundation. Every step of the process can either be reinforced or inhibited by diet. The interactions between NF-κB, AMPK, eicosanoids and resolvins are decisive. (vb)

Also read: Ingredients in food that cause inflammation.

Author and source information

This text complies with the requirements of specialist medical literature, medical guidelines and current studies and has been checked by medical professionals.

Author:

Diploma-Editor (FH) Volker Blasek

Swell:

  • Barry Sears, Mary Perry, Asish K. Saha: Dietary Technologies to Optimize Healing from Injury-Induced Inflammation; in: Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 2020, eurekaselect.com
  • Inflammation Research Foundation: Dietary control of the healing of injury-induced inflammation (veröffentlicht: 10.08.2020), eurekalert.org

Important NOTE:
This article is for general guidance only and should not be used for self-diagnosis or self-treatment. He can not substitute a visit at the doctor.

.

This diet relieves inflammation – naturopathy & naturopathic specialist portal

Dietary interventions for the healing of inflammation

Our bodies use inflammation to respond to damage. However, persistent inflammation can be the cause of chronic diseases and accelerate the aging process. A research team has now shown that a certain type of diet can fight inflammation in the body.

Researchers at the Inflammation Research Foundation documented how dietary interventions affect the inflammation in the body that develops as a result of injuries. A low-calorie diet that is rich in omega-3 fatty acids and polyphenols therefore helps to resolve inflammatory processes in the body more quickly. The results were published in the medical journal “Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry“Published.

Cure inflammation through proper nutrition

Our body reacts to injuries with an inflammatory process to bring the damage under control. As the inflammation resolves, healing is usually associated with it. However, this process is still not fully characterized. The current research indicates that the nutrients from the food that we ingest are involved to a large extent in inflammatory processes and their breakdown. The researchers also propose a nutritional approach that has a positive effect on the healing of inflammatory damage.

Inflammation is a common cause of disease

The researchers point out that unresolved inflammation is associated with the development of numerous diseases, including metabolic disorders, Diabetes, Autoimmune diseases, neurogenerative diseases as well Krebs.

Which hormones and genetic factors are involved in inflammation?

As the research team reports, successful resolution of injury-related inflammation requires a continuous balance of hormonal and genetic factors. The hormones eicosanoids and resolvins are primarily involved in the inflammation. In addition, the inflammation is controlled by the gene transcription factor NF-κB.

Omega-3 fatty acids against inflammation

The results of the study show that hormones from the group of resolvins can balance the hormones from the group of eicosanoids, which has a positive effect on the resolution of the inflammatory process. The formation of resolvins is promoted by omega-3 fatty acids. Many omega-3 fatty acids are found in fish, vegetable oils, vegetables, nuts, seeds and soy, for example.

AMPK – the main switch of metabolism

Furthermore, according to the study, the gene transcription factor NF-κB must be balanced by the activation of AMPK. AMPK is an enzyme that plays an important role in the regulation of biosynthetic processes and acts as a kind of genetic master switch for metabolism. AMPK and NF-κB make a significant contribution to the repair of damaged tissue.

In their study, the researchers describe that the uptake of polyphenols has a beneficial effect on the activation of AMPK, which accelerates the healing process. Many polyphenols are found in cloves, peppermint, star anise, real cocoa powder, berries, plums, cherries, grapes, apples, nuts, artichokes and chicory.

Systems-based approach to inflammation

“The balancing act between the initiation of the inflammation and its final resolution, which leads to healing, is a system-based approach,” explains Dr. Barry Sears, President of the Inflammation Research Foundation. Every step of the process can either be reinforced or inhibited by diet. The interactions between NF-κB, AMPK, eicosanoids and resolvins are decisive. (vb)

Also read: Ingredients in food that cause inflammation.

Author and source information

This text complies with the requirements of specialist medical literature, medical guidelines and current studies and has been checked by medical professionals.

Author:

Diploma-Editor (FH) Volker Blasek

Swell:

  • Barry Sears, Mary Perry, Asish K. Saha: Dietary Technologies to Optimize Healing from Injury-Induced Inflammation; in: Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 2020, eurekaselect.com
  • Inflammation Research Foundation: Dietary control of the healing of injury-induced inflammation (veröffentlicht: 10.08.2020), eurekalert.org

Important NOTE:
This article is for general guidance only and should not be used for self-diagnosis or self-treatment. He can not substitute a visit at the doctor.

.

Intensity, place and time determine the effect – naturopathy & naturopathic specialist portal

Inflammation treatable with the help of acupuncture?

Acupuncture can be used against a variety of ailments, with inflammation being a potential area of ​​application according to a recent study. The research team, led by neuroscientists from Harvard Medical School, has successfully used acupuncture to counteract the cytokine storm in mice with systemic inflammation – with surprising results.

Although acupuncture in the traditional for centuries chinese medicine is used, little is known about the exact mechanisms of action. The research team led by Professor Qiufu Ma from Harvard Medical School and the Dana-Farber Cancer Institute has now used mice to study the activation of the signaling pathways in acupuncture and the effect against bacterial inflammation with a cytokine storm. Their results were published in the specialist magazine “Neuron“.

“Acupuncture, which has its roots in traditional Chinese medicine, has recently been increasingly integrated into Western medicine, particularly for the treatment of chronic pain and gastrointestinal diseases,” the researchers report. The mechanical stimulation of certain points on the body surface is intended to trigger nerve signals and influence the functions of internal organs.

Investigations with electro acupuncture

In the current study, the researchers used electro acupuncture – a modern version of traditional manual acupuncture. “Instead of needles, very thin electrodes are used in electroacupuncture, which are inserted into the skin and connective tissue and enable better control of the stimulation intensities,” the researchers report. In mice, they investigated the effects on the activation of signaling pathways and on the regulation of inflammation.

What is a cytokine storm?

To do this, they used mice with bacterial inflammation and a cytokine storm, which they subjected to electroacupuncture at different points, with different intensities and at different times. A cytokine storm describes the rapid release of large amounts of inflammatory molecules, so-called cytokines. Cytokine storms also play a role in COVID-19 (diseases caused by the new coronavirus), for example, but can generally occur as an abnormal immune reaction with every infection and are also known as a hallmark of sepsis (blood poisoning).

Investigated effects on certain cell types

Building on earlier research that pointed to the importance of neurotransmitters in regulating inflammation, the researchers focused their further investigations on two specific cell types that are known to produce or secrete these neurotransmitters. First, the chromaffin cells that are located in the Adrenal glands, and second, the noradrenergic neurons, which are located in the peripheral nervous system and are connected directly to the spleen by an abundance of nerve fibers.

Vagus-adrenal axis activated

In the body, the chromaffin cells are the main producers of the stress hormones adrenaline and noradrenaline, as well as dopamine, while noradrenergic neurons release noradrenaline, the researchers explain. In a series of experiments, they used low-intensity electroacupuncture (0.5 milliamps) at one point on the hind legs of mice with a cytokine storm (caused by a bacterial toxin). This stimulation activated the vagus-adrenal axis and induced the secretion of dopamine from the chromaffin cells of the adrenal glands.

Improved survival rate through acupuncture

According to the research team, treated animals had lower levels of three main types of inflammation-inducing cytokines and a higher survival rate than control mice. “60 percent of the acupuncture-treated animals survived, compared with 20 percent of the untreated animals,” reports the Harvard Medical School of the study results.

Place, time and intensity are decisive

In further experiments, the researchers were also able to prove that the location of the acupuncture as well as the time and intensity are decisive for the effect. For example, the vagus-adrenal axis could be activated by electroacupuncture of the hind limbs, but not by acupuncture points in the abdomen.

High-intensity electroacupuncture (3 milliamps) on the same hind leg acupuncture point and on an acupuncture point on the abdomen was also successful if used immediately before the development of the cytokine storm, but such treatment intensified after the onset of the disease and during the height of the cytokine storm the inflammation, reports the research team.

Adverse effect if used improperly

The results show how the same stimulus can produce dramatically different results depending on its location, time and intensity, the researchers continue. “This observation supports the idea that acupuncture, if used improperly, could have detrimental results, which I don’t think people necessarily consider,” said Professor Ma.

Can acupuncture be used against inflammation and sepsis?

“Our results represent an important step in the ongoing efforts to not only understand the neuroanatomy of acupuncture, but also to find ways to integrate it into the treatment arsenal of inflammatory diseases, including sepsis,” emphasizes the study director.

If the results are confirmed in further research, electroacupuncture could one day be used as a versatile treatment modality – from accompanying therapy for sepsis to more targeted treatment of site-specific inflammations, such as inflammatory diseases of the gastrointestinal tract, so that Conclusion from Professor Ma. (fp)

Author and source information

This text complies with the requirements of specialist medical literature, medical guidelines and current studies and has been checked by medical professionals.

Author:

Dipl. Geogr. Fabian Peters

Swell:

  • Shenbin Liu, Zhi-Fu Wang, Yang-Shuai Su, Russell S. Ray, Xiang-Hong Jing, Yan-Qing Wang, Qiufu Ma: Somatotopic Organization and Intensity Dependence in Driving Distinct NPY-Expressing Sympathetic Pathways by Electroacupuncture; in: Neuron (veröffentlicht 12.08.2020), cell.com
  • Harvard Medical School: Quieting the Storm (veröffentlicht 12.08.2020), harvard.edu

Important NOTE:
This article is for general guidance only and should not be used for self-diagnosis or self-treatment. He can not substitute a visit at the doctor.

.

This diet heals inflammation – naturopathy & naturopathic specialist portal

Dietary interventions for the healing of inflammation

Our bodies use inflammation to respond to damage. However, persistent inflammation can be the cause of chronic diseases and accelerate the aging process. A research team has now shown that a certain type of diet can fight inflammation in the body.

Researchers at the Inflammation Research Foundation documented how dietary interventions affect the inflammation in the body that develops as a result of injuries. A low-calorie diet that is rich in omega-3 fatty acids and polyphenols therefore helps to resolve inflammatory processes in the body more quickly. The results were published in the medical journal “Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry“Published.

Cure inflammation through proper nutrition

Our body reacts to injuries with an inflammatory process to bring the damage under control. As the inflammation resolves, healing is usually associated with it. However, this process is still not fully characterized. The current research indicates that the nutrients from the food that we ingest are involved to a large extent in inflammatory processes and their breakdown. The researchers also propose a nutritional approach that has a positive effect on the healing of inflammatory damage.

Inflammation is a common cause of disease

The researchers point out that unresolved inflammation is associated with the development of numerous diseases, including metabolic disorders, Diabetes, Autoimmune diseases, neurogenerative diseases as well Krebs.

Which hormones and genetic factors are involved in inflammation?

As the research team reports, successful resolution of injury-related inflammation requires a continuous balance of hormonal and genetic factors. The hormones eicosanoids and resolvins are primarily involved in the inflammation. In addition, the inflammation is controlled by the gene transcription factor NF-κB.

Omega-3 fatty acids against inflammation

The results of the study show that hormones from the group of resolvins can balance the hormones from the group of eicosanoids, which has a positive effect on the resolution of the inflammatory process. The formation of resolvins is promoted by omega-3 fatty acids. Many omega-3 fatty acids are found in fish, vegetable oils, vegetables, nuts, seeds and soy, for example.

AMPK – the main switch of metabolism

Furthermore, according to the study, the gene transcription factor NF-κB must be balanced by the activation of AMPK. AMPK is an enzyme that plays an important role in the regulation of biosynthetic processes and acts as a kind of genetic master switch for metabolism. AMPK and NF-κB make a significant contribution to the repair of damaged tissue.

In their study, the researchers describe that the uptake of polyphenols has a beneficial effect on the activation of AMPK, which accelerates the healing process. Many polyphenols are found in cloves, peppermint, star anise, real cocoa powder, berries, plums, cherries, grapes, apples, nuts, artichokes and chicory.

Systems-based approach to inflammation

“The balancing act between the initiation of the inflammation and its final resolution, which leads to healing, is a system-based approach,” explains Dr. Barry Sears, President of the Inflammation Research Foundation. Every step of the process can either be reinforced or inhibited by diet. The interactions between NF-κB, AMPK, eicosanoids and resolvins are decisive. (vb)

Also read: Ingredients in food that cause inflammation.

Author and source information

This text complies with the requirements of specialist medical literature, medical guidelines and current studies and has been checked by medical professionals.

Author:

Diploma-Editor (FH) Volker Blasek

Swell:

  • Barry Sears, Mary Perry, Asish K. Saha: Dietary Technologies to Optimize Healing from Injury-Induced Inflammation; in: Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 2020, eurekaselect.com
  • Inflammation Research Foundation: Dietary control of the healing of injury-induced inflammation (veröffentlicht: 10.08.2020), eurekalert.org

Important NOTE:
This article is for general guidance only and should not be used for self-diagnosis or self-treatment. He can not substitute a visit at the doctor.

.

Place, time and intensity determine the effect – naturopathy & naturopathic specialist portal

Inflammation treatable with the help of acupuncture?

Acupuncture can be used against a variety of ailments, with inflammation being a potential area of ​​application according to a recent study. The research team, led by neuroscientists from Harvard Medical School, has successfully used acupuncture to counteract the cytokine storm in mice with systemic inflammation – with surprising results.

Although acupuncture in the traditional for centuries chinese medicine is used, little is known about the exact mechanisms of action. The research team led by Professor Qiufu Ma from Harvard Medical School and the Dana-Farber Cancer Institute has now used mice to study the activation of the signaling pathways in acupuncture and the effect against bacterial inflammation with a cytokine storm. Their results were published in the specialist magazine “Neuron“.

“Acupuncture, which has its roots in traditional Chinese medicine, has recently been increasingly integrated into Western medicine, particularly for the treatment of chronic pain and gastrointestinal diseases,” the researchers report. The mechanical stimulation of certain points on the body surface is intended to trigger nerve signals and influence the functions of internal organs.

Investigations with electro acupuncture

In the current study, the researchers used electro acupuncture – a modern version of traditional manual acupuncture. “Instead of needles, very thin electrodes are used in electroacupuncture, which are inserted into the skin and connective tissue and enable better control of the stimulation intensities,” the researchers report. In mice, they investigated the effects on the activation of signaling pathways and on the regulation of inflammation.

What is a cytokine storm?

To do this, they used mice with bacterial inflammation and a cytokine storm, which they subjected to electroacupuncture at different points, with different intensities and at different times. A cytokine storm describes the rapid release of large amounts of inflammatory molecules, so-called cytokines. Cytokine storms also play a role in COVID-19 (diseases caused by the new coronavirus), for example, but can generally occur as an abnormal immune reaction with every infection and are also known as a hallmark of sepsis (blood poisoning).

Investigated effects on certain cell types

Building on earlier research that pointed to the importance of neurotransmitters in regulating inflammation, the researchers focused their further investigations on two specific cell types that are known to produce or secrete these neurotransmitters. First, the chromaffin cells that are located in the Adrenal glands, and second, the noradrenergic neurons, which are located in the peripheral nervous system and are connected directly to the spleen by an abundance of nerve fibers.

Vagus-adrenal axis activated

In the body, the chromaffin cells are the main producers of the stress hormones adrenaline and noradrenaline, as well as dopamine, while noradrenergic neurons release noradrenaline, the researchers explain. In a series of experiments, they used low-intensity electroacupuncture (0.5 milliamps) at one point on the hind legs of mice with a cytokine storm (caused by a bacterial toxin). This stimulation activated the vagus-adrenal axis and induced the secretion of dopamine from the chromaffin cells of the adrenal glands.

Improved survival rate through acupuncture

According to the research team, treated animals had lower levels of three main types of inflammation-inducing cytokines and a higher survival rate than control mice. “60 percent of the acupuncture-treated animals survived, compared with 20 percent of the untreated animals,” reports the Harvard Medical School of the study results.

Place, time and intensity are decisive

In further experiments, the researchers were also able to prove that the location of the acupuncture as well as the time and intensity are decisive for the effect. For example, the vagus-adrenal axis could be activated by electroacupuncture of the hind limbs, but not by acupuncture points in the abdomen.

High-intensity electroacupuncture (3 milliamps) on the same hind leg acupuncture point and on an acupuncture point on the abdomen was also successful if used immediately before the development of the cytokine storm, but such treatment intensified after the onset of the disease and during the height of the cytokine storm the inflammation, reports the research team.

Adverse effect if used improperly

The results show how the same stimulus can produce dramatically different results depending on its location, time and intensity, the researchers continue. “This observation supports the idea that acupuncture, if used improperly, could have detrimental results, which I don’t think people necessarily consider,” said Professor Ma.

Can acupuncture be used against inflammation and sepsis?

“Our results represent an important step in the ongoing efforts to not only understand the neuroanatomy of acupuncture, but also to find ways to integrate it into the treatment arsenal of inflammatory diseases, including sepsis,” emphasizes the study director.

If the results are confirmed in further research, electroacupuncture could one day be used as a versatile treatment modality – from accompanying therapy for sepsis to more targeted treatment of site-specific inflammations, such as inflammatory diseases of the gastrointestinal tract, so that Conclusion from Professor Ma. (fp)

Author and source information

This text complies with the requirements of specialist medical literature, medical guidelines and current studies and has been checked by medical professionals.

Author:

Dipl. Geogr. Fabian Peters

Swell:

  • Shenbin Liu, Zhi-Fu Wang, Yang-Shuai Su, Russell S. Ray, Xiang-Hong Jing, Yan-Qing Wang, Qiufu Ma: Somatotopic Organization and Intensity Dependence in Driving Distinct NPY-Expressing Sympathetic Pathways by Electroacupuncture; in: Neuron (veröffentlicht 12.08.2020), cell.com
  • Harvard Medical School: Quieting the Storm (veröffentlicht 12.08.2020), harvard.edu

Important NOTE:
This article is for general guidance only and should not be used for self-diagnosis or self-treatment. He can not substitute a visit at the doctor.

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very cheap and long-known drugs help save the lungs with coronavirus

Cloving hospital on the basis of the Medical Scientific and Educational Center (ISSC) Moscow State University named after M.V.Lomonosov took the first patients on April 21 and completed his work on June 13. It turned out that it was possible to achieve the best treatment results for COVID-19 in Moscow. Over the entire period, 4 patients died, and among severe patients who got mechanical ventilation, the mortality rate was less than 14% (for comparison, the average for the city and the world was up to 70 – 80%). Eighteen doctors out of 220 employees of the hospital were infected with coronavirus, there were no deaths among the medical staff.

What approaches were used at the University Hospital of Moscow State University to achieve such results? We continue the conversation with the head. Department of Therapy, Faculty of Fundamental Medicine, Moscow State University, Head of the Department of Age-Associated Diseases, Medical Scientific and Educational Center, Doctor of Medical Sciences, Cardiologist Yana Orlova.

MEDICINE FOR COUGH FOR 80 RUBLES

– Most of those who are ill or are afraid to get sick are worried about fibrotic changes in their lungs. They say that you have developed special therapy that can reduce the risk of developing fibrosis. Is it possible?!

– Yes, we launched an appropriate clinical study. There are no final results yet, but we have developed clinical practice.

“What did you do to save the lungs?”

– We used a combination of bromhexine and spironolactone (both are long-known very cheap drugs. – Ed.). Bromhexine is an expectorant that has been prescribed to patients with pneumonia and cough for many years. At the same time, experimental data showed that this drug can block a specific enzyme and impede the penetration of coronavirus into cells. True, it was on this effect that we counted to a lesser extent in inpatients, since such an effect is important mainly in the early stages of the disease. But the expectorant effect of bromhexine really helps patients with COVID. I heard that our colleagues in Peter launched a study of bromhexine for prophylactic purposes. We will wait for the results.

Coronavirus infected 18 doctors from 220 employees of the hospital, there were no deaths among the medical staffPhoto: Ivan MAKEEV

FIBROSIS OBSTACLE

– The second drug – spironolactone – is traditionally widely used in cardiology for the treatment of heart failure, severe hypertension. It has a small diuretic, magnesium and potassium-preserving effect, continues Yana. Orlova. – It has several mechanisms through which it can be useful in coronavirus infection.

Firstly, a mechanism that prevents the development of fibrosis in general in the body. There are works that, in particular, show that spironolactone reduces fibrosis in the heart. At the same time, it is known that the tendency to fibrosis is not local, but systemic – where there is more inflammation, there will certainly be fibrosis. And we see, of course, fibrotic changes in the “covide” in our patients. Therefore, we prescribed spironolactone as a drug for the prevention of this process.

Secondly, this drug blocks sex hormone receptors, in particular testosterone. Some published studies suggest that “high-testosterone” men suffer from “covid” more often and develop more severe fibrotic changes. Therefore, blocking these receptors for several weeks during COVID treatment may be useful in reducing the severity of complications. We are not talking about a longer intake, since male patients are unlikely to agree with a decrease in testosterone levels in the long term.

And perhaps the most important point. In almost all of our patients, we observed hypokalemia (a decrease in potassium levels. – Ed.). With coronavirus infection, potassium is intensely excreted from the body, and scientific articles even suggest that hypokalemia serves as the trigger for a cytokine storm. So spironolactone has a real chance to reduce the risk of this dangerous complication. But the main thing, in my opinion, is that lowering the level of potassium in the body is extremely harmful to the heart and triggers life-threatening rhythm disturbances, increasing the risk of sudden death. We, like all others, replenished potassium with droppers, but it was more effective to retain it in the body with the help of spironolactone.


Men certainly get worse than women;  the elderly are heavier than the young;  overweight people are heavier than patients without excess weight Photo: Ivan MAKEEV

Men certainly get worse than women; the elderly are heavier than the young; overweight people are heavier than overweight patientsPhoto: Ivan MAKEEV

WHEN PRESCRIBED PATIENTS

– Yana Arturovna, how many patients did you have on average?

– About 10 – 14 days. But someone and 50 days.

– Have you noticed signs by which it can be assumed that the disease in the person brought is likely to go the hard way?

– Such studies were carried out in the world, our clinical practice confirmed them. Men certainly get worse than women; the elderly are heavier than the young; overweight people are heavier than overweight patients. Men with a classic male type of baldness, a lot of facial hair, we can say brutal men get sick harder.

– Under what conditions did you discharge patients?

– We acted as close as possible to the recommendations Ministry of Health: so that the temperature for three days was not higher than 37.5 degrees; so that C-reactive protein (an indicator of inflammation) is lower than 10 mg / l, and saturation, that is, the level of oxygen in the blood, is higher than 96%.

“HEAD OF EPIDEMIOLOGY DEPARTMENT OF ITSELF WORKED AT SANPROPUSNIK”

– How often do you get sick doctors and nurses?

– In the first month no one got sick at all. We have a very powerful epidemiological service. The head of the sanitary-epidemiological department, a senior researcher, correctly organized the whole process, and for the first two weeks she personally worked in the sanitary inspection room at the exit from the “red zone” and helped doctors and nurses who were exhausted after the shift safely remove protective clothing.

Then both people’s fatigue and viral load accumulated. By the middle of the second month, sick people began to appear. There were no seriously ill patients. We treated part of the staff in our observation, part of it was treated at home. In total, 18 people were infected from the medical staff (less than 10%).

– Doctors take something for prevention? Vitamins C, D, Zinc?

– I saw the recommendations of American nutritionists, they speak out positively about taking zinc, melatonin and vitamin C. There were somewhat conflicting data on vitamin D. But we did not give any such recommendations to our employees. We have all the prevention was associated with minimizing contacts and other measures of epidemiological safety.

Physicians are the heroes of our time.“If you think that you are special and that a pandemic will not affect you, you are deeply mistaken,” listen to what the doctors who are fighting with coronavirus say

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