According to researchers at Linköping University, patients with stable coronary artery disease suffer from silent, low-grade inflammation driven by dysregulated immune cells known as neutrophils, which fail to die off as expected even when optimally treated. Over 20,000 people in Sweden experience a heart attack every year, and while modern treatments like balloon angioplasty and … Read more
Researchers at Trinity College Dublin and St. James’s Hospital have demonstrated that dexamethasone, a commonly prescribed anti-inflammatory steroid, reduces harmful inflammation triggered by Mycobacterium avium without weakening the ability of human immune cells to control the infection, according to a study published in the Journal of Infectious Diseases. Understanding Nontuberculous Mycobacterial Disease and Treatment Challenges … Read more
According to researchers at McMaster University, the naturally occurring hormone GDF15 protects the liver from inflammation and slows the progression of scarring through a brain-to-liver signaling pathway independent of weight loss. Published in Cell Metabolism, the findings challenge longstanding assumptions about the hormone, which is best known for suppressing appetite and promoting weight loss. Understanding … Read more
A combination of omega-3 and low-dose acetylsalicylic acid (ASA) achieved clinical results comparable to antibiotics in treating severe periodontitis, according to a study published in the May issue of the Journal of Periodontology. Researchers affiliated with Albert Einstein Israelite Hospital, Guarulhos University, the University of Taubaté, and the Ribeirão Preto School of Dentistry at USP … Read more
Researchers at the Memorial Sloan Kettering Cancer Center have identified a single protein called ZFP36L2 that acts as a molecular switch linking the gut’s damage-sensing system to cellular identity shifts, according to a study published August 5 in Nature. According to physician-scientist Karuna Ganesh, senior author of the study, the protein controls how cells detect … Read more
Traditional Japanese medicine Bofutsushosan, widely used to treat obesity, may also protect aging tissues from destructive fibrosis, according to a preclinical study published in Phytomedicine. Researchers at the University of Osaka and Kobayashi Pharmaceutical Co., Ltd. found that the multi-ingredient formula reduced scar-like tissue buildup in the liver and fat tissue of mice fed a … Read more
According to a laboratory study published in Scientific Reports by researchers including D. Mirra and colleagues, cigarette smoke extract (CSE) compromises human airway epithelial barriers and increases cellular vulnerability to polystyrene nanoparticles (PS-NPs). The research team investigated how sequential exposure to these environmental stressors reduces cell metabolic activity and alters structural proteins in human bronchial … Read more
Higher levels of trimethylamine N-oxide (TMAO) are independently associated with a greater prevalence of atrial fibrillation (AF), according to a study published in The Journal of Clinical Investigation. Researchers found that TMAO, a metabolite produced by gut microbes from nutrients like choline, may trigger AF by inhibiting muscarinic receptor 2 signaling and disrupting autonomic regulation … Read more
Preventative neurology experts recommend specific dietary habits, heavy strength training routines, and mental novelty to actively reduce the long-term risk of developing Alzheimer’s disease and dementia. According to Dr. Kellyann Niotis, a preventive neurologist and assistant professor of neurology at Weill Cornell Medicine, traditional medical advice has historically lacked concrete, actionable lifestyle guidance for brain … Read more
Primary biliary cholangitis is a rare autoimmune disease affecting small bile ducts within the liver, causing bile to build up and trigger progressive liver damage that can eventually lead to cirrhosis, according to recent medical studies. Because the immune system attacks these vital ducts, roughly 40% of patients fail to respond adequately or cannot tolerate … Read more