study

Researcher: Mouthwash can prevent corona infection

by

Bochum.
Commercially available mouthwashes make the virus in the mouth and throat disappear completely after 30 seconds. This reduces the risk of infection.

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Mundspülung gegen Coronaviren? Forscher von Wirksamkeit überrascht

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Acht handelsübliche Mundspülungen getestet

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Nicht zur Behandlung von infizierten Patienten geeignet

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Vitamin D does not protect against depression

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Vitamin D can lower the risk of depression in women and men – this is the popular belief. A new study now refutes this statement.

Several observational studies show that people with a Vitamin D-Deficiency also have an increased risk of depression. A new, long-term clinical study, in which the participants were not only observed but also treated with the so-called sun hormone, now refutes this statement.

No effect on depression risk or mood

The randomized study by Dr. Olivia I. Okereke, Associate Professor for psychiatry at the Harvard Medical School, 18,353 women and men over the age of 50 took part. At the beginning of the observation they had neither depression nor clinically relevant, depressive symptoms. Over a period of five years, half of the subjects were given supplements with a higher vitamin D3 content. The other half received ineffective placebo pills.

At the end of the study, the research team found that the subjects who were given the vitamin D3 had no significantly lower risk of depression than the subjects from the control group. A change in the mood values ​​that were checked during the examination could not be determined either. The researchers therefore concluded that taking vitamin D3 cannot prevent depression.

But despite the results, Dr. Okereke refrained from disposing of vitamin D supplements or those prescribed Medication discontinue without medical consultation. It is not yet time for that, says the scientist.

Important NOTE: The information is in no way a substitute for professional advice or treatment by trained and recognized doctors. The contents of t-online.de cannot and must not be used to make independent diagnoses or to start treatments.

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news, scientists, research, vaccine, obesity, coronavirus, covid-19, 2019-ncov, coronavirus covid-19

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At the moment, scientists around the world are developing a vaccine against COVID-19.

The development of the drug is nearing completion: clinical trials are underway in some countries.

However, experts admit that the vaccine will not be as effective for obese people. This is reported by the American media.

The fact is that with excess weight, the patient is highly likely to face complications of diseases and the need for long-term medication therapy.

Also, scientists recalled that other well-known vaccines in the early periods of their existence were not so effective for obese people.

However, experts note: before the start of mass vaccination, the drug against COVID-19 must be tested on different people.

However, overweight volunteers usually do not take part in vaccine clinical trials. But this time it would be logical to make an exception, scientists say.

According to the latest data, about 40 percent of adults in the United States are obese. Doctors warn that being overweight increases the risk of severe COVID-19 in case of infection.

Фото: Pixabay

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very cheap and long-known drugs help save the lungs with coronavirus

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Cloving hospital on the basis of the Medical Scientific and Educational Center (ISSC) Moscow State University named after M.V.Lomonosov took the first patients on April 21 and completed his work on June 13. It turned out that it was possible to achieve the best treatment results for COVID-19 in Moscow. Over the entire period, 4 patients died, and among severe patients who got mechanical ventilation, the mortality rate was less than 14% (for comparison, the average for the city and the world was up to 70 – 80%). Eighteen doctors out of 220 employees of the hospital were infected with coronavirus, there were no deaths among the medical staff.

What approaches were used at the University Hospital of Moscow State University to achieve such results? We continue the conversation with the head. Department of Therapy, Faculty of Fundamental Medicine, Moscow State University, Head of the Department of Age-Associated Diseases, Medical Scientific and Educational Center, Doctor of Medical Sciences, Cardiologist Yana Orlova.

MEDICINE FOR COUGH FOR 80 RUBLES

– Most of those who are ill or are afraid to get sick are worried about fibrotic changes in their lungs. They say that you have developed special therapy that can reduce the risk of developing fibrosis. Is it possible?!

– Yes, we launched an appropriate clinical study. There are no final results yet, but we have developed clinical practice.

“What did you do to save the lungs?”

– We used a combination of bromhexine and spironolactone (both are long-known very cheap drugs. – Ed.). Bromhexine is an expectorant that has been prescribed to patients with pneumonia and cough for many years. At the same time, experimental data showed that this drug can block a specific enzyme and impede the penetration of coronavirus into cells. True, it was on this effect that we counted to a lesser extent in inpatients, since such an effect is important mainly in the early stages of the disease. But the expectorant effect of bromhexine really helps patients with COVID. I heard that our colleagues in Peter launched a study of bromhexine for prophylactic purposes. We will wait for the results.

Coronavirus infected 18 doctors from 220 employees of the hospital, there were no deaths among the medical staffPhoto: Ivan MAKEEV

FIBROSIS OBSTACLE

– The second drug – spironolactone – is traditionally widely used in cardiology for the treatment of heart failure, severe hypertension. It has a small diuretic, magnesium and potassium-preserving effect, continues Yana. Orlova. – It has several mechanisms through which it can be useful in coronavirus infection.

Firstly, a mechanism that prevents the development of fibrosis in general in the body. There are works that, in particular, show that spironolactone reduces fibrosis in the heart. At the same time, it is known that the tendency to fibrosis is not local, but systemic – where there is more inflammation, there will certainly be fibrosis. And we see, of course, fibrotic changes in the “covide” in our patients. Therefore, we prescribed spironolactone as a drug for the prevention of this process.

Secondly, this drug blocks sex hormone receptors, in particular testosterone. Some published studies suggest that “high-testosterone” men suffer from “covid” more often and develop more severe fibrotic changes. Therefore, blocking these receptors for several weeks during COVID treatment may be useful in reducing the severity of complications. We are not talking about a longer intake, since male patients are unlikely to agree with a decrease in testosterone levels in the long term.

And perhaps the most important point. In almost all of our patients, we observed hypokalemia (a decrease in potassium levels. – Ed.). With coronavirus infection, potassium is intensely excreted from the body, and scientific articles even suggest that hypokalemia serves as the trigger for a cytokine storm. So spironolactone has a real chance to reduce the risk of this dangerous complication. But the main thing, in my opinion, is that lowering the level of potassium in the body is extremely harmful to the heart and triggers life-threatening rhythm disturbances, increasing the risk of sudden death. We, like all others, replenished potassium with droppers, but it was more effective to retain it in the body with the help of spironolactone.


Men certainly get worse than women; the elderly are heavier than the young; overweight people are heavier than patients without excess weight Photo: Ivan MAKEEV

Men certainly get worse than women; the elderly are heavier than the young; overweight people are heavier than overweight patientsPhoto: Ivan MAKEEV

WHEN PRESCRIBED PATIENTS

– Yana Arturovna, how many patients did you have on average?

– About 10 – 14 days. But someone and 50 days.

– Have you noticed signs by which it can be assumed that the disease in the person brought is likely to go the hard way?

– Such studies were carried out in the world, our clinical practice confirmed them. Men certainly get worse than women; the elderly are heavier than the young; overweight people are heavier than overweight patients. Men with a classic male type of baldness, a lot of facial hair, we can say brutal men get sick harder.

– Under what conditions did you discharge patients?

– We acted as close as possible to the recommendations Ministry of Health: so that the temperature for three days was not higher than 37.5 degrees; so that C-reactive protein (an indicator of inflammation) is lower than 10 mg / l, and saturation, that is, the level of oxygen in the blood, is higher than 96%.

“HEAD OF EPIDEMIOLOGY DEPARTMENT OF ITSELF WORKED AT SANPROPUSNIK”

– How often do you get sick doctors and nurses?

– In the first month no one got sick at all. We have a very powerful epidemiological service. The head of the sanitary-epidemiological department, a senior researcher, correctly organized the whole process, and for the first two weeks she personally worked in the sanitary inspection room at the exit from the “red zone” and helped doctors and nurses who were exhausted after the shift safely remove protective clothing.

Then both people’s fatigue and viral load accumulated. By the middle of the second month, sick people began to appear. There were no seriously ill patients. We treated part of the staff in our observation, part of it was treated at home. In total, 18 people were infected from the medical staff (less than 10%).

– Doctors take something for prevention? Vitamins C, D, Zinc?

– I saw the recommendations of American nutritionists, they speak out positively about taking zinc, melatonin and vitamin C. There were somewhat conflicting data on vitamin D. But we did not give any such recommendations to our employees. We have all the prevention was associated with minimizing contacts and other measures of epidemiological safety.

Physicians are the heroes of our time.“If you think that you are special and that a pandemic will not affect you, you are deeply mistaken,” listen to what the doctors who are fighting with coronavirus say

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Virologist told whether it is possible to disinfect masks from coronavirus in sunlight

And also why the epidemic is gaining strength in southern countries and whether the sun affects the incidence – all this in an interview with George Vikulova (details)

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Experts called the regions with the most affordable housing :: Society :: RBC

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The most affordable housing for an average family in the regions of the Far North of Russia. This is evidenced by a study conducted by experts of RIA Novosti.

When calculating, the authors of the study used the minimum number of years for which a family with one child will be able to save 60 square meters for an apartment. m. in its region without borrowed funds. Housing prices were used at the beginning of 2020. When assessing savings, the average salaries in the region were taken, from which the subsistence minimum was deducted.

The leaders were the northern subjects – Magadan Oblast, the Khanty-Mansi Autonomous Okrug – Ugra and the Nenets Autonomous Okrug. A family will need less than three years to save up for a typical kopeck piece. In the Tyumen region, it will take three years to save money on buying an apartment, in Murmansk – 3.2 years, and in Kamchatka – 3.3 years. Prices for standard apartments in these regions range from 2.6 to 3.6 million rubles.

Experts have estimated the potential rise in housing prices in Russia

Among the outsiders are Sevastopol, Chechnya, Karachay-Cherkessia, Dagestan and Kabardino-Balkaria. There, the purchase of an apartment will have to be postponed from 13.2 to 15.5 years. At the same time, the average cost of a piece in Sevastopol amounted to 4.9 million rubles, and in the republics of the North Caucasus it varies from 2 to 2.9 million rubles.

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The death of sick children of the Covid-19 are very rare, according to a study

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The disease is essentially benign in children. The deaths Covid-19 are extremely rare, and only occur in less than 1 % of cases, confirms a study in european international.

82 health facilities that participated in this first european study with children and adolescents (aged from 3 days to less than 18 years of age), published in the journal The Lancet Child & Adolescent Health.

→ TO READ. Health crisis : the return of accusations of conflict of interest

Led by experts from Great Britain, Austria and Spain, the study shows that out of the nearly 600 children under the age of 18 years, infected by the new coronavirus, only a quarter had pre-existing medical conditions.

Four deaths on 600 patients

This contrast, while the proportion of adults with co-morbidities (diseases) is generally much higher in the studies, are the authors. On the 582 patients studied, a positive virologic test (RT-PCR), only four have died, all older than 10 years, two of which were suffering from medical problems pre-existing.

A low proportion but significant has developed a serious illness requiring treatment in the intensive care unit (8 %, or 48/582 case) ; but the study based on the hospital would not have included the mild cases, who did not need help or a doctor.

→ TO READ. A campaign of tests at Covid launched in 30 towns of the Île-de-France

In contrast, more than 90 children, or 16 %, had no symptoms. The true case-fatality rate in children is likely to be much lower than that observed in the study, notes the journal.

Reassuring results

“Children in whom viruses were detected in the airways at the same time that the SARS-CoV-2 were more likely to be admitted to an intensive care unit. This could have important implications for the next winter season, when the infections by the common cold and the flu will be most common “ note one of the main authors, Dr. Begoña Santiago Garcia of the university hospital Gregorio Marañón in Madrid.

For his part, Marc Tebruegge of Great Ormond Street’s Institute of Child Health, University College London judge the results reassuring. “The case fatality rate in our cohort (child, editor’s note) was very low ; it should still be much lower, given that many children with mild disease would not have been brought to the attention of a physician and were therefore not included in this study “says this co-author. “Overall, the vast majority of children and young people suffer only a mild illness “, he insists.

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“no beneficial effect” of hydroxychloroquine according to a british study

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Yet another reversal in the scientific debates around the hydroxychloroquine. The molecule shows “no beneficial effect “ for the sick of the Covid-19, according to the officials of the clinical trial british Recovery, which were announced Friday, June 5 in a press release on the judgment “immediate “ the inclusion of new patients for this treatment.

Recovery, clinical trial a major of which the results were very expected, was one of the only ones not to have suspended his tests on hydroxychloroquine after a controversial paper in the Lancet, who pointed to the ineffectiveness or even adverse effect of the molecule to treat the Covid-19.

Global Divisions

The researchers of Recovery have made clear that they had decided to make public these “preliminary results because they have important consequences for the management of patients and public health “. The study of the scientific journal The Lancet had caused the arrest of several clinical trials on the hydroxychloroquine, in particular, the european Discovery (Europe, coordinated by the Inserm).

“It is disappointing that the treatment is ineffective,” commented Peter Horby, senior in charge of the test. ” Mais this allows us to focus on care and research on drugs most promising “, he added.

While this treatment has been prescribed heavily in many countries “in the absence of reliable information “, “these findings should change medical practice around the world “, has chimed in his assistant Martin Landray.

Published on may 22nd, the conclusions of The Lancet had, among others, also pushed France to banish the molecule of its treatments against the Covid-19 whereas the world health Organization announced Wednesday, June 3, to resume its clinical trials with hydroxychloroquine. Discovery plans to do the same.

Wednesday, 3 June, another clinical trial conducted in the United States and Canada, at least of patients that Recovery, had also concluded that the molecule was ineffective in the prevention of Covid-19.

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Scientists have developed a diet that can kill resistant cancer

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In a joint study, scientists from the United States and Italy were able to provide evidence that a specific diet combined with vitamin C can kill cancer.

“The combination of diet and vitamin C showed an amazing result. It killed almost all the cancer cells in the culture, ”the scientists said.

It is noted that specialists took a low-calorie plant-based diet and vitamin as the basis for the proposed treatment system.

In addition, scientists tested the effect of treatment in turn: a separate diet, a separate vitamin C.

As a result of this, it became known about a decrease in the growth of cancer cells and a slight increase in their death.

At the moment, studies have been conducted on mice, as a result of which rodents managed to get rid of cancer cells.

According to experts, positive dynamics were achieved only in cancer cells with the KRAS mutation, which is considered one of the most difficult goals in cancer therapy, PressRoom writes.

The team is currently studying the effects of starvation or a low-calorie plant-based diet in combination with other anti-cancer drugs in patients with breast and prostate cancer.

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it affects not only the lungs, but the whole body

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The first 10 days after the onset of symptoms of the disease, the 38-year-old American was feeling quite well. He was not at risk; he had no chronic diseases.

– The man was examined, the disease was mild. The patient had a slight cough. Therefore, he was sent home for treatment, ”says the head of the Department of Vascular Surgery at Westchester Medical Center Sean Wengerter.

And then the incredible happened.

One morning, a man woke up with icy and numb legs. The body was constrained by terrible weakness; there was not even the strength to get out of bed.

The examination showed that the patient had aortic occlusion – a large blood clot formed in the main artery at the place where the artery diverged in two directions – to the right and left leg. Because of this clot, blood enriched with oxygen did not enter the iliac arteries.

“This is extremely dangerous.” From this can die from 20% to 50% of patients, – notes Vangerter. – But such things are not typical for 38-year-olds.

An emergency operation to remove a blood clot could save the patient’s life. But doctors working with patients with COVID-19 are everywhere faced with rather strange and frightening phenomena in infected patients. For example, the formation of blood clots (actually blood clots) of various sizes throughout the body, renal failure, inflammation of the heart muscle and malfunctions of the immune system.

“Coronavirus occurs in each patient in its own way,” notes Scott Brackenridge, associate professor of emergency surgery at the College of Medicine at the University of Florida. – In some cases, the patient has a problem with breathing, in others, the internal organs begin to fail. In children, the immune system as a whole begins to rebel.

Coronavirus is not just a respiratory diseasePhoto: Ivan MAKEEV

MYSTERIOUS STROKES

A new type of coronavirus is considered to be a respiratory virus, although it is already becoming obvious – the infection affects the entire human body. The most common symptoms are fever, pneumonia, and acute respiratory distress syndrome.

In this case, the virus attacks some organs directly. First of all, the mucous membrane of blood vessels, which entails unnatural coagulation of blood.

– COVID-19 provokes a local inflammatory reaction that leads to the formation of blood clots, – explains Wengerter. – This is due to the direct effect of the virus on the arteries.

A number of doctors recorded strokes in young patients with coronavirus, as well as the formation of blood clots in the lungs. Blood clots were found even in the smallest vessels.

“Since each organ feeds on blood vessels, and the virus attacks them first and foremost, we end up with damage to internal organs,” adds Dr. Scott Brackenridge.

Another serious symptom that is observed in some patients who become ill with the new coronavirus is the “co-fingers.” The infected toes swell, becoming red or purple. It is possible that the reason for this is blockage of blood vessels. But doctors say that usually this does not have serious consequences.

Kawasaki Syndrome

One of the most alarming reactions to COVID-19 is observed in children. It has already been named as a children’s multisystem inflammatory syndrome. In newYork Doctors have identified more than 100 cases.

This syndrome is characterized by a rather long fever, inflammatory process, malfunction of one or more internal organs, as well as the general condition, which is usually observed with shock. Pediatricians also compare these symptoms with the syndrome. Kawasaki.

Kawasaki syndrome is a rare disease that affects children aged 3 to 10 years. It is characterized by damage to the medium and small arteries, thrombosis, the formation of aneurysms and rupture of the vascular wall. Cases of infection are rare. However, recently, doctors have noted an increase in the number of patients with this syndrome.

Both childhood multisystem inflammatory syndrome and Kawasaki syndrome lead to an overly aggressive immune system response to coronavirus. This may be accompanied by inflammation of the blood vessels and heart muscle.

KILLER CELLS

However, scientists note that coronavirus is not able to cause a strong immune response, but, on the contrary, suppress the entire immune system. And this can allow the infection to freely attack the internal organs.

Partly this theory was confirmed by Chinese experts, led by Dr. Zhang Zhang. Scientists analyzed samples of immune cells taken from the lungs of 9 patients infected with coronavirus. The results of the study showed an abnormally high level of leukocytes – macrophages and neutrophils responsible for the destruction of harmful pathogen – in severe patients. At the same time, these patients had a rather low level of CD8 T cells, which are called killer cells. They are responsible for killing virus-infected cells.

But doctors are reassuring, noting that they have drugs that can thin the blood, and also help the work of white blood cells that resist infection.

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