Abnormally large giant-nucleus cells that survive iron-induced oxidative stress form the foundation of early-stage cancer, according to a Japanese research team at the Nagoya University Graduate School of Medicine whose findings were published in the journal Redox Biology. While excess iron damages cells and increases cancer risk, a subset of cells survives the damage by … Read more
According to a randomized clinical trial published in the journal Cell Metabolism, a very-low-carbohydrate ketogenic diet reduces liver fat and improves insulin sensitivity significantly more than Mediterranean or plant-forward diets when participants achieve a comparable 10% weight loss. Researchers found that dietary macronutrient composition independently alters metabolic responses, yielding a 67% reduction in hepatic triglycerides … Read more
According to a recent review published in the journal npj Viruses, researchers have discovered that mosquito-borne orthoflaviviruses drive distinct cellular damage in human hosts while establishing lifelong, non-lethal infections in mosquito vectors. This divergence stems from how these viruses manipulate host mitochondrial dynamics, offering new avenues for targeted antiviral strategies against pathogens like dengue, Zika, … Read more
According to a laboratory study published in Scientific Reports by researchers including D. Mirra and colleagues, cigarette smoke extract (CSE) compromises human airway epithelial barriers and increases cellular vulnerability to polystyrene nanoparticles (PS-NPs). The research team investigated how sequential exposure to these environmental stressors reduces cell metabolic activity and alters structural proteins in human bronchial … Read more
According to a narrative review published in the journal Nutrients by researchers at the University of Guelph and ImmunoCeutica Inc., iodine intake follows a narrow U-shaped relationship that dictates how the micronutrient influences immune defenses across humans and domesticated mammals. While adequate intake supports leukocyte metabolism and thyroid-driven immunity, both chronic deficiency and sustained excess … Read more
Researchers have identified blood metabolic pathways that link diet and physical activity to better cognitive and physical function in aging adults. According to a study in Scientific Reports, these lifestyle-modulated metabolic pathway scores (LMPS) correlate with improved mobility, cognition, and independence across the spectrum from healthy aging to Alzheimer’s disease. How do diet and exercise … Read more
Researchers at the MUSC Hollings Cancer Center have identified a mechanism that allows prostate cancer cells to survive treatment by hijacking a protein called PIM1. According to a study published in Cancer Letters, traditional therapies that block PIM1 signaling inadvertently trigger a survival response, prompting the team to develop a “degrader” compound known as PIMTAC … Read more
Researchers found that fatigue in healthy adults is linked to specific shifts in gut bacteria and fecal metabolites. According to a study in Scientific Reports, these microbial patterns overlap significantly with those found in ME/CFS and psychiatric disorders, suggesting gut dysbiosis may serve as an early indicator for these conditions. What microbial changes are linked … Read more
The Hidden Link Between Preservatives and Heart Health For decades, food preservatives have been the unsung heroes of the industrial food chain, extending shelf life and preventing spoilage. However, new evidence suggests that these additives may come with a significant cost to our cardiovascular systems. heart health warning labels A comprehensive study published in the … Read more
Could a Common Weed Be the Key to Fighting Alzheimer’s? Dandelion Shows Promise A surprising ally in the fight against neurodegenerative diseases like Alzheimer’s may be growing in your backyard. New research suggests that dandelion – often dismissed as a pesky weed – contains compounds that could protect brain health. Specifically, polyphenols found in dandelion … Read more