Prioritizing Phenotypes Over Escalation “Management of RA, and D2T RA patients in particular, requires a holistic approach, always,” Jaap M. van Laar stated. A new diagnostic algorithm for difficult-to-treat rheumatoid arthritis (D2T RA) prioritizes patient phenotyping over immediate treatment escalation, according to Bryant R. England, MD, PhD, of the University of Nebraska Medical Center. Presented … Read more
Global Study Maps Pain Across 6.1 Million Individuals Pain prevalence peaks before age 55 for several common anatomical sites, while musculoskeletal back and joint pain continue rising into old age, according to a sweeping global analysis published in Nature Medicine. The study examined self-reported pain data from 6,125,459 participants across 902 population-based data sources in … Read more
Low-dose radiation therapy significantly reduces long-term disability and structural joint damage in early knee osteoarthritis patients, according to an integrated analysis of a 12-year randomized trial presented at the American Society for Radiation Oncology (ASTRO) Annual Meeting. Researchers tracked 292 participants and found that those treated with 4.5 Gy of radiation alongside standard medications experienced … Read more
Chronic postsurgical pain affects 15% to 17% of women three to six months after cesarean delivery, driving substantial impairments in everyday functioning, sleep, and mental health according to a systematic review published in Anaesthesia. Led by Dr Sarah Ciechanowicz of University College London Hospitals NHS Foundation Trust and first author Samira Alwahabi of Florida Atlantic … Read more
Odonkor, M.R. Dodurgali, F.R. Cox, I.J. Klimov, and A. Abd-Elsayed in the journal Nutrients, glucagon-like peptide-1 receptor agonists (GLP-1 RAs) may alleviate chronic pain by interacting with the gut microbiome and the gut-brain axis. The study examines how microbial metabolites, spinal microglia, and dietary signaling intersect with pain sensitization pathways. Gut Microbiota and GLP-1 Signaling … Read more
According to a study published in the Journal of Clinical Oncology, cancer survivors who pick their own mind-body therapy achieve recovery results just as strong as those assigned a program at random, meaning personal choice neither boosts nor hinders symptom relief. Led by researchers including Dr. Linda E. Carlson, the trial evaluated 587 participants to … Read more
Exercise-based cardiac rehabilitation reduces all-cause hospital admissions by 35% and cuts heart attack risk by 28% for patients with coronary heart disease, according to a Cochrane systematic review published by researchers at the University of Glasgow. The meta-analysis of 107 randomized controlled trials involving 26,886 participants demonstrates that structured physical activity programs deliver significant long-term … Read more
Mindfulness practices and tai chi help cancer survivors manage long-term side effects such as pain, fatigue, and sleep disturbances, according to a study published in the Journal of Clinical Oncology. Researchers from the University of Calgary, University of Toronto, and Mass General Brigham found that over 500 cancer survivors participating in these mind-body interventions experienced … Read more
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Humanized antibodies targeting the Nav1.7 sodium ion channel provide long-lasting relief from neuropathic pain in preclinical rat models while preserving normal pain sensation and motor function, according to a study published on June 21, 2026, in Volume 18 of Pharmaceutics. Researchers led by Associate Professor Daisuke Uta of the University of Toyama and Dr. Sosuke … Read more
Up to one in every three people in Ireland lives with chronic pain, driving patient advocates to demand a fully-funded, time-bound implementation plan for a new government management strategy, according to Chronic Pain Ireland, the Irish Pain Society, and the Societal Impact of Pain (SIP) Ireland. According to Prof Brian McGuire, a professor of clinical … Read more