Europe prepares the revolution of precision medicine – Biotech

The roadmap is ready that in the next decade will allow Europe to revolutionize healthcare thanks to precision medicine: by exploiting the most recent scientific discoveries and new technologies for the study of the single cells of the human body, it will always allow diagnosis. more precocious and personalized treatments for cancers, cardiovascular, neurological, chronic inflammatory and infectious diseases, with important repercussions on people’s health and savings for welfare.

The plan, which has already garnered support from hundreds of doctors, researchers, entrepreneurs and policy makers, is featured in the journal Nature by the Lifetime consortium. Mini organs in test tubes, artificial intelligence, single-cell imaging techniques: these are just some of the innovations the consortium focuses on, which brings together more than one hundred institutions including universities and research centers as well as 80 companies, coordinated by the Max Molecular Medicine Center Delbrueck of Berlin and the Curie Institute of Paris.

Italy also participates with a large group led by the State University of Milan with Giuseppe Testa and Massimiliano Pagani, teachers of Molecular Biology in the Departments of Oncology and Hemato-Oncology and of Medical Biotechnology and Translational Medicine.

“Transforming healthcare through a precise understanding of the mechanisms by which a disease begins in each patient and develops over time remains an enormous challenge, but today we are finally beginning to see its feasibility”, comments Giuseppe Testa, full professor of Molecular Biology at the University. Statale di Milano, director of the Neurogenomics Center of Human Technopole and director of the Laboratory of High Definition Disease Models of the European Institute of Oncology (Ieo).

“We are preparing to choose how to project our country towards rebirth through the Recovery fund: here, LifeTime in this sense is a trace of how to do it, in the biomedical field, of how to open the future while remaining anchored to the needs of today than never before. they appeared to us with so much drama “.

Covid-19 could be one of the test beds of the new European strategy outlined by Lifetime, as underlined by Massimiliano Pagani, professor of molecular biology at the State University of Milan and head of the Ifom molecular oncology and immunology laboratory.

“In the Lifetime consortium there are many research groups that are already investigating the effects of Covid on individual organ cells to better understand the mechanisms of the disease and the therapeutic opportunities: the new coronavirus in a sense is a case study that could revolutionize the our way of interpreting and dealing with new situations, such as those that could arise in the future with the arrival of new pandemics “.

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Scientists have developed a diet that can kill resistant cancer

In a joint study, scientists from the United States and Italy were able to provide evidence that a specific diet combined with vitamin C can kill cancer.

“The combination of diet and vitamin C showed an amazing result. It killed almost all the cancer cells in the culture, ”the scientists said.

It is noted that specialists took a low-calorie plant-based diet and vitamin as the basis for the proposed treatment system.

In addition, scientists tested the effect of treatment in turn: a separate diet, a separate vitamin C.

As a result of this, it became known about a decrease in the growth of cancer cells and a slight increase in their death.

At the moment, studies have been conducted on mice, as a result of which rodents managed to get rid of cancer cells.

According to experts, positive dynamics were achieved only in cancer cells with the KRAS mutation, which is considered one of the most difficult goals in cancer therapy, PressRoom writes.

The team is currently studying the effects of starvation or a low-calorie plant-based diet in combination with other anti-cancer drugs in patients with breast and prostate cancer.

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Photo of Nadezhda Kadysheva without Photoshop shocked fans

The star of the folk song theater “Golden Ring” Nadezhda Kadysheva invariably delighted admirers of her talent with a well-groomed appearance. Intricate hairstyles, vibrant outfits, catchy makeup – at 60, the singer carefully monitors her stage image. Hope appears from time to time on the covers of glossy magazines, and on the posters of the Golden Ring theater she invariably shines with youth and beauty. What was the surprise of Instagram users when they saw fresh pictures of the artist without photoshop. In the photographs, Kadysheva looks very tired and sharply aged.

Dark circles under the eyes and an extinct look shocked the fans of the Russian folk song and made them worry. On the Web they discuss: is everything all right with the health of Hope, and does it hide some kind of illness? However, perhaps the artist in recent months has overworked – before Russia the pandemic seized, and all concerts were canceled, Kadysheva had a very busy tour schedule. Fans wish her health and hope that the artist will take advantage of the period of self-isolation in order to properly relax.

New photos of Nadezhda Kadysheva surprised her fans.

Instagram users compare Nadezhda Kadysheva with her colleague, singer Nadezhda Babkina. Nadezhda Georgievna is 10 years older than Kadysheva, but she looks much younger. Probably the whole thing is plastic surgery: Babkina does not hide the fact that the surgeon’s scalpel helped wipe her face for several years and extended her youth. She made a circular facelift and blepharoplasty, lifting her eyelids and removing wrinkles around her eyes.

With her husband and colleague in the ensemble “Golden Ring” Alexander Kostyuk Nadezhda Kadysheva has been living for 37 years – they got married in 1983. This is a rare example of family longevity in show business. At couples have an adult son.

The singer looks tired. Perhaps the reason for this is a busy tour schedule.

Doctors more than once saved the singer and literally pulled her out of the next world. At 30 years old her found a breast tumor, for two years she lived between life and death – Hope was sure that she would die from oncology. But during the operation, the diagnosis was not confirmed. The next time doctors saved the artist when she was 49 years old: he almost died of acute tachycardia. Doctors miraculously prevented a heart attack.

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The web discusses the beautiful daughter of Abdulov burned out of cancer

Alexandra Abdulova He died when his daughter Eugenia was only a year old: the 54-year-old actor burned out from cancer. The girl from childhood grew up in an artistic environment, the second wife of the artist Julia gave her to study at a theater studio. Recently, 13-year-old Zhenya has grown a lot and is slowly turning into a charming girl. Looking at her pictures on social networks, fans discuss how she matured.

“She’s quite grown up, and so looks like a father”, “A real beauty grows like a dad”, “His eyes, nose, lips are spilled Abdulov”, “I became so beautiful and sweet”, “Genes are immediately visible in you great Abdulova, ”they write on the Web.

13-year-old Zhenya Abdulova became quite an adult. Photo: Instagram.

Many believe that Eugene has a great future in the cinema. The girl already has experience on the set. He played his debut role in the film by Alla Surikova “Love and Sax”. The director was satisfied with the work of the young actress: she is sure that Zhenya not only looks like her father, but also inherited his acting talent.

The role in the play was offered to the girl by the late artistic director “Lenkoma»Mark Zakharov. The head of the theater, where Alexander Abdulov served for many years, wanted the artist’s daughter to take the stage in the final of the Royal Games performance. The girl was preparing for the premiere, but then refused to participate in the play, saying that she did not like to rehearse.

“She never went on stage.” Sasha’s character! She was always the most important at children’s parties, she built all, commanded. Recently, however, she starred in a small role in the film with Maxim Averin, but so far, school is in priority, ”a close friend of the Abdulov family told reporters then.


The girl is very similar to her star father. Photo: Instagram.

The girl is very similar to her star father. Photo: Instagram.

Alexander Abdulov met his wife Zhenya’s lawyer two years before his death. The spectacular brunette immediately liked the famous actor, behind whom there were many novels with the most beautiful women of the country. Couple she got married in 2006, and in March 2007 they had baby Eugene.

Alexander Gavrilovich died of cancer in January 2008. He struggled with oncology for a long time – he was diagnosed with lung cancer of the fourth stage. Doctors did everything possible to cure the artist, but the disease was stronger. Probably, oncology could be provoked by long-term smoking: Abdulov was a heavy smoker and did not part with cigarettes for several decades in a row.

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Named Common Diseases Prior to Cancer | In the world

Japanese researchers have identified a link between a number of infectious diseases and the development of oncology over the next six years.

As part of the work, health data of more than 48 thousand people were studied, annual prevalence rates of influenza, hepatitis, gastroenteritis and pneumonia were taken into account, writes Eurekalert.

Scientists noted that cancer develops in an inflammatory environment, which is often caused by exposure to chemical carcinogens, as well as impaired immune systems.

Patients with gastric cancer were more likely than others to suffer from pneumonia, hematological cancer was often preceded by hepatitis, and testicular cancer was influenced.

However, the study had several limitations. In particular, it did not contain any information about the effects of the environment, lifestyle and genetics.

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The coronavirus pandemic forces changes in cancer treatments

The new coronavirus pandemic (Covid-19) it is affecting more than ever the provision of medicines, medical care and even the very life of cancer patients. In this second installment, PROFILE continues to report the changes that patients and doctors are already facing to adapt treatments to the new context.

He National Cancer Institute (INC), which belongs to the Ministry of Health, considers the cancer patient within the Covid-19 risk group, since various treatments weaken the immune system, such as chemotherapy, extensive radiation therapy, and bone marrow transplants. This medium consulted the main oncology associations, specialized doctors, official sources, and an association that assists patients and families to answer how treatment guidelines will change; what are the keys to mobilize in quarantine; which obstacles continue to be registered; and where to get free assistance and information.

What will happen with the treatments

Oncologists are preparing for the month of May, when the pandemic is expected to reach its peak in Argentina. Still, the Argentine Association of Clinical Oncology He already talks about the lack of resources at the present time: “We are with moderately limited health resources” and this forces us to “prioritize treatments with greater potential benefits” for the patient and to postpone others.

One of the points that must be modified is the form and times of attention. In a virtual exhibition held last Thursday, the oncologist Federico Losco, from the Alexander Fleming Institute (also Argentine Association of Clinical Oncology), he explained to his colleagues that they will no longer be able to continue with their activities as they had been doing until before the arrival of the new coronavirus.

For outpatient care, Losco proposed “minimize visits, space the shifts of patients in treatment and evaluate attending more days a week to avoid contact between patients.” He also recommended “perform a pre-test on patients who will have to attend shifts, call them and detect symptoms of the coronavirus or exposure to confirmed or suspected cases.”

Regarding intravenous treatments, the Association suggests changing them to oral treatments when possible and do not harm the patient. It also recommends that subcutaneous and intramuscular applications be applied by nurses in patients’ homes. The same with blood draws.

Regarding radiotherapy, they state that there are adult patients with certain types of cancer who will not be able to see their treatments postponed, such as those suffering from digestive tumors, cervical-uterine tumors, mammary glands in positive nodes, head and neck tumors.

Although the official decision is not to postpone any oncological surgery, the medical institution advises to reprogram as many as possible, so oncologists must “decide individually each case and taking into account the potential harm of delaying the surgery.” This is because abroad, where the virus advanced earlier and faster, it was detected that “Patients who underwent surgery one month prior to becoming infected with SARS-Cov-2 (or covid-19) had an increased risk of severe events” from the infection.

As for immunotherapy, this type of treatment does not expose the patient to greater immunosuppression, as chemotherapy does. “The recommendation is that they continue to carry out the treatment but that the doctors pay special attention to respiratory symptoms,” Losco added in his presentation.

What are the 48 “essential activities” excepted from social confinement

Go into quarantine

There are patients who must do tens of kilometers to reach the health centers. PROFILE asked the Executive about the exceptions that must be claimed to be able to circulate.

Those who must move for a treatment or purchase of medicines are exempt from the single movement certificate, as they are covered by the exception people who must deal with a situation of force majeure”Of the Decree of Need and Urgency (DNU), as reported in Government. They must carry something that proves it: medical order, hospitalization, oncologist certificate or medical institution.

Regarding family members, they must carry out an online certificate on the Remote Procedures platform, where they will find the exception for family members who must accompany or assist sick people. In urgent cases, they can also appeal to cases of “force majeure” and “assistance to relatives”.

PROFILE already mentioned that one of the problems of patients is the restriction to move. Santiago Bella, from the Argentine Association of Clinical Oncology, He explained that he has an office in Córdoba and cares for patients from other provinces who can no longer continue with their treatments, especially in Catamarca and San Luis, where the restrictions to leave and enter provincial territory are much stricter, he explains.

Given these obstacles, many oncologists are trying to relocate their patients with other doctors. These problems forced many patients to postpone their treatments for up to three weeks. Treatments that preserve their life. “We are receiving cancer patients who are wandering in front of the closure of some oncology areas because their hospitals put all their resources into the fight against Covid-19. We have to see which colleagues we refer them to, ”said a medical oncologist in off.

Where to find assistance

The Argentine Association of Clinical Oncology (AAOC) created a free service for cancer patients and their family environment to consult about covid-19 and cancer. It will be free and the entity’s doctors will respond via email to the address prevention@aaoc.org.ar.

Another consultation site for patients and families is www.mundocancer.org, from the Know Where to Be Foundation, which includes information to carry out ANSES, PAMI and permits during the quarantine.

Vicky Viel Temperley, founder of the entity, told PROFILE that they carried out a survey of 27 hospitals and health centers in the country. Their volunteers found that, in some cases, nursing staff who used to care for cancer patients were referred to Covid-19 treatment; Volunteers accompanying patients during chemotherapy sessions can no longer enter the wards; Nor, in some cases, can the relatives of patients who must be hospitalized for days enter.

“We are seeing that for fear of the pandemic, some doctors closed their agendas. For this reason, a network of oncologists is being set up to offer their offices in the City of Buenos Aires so that other colleagues can attend to their patients in health centers in a more protected and controlled manner, ”said Julia Ismael, a clinical oncologist, former Director of the National Cancer Institute (INC) and member of the AAOC. “We are trying to refer everything to telemedicine as possible, but some patients need personal follow-up,” Ismael added.

The modernity

Last Thursday, the Ministry of Health sent a brief report (less than three pages of content) with general recommendations to oncologists and patients: the basic ones (distancing and social isolation) and some more specific ones, such as telemedicine.

However, virtual care is not for everyone. The lack of preparation of some health centers for telemedicine or virtual assistance -both public and private- is another of the weaknesses of the system that this pandemic left in evidence, the doctors consulted, patients and relatives agree.

As a consequence of this failure, in many centers, they stopped granting shifts for new treatments because the administrative and nursing staff are on leave, in preventive isolation or redirected to the areas dedicated to the pandemic, Viel Temperley said. “There are clinics where they are doing little chemo,” he explains.

At IOMA, the social work of the province of Buenos Aires, there were delays in the delivery of medication. At the institution, they told PROFILE that complaints are common. “We always claim. Thousands of cancer treatments are performed and each history of affiliations is unique ”. The institution has 2.2 million members.

Viel Temperley explained that her foundation assists patients with difficulties in accessing medications, both in Ioma and PAMI and in official drug banks. “The problem now is that no one attends them through quarantine to process claims. The windows are closed. “

ED / DS

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Coronavirus: what are the implications for cancer patients?

Grandstand. With the coronavirus, we are living much more than a health crisis. It is also a test of resistance for our health systems, even for the countries considered as “best ranked” by the various evaluation institutes or bodies. The indicators used, such as economic performance criteria, minimization of the cost of production, satisfaction of a standard of equity specific to each company, now appear to be poorly calibrated and insufficient in the face of such an epidemic crisis. As this pandemic progresses, we understand less the absence of indicators relating to the conditions of practice of those who provide care and to their dedication.

The fight against Covid-19 goes beyond a fight against the epidemic. It is also a struggle to maintain care for other chronic or acute pathologies that have not disappeared during this epidemic period. No one can also conceal the social and economic consequences, possible obstacles to access to care for all. An estimated 3.5 million French people are affected by cancer in France and 382,000 new annual cases in 2018, i.e. around 1,450 new cases diagnosed every day of the week. The Minister of Solidarity and Health regretted that cancer screenings were no longer carried out, “Calling the French” to return to their doctor for these diagnostic procedures. This announcement is important but may not be sufficient or essential to avoid the potential serious consequences of delayed or unannounced diagnoses, treatments degraded by necessity, renunciations of care or the interruption of inclusions in therapeutic trials.

A national strategy to be implemented

It would now be necessary to quickly implement a coordinated national strategy with a coherent territorial variation adapted to the local epidemiological and health situation, even when efforts are made to limit the spread of the virus by containment and barrier measures. The paradox of our society overdone with inflationary regulations and saturated with organizations of all kinds, but which ultimately finds it very difficult to organize or impose cooperation in this unprecedented context. Yet we have entered a period when things that once seemed impossible are inevitable.

Read also “My confinement started in January, when the pain put me in bed”

Since the epidemic crisis and the post-containment period are expected to last several months, the fear of the medical community with which I associate and of the nursing staff of my establishment specialized in the fight against cancer is that we are faced with a first “wave” of more serious cases than before linked to deferred care. After this period of crisis, the duration of which no one can seriously determine, health facilities that have been under tension for many years may find it difficult, especially if they have been considered as “Covid-19 hospitals”, to be absorbed into reasonable times the care of patients awaiting treatment as well as the flow of patients with newly diagnosed cancer reintegrating a course of care. It will most certainly take months to restore optimal organization. In addition, even if the epidemic crisis ends, the deterioration of the economy could accentuate inequalities with all its consequences on access to healthcare, particularly in the case of cancer.

Towards an increase in mortality?

For breast cancer, the most frequent cancer in women, whose annual number of new cases is estimated at 54,000 in France, the surgical management of patients with favorable prognostic criteria has been postponed, in accordance with the opinion of the High Council of Public Health available from mid-March and on the recommendations of learned societies. Even if these are remarkable recommendations which are unanimous during this period, it should not be forgotten that these are expert agreements for degraded care which should not last, at the risk a loss of luck for patients with even cancer said to have a good prognosis. Other examples could be taken, such as pancreatic cancer, the incidence of which has more than doubled over the past twenty years and whose unfavorable prognosis means that any delay in diagnosis by limiting access to radiology services, that any delay in surgical management due to the absence of an available operating theater or access to post-operative resuscitation could inevitably lead to an increase in mortality.

The Lombardy region of Italy, very affected as everyone knows by the pandemic, has managed to organize itself to maintain adequate care for cancer patients during this epidemic plague. Several platforms (HUB centers) have been set up, dedicated solely to the treatment of cancer patients (including the European Institute of Oncology and the National Cancer Institute in Milan). They receive newly diagnosed surgical candidates from area hospitals more dedicated to treating Covid-19 patients. These Covid-19-free cancer hospitals can continue to care for cancer patients even if they are small cancers with good prognosis.

This attention-grabbing pandemic should not make us lose our minds. After having wagered on economic performance for years, we suddenly moved on to the almost exclusive total fight against the Covid-19. It must be remembered that there is a middle way in everything that avoids extreme attitudes while preserving the future.


Emmanuel Barranger Surgeon oncologist, director general of the Center for the fight against cancer Antoine Lacassagne, Nice (Fédération Unicancer)

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Doctors told what cough indicates oncology | In the world

April 11, 2020, 09:21

Specialists of the National Health Service of Great Britain (NHS) told what cough indicates oncology.

According to the British newspaper Express, you should be wary if the cough does not go away within three weeks.

Oncology can also indicate sputum of a rusty color and the appearance of blood when coughing. Experts note that such symptoms occur not only with cancer, but also with bronchitis, nosebleeds and chest infections. Nevertheless, this is a serious reason to go to the hospital.

In addition, many patients note that oncology is accompanied by chest pain, and also sometimes shortness of breath and hoarseness.

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Are you panicking? Then the coronavirus comes to you!

I could take this interview by phone. Which, incidentally, was suggested by my interlocutor, one of the most respected virologists in the country, corresponding member of the Russian Academy of Sciences, doctor of medical sciences Alexander Lukashev. But I, to his obvious surprise, asked for a meeting.

EVERYTHING AT THE INSTITUTE IS QUIET

… Five minutes walk from the Sportivnaya metro station, and I am at the building with the sign “Institute of Medical Parasitology, Tropical and Vector-borne Diseases named after E.I. Marcinovsky First MGMU them. THEM. Sechenova. ”

I believe that his employees are better than us, mere mortals, aware of all the dangers, the insidiousness of the infamous coronavirus, which put the planet on its ears. WHO recently announced a pandemic, as COVID-19 has hit more than a hundred countries. Trump did cover his native America for a whole month from guests from Of Europeexcluding citizens Great Britain. But Britannia still an island. All of Italy in quarantine …

In many countries, mass events such as forums, concerts, sporting events, car dealerships are canceled, museums, exhibitions are closed … Moscow also already “more than five thousand do not gather!”

On television, our scientists, doctors radiate confidence, they say, do not panic, citizens, everything is under control. Well, well, let’s see how they behave in the workplace.

That’s why, I confess, I asked for a meeting with Lukashev.

… I wander around the institute, hoping to see the virologists rushing about, with heads chemical protection packed to overalls, like in Hollywood blockbusters about epidemics. No, silence. Carefully opened the door to a couple cabinets. People work calmly, even without masks.

Having not found any signs of panic, I head to the director’s office. Lukashev, warned by guards about the arrival of a journalist, meets at the door: “I thought you were lost. I wanted to go in search already. ” And she gives a sympathetic hand.

I automatically stretch mine.

“Well, haven’t the handshakes been canceled yet?” – involuntarily breaks off the tongue. – On the box showed how the Chancellor Merkel welcomed colleagues at the meeting with a gesture, and oil ministers in Vienna – “hello” legs.

– We can shake hands so far.

– When will it be impossible?

– When in Moscow or in the country a significant number of cases appear, well, for example, one hundred or a thousand. Then you have to think about more serious preventive measures, including keeping a distance.

– But, Alexander Nikolaevich, they scared in social networks that there were already twenty thousand patients in Moscow, but the authorities were hiding this! Tragic messages also come to us at Komsomolka, they say, why don’t you sound the alarm, journalists ?!

– In no developed country was it possible at the very beginning to identify the distribution chains of COVID-19 – not in USAnor in Italy, GermanySouth Korea, Of Japan… Everywhere, the coronavirus began to spread before it was detected. Therefore, I do not exclude that in the capital there may be uncommitted single cases of the virus. But it is impossible to hide 20 thousand patients. Therefore, I do not even want to comment on this nonsense.

“JUMPER”

– So, Alexander Nikolaevich, Russians and other earthlings lived, they didn’t. And suddenly, unexpectedly, a mysterious virus fell on our heads. Yes, not simple, but “crowned” …

“Well, why unexpectedly?” Since 2014, our institute has been dealing with the fundamental problems of the emergence of new viruses. In May 2019, we received a grant from the Russian Science Foundation. Emerging Viruses: Ecology and Evolution (document shows). From the point of view of evolution, the appearance of COVID-19 is a completely natural event. The standard way the virus exists in the biosphere. It is not the virus that is well adapted to one host that survives, but the one that can “jump” between the hosts. And adapt to new owners and new ecological niches. COVID-19 from the bat moved to the pangolin, and from him to the man.

– At the very beginning it was said that the transmission link from mice to humans is cobras, which the Chinese eat.

– It was not a very competent job, a method of the 70s. We own this method, I sometimes give it to students as an educational task. But we never draw conclusions based on it. In the bat, COVID-19 was no more than a hundred years ago. Well, the maximum is 200. And in the pangolin – no more than ten years ago.

– Unfortunate relic animal! Due to supposedly healing scales, it has become the best-selling endangered species in the world. Over the past ten years, poachers have caught more than a million pangolins in Asian and African forests and transported mainly to China.

– Yes, his meat is a delicacy for the Chinese. And they rub the scales and make different droplets, ointments. It is curious that the composition of the scales of pangolin is not very different from our nails …

How COVID-19 came about is understandable. Another thing is that it is impossible to predict when and what specific virus will appear.

– Why? This virus seems to have woken up global warming. There is such a version.

– It is always an accident. While we are talking, viruses have already tried to move from animals to humans several hundred times. IN AfricaSoutheast Of asia… Almost all of these attempts ended unsuccessfully. The virus either cannot infect a person or causes a limited infection and cannot spread. But he tries all the time. In rare cases, this succeeds. And it begins to be transmitted from person to person. Or not a very long time, as in the case of SARS. The new virus seems to have adapted better to humans. And, most likely, will stay with us for a long time.


In the square at the Trevi Fountain in Rome, you usually do not push. But now in Italy quarantine Photo: REUTERS

In the square at the Trevi Fountain in Rome, you usually do not push. But now in Italy quarantineA photo: REUTERS

Cats, whales, parrots get sick

– Enlighten about coronaviruses.

“They appeared on the planet millions of years ago.” We know that in the last 2 thousand years, new human coronaviruses have appeared repeatedly, there are even approximate dates.

-Let me, for the first time, human coronavirus was detected in 1965, – the journalist flashed with erudition.

– This, of course, is so. And before people sneezed, coughed, had a fever, but what exactly caused these ailments, the doctors did not know. But now we can analyze the genome of viruses and calculate when and from whom to whom they “jumped”.

– Why, by the way, is called – coronavirus?

-In the electron micrograph, he has very characteristic large stilettos, like on a crown. With these hairpins, the virus binds to cells, and it is they who are primarily responsible for the ability to infect a particular type of cell and cause various diseases.

Many coronaviruses are known today. In dogs, cats, cattle, horses, pigs, whales, leopards, seals, chickens, geese, turkeys, nightingales, parrots, the same bats, fish, etc.

Four human viruses – completely harmless, cause the usual ARI. Each season, they account for 10-15 percent of people with acute respiratory infections. In 2002 in the same China SARS coronavirus appeared, causing an outbreak of SARS. Mortality is 9 percent. In 2012, the coronavirus MERS (Middle East respiratory syndrome). Mortality -37 percent.

WORSE THAN INFLUENZA

– And now COVID-19 has appeared. Mortality is only 2-3 percent. Much lower than that of his two brothers. Why is there such a panic, strict quarantine measures, a ban on mass events, and the closure of borders? It is rightly written that tens of thousands die in the same America in the same America, up to 650 thousand people worldwide, and no one announces a pandemic.

– Let’s start with the brothers. Each claimed less than a thousand lives. The number of cases was small, the outbreaks were local in nature. SARS has already disappeared, MERS is fixed annually in isolated cases. In the first weeks, it was hoped that the new coronavirus would disappear just like SARS. Now there is practically no such hope. Already sick more than a hundred thousand people in more than a hundred countries. Therefore, a pandemic is declared. How it will spread further is impossible to predict.

As for flu comparisons … COVID-19 is definitely worse than seasonal flu. By mortality. 0.1 percent of people die from the flu. There will be, apparently, not 2-3 percent, as they frighten, but less, “only” 0.5-0.7 percent. WHO is also inclined to these figures. It is possible that in Chinese Wuhan, which accounts for the majority of patients, were not easily registered patients. But this is still several times more than with the flu. In addition, we know a lot about the flu, there are annual vaccinations. COVID-19 has a lot more “whites spots. “

-For instance?

– We do not know about its true mortality, the frequency of asymptomatic carriage, environmental stability, and the dependence of transmission efficiency on weather.

– How to distinguish it from the flu, acute respiratory infections?

– Very hard. A light form cannot be distinguished from ARI. Same runny nose, sore throat, cough. True, the temperature is rarely high. 39 is a rarity. Unlike the flu. Therefore, for accurate detection of the disease, laboratory tests are needed.

WAITING FOR A VACCINE

– Have effective drugs appeared over the months? Many drugs were tested …

“There are no drugs with proven efficacy yet, although, indeed, doctors tested and used a lot of things.” But I did not see the initial clinical data, where comparisons would be made: 100 people were treated with this, 100 were given a placebo, the results were such and such …

– In recent weeks, media reports periodically appear: Israeli (English, Russian) scientists have almost created a vaccine for the new coronavirus. Trump recently met with the leaders of the largest US pharmaceutical companies. He asked me to do him a favor, to speed up work on the vaccine. And they promised, Trump tweeted.

– It’s not so simple with her either. There are fundamental problems. For example, antibody-dependent enhancement of pathogenesis is known for other coronaviruses. Antibodies, if they are incorrect or few, can, on the contrary, enhance the process of the disease. This is unacceptable for medicine, where the main principle is “Do no harm!”

It’s easy to make a vaccine from a new strain of influenza. The conveyor is debugged, control too. You take the old technology and a new strain or even pieces of a new strain …

For human coronaviruses, not a single vaccine is produced.

– For the chicken, the British did!

– For chickens, immunity is sufficient for a short time while they are racing, and the price of an error there is only money. And for a person it is important what effect the vaccine can have in many years. So in the coming months, a licensed vaccine from COVID-19 is not to be expected.

Measures for the prevention of viral infections.

HOPE FOR SUMMER!

– The quarantine also does not work for one hundred percent, the experience of China has shown this.

– Completely stopping the spread of the virus is not realistic. Another thing is that strict quarantine measures allow us to identify some of the diseased. And give hope – which is very important for Of Russia! – slow down the pandemic, gain time by summer. Other coronaviruses are known to spread actively from December to April. In summer, it is much worse in countries with such a climate as ours.

– The weather is already working for us, the heat has come.

– No, a noticeable effect on the weather can be expected when it becomes more than 20 degrees!

It is also encouraging that China, albeit at the cost of very large economic losses, has completely stabilized the situation.

“It is curious why there is no such massive outbreak of coronavirus in India, although there are also more than a billion people living there, unsanitary conditions …”

– At first I myself was very surprised. Believed that the first to fall India, Indonesia. Apparently, it’s all about the weather. That is why I hope for warm weather. And this hope is not illusory. The disease spreads where it is colder +15. And where +20 and above, no. Although COVID-19 was introduced into Vietnam, Malaysia, Thailand, Singapore, Indonesia, to the Philippines, but there the virus does not spread at all as intensively as in the “colder” countries.

And in South Korea, one of the countries most affected by the coronavirus, he specifically specified that the outbreak began when there was plus 5-10 on the street.

– In this regard, everything is clear with Italy, which is now fully quarantined. It all started just in the north of the country. And it’s cool in Iran.

Iran – The most developed country in the region, and so far it cannot control its outbreak. But at least they were able to identify the virus. I am more concerned about the countries of Central Asia with less efficient health systems and more closed regimes.

– And located next to us.

– Exactly!


Fifth Quarantine Day in Venice Photo: REUTERS

Fifth Quarantine Day in VeniceA photo: REUTERS

FOLLOW HANDS!

– Explain another such paradox. Usually the main targets of influenza, acute respiratory infections are children and senior citizens. Judging by large-scale Chinese statistics, in the age group of 0-20 years, only one percent of patients with COVID-19.

– Yes, and then in a light form. Although other coronaviruses are more affected by children. This is another of the “blank spots” of the new virus. In general, for people under 30, this disease is relatively safe.

Mortality really begins to grow from 40 years old. The virus is especially dangerous for those over 80! Such veterans with chronic illnesses have a 15% risk of dying.

– What are the most dangerous chronic diseases?

-Cardiovascular, pulmonary, hypertension, diabetes, oncology …

– How can we not get sick until the summer?

– It is quite possible to reduce the risk of infection. The virus is transmitted by airborne droplets (sneezing, coughing) – here you can “keep your distance.” You can also catch it through infected surfaces – elevator buttons, door handles, handrails in public transport, etc. It cannot penetrate the body through the skin. Only through the mucous membranes … Therefore, watch your hands! Do not rub on the street, in public places eyes, lips, do not pick your nose, I apologize, in the nose. And wash your hands more often with soap.


Disinfection of public transport in Moscow Photo: REUTERS

Disinfection of public transport in MoscowA photo: REUTERS

– Controversial tips about masks. Needed – not needed …

– Masks help, and are primarily needed for people aged and with chronic diseases. On the street, they are definitely not needed – only where there are people at a distance of less than three meters. Unfortunately, there are simply no several masks per person per day, so wearing them all is always not very realistic. But speculators selling them at 10-20 times the price should, I think, deal with law enforcement.

Pensioners at risk are especially advised to avoid public events and crowded places. And even better – to go to the country, in the village. Indeed, in the city they can be infected by younger relatives who can easily tolerate a mild form of the disease, without even realizing that it is COVID-19. Just think, a slight cough, fever … But for a veteran, this can turn into a mortal danger.


Tourists near the Louvre Museum Photo: REUTERS

Tourists near the Louvre MuseumA photo: REUTERS

– There is information on the Web with reference to unnamed scientists that smokers have a 20 times less risk of contracting a coronavirus than non-smokers.

“I guess fake.” There are no official statistics yet, but it is absolutely certain that people with chronic lung diseases have a more severe illness. And every second smoker has chronic bronchitis, and even emphysema.

Therefore, smokers have a significantly higher risk of death in coronavirus.

– It seems that alcohol helps.

“If, when you return home, you moisten a napkin with vodka and disinfect your hands, then perhaps …”

– Comment on the reports that several people who recovered in China again became infected with the coronavirus?

– Very doubtful. Nowhere else have such data been voiced, so you need to carefully exclude the laboratory error.

– It seems to be a doggie somewhere in Hong Kong got infected from the owner. Could this be?

– Very unlikely. In China, in recent years, almost a million pangolins have been eaten, and the virus has been transmitted to humans only once.

– How to increase immunity, Alexander Nikolaevich, in order to confront the new infection? They say pharmacy immunomodulators do not help.

“I can’t say anything about them.” I’m not sure if at least one of these “drugs” is licensed in countries with developed evidence-based medicine. The biggest threat to the immunity of modern man is chronic stress. Therefore, you need to analyze your life, reduce the amount of stress, get enough sleep, be more calm about life – it’s both free and really works.

And do not panic in front of the coronavirus. Alarmists, on the other hand, will be more susceptible to COVID-19. I declare this with all responsibility.

Yes, people are afraid of everything incomprehensible. But, the more new data about COVID-19 appears, the more confident we virologists are about this problem. The problem is, indeed, a serious one, we still have to survive it. But now it’s clear that mortality is not as high as it seemed at the very beginning, the disease can be at least partially contained, controlled. In any case, this is not a planetary catastrophe.

It is too early to give forecasts, but this is certainly not the worst epidemic in the history of mankind. Yes, there will be human casualties and economic losses, but in any case, our life is filled with risks every day. The virus can hit a specific person, can bypass, but a day in fear and depression in any case is deleted from life.

AUTHORITATIVELY

WHY COVID-19 IS AFRAID OF SOAP

Alexey Moskalev, geneticist, corresponding member of the Russian Academy of Sciences, Doctor of Biological Sciences.

The new coronavirus, which in elderly or debilitated people can cause pneumonia, is a self-assembled nanoparticle. Inside her there is single-stranded RNA surrounded by a membrane lipid vesicle. В нем плавают “шипики” белков, которыми вирус прицепляется к поверхности клеток человека. А именно – к своему рецептору, белку ACE2, отвечающему за нормализацию артериального давления.


Алексей Москалев, генетик, член-корреспондент РАН, доктор биологических наук. Фото: Личная страничка героя публикации в соцсети

Алексей Москалев, генетик, член-корреспондент РАН, доктор биологических наук.A photo: Личная страничка героя публикации в соцсети

Мембранная оболочка вируса не выдерживает соприкосновения с обычным мыльным раствором. Поэтому призыв чаще мыть руки имеет реальную основу, а не просто для снижения паники. РНК более всего не любит ультрафиолет. Поэтому помогут избавиться от вируса на поверхностях и предметах прямые солнечные лучи или кварцевание помещений. Но помещение при кварцевании нужно покинуть, так как ДНК клеток кожи жёсткий ультрафиолет тоже повреждает, что ведет к риску старения кожи или даже меланомы. Наконец, белковый компонент вируса денатурирует под действием высокой температуры. Кипячение заражённых тканей должно его обезвредить.

Как правильно мыть руки.Лучший способ защититься от коронавируса – чаще мыть руки. Только делать это нужно не только часто, но и правильно. Но что значит «правильно»?

Размер вирусной частицы Covid-19 всего 125 нм по данным электронной микроскопии, поэтому его вдыхание могут предотвратить респираторы класса Р3. Однако вирус может проникать и через другие барьеры, например, слизистые глаз. Здесь могут помочь специальные защитные очки.

Мишень коронавируса на клетках человека, ACE2, более представлена в ткани лёгких пожилых людей, его экспрессия с возрастом нарастает. Компенсаторно уровень ACE2 увеличивается и при приеме определенных классов препаратов от давления, таких, как Эналаприл. По-видимому, с этим связано более острое протекание заболевания у пожилых или людей с гипертонией.

Coronavirus: only without hands !.With a slight movement, the handshake turns into a handshake! And from kisses and hugs have to abstain. Coronavirus changes age-old habits. But WHO recalls: the main thing is to wash your hands!

ТЕМ ВРЕМЕНЕМ

Контроль в аэропортах и на вокзалах усилить, мероприятия сократить: в России заработал координационный совет по борьбе с коронавирусом

В России появился координационный совет по борьбе с коронавирусом. Об этом в субботу, 14 марта, объявил премьер-министр Михаил Мишустин. В совет включены члены уже созданного ранее оперштаба по борьбе с коронавирусом, комиссия по экономической ситуации, руководители регионов (подробности)

Что сделала Москва, чтобы остановить коронавирус

Власти Москвы продолжают принимать меры необходимые для остановки распространения коронавируса. Напомним, в городе инфекция подтверждена у 24 человек, при этом 1 пациент выздоровел. Так что же уже сделано, чтобы остановить COVID-19 (подробности)

Из-за коронавируса Россия ограничивает авиасообщение с Европой: что надо знать пассажирам

С 16 марта Россия вводит новые, более серьезные ограничения на полеты в Европу. “КП” объясняет, как они будут работать (подробности)

ВАЖНО

Как не заразиться коронавирусом: все главные правила

Виктор Малеев – признанный эксперт в области эпидемиологии и клиники инфекционных болезней с более чем полувековым опытом работы в этом направлении. Академик РАН и инфекционист Виктор Малеев работал в очагах опасных инфекций – таких как холеры, чумы, сибирской язвы, риккетсиозов, геморрагических лихорадок, атипичной пневмонии. Именно Виктор Васильевич Малеев помогал в Гвинее местным врачам предотвращать эпидемию вируса Эбола и консультировал эпидемиологов США в связи с угрозой эпидемии сибирской язвы.

Эксперт поделился с читателями “Комсомолки” своими правилами профилактики новой болезни – коронавируса. Приводим их полностью от первого лица (подробности)

Коронавирус в инфографике: сколько человек вылечились и как правильно защищать от вируса

В большом потоке информации о коронавирусе не сложно запутаться. Корреспонденты сайта kp.ru собрали все, что на сегодняшний день известно об инфекции в простой и понятной инфографике (подробности)

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Combination of effective immunotherapy drugs for patients with fast growing neuroendocrine tumors

Many patients with rare and rapidly growing neuroendocrine tumors respond well to a common combination of immunotherapy drugs, according to DART’s first peer-reviewed publication, short for Dual Anti-CTLA-4 and Anti-PD-1 Blockade in Rare Tumors, one unique clinical study on rare cancer.

DART offers the combination of ipilimumab and nivolumab immunotherapy to patients with 53 rare tumor classes through an innovative “basket” design, which allows testing of a single drug or combination of drugs in a variety of tumor types. The study rapidly expanded the opportunities for developing immunotherapy drugs in rare cancers, which account for almost a quarter of all diagnosed cancers worldwide.

DART is managed by the SWOG Cancer Research Network, a group of clinical trials that is part of the National Cancer Institute (NCI) National Clinical Trials Network (NCTN), the oldest and largest publicly funded cancer research network in the United States.

The results of the study appear in Clinical cancer research. When they were presented in March 2019 during the American Association of Cancer Research annual meeting, the initial results were greeted with enthusiasm. This is because patients with high-grade or fast-growing neuroendocrine cancer have few treatment options.

We are very encouraged by these results. Based on the response, we opened another study that only enrolled patients with high-grade neuroendocrine carcinoma to see if we can replicate our results. We look forward to sharing these results later this year. “

Sandip Pravin Patel, MD, the DART clinical study chair, associate professor of medicine at the University of California at the San Diego School of Medicine and a medical oncologist with Moores Cancer Center at UC San Diego Health

Patel’s other DART chairs are Razelle Kurzrock, MD, from UCSD Moores Cancer Center and Young Kwang Chae, MD, PhD, from Northwestern University.

For this neuroendocrine cohort, 32 eligible patients received the combination ipilimumab and nivolumab. Of the 32, 18 had high-grade carcinoma, with tumors that most commonly appear in the lungs or gastrointestinal tract. Regardless of where their tumors appeared, eight out of 18 high-grade patients – or 44 percent – saw them partially or completely shrink. In contrast, patients with intermediate or low-grade tumors saw no response.

Since its launch in 2017, doctors from 823 cancer centers, academic and clinical clinics, and community hospitals have opened DART. As of February 13, 715 patients signed up with a goal of 818: beat all expectations. Historically, rare cancer studies have found it difficult to find patients, leading many researchers to abandon research on rare cancer.

Source:

Journal reference:

Patel, S.P., et al. (2020) A phase II basketball trial of double block Anti-CTLA-4 and Anti-PD-1 in rare cancers (DART SWOG 1609) in patients with non-pancreatic neuroendocrine tumors. Clinical cancer research. doi.org/10.1158/1078-0432.CCR-19-3356.

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