Sky Q app is now also available for download free of charge on LG Smart TVs

The popular one with Sky customers Sky Q app is up after the successful launch Samsung Smart TVs (with Tizen operating system) and the Apple TV box (from the 4th generation) now also for Smart TVs from LG Electronics (with operating system Web OS 2.0 or higher) available. The app is available for free https://de.lgappstv.com/main/tvapp ready for download. An additional cable or satellite connection is not necessary.

With the Sky Q app, customers have the option of enjoying their program on any other television set in addition to the Sky Q receiver, whether with one of the over 100 linear TV channels or the best series and cinema blockbusters on demand. On-demand content started on another device can easily be continued with the Sky Q app. With the autoplay function, serial episodes can be seamlessly waxed.

Max Konstantin Ehrhardt, Director Product Management at Sky Deutschland: “With the Sky Q app, the Sky Q Mini and the mobile Sky Go app, the Sky program can be enjoyed in all rooms easier and more flexibly than ever. With the LG Smart TVs, we are now expanding the availability of the Sky Q app by a significant platform that is very popular with many of our customers.

Andreas Urbach, Head of Product Marketing Home Entertainment, LG Electronics Deutschland GmbH: “We are pleased that with Sky Q we are offering another popular TV offer on LG Smart TV and can thus offer our customers an even wider range of entertainment options.

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DuMont invests in regional titles – “Express” editor-in-chief leaves

Neven DuMont house Cologne

After selling several regional newspapers, the DuMont media group plans to invest millions in digital journalism for the remaining Cologne titles.


(Photo: dpa)

Cologne After selling several regional newspapers, the DuMont media group plans to invest millions in digital journalism for the remaining Cologne titles. The journalistic activities in the business area regional media are brought together in an integrated media house in Cologne, which concentrates primarily on the digital further development of “Kölner Stadt-Anzeiger” and “Express”, as the media group announced on Thursday. The printed editions of the newspapers will continue to exist at the same time.

The realignment also has personnel consequences: DuMont boss Christoph Bauer is interim chairman of the management of the media house, and the previous managing director Philipp Froben will leave the company “by mutual agreement” at the end of April. “Express” editor-in-chief Constantin Blaß leaves the company, the position will no longer exist.

The editor-in-chief of the “Kölner Stadt-Anzeiger”, Carsten Fiedler, will also take over the function of managing editor-in-chief, Newsroom, on May 1, and will be responsible for the journalistic management of the two newspaper titles.

DuMont intends to spend a double-digit million amount for editorial development, digitization and marketing in the next few years and thus strengthen the two brands. The editors of the Blätter already worked together in a joint newsroom in Cologne.

The realignment should not change the editorial size of the media house. As an independent publisher, the house will also take care of areas such as advertisements, radio and event business, it said.

The chairman of the supervisory board, Isabella Neven DuMont, emphasized: “At our home location in Cologne, we will implement the digital transformation of our flagships” Kölner Stadt-Anzeiger “and” Express “with all our might. We are convinced that in the long term we will establish a sustainably successful, primarily digital business model. “

The number of copies of the two regional titles (and “Kölnische Rundschau”) sold in the first quarter of 2020 was 301,961 from Monday to Saturday, according to figures from the information community to determine the distribution of advertising media (IVW), of which 29,168 as e-paper. Circulation numbers have been declining for years – as in the entire media industry in Germany.

DuMont had separated from a total of four regional titles in its portfolio since last autumn: “Berliner Zeitung”, “Berliner Kurier”, “Mitteldeutsche Zeitung” and most recently “Hamburger Morgenpost”. In addition to the regional newspaper section, the Cologne media house has two further pillars: business information – here DuMont prepares data for companies and institutions – and marketing technology with marketing software for sales and communication.

DuMont boss Bauer emphasized: “Today, DuMont already generates around half of its group sales and two thirds of its operating profit with digital added value.” The focus is on the further digitization of all business areas.

More: Film productions in the stress test: will broadcasters and streaming services soon run out of content?

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Schramböck: Already 100 members in the Digital Team Austria

“Economy helps economy” – Free digital tools for SMEs

Vienna (OTS / BMDW) Many companies are switching to home office in the current corona crisis. However, many companies do not have the necessary digital tools. The Digital Team Austria was founded on the initiative of Digital and Economics Minister Margarete Schramböck together with the Internet Offensive Austria and fit4internet. Since March 16, providers have been able to www.oesterreich.gv.at/kmu to offer their digital services to small and medium-sized businesses for free. The services are ordered via the website of the respective provider and are free for three months without any commitment.

“When coping with the Corona crisis, it is important to me that our companies remain liquid and that jobs in Austria are secured. All of our measures are aimed at this. All companies – large, medium and small – provide maximum support. With the ‘Digital Team Austria’, large companies support small and medium-sized companies to enable mobile work, ”said the Minister for Digital and Economic Affairs.

Within five weeks, 100 companies with 113 different services have registered. The services are offered in the areas of video conferencing and online meeting, communication and collaboration, cyber security, internet access and digital training and further education.

“Economy helps economy. The offer of the Digital Team Austria includes a mix of measures to make it easier for people to work from home and at the same time to be able to look after the children from home. My big thanks go to the involved companies from the digitization industry, ”says Schramböck.

Home office is an effective way to reduce physical contacts and thus the risk of contracting the coronavirus as much as possible. “As the federal government, we have taken quick and targeted measures to prevent the spread of the corona pandemic. Our explicit recommendation continues to rely on home office and teleworking wherever possible. We are grateful to all entrepreneurs and their employees for helping so far to contain the virus. Let’s not give up now! Now everything has to be done to avoid jeopardizing a positive trend, ”said Schramböck.

All offers of the Digital Team Austria and further information can be found at www.oesterreich.gv.at/kmu.

Questions & contact:

Federal Ministry for Digitization and Business Location
Kathrin Schriefer
Press spokeswoman for the Federal Minister Margarete Schramböck
+43 1 711 00-805140
kathrin.schriefer@bmdw.gv.at

BMDW press department
+43 (0) 1 711 00-805130
press department@bmdw.gv.at
www.bmdw.gv.at

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▷ Diabetes and COVID-19: Self-test now helps optimize oral immune defense

04/10/2020 – 11:33

The Mundgesundheitsstiftung GmbH

Diabetes and COVID-19: Self-test now helps optimize oral immune defense

Solingen (ots)

An effective barrier through the oral mucosa and an intact oral immune system are extremely important to protect against infection with SARS-CoV-2, according to a current statement by Chinese scientists. The WHO also warns of higher complication rates in diabetes patients with COVID-19 infection. At least this applies to older patients and those with other comorbidities, according to the Robert Koch Institute. With a simple saliva test, everyone can determine at home how fit their oral immune system is. People with diabetes in particular suffer from periodontitis, often unnoticed. This weakens the immune system, making it easier for bacteria and viruses to penetrate the body. Against the background of the corona pandemic, measures to optimize oral hygiene are therefore more important than ever, and knowledge of the oral immune system is paramount.

The oral cavity as a source of bacterial infections

Infection with the SARS-CoV-2 virus poses a major challenge to the immune system. An additional bacterial infection puts an enormous strain on the body and contributes to a more severe course of COVID-19. Because these bacteria can lead to pneumonia and sepsis (1).

The oral cavity in particular is a focus for pathogenic germs that can get into the body from there and lead to serious complications. If an illness-causing germ gets from the mouth into the lower respiratory tract, it can cause serious infections there, as an Italian study shows. (2)

The good news: Effective dental hygiene measures reduce the risk of pneumonia by up to 66 percent, as shown by a large-scale population study with 100,000 people over a period of 11 years. (3)

Periodontitis and diabetes are mutually beneficial

Periodontitis and diabetes are common, complex and chronic diseases that are closely related. Not only are people with diabetes more likely to have periodontitis, but they are also more likely to have more severe periodontitis. The worse the blood sugar is set, the more pronounced the severity. (5)

A recent Greek study found that over a quarter of all dental patients have high blood sugar levels without knowing it. A simple saliva test for aMMP-8 (activated matrix metallo-proteinase-8), which determines the oral immune system and collagen breakdown in the mouth, uncovered this. The aMMP-8 test is therefore suitable as a screening test for previously undiagnosed diabetes and poorly adjusted blood sugar levels. (6)

The oral cavity is the entry point for SARS-CoV-2

Researchers found in February that the oral cavity is the main entry point for the SARS-CoV-2 virus. Because most of the receptors that the virus needs to get into the body are in the mouth. There the virus multiplies and gets into the lungs. That is why a healthy oral immune system is the first hurdle for the virus. This is why the authors of the study are calling for new prevention concepts for oral health. (7)

A healthy oral immune system and oral hygiene measures can be an important building block for a mild course of a COVID-19 infection. Experts recommend regularly checking the condition of the oral immune system using an appropriate test.

Why are bacterial infections with COVID-19 so dangerous and affect every second person?

Infection with SARS-CoV-2 places a heavy burden on the body and its immune system. An existing bacterial infection in the mouth puts additional strain on the immune system. According to the World Health Organization (WHO), 20 percent to 50 percent of the world’s population suffers from an unknown bacterial infection in the mouth. Adolescents are already affected. This may be related to severe courses of COVID-19 disease in young patients. (8th)

Since almost half of the world’s population is affected by an infection in the mouth, it makes sense to check the condition of the oral immune system with a suitable test.

The aMMP-8 saliva test detects bacterial infections of the oral cavity

The aMMP-8 saliva test (PerioSafe Home) developed by researchers from the University of Helsinki and German biotech experts has proven in more than 400 studies worldwide that it reliably detects the condition of the oral immune system and related diseases such as diabetes and chronic heart diseases. (5) (6) (9)

The enzyme aMMP-8 (active matrix metalloproteinase-8) is responsible for tissue breakdown in the mouth. Inflammation in the mouth and periodontitis lead to permanently increased aMMP-8 concentrations. The collagen breakdown caused by this makes the oral mucosa permeable and pathogens can penetrate the body more easily.

In the wake of the corona epidemic, the aMMP-8 self-test provides an important component in prevention. A healthy oral immune system and oral hygiene measures can therefore contribute significantly to a milder course of a COVID-19 infection.

Experts recommend testing the oral immune system

Experts recommend that especially patients with diabetes or chronic heart diseases should regularly determine their aMMP-8 values ​​in order to take preventive measures in good time. With the aMMP-8 self-test, this can be done quickly and easily at home.

“Only deficits that you know can be optimized. In my opinion, knowledge of the oral immune status is of similar importance to regular blood sugar monitoring,” said Prof. Dr. Dr. Andreas Pfützner from the Diabetes Center in Mainz. In a new publication, he confirmed the importance of oral prevention in connection with COVID-19 in diabetes patients. Prevention measures should therefore include the mouth and throat area. The established diagnostic aMMP-8 test is well suited for the identification of particularly vulnerable patients. Current recommendations for the prevention of COVID-19 disease should be expanded to include aspects of measuring and rehabilitation of the mouth and throat area and regular daily disinfection of this area. (10)

The German Society for Periodontology (DG PARO) and the German Society for Dental, Oral and Maxillofacial Medicine (DGZMK) have been recommending the aMMP-8 test since 2015 for people with obesity, diabetes and suppressed immune systems, especially outside of dental practice. (11) The a-MMP-8 self-test is therefore particularly important in times of the corona pandemic, as many dental practices are only open to emergencies.

What can I do as a patient – suitable preventive measures

Washing hands is important – good oral hygiene is essential.

If the aMMP-8 value is increased, there are suitable measures to support the oral immune system. This includes thorough and regular oral hygiene – ideally professional dental hygiene. Given the current situation, this is often impossible.

However, everyone can take prophylactic measures:

– aMMP8 measurement of the oral immune system (twice a year)

– regular brushing of teeth (two to three times a day)

– daily cleaning of the interdental spaces (interdental brushes, dental floss)

– Regular use of suitable antimicrobial mouthwash solutions

The same measures basically apply to people who have already been diagnosed with a viral infection with SARS-CoV-2. It is important to take all measures to prevent the spread of a bacterial infection in the already weakened immune system.

About DMS – The Oral Health Foundation

DMS – The Oral Health Foundation provides educational and public relations work, both for doctors from various areas and for patients in the corresponding risk groups. The foundation has committed itself to maintaining health and preventing periodontitis and peri-implantitis as well as associated general diseases such as diabetes, chronic heart diseases, rheumatism and infertility.

The foundation promotes interdisciplinary cooperation between medicine and dentistry for the purpose of early diagnosis and timely therapy of periodontal inflammation and destruction processes. For this purpose, the foundation carries out intensive educational and public relations work, both with colleagues from various areas of the medical and dental field (e.g. internists, diabetologists, general practitioners, cardiologists, rheumatologists, gynecologists, periodontists and dentists), as well as with patients in the corresponding risk groups.

Interdisciplinary cooperation and inflammation prevention can make a significant contribution to improving oral health – for the benefit of the patient.

sources

- (1) Clinical course and risk factors for mortality of adult inpatients with
  COVID-19 in Wuhan, China: a retrospective cohort study. Fei Zhou, Ting Yu,
  Ronghui Du, Guohui Fan, Ying Liu, Zhibo Liu, et al.; Published:March 11, 2020
  DOI: http://ots.de/DZOk1L
- (2) Elevated Matrix Metalloproteinase Levels in Bronchi Infected with
  Periodontopathogenic Bacteria. Luca Bernasconi, Liza L. Ramenzoni, Ahmed
  Al-Majid, Gabrielo M. Tini, Sereina M. Graber, Patrick R. Schmidlin, and
  Sarosh Irani. PLoS One. 2015; 10(12): e0144461. doi:
  10.1371/journal.pone.0144461
- (3) The Association of Periodontal Treatment and Decreased Pneumonia: A
  Nationwide Population-Based Cohort Study. Li-Chiu Yang, Yih-Jane Suen, Yu-Hsun
  Wang, Tai-Chen Lin, Hui-Chieh Yu and Yu-Chao Chang. Int. J. Environ. Res.
  Public Health 2020, 17, 356; doi:10.3390/ijerph17010356
- (4) Consensus of Chinese experts on protection of skin andmucous membrane
  barrier for health-care workers fighting against coronavirus disease 2019.
  Yicen Yan et al.2020. Dermatologic Therapy. 2020;e13310
- (5) Diabetes and periodontal disease: a two-way relationship. L. Casanova, F.
  J. Hughes and P. M. Preshaw. British Dental Journal 2014; 217: 433-437. DOI:
  10.1038/sj.bdj.2014.907
- (6) Prediabetes/Diabetes Can Be Screened at the Dental Office by a Low-Cost
  and Fast Chair-Side/Point-of-Care aMMP-8 Immunotest; Andreas Grigoriadis, Timo
  Sorsa, Ismo Räisänen, Pirjo Pärnänen, Taina Tervahartiala, and Dimitra
  Sakellari; Diagnostics 2019, 9, 151; doi:10.3390/diagnostics9040151
- (7) High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of
  oral mucosa. Xu, Hao & Zhong, Liang & Deng, Jiaxin & Peng, Jiakuan & Hongxia,
  Dan & Zeng, Xin & Li, Taiwen & Chen, Qianming. (2020). International Journal
  of Oral Science. 12
- (8) Active Matrix Metalloproteinase-8 Point-of-Care (PoC)/Chairside Mouthrinse
  Test vs. Bleeding on Probing in Diagnosing Subclinical Periodontitis in
  Adolescents. Ismo T. Räisänen , Timo Sorsa, Gerrit-Jan van der Schoor, Taina
  Tervahartiala, Peter van der Schoor, Dirk-Rolf Gieselmann and Anna Maria
  Heikkinen. Diagnostics 2019, 9, 34; doi:10.3390/diagnostics9010034
- (9)Neutrophil proteolytic activation cascades: a possible mechanistic link
  between chronic periodontitis and coronary heart disease. Hatem Alfakry, Ernst
  Malle, Chintan N Koyani, Pirkko J Pussinen, Timo Sorsa. Innate Immunity 2015;
  22:1.
- (10) Warum sind Diabetiker durch das Coronavirus (CoV-2) besonders gefährdet -
  Möglichkeiten für die orale Diagnostik und bedarfsgerechte Prävention für
  Patienten und Fachärzte. Andreas Pfützner, Timo A. Sorsa, Solomon O. Nwhator,
  Ismo T. Räisänen, Dimitra Sakellari, Jan Kunde, Bernd Kleine-Gunk, Roland
  Frankenberger. 2020. Zur Publikation eingereicht
- (11) Parodontitis-Diagnostik mit dem Entzündungsmarker MMP-8. Gemeinsame
  Wissenschaftliche Mitteilung der Deutschen Gesellschaft für Parodontologie (DG
  PARO) und der Deutschen Gesellschaft für Zahn-, Mund- und Kieferheilkunde
  (DGZMK). 2015. https://www.dentognostics.de/wp-content/uploads/2020/04/Pressem
  itteilung-2016.pdf 

Press contact:

The Mundgesundheitsstiftung GmbH
Bonner Str. 84
D-42697 Solingen
info@mundgesundheitsstiftung.de
Dr. Jan Kunde (jan.kunde@mundgesundheitsstiftung.de)
Tel .: 0212-64 57 479 36

Original content from: Die Mundgesundheitsstiftung GmbH, transmitted by news aktuell

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TYROLEAN DAILY NEWSPAPER “Editorial” from April 9, 2020 by Karin Leitner “Reifeprüfung für das Leben”

Innsbruck (OTS) After a long back and forth, students, parents and teachers know what is going on when it comes to Matura. Despite hygiene, what the Minister of Education now specifies is infectious. There would have been other variations.

It should have taken place from May 5th to 13th. On March 11th, ÖVP Minister of Education Heinz Faßmann announced that the Central Matura due to the Coronavirus will be postponed. That was fixed on March 17th. The earliest it will be on May 18. It is about the written and the oral exams. Then it was said that on May 19, German would be started – with two weeks “lead time”. The date will be announced “in time”, was heard later. It could also be that the oral Matura “slips” further into June. On March 31, Fassmann said that he would let anyone know what happened when and after Easter. The pupils concerned, their parents and teachers were unsettled. What actually applies? What is, hardly pronounced, revised? They wanted clarity. Rightly so. There are now.
From May 25th, students must graduate – only in writing and in three subjects. The young people should prepare for this in the three weeks before at school – in gymnasiums, ballrooms, larger classes. Under hygienic conditions, as Fassmann emphasizes. An infection-risky venture, disinfection or not. Other things would have been possible to make it possible for eight-year-olds to graduate: canceling the high school diploma, as is the case in France and Great Britain. There is based on what has been achieved so far. Why doesn’t this happen in this country? The pre-scientific work is also available. Oral tests, for example in German or a foreign language, would have been a variant – online, via video conference. “Keep your distance” is the appeal of the government.
Anyone who calls out that a Matura shouldn’t be cheap can even be given away: should you envy a student who has to take one under the current circumstances? A matriculation exam creates enormous stress, as everyone who has done it knows. The corona crisis with all its side effects – fear of illness, isolation – increases the pressure. Anyone who can withstand this, including learning in the home office – this is particularly difficult in mathematics, for example – has learned a lot that the tens of years before him did not have. He is probably ripe for what is required at a university and in the job apart from theoretical knowledge. He can count on having successfully completed life school at a young age.

Questions & contact:

Tyrolean daily newspaper
0512 5354 5101
chief editorial office@tt.com

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Springer Medizin launches Corona Webinar initiative, Springer Medizin Verlag GmbH, press release

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But how does the scanning of this QR code work? – Our graphic shows the three simple steps.

All you need is an internet-enabled cell phone or smartphone with a built-in camera and QR code reading software.

QR stands for Quick Response – with one step you can quickly get to a website. QR codes work like bar codes, which you can find on your milk carton, for example. Software decrypts the QR code and takes you directly to a website – you don’t even need to know the Internet address to reach it.

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Corona: Rely on Viennese Research | PID press

In Vienna, universities and research institutions are intensively concerned with “SARS-CoV-2”. The results are impressive and the support from politicians and funding agencies is great

Vienna (OTS / RK) In addition to medical and psychosocial crisis management measures to support all Viennese, the efforts of the city of Vienna are great in all areas of life. Examples include the ten million euros in home office funding for small businesses, the special bonus for 24-hour supervisors, the immediate delogation stop at Wiener Wohnen and funding for cultural institutions and freelance artists. “The corona crisis shows just how important science is for our society. Just as scientists support us in dealing with the current situation correctly every day, we have to ensure that these experts can continue to work and research unhindered, ”explains Vienna’s City Councilor Veronica Kaup-Hasler.

One million for 24 research projects

Research is currently being feverishly carried out in all well-known universities and research institutions in various disciplines – from natural sciences to education and economics – for solutions in all areas. The focus is on six categories: understanding and fighting the virus; Expansion of test capacities; Epidemiology and public health; Society in crisis; Education and school as well as business and logistics.

The Vienna Science, Research and Technology Fund (WWTF) is providing a total of one million euros and is supporting 24 projects with a maximum of 50,000 euros each. With this “COVID-19 Rapid Response Funding”, potentially life-saving research can be carried out promptly and valuable data can be collected. WWTF managing director Michael Stampfer said: “Science has the task of collecting data in this exceptional situation and deriving important lessons from it. Vienna and Austria can rely on their research community! ”

Top medicine in Vienna

One of the funded projects started the CeMM – Research Center for Molecular Medicine of the Austrian Academy of Sciences and the Medical University of Vienna (MedUni) together with partners. Using the latest sequencing and analysis methods, valuable knowledge about the genome development and the mutation course of the virus should be gained. Corona probably started in China in November 2019 and was transmitted from wild animals to humans. By the end of March, it had spread to 180 countries. Analyzing this evolution in the human population requires that the genomes of the circulating viruses in many parts of the world be collected and published in freely accessible databases. The Viennese researchers are now supplementing the previously missing virus genomes from Austria. “Our analyzes address important issues such as the monitoring of infection chains, as well as a better molecular understanding of the development of virus mutations and their possible influence on the course of the pandemic and the acute respiratory disease caused by Sars-CoV-2,” says Andreas Bergthaler, project coordinator and research group leader at CeMM. As of Friday April 3rd, 21 viral genomes out of a target 1,000 were published in the database. This information is intended to provide a clear picture of virus evolution in Austria and enable comparative analyzes worldwide.

The WWTF is also funding the new association of 20 Viennese research institutes to form the “Vienna COVID-19 Diagnostics Initiative” (VCDI). The goal is to set up a new diagnostic pipeline and develop a series of high-throughput tests. An automated pipeline has already been created at the Vienna BioCenter. Since the same reagents are required for tests worldwide, bottlenecks are slowly emerging. Vienna researchers have now developed them themselves, which makes them independent of external deliveries. They also make their knowledge and research results available to other laboratories and universities.

Active ingredient from Vienna shows activity against virus

The international research team around the Viennese geneticist Josef Penninger has high hopes in the search for a cure. The founding director of the IMBA (Institute for Molecular Biotechnology of the Austrian Academy of Sciences) is currently doing research in Canada and has already researched impressive findings in 2005 about a related coronavirus, which caused the outbreak of the lung disease SARS in 2003. This research was quickly built on because the new SARS-CoV-2 virus enters the cell via the same mechanism. The IMBA has also been familiar with the method since 2018. Organoids, i.e. tiny, organ-like structures, a kind of mini-organs are developed from human stem cells. How the virus attacks the tissue and reproduces itself provides important information. “Our previous work on the IMBA helped to quickly identify ACE2 as the entry point for SARS-CoV-2, which explains a lot about the disease,” says Josef Penninger, “An organoid is not a patient, but it allows us to be targeted and study under controlled conditions how the virus affects human tissue and how to stop it. “

The research team has found that an active ingredient developed by the Viennese biotech company Apeiron as a drug candidate can reduce the infection in these artificially produced human tissues. “Of course, this motivates us all the more to test the effectiveness in controlled clinical studies,” says Peter Llewellyn-Davies, CEO of Apeiron Biologics AG about the successful collaboration. Apeiron is currently preparing a Phase 2 clinical trial in Europe at COVID-19 and is reviewing options for further clinical development, including: B. in China.

Successful life sciences in Vienna and around the world

Under the direction of the University of Natural Resources and Applied Life Sciences (BOKU) and the University of Veterinary Medicine Vienna (Vetmeduni Vienna), a project was started that is dedicated to the number of unreported cases of Covid19 sufferers. Because even if this group shows no symptoms, it develops a protective immune response. The protocol of the first non-commercial antibody test, which was developed by an Austrian in New York, is to be used for the detection. Also involved are the MedUni Vienna and the University of Salzburg, as well as other research institutions that provide equipment and expertise.

Imaging techniques allow radiologists to examine the effects of infection and therapeutic measures on the lungs. At the MedUni Vienna spin-off contextflow, every effort is being made to increase the benefits by quickly finding comparable cases using specialized image and text searches. The software has now been specially optimized for faster evaluation of corona scans. And the Austrian Society for Laboratory Medicine and Clinical Chemistry (ÖGLMKC) is now publishing the standards for laboratory diagnostics for COVID-19: www.oeglmkc.at/corona.html

The efforts at non-university research institutions such as institutes of the Austrian Academy of Sciences, the Institute for Advanced Studies, the St. Anna Children’s Cancer Research, but also the Complexity Science Hub, the Ludwig Boltzmann Society and many other organizations are enormous.

The research center Complexity Science Hub Vienna CSH in turn collected the various measures from 41 countries, divided them into categories and published them in a database. In this way, exit restrictions, the blocking of places and the obligation to wear a protective mask can be related to growth rates and compared on a country-by-country basis. Ultimately, the effectiveness of measures can be checked against reality. Scientists can download this “CSH Covid-19 Control Strategies List (CCCSL) and use it for their own analysis.

Data processing also makes important contributions to understanding the virus and its development and ultimately being able to defeat it. The Viennese communication specialist Biolution has created an easy-to-understand video to explain the virus. The Viennese company dwh GmbH – Simulation Services and Technical Solutions, together with the Vienna University of Technology, created a model calculation for epidemic spread.

More information about life sciences in Vienna can also be found at: www.lisavienna.at/de/life-sciences-in-wien/covid-19

(Close) lift

Questions & contact:

PID town hall correspondence
City of Vienna Press and Information Service (MA 53)
City Editor, Duty Editor
01 4000-81081
dr@ma53.wien.gv.at
www.wien.gv.at/presse

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NEW twice: Vitamin C and Vitamin C + Zinc from Zein-Pharma, ZeinPharma® Germany GmbH, press release

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3 steps: Scan a QR code: The guide to your press release – without typing! With the help of the QR codes, which are shown on the print version of each press release, you can always return to the corresponding online page of lifePR by mobile phone – without having to laboriously type in the URL.

But how does the scanning of this QR code work? – Our graphic shows the three simple steps.

All you need is an internet-enabled cell phone or smartphone with a built-in camera and QR code reading software.

QR stands for Quick Response – with one step you can quickly get to a website. QR codes work like bar codes, which you can find on your milk carton, for example. Software decrypts the QR code and takes you directly to a website – so you don’t even need to know the Internet address to reach it.

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▷ Active ingredient from Vienna helps COVID-19 “sick” organoids

04/03/2020 – 09:51

IMBA Institute of Molecular Biotechnology

Vienna (ots)

An international team of researchers with the participation of the IMBA – Institute for Molecular Biotechnology of the Austrian Academy of Sciences – is using organoids for the first time to show how SARS-Cov-2 affects blood vessels and kidneys and how the virus infection can be stopped by the active ingredient hrACE2. The current issue of Cell magazine reports on this project, led by scientist Josef Penninger.

In the wake of the current global crisis caused by the Corona Virus, research teams worldwide are working on strategies to contain this pandemic. It is a race against time. In order to save the world’s health systems from collapse, medication is needed quickly, which can be used especially in severe cases. Josef Penninger, researcher and founding director of the IMBA (Institute for Molecular Biotechnology of the Austrian Academy of Sciences) and an international team are taking a particularly promising approach around the enzyme ACE2 (angiotensin converting enzyme 2). A therapeutic approach has now been tested in the laboratory on COVID-19 “diseased” organoids. Current results of this study confirm the effectiveness of human recombinant ACE2 (hrACE2), as has been demonstrated in current studies on cell cultures and human organoids.

Organoids in corona use

Organoids are tiny, organ-like structures that can be cultivated from human stem cells to model diseases and to test drugs in the human cell structure. Infectious diseases can also be studied there. At IMBA, one of the leading centers of this technology in Europe, brain organoids were used to investigate how certain viruses trigger malformations in the brain.

In the current study, the scientists used blood vessel organoids, which were developed by Penninger’s team at IMBA in 2018, and kidney organoids. It was shown that the virus can directly infect the organoids and reproduce in these tissues. This provides important information about the development of the disease and the fact that severe cases of COVID-19 are associated with multi-organ failure and signs of cardiovascular damage. The administration of the active ingredient hrACE2 reduced the SARS-CoV-2 infection in these artificially produced human tissues. In cell cultures, the viral load was reduced by a factor of 1,000-5,000 through hrACE2.

Knowledge as an advantage

Back in 2005, Josef Penninger and his team at the IMBA published fundamental findings on a related coronavirus, which caused a global outbreak of SARS in 2003. Research at the time was quick to build on in the face of the new pandemic because it was shown that the new SARS-CoV-2 virus uses the same mechanism to penetrate the cell. As with the SARS virus, the SARS-Cov-2 protein ACE2 is the entry point for viruses to infect cells in the lungs. At the same time, ACE2 has a second, important function as a blood pressure regulator. SARS-CoV-2 is closely related to the then SARS virus and it was shown that its typical “spikes”, structures made of proteins on the surface of the virus, dock even more specifically to the ACE2 receptors of the cell surface. These docking points are not only in the lungs, but also in the heart, in the blood vessels, in the intestine and in the kidneys, which can explain the severe course of disease of COVID-19 due to organ failure and sepsis. As clinical trials begin, organoids offer researchers an alternative human model system to test possible therapies against COVID-19 in the laboratory in advance.

One active ingredient – double protection

According to the scientists, hrACE2 could work in two ways. On the one hand, it can bind the viruses and absorb them like a kind of sponge so that they can no longer infect cells. On the other hand, it offers active protection against lung failure in the event of an infection.

“We are delighted that this international, so successful collaboration has created a solid database that supports our proposed mode-of-action for the effects of rhACE2, also known as APN01. This naturally motivates us all the more to test the efficacy of APN01 in COVID-19 patients as part of controlled clinical trials, “said Peter Llewellyn-Davies, CEO of Apeiron Biologics AG.” Our previous work at IMBA has helped ACE2 quickly become the entry point for SARS-CoV -2 being able to identify what explains a lot about the disease, “adds Josef Penninger,” Now we know that a soluble form of hrACE2 ‘sucks’ the virus out of human organoids. An organoid is not a patient, but it allows us to study specifically and under controlled conditions how the virus affects human tissue and how it can be stopped. Now is the time to back up these results with results from the clinical studies. ”

Original publication: “Inhibition of SARS-CoV-2 infections in engineered human tissues using clinical-grade soluble human ACE2”, Monteil et al., Cell, 2020; DOI: 10.1016 / j.cell.2020.04.004

Press photos: https://www.imba.oeaw.ac.at/about-imba/information-material-download/

The current study was carried out with the participation of the Karolinska Institute and the Karolinska University Clinic, the National Veterinary Institute, Uppsala; the Institute for Bioengineering in Catalonia (IBEC), the Barcelona Institute of Technology (BIST), Barcelona, ​​the IMBA – Institute for Molecular Biotechnology of the Austrian Academy of Sciences, STEMCELL Technologies Inc., Vancouver, Canada, the Center for Applied Medical Research (CIMA), Navarra University, Pamplona, ​​Apeiron Biologics, University of Toronto, Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, ​​Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina, Madrid , Spain, and the Department of Medical Genetics, Life Science Institute, University of British Columbia, Vancouver, Canada.

About IMBA

The IMBA – Institute for Molecular Biotechnology is the largest institute of the Austrian Academy of Sciences (ÖAW) with a focus on future-oriented basic research. 16 research groups face the molecular puzzles and unexplored areas of molecular biology and medicine. Findings from the fields of cell and RNA biology, molecular medicine and stem cell biology form the breeding ground for a medicine of the future. The stem cell initiative at the IMBA is funded by the Federal Ministry of Science and the City of Vienna.www.imba.oeaw.ac.at

About Apeiron Biologics

Apeiron Biologics AG is a European private biotechnology company based in Vienna that specializes in the discovery, development and commercialization of novel immunotherapies for cancer. APN01 is a recombinant human angiotensin converting enzyme 2 (rhACE2) that has undergone several phase 1 and 2 clinical trials in ARDS (acute lung failure), ALI (acute lung injury) and PAH (pulmonary arterial hypertension). APN01 has proven to be safe and compatible. It has recently been shown that ACE2 acts as a cellular entry receptor for the new coronavirus SARS-CoV-2. Therefore, Apeiron is currently preparing a phase 2 clinical trial in Europe for COVID-19 and examining options for further clinical development, e.g. B. in China. https://www.apeiron-biologics.com/

Press contact:

Mag.a Ines Méhu-Blantar
Senior Communications Manager
IMBA – Institute of Molecular Biotechnology
of the Austrian Academy of Sciences
Dr. Bohr-Gasse 3, 1030 Vienna
T: +43 1 79044 – 3628
M: +43 664 808473628

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With medicinal plants against viruses CGC Cramer-Gesundheits-Consulting GmbH, March 31, 2020

Dr. Dr. Erwin Häringer, family doctor, Munich: “With seasonal, viral respiratory infections, therapy with phytopharmaceuticals is a treatment option” (PHOTO)

Romanshorn (ots) Both the acute respiratory infections that occur frequently in the cold season and the current spread of the new corona virus Sars-CoV-2 make it clear that there is a great need for active ingredients that can help against viruses and, at best, do not lead to resistance. It is known that antibiotics do not work against viruses, but only against bacteria. One of the reasons why viruses are so difficult to fight is because they can change their genetic information in a very short time. Therefore, for example, the flu vaccination must be repeated every year. In the case of the novel lung disease COVID-19, a vaccine is not expected until the summer of 2021 at the earliest [1]. “When looking for effective alternative treatment approaches, it is worth taking a look at nature,” says Dr. Dr. Erwin Häringer, doctor for naturopathy and general medicine, Munich. Because various plant substances, such as tannins, essential oils or mustard oils, showed a pronounced antiviral effect in laboratory tests. Mustard oils in particular are among the very well-studied medicinally active plant substances. With regard to their activity against viruses, scientific studies in the 1950s already showed that mustard oils from nasturtium and horseradish can effectively inhibit the multiplication of influenza viruses [2,3]. The mustard oil mixture also fights the most common cold viruses and has been proven to reduce the frequency of colds by around 50 percent [4]. “Therefore, treatment with mustard oils is always worth trying for seasonal viral infections of the respiratory tract,” says Häringer.

The current spread of the new corona virus SARS-CoV-2 and the associated uncertainty among the population has prompted the WHO to dispel COVID-19 by creating myths about the novel lung disease. For example, the rumor is rebutted that a flu shot also protects against the new corona virus [5]. Due to their great versatility, viruses can adapt to new environmental conditions in a very short time and, for example, develop resistance to possible new therapies very quickly. The development of a vaccine against COVID-19 is therefore time consuming. Two Swiss biotech companies are also researching new substances. However, it could take years for the drug to be on the market [6]. In this context, the German Center for Infection Research (DZIF) points out that the development of new antivirals is difficult to plan anyway, since it cannot be predicted which virus will appear next and which will pose a risk to humans [7].

Mustard oils have a triple effect – against viruses, bacteria and anti-inflammatory

Different plants produce substances with which they defend themselves effectively against viruses, bacteria and fungi. These substances include mustard oils from nasturtium and horseradish. Mustard oils have been used in natural medicine for centuries to treat respiratory and urinary tract infections. It was discovered early in laboratory tests that mustard oils from nasturtium and horseradish inhibit the multiplication of influenza viruses [2,3].

In clinical studies with adults and children, the efficacy and tolerability of the herbal medicinal product in acute bronchitis, acute sinusitis and cystitis compared to various antibiotics [8,9] proven. As the mustard oil mixture has been proven to reduce the frequency of colds by around 50% [4], it is also a recommended treatment option to extend the symptom-free time for frequently recurring respiratory infections. The mustard oils not only fight viruses, they are also antibacterial [10-16] and anti-inflammatory [17-25]. Because of the triple effect of the plant substances – antiviral, antibacterial and anti-inflammatory – unpleasant cold symptoms are quickly relieved and possible bacterial super infections are counteracted.

“Due to the extensive mechanism of action of mustard oils, the development of possible resistance mechanisms against these plant substances is made significantly more difficult for viruses and bacteria. Further investigations are therefore of great interest and have already been started,” explains Häringer.

“Don’t get infected” – what else can you do?

The concern with the corona virus SARS-CoV-2 to infect, is currently a lot of people. How do I behave in everyday life to avoid virus transmission? The Federal Office of Public Health (BAG) gives on the page This is how we protect ourselves appropriate advice. In general, we recommend the measures that are generally advisable for all infectious diseases, such as influenza and other respiratory diseases. These include compliance with the Cough and sneeze etiquette (cough and sneeze in a handkerchief or crook), a good one Hand hygiene (Thoroughly soap and wash hands several times a day; each for about 20-30 seconds) and Keep away from the sick (about 1 to 2 meters). When greeting people, shaking hands should also be avoided. Acute sufferers should stay at home to recover if possible so that the virus is not spread further.

You can request literature sources 1-25 from etzel@cgc-pr.com

Questions & contact:

Press contact:
CGC Cramer Gesundheits-Consulting GmbH
Frank Etzel T: 06196/77 66 113
etzel@cgc-pr.com

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