Researchers at Ludwig Princeton have discovered that tumors can manipulate distant organs to evade the immune system, according to a study published in Cell Metabolism. Led by Yibin Kang and Yong Tang, the research demonstrates how cancer cells send signals across the body to alter fat metabolism in the liver and immune responses in CD8⁺ … Read more
According to research published in the Chinese Medical Journal, a mitochondrial matrix protein known as RTN4IP1 drives the progression and metastasis of triple-negative breast cancer by disrupting cellular energy metabolism. Triple-negative breast cancer accounts for roughly 15% of all breast cases and lacks estrogen, progesterone, and HER2 receptors, leaving patients with high risks of recurrence … Read more
Emami and colleagues, the MYH9 gene is emerging as a central player in both cancer biology and inherited genetic conditions, offering fresh perspectives on precision medicine and targeted therapeutics. MYH9 Gene Structure and Core Cellular Functions The MYH9 gene dictates the production of non-muscle myosin IIA, known structurally and functionally as NMIIA. Did you know? … Read more
Researchers at the Memorial Sloan Kettering Cancer Center have identified a single protein called ZFP36L2 that acts as a molecular switch linking the gut’s damage-sensing system to cellular identity shifts, according to a study published August 5 in Nature. According to physician-scientist Karuna Ganesh, senior author of the study, the protein controls how cells detect … Read more
< div> According to peer-reviewed research published in July in Cancer Research, sildenafil—the active ingredient in Viagra—disrupts cancer cells’ cholesterol supply to stop the spread of metastases. Researchers at the Weizmann Institute of Science, alongside teams from the US National Cancer Institute and Clalit Health Services, found that the drug targets the protein transporting essential … Read more
Researchers at the University of Illinois Chicago have identified a molecular switch, the ion channel protein KCNMB1, that regulates cancer cell stiffness. By activating this pathway, scientists can make metastatic cells more rigid, rendering them vulnerable to destruction by the immune system, according to a study published in the journal Developmental Cell. The Physics of … Read more
Research from the University of Virginia (UVA) Comprehensive Cancer Center indicates that a buildup of bile acids, triggered by an unhealthy gut microbiome, can drive hormone receptor-positive (HR+) breast cancer to metastasize to other organs, particularly the lungs. According to Melanie Rutkowski, PhD, this mechanism suggests that FDA-approved bile acid sequestrants or microbiome replenishment could … Read more
Adaptor proteins serve as critical molecular scaffolds that dictate whether tumor-associated macrophages (TAMs) attack cancer cells or promote tumor growth, according to a review published May 22, 2026, in Oncoscience. Researchers led by Khandu Wadhonkar and Mirza S. Baig at the Indian Institute of Technology Indore found that these proteins integrate complex signaling pathways, offering … Read more
Researchers at the Hackensack Meridian Center for Discovery and Innovation (CDI) and Georgetown University’s Lombardi Comprehensive Cancer Center have identified “adipomes”—extracellular vesicles released by fat tissue—as active drivers in the spread of triple-negative breast cancer (TNBC). By isolating these vesicles, the team discovered they deliver a “lipid code” that reprograms cancer cells to form invadopodia, … Read more
The loss of the transcription factor GATA6 acts as a biological switch that reprograms colorectal cancer cells to metastasize to the liver, according to research published June 22 in Cell Stem Cell. By silencing this “identity keeper,” cancer cells adopt a flexible, fetal-like state that allows them to travel through the bloodstream and colonize distant … Read more