According to research published in EMBO Molecular Medicine by teams at Adelaide University and the Olivia Newton-John Cancer Research Institute, a molecular switch driven by low levels of the naturally occurring molecule miR-342 and high activity of the E2F pathway fosters metastatic triple-negative breast cancer. While this aggressive subtype accounts for 10 to 15 percent … Read more
According to research published in the Chinese Medical Journal, a mitochondrial matrix protein known as RTN4IP1 drives the progression and metastasis of triple-negative breast cancer by disrupting cellular energy metabolism. Triple-negative breast cancer accounts for roughly 15% of all breast cases and lacks estrogen, progesterone, and HER2 receptors, leaving patients with high risks of recurrence … Read more
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Folic acid prevents serious neural tube birth defects by interacting with an enzyme called ALDH1L1 to produce retinoic acid, according to a study published in the Proceedings of the National Academy of Sciences (PNAS). Researchers from the Hebrew University of Jerusalem and NOVA Medical School discovered that without this specific enzyme pathway, vitamin B9 loses … Read more
Researchers at the University of Colorado Anschutz Cancer Center have identified a metabolic weakness in the stem cells driving high-risk myelodysplastic syndromes, uncovering an unusual cellular energy dependency that could enable more targeted treatments for the aggressive blood cancer, according to a study published in Blood Cancer Discovery. NAD Dependence in High-Risk MDS Stem Cells … Read more
Researchers at The University of Texas at Austin have developed an experimental drug that tricks aggressive cancer cells into consuming more sugar than usual while simultaneously blocking their backup fat metabolism. According to a study published in Nature Chemical Biology, the compound successfully treated an aggressive form of melanoma in mice by attacking both cellular … Read more
According to researchers at the Ludwig-Maximilians-Universitaet Muenchen (LMU), a newly discovered signaling pathway in mice reveals how dietary shifts during weaning directly instruct the developing immune system to tolerate harmless environmental substances. Published in Nature Communications, the study shows that transitioning to solid food triggers an interferon-gamma-mediated circuit that activates specialized dendritic cells in the … Read more
Researchers at VCU Massey Comprehensive Cancer Center have developed an experimental molecule called an autophagy-targeting chimera (AUTAC) that dismantles the MCL1 survival protein to kill multiple myeloma cells. According to a study published in Cell Death & Disease, this targeted protein degrader works with existing proteasome inhibitors to reduce cancer cell viability by 50% within … Read more
Researchers have identified a potential therapeutic pathway for Alzheimer’s disease by targeting DNA damage within brain neurons. A study published in FEBS Open Bio reports that the molecule KCL-286 successfully repairs neuronal DNA in mouse models, simultaneously reducing brain inflammation and abnormal immune activity associated with neurodegeneration. How does KCL-286 target Alzheimer’s disease? The drug … Read more
Researchers have identified 63 high-confidence activators of poly(A) site usage, a critical process in gene expression. Led by Gene Yeo of UC San Diego and Yongsheng Shi of UC Irvine, the study, published June 26, 2026, in Molecular Cell, provides a new programmable framework for manipulating RNA processing in human cells. How do these newly … Read more
Researchers at the Yale School of Medicine have developed a two-part vaccination strategy that successfully prevented genital herpes infection in preclinical models. Published June 19 in Science Immunology, the study uses “prime and pull” technology—an initial intramuscular injection combined with localized nanoparticle delivery—to trigger a robust immune response at the vaginal lining, a feat traditional … Read more