Exposure to per- and polyfluoroalkyl substances, widely known as PFAS or “forever chemicals,” may play a role in the development of inflammatory bowel disease years before clinical symptoms emerge. A new five-year investigation funded by a $3.3 million National Institutes of Health R01 grant aims to track these environmental toxins at the Icahn School of … Read more
Low-dose radiation therapy significantly reduces long-term disability and structural joint damage in early knee osteoarthritis patients, according to an integrated analysis of a 12-year randomized trial presented at the American Society for Radiation Oncology (ASTRO) Annual Meeting. Researchers tracked 292 participants and found that those treated with 4.5 Gy of radiation alongside standard medications experienced … Read more
Odonkor, M.R. Dodurgali, F.R. Cox, I.J. Klimov, and A. Abd-Elsayed in the journal Nutrients, glucagon-like peptide-1 receptor agonists (GLP-1 RAs) may alleviate chronic pain by interacting with the gut microbiome and the gut-brain axis. The study examines how microbial metabolites, spinal microglia, and dietary signaling intersect with pain sensitization pathways. Gut Microbiota and GLP-1 Signaling … Read more
According to recent research published in Nature Communications by the Garvan Institute of Medical Research, primary sclerosing cholangitis (PSC) and ulcerative colitis are fundamentally different bowel diseases despite currently receiving identical treatments. The findings reveal why PSC patients face a colorectal cancer risk three times higher than those with ulcerative colitis alone, offering new pathways … Read more
Polystyrene nanoplastics can enter living organisms, circulate through biological systems, and potentially reach reproductive tissues, according to a review published in the journal New Contaminants. Researchers at the University of South China screened 285 publications and analyzed 114 peer-reviewed studies to examine how these microscopic particles impact male and female reproductive health, as well as … Read more
According to a study published in the Journal of Asthma and Allergy by researchers C.-T. Hung, C.-Y. An, C.-W. Suk, T.-W. Lee, and S.-H. Hung, adult patients with asthma and type 2 diabetes who use tirzepatide experience a similar risk of asthma exacerbations over a 12-month period compared to those using semaglutide. The retrospective cohort … Read more
Food and Drug Administration this week to test genetically engineered CAR T-cell immune cells in adults with advanced colorectal cancer and pediatric patients with solid tumors, according to university announcements. The experimental therapy attacks two specific targets, B7-H3 and IL-8, aiming to overcome the defenses of solid tumors where standard treatments have failed. University of … Read more
Early intervention with disease-modifying antirheumatic drugs within six weeks of symptom onset can prevent permanent joint damage in rheumatoid arthritis patients, according to an international review published in JAMA by researchers at the Medical University of Vienna and Stanford University. The study underscores that achieving remission within six months remains the primary clinical target for … Read more
According to researchers publishing in BIO Integration, a comprehensive single-cell immune atlas of human myocardial infarction maps 44,574 cells to reveal how myeloid subtypes drive post-injury inflammation. Scientists analyzed single-cell RNA sequencing data to decode cardiac microenvironment remodeling, identifying C1 S100A4+ macrophages as a primary signaling hub orchestrating tissue repair. Mapping the Post-Infarction Immune Microenvironment … Read more
Researchers at Johns Hopkins Medicine have identified human resistin as a critical driver of immune system activation, providing a new mechanism to explain how chronic inflammation is triggered and sustained across conditions like cardiovascular disease and diabetes. According to a study published in PLOS One, the protein acts as a molecular switch that primes and … Read more