Platinum-based chemotherapy drugs cause extensive DNA damage in healthy tissues and accelerate cellular aging in pediatric cancer patients, according to a landmark study published September 10 in Science. Researchers from the Wellcome Sanger Institute, the University of Cambridge, the Francis Crick Institute, and King’s College London used advanced genomic sequencing to analyze samples from children … Read more
Hepatocellular carcinoma, currently the sixth most common malignancy and the third leading cause of cancer-related death globally, is facing a paradigm shift in precision management according to a comprehensive review published in Cancer Biology & Medicine. Researchers from the Eastern Hepatobiliary Surgery Hospital at Naval Medical University in Shanghai and the First Affiliated Hospital of … Read more
Scorpion venom peptides are emerging as targeted drug candidates for inflammatory pathways and hepatitis viruses, according to a recent review published in the journal iLIVER. Researchers summarized how these molecules, sourced from over 2,700 documented scorpion species, target receptor proteins and voltage-gated ion channels to treat chronic inflammatory and hepatic disorders without the broad toxicity … Read more
According to researchers at Wuhan University, more than 3 billion people worldwide currently suffer from obesity, a figure forecasted to exceed 4 billion by 2035. To combat weight rebound and inflammation-suppressed fat browning linked to single-agent therapies, scientists developed an adipose-targeted composite microneedle patch named LRSG-SG@MN, which co-delivers semaglutide and rosiglitazone to modulate immune response … Read more
According to Tufts University researchers, a colorless tomato compound called phytoene sharply reduces fatty liver disease in mice, helping explain why whole tomato powder often protects the liver more effectively than purified lycopene alone. Metabolic dysfunction-associated steatotic liver disease affects up to 38 percent of U.S. adults. Why Lycopene Was Not the Whole Story Lycopene … Read more
According to a randomized clinical trial published in the journal Cell Metabolism, a very-low-carbohydrate ketogenic diet reduces liver fat and improves insulin sensitivity significantly more than Mediterranean or plant-forward diets when participants achieve a comparable 10% weight loss. Researchers found that dietary macronutrient composition independently alters metabolic responses, yielding a 67% reduction in hepatic triglycerides … Read more
Researchers at Ludwig Princeton have discovered that tumors can manipulate distant organs to evade the immune system, according to a study published in Cell Metabolism. Led by Yibin Kang and Yong Tang, the research demonstrates how cancer cells send signals across the body to alter fat metabolism in the liver and immune responses in CD8⁺ … Read more
According to a study published on April 30, 2026, in Hepatobiliary & Pancreatic Diseases International, a combined bio-histological framework known as the Seven-Up score can substantially reduce overtreatment of early T cell-mediated rejection (TCMR) after liver transplantation. Conducted at Université catholique de Louvain in Brussels, Belgium, under the leadership of Prof. Jan P. Lerut, the … Read more
Researchers at the Walter and Eliza Hall Institute (WEHI) in Melbourne, Australia, have developed a new vaccination approach that uses antimalarial drug compounds to transform mosquito bites from a source of deadly infection into natural immune boosters, according to a study published in Science. Targeting the Late Liver Stage to Build Durable Immunity The preclinical … Read more
According to researchers at McMaster University, the naturally occurring hormone GDF15 protects the liver from inflammation and slows the progression of scarring through a brain-to-liver signaling pathway independent of weight loss. Published in Cell Metabolism, the findings challenge longstanding assumptions about the hormone, which is best known for suppressing appetite and promoting weight loss. Understanding … Read more