15% of severe forms explained by genetic and immune abnormalities, according to study

Nearly 15% of severe forms of Covid-19 are explained by genetic and immune abnormalities leading to the failure of a powerful antiviral molecule, naturally produced by the body in the event of infection, according to the work of a French team -american.

This discovery could make it possible to screen people at risk of developing a severe form and to better treat them, according to the researchers.

This research, which specifically points to a defect affecting proteins of the immune system, type 1 interferons (IFNs), are detailed in two articles published by the American journal Science.

“This is a defect in the production or action of type 1 interferons”, underlines Professor Jean-Laurent Casanova (Imagine Institute, Paris and Rockefeller University in New York).

Researchers have demonstrated in some patients genetic abnormalities (mutations of 13 genes) which decrease the production of type I IFNs (3-4% of severe forms).

They also identified in other patients aged 25 to 87 years a form of autoimmune disease, in this case the presence at very high levels in the blood of misdirected antibodies, called autoantibodies. . These neutralize the anti-viral action of type 1 IFNs (in at least 10% of severe forms of Covid) instead of attacking the virus.

This anomaly affects more men than women, according to the study, while autoimmune diseases (dysfunction of the immune system that causes it to attack some of its normal constituents) generally affect women much more. .

The study also suggests that the frequency of these antibodies increases with age.

Prof. Casanova led this research with Prof. Laurent Abel (Imagine Institute / Inserm), in collaboration with Helen Su from the American National Institute of Allergies and Infectious Diseases (NIAID / NIH).


The first man to be cured of HIV is terminally ill with cancer

Timothy Ray Brown, the American originally known as the “Berlin patient” and who in 2008 became the first man to be cured of HIV, is terminally ill with cancer, his companion announced.

“Timothy is not dying of HIV, let’s be clear,” Tim Hoeffgen told activist and author Mark King, who posted a blog post on Tuesday and wrote that the couple wanted to come through him to break the news. “HIV has not been detected in his blood since he was cured. It’s gone. There, it’s leukemia. My God, I hate cancer.”

“He’s someone you can’t help but love, he’s so kind. The cancer treatments have been very tough. Sometimes I wonder if they’re not worse than the disease,” he said. added Tim Hoeffgen.

Mark King told AFP he spoke to the couple last Saturday on the phone. Timothy Ray Brown, 54, is in hospice care at their home in Palm Springs, California.

“I will keep fighting until I can no longer fight,” the patient told Mark King. In one photo, he appears bedridden, thin and hairless.

Timothy Ray Brown has written a page in the medical history of HIV, the virus that causes AIDS.

In 1995 he was living in Berlin when he learned he had been infected with the virus. Then in 2006, he was diagnosed with leukemia.

To cure him of leukemia, his doctor at the University of Berlin used a stem cell transplant from a donor who had a rare genetic mutation that gave him natural resistance to HIV, in the hope that the transplant cures both diseases.

It took two transplants, heavy and dangerous operations, but the bet succeeded: in 2008, Timothy Ray Brown became cured of both diseases. The initial announcement had preserved his anonymity as a “patient from Berlin”.

In 2010, he agreed to disclose his name publicly, and has since become a public figure, speaking in interviews and conferences.

“I am living proof that there can be a cure for AIDS,” he told AFP in 2012. “It is wonderful to be cured of HIV.”

Since then, only one other remission has been announced, in March 2019, thanks to the same method, in the “patient from London”, who also revealed his identity afterwards, Adam Castillejo, and is now considered cured.

Because of its heaviness and the risks (it is necessary to suppress the immune system of the recipient beforehand by chemotherapy, in order to “replace” it by that of the donor), the method of the transplant of stem cells is not considered as a way of generalizable treatment, especially today where antiretroviral treatments allow people to live a normal life with HIV.

“We must balance the mortality rate of 10% for a transplant of stem cells and the risk of death if we do nothing”, explained last March to AFP the virologist Ravindra Gupta, of the University of Cambridge , who followed the patient from London.


Coronavirus. By injecting an attenuated version of the virus, it would be possible to vaccinate more

A new experimental vaccine against Covid-19 enters final phase of testing announced Thursday, September 24 the company which developed it, Novavax. This is the eleventh vaccine against coronavirus which is entering this final phase of clinical trials.

Other companies are trying to develop solutions they deem more effective against this virus. This is the case of the start-up Codagenix . The principle: injecting a live but attenuated virus into the body. Each virus, whether it is the flu, Zika or the common cold, uses the machinery of the host cell (ribosome) to translate its genome and synthesize its proteins, explains the start-up. Our computer algorithm recodes and attenuates the codons of viral genes, placing the genes in language that is read more slowly by the host cell’s ribosome., explains the creators of the start-up on their site.

This principle causes a reaction of the immune system

Usually, the coronavirus can replicate 100 million times inside a cell in 24 hours, explains the site Futura Health . This figure could be halved based on laboratory tests. In the body, this will give the immune system more time to react, describes Robert Coleman, president of Codagenix, in Technology Review .

Where the candidate vaccines currently developed by various laboratories will only protect part of the virus, the advantage of using a live attenuated strain would be to allow the body to produce, of course, antibodies, but also T lymphocytes, those particularly important in immunity against this new coronavirus.

“A risk that is not necessary”

This concept is well known since it is the version used for chickenpox, polio or even yellow fever. However, it is not without risk due to possible mutations in the virus, negative responses for a person with a weakened immune system. Some scientists therefore do not see the point of developing such a version of the vaccine, Covid-19 being a virus easy to vaccinate, says Michael Farzan, professor of immunology and microbiology at the Scripps Research Institute. According to him, you only need live attenuated viruses when you don’t have a safer one. Because it carries a risk that is not necessary.

Important to “imitate the course of the disease”

But Codagenix recalls that the other advantage of the attenuated version is the possibility of rapidly producing billions of doses and of vaccinating through the nose, without needing to use a syringe and, therefore, more widely.

According to Rajeev Dhere, director of Serum Institute of India, if you want to complete the immunological response, you have to mimic the course of the disease, and this can only be done with a live attenuated vaccine.


More than 60 percent of patients die in Aceh due to comorbidities

Corona illustration. © 2020 Merdeka.com/shutterstock

Merdeka.com – Deputy Director of Regional General Hospital dr. Zainoel Abidin (RSUDZA) Banda Aceh, Endang Mutiawati said, more than 60 percent of Covid-19 patients who died in Aceh were due to comorbid diseases.

Based on data as of September 14 last week there were 91 Covid-19 patients who died from comorbidities. Until Tuesday (23/9) yesterday the death rate due to the corona virus was recorded at 142 people. This means that only 51 people died because they had contracted Covid-19.

“Most of the Covid-19 Aceh patients who died were due to other diseases. Well, this Covid can exacerbate the disease experienced by previous patients,” said Endang in Banda Aceh, Wednesday (23/9).

Comorbidity and comorbid means comorbidities, a medical term that describes the condition that there is another disease being experienced apart from the main disease. Endang said, several comorbidities that often cause death in Covid-19 patients include diabetes, hypertension and kidney failure.

“Complementary diseases worsen the clinical course of Covid-19, especially if the comorbid factors are not well controlled,” said Endang.

When viewed from the perspective of age, the patient died of comorbidities and was exacerbated by exposure to Covid-19 who was elderly. A total of 69 patients who died were even over 50 years old. Meanwhile, the two people who died were still in their teens.

“The explosion of comorbid patients who died and were recorded as Covid patients occurred in August and September. In August there were 47 cases and from September to 14 recorded 33 cases,” said Endang.

Most patients came from Banda Aceh, namely 33 people and Aceh Besar 22 people. Meanwhile, Pidie Jaya, Sabang and Aceh Tamiang were the regions with the lowest cases, namely 1 patient.

The central government itself plans to make a classification of reporting cases of Covid-19 patient deaths. The classification is related to death due to Covid-19 or death due to comorbidities (comorbid).

Endang said, this was as conveyed by the Expert Staff of the Minister of Health for Health Economics, M. Subuh. He said there needed to be an intervention regarding the operational definition of the death of Covid-19 patients.

“We must intervene to reduce the mortality rate by making a correct operational definition, dying from Covid-19 or because of comorbidities in accordance with WHO guidelines, and also BPJS Health support in filing claims for the cost of death for patients accompanied by Covid-19,” said Endang.

Endang said, the classification for data collection of patients who died because of Covid-19 or its comorbids, must be done carefully and approach the facts.

Moreover, the World Health Organization or WHO has provided guidelines for the classification of data on covid-19 deaths in two groups, namely deaths with Covid-19 accompanied by comorbids or death cause due to Covid-19.l, and deaths due to Covid-19 or death with Covid-19.

“If the guidelines are used, then patients who die because of being infected with Covid-19 in Aceh will drastically decrease,” said Endang.

Even so, Endang emphasized that all health workers in Aceh have worked as much as possible in carrying out healing steps for the community, both those who were exposed to Covid and those who were exposed to Covid but had comorbidities.

“Therefore, we hope to all elements of society to provide support by taking preventive steps as recommended by the government,” said Endang. (mdk/gil)


Recent Study: Coronavirus Mutates to Be Easier to Contagious

Merdeka.com – A new study examining the mutation of the coronavirus did not impact the clinical outcome of the disease or make it deadly, but one of the mutations could make it more infectious.

A new study conducted by scientists in Houston and published in MedRxiv has revealed a new mutation of the coronavirus that is potentially stronger and more volatile.

“We have given a lot of room for this virus. Out there their population is now very large, “said James Musser, one of the study authors told The Washington Post, quoted from the Sputnik page, Thursday (24/9).

David Morens, a virologist at the National Institute of Allergic Diseases and Infectious Diseases, also said that when the virus circulates throughout the population it has the potential to become more contagious and could negatively impact the ability to control it.

So the virus adapts to the use of masks?

He described the virus may be adapting to measures such as wearing masks, maintaining distance and washing hands that could potentially affect vaccine formulations.

“Even though we don’t know yet, there is still a chance that this coronavirus, when our population level immunity is high enough it will find a way to evade our immunity, and if that happens we will be in the same situation as the flu, we have to catch up with the virus. , when the virus mutates we have to tamper with our vaccine, “he added.

There are currently more than 31 million cases of Covid-19 registered worldwide with at least 1 million related deaths, according to John Hopkins University data.

The United States remains the worst-affected country with more than 6.9 million cases and more than 200,000 deaths.

Reporter Magang: Galya Nge [pan]

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Professor Didier Raoult asserts that the virus is mutating, “it’s another disease!”

“There is an increase in diagnosed cases, with no increase at all in death,” said Professor Didier Raoult. “The virus is mutating. The current epidemic has nothing to do with March April, it’s another disease! », He continued.

However, other doctors, in particular Bruno Megarbane, do not share this opinion: “I would not say that it is about another disease, but possibly a disease with a modified epidemic profile due to the interventional measures which have been taken to prevent contamination, ”he explained.


Does a vaccination against Covid-19 protect for life?

After encouraging results with the first corona vaccines, scientists see them as the most powerful weapon against the corona pandemic. But how long could one vaccine dose provide protection?

Experts consider vaccinations to be the most effective measure against corona. However, multiple vaccinations will probably be necessary, said Clemens Wendtner, chief physician at the Infectious Disease Clinic at the Schwabing Clinic in Munich in July. “It could also be a Covid-19vaccine be that, as with the influenza vaccination, you have to be vaccinated again regularly. “

An effective vaccine remains the great hope in the fight against Covid-19. “The only illusion to have is that one vaccination against Covid-19 lasts a lifetime, “said Wendtner.” It is not uncommon for vaccinations not to last for years but to have to be refreshed regularly.

Vaccination against influenza lasts for a few months

At Influenza hold the immunization for a few months – that’s enough to be well prepared for the annual flu season in winter. A certain summer effect can also be seen with Corona: warmth and UV radiation insulated that Virus something a. “You should see what a vaccination can do for all of us,” said Wendtner and with a view to the longer-term consequences: “Everyone who Covid-19 has been through is a warning example for anti-vaccination opponents. “

Experts expect an approved vaccine in the course of the coming year at the earliest. “So patience and understanding for the important protective measures of each individual is still required,” said Wendtner. The first corona patients nationwide were treated at the Munich Clinic Schwabing in January.

Important NOTE: Under no circumstances does the information replace professional advice or treatment by trained and recognized doctors. The content of t-online.de cannot and must not be used to make independent diagnoses or to start treatments.


The 6 p.m. news – Wastewater: the coronavirus is again very present in Île-de-France

Second wave? Resumption of the epidemic? Experts have been fighting each other on the subject for weeks, so much so that we no longer really know who to believe. This is an indisputable element this evening. It concerns wastewater in Île de France. The coronavirus is now at the same level as in March. This is what Vincent Maréchal, a virologist who is in charge of monitoring this wastewater, explains to us.

“Since the end of July and early August, there has been a further increase in the number of people carrying the virus. The levels we have today are indeed around those we had at the beginning of March“, concedes the virologist before continuing:” We do not know if we are at the beginning of a second peak of the same intensity. We must absolutely avoid finding ourselves in the situation we found ourselves in in March. We have multiple indicators that show that the virus is re-circulating, that it is actively re-circulating. More and more, the signals are coming on and the quantities of viruses that are detected are increasing, but they are increasing very slowly, ”explains Vincent Maréchal.

A different scenario, however

Irrefutable figures therefore since this wastewater is that of the entire population, not just figures from those tested. We therefore learn today that there are as many viruses in the stools of inhabitants of Île-de-France until early March. But be careful, this does not mean that we are in the same scenario.

Indeed, today’s sick population is younger. The 15-44 year olds are the most affected, and they are less likely to develop a severe form. In addition, this study proves that the virus circulates less quickly. In March-April, the rate detected in wastewater suddenly increased, today it is the opposite, it has been increasing very slowly since mid-June.

The virus circulates less quickly, resulting in: hospitals manage to manage the situation. In March, the intensive care units were completely saturated, which is not the case today. According to the ARS there are 1,300 intensive care beds reserved for Covid-19 patients throughout the Île-de-France, and of these 1,300 beds, only 278 are occupied.

Also to listen in this journal

Miscellaneous – “Look at that bitch in a skirt”: a 22 year old student claims to have been assaulted in the street and in front of witnesses for his dress. Three men allegedly attacked her violently, after having insulted her on several occasions. An investigation has been opened.

Politics – Emmanuel Macron went to an Ehpad in Loir-et-Cher on Tuesday, September 22. The president said it: he wants at all costs avoid confinement of seniors : “We should not ask too many sacrifices of our elders”, declared the head of state.

SNCF – The French railway company storms Spain with its subsidiary Ouigo and will thus compete there the incumbent operator. The first departure is scheduled for March 15th.

Read more


Mexico at high risk of outbreaks due to COVID-19: López-Gatell – Noticieros Televisa

Hugo Lopez Gatell, Undersecretary of Prevention and Health Promotion, said at the conference this Sunday that the opening of activities must be in an orderly manner and the number of people who are outside must be taken care of to avoid contagion, because there is a high risk of outbreaks and infections from COVID-19.

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“There is no guarantee that there will not be sprouts and Mexico and the rest of the countries of the American continent are susceptible to outbreaks, rebounds, a change in the trend, in Mexico we have been in a decreasing trend for seven consecutive weeks, since mid-July the number of cases, the number of daily infections, the number of sick people who are hospitalized daily and fortunately began to decrease the number of people who die from this lethal disease, what can happen is that this trend is reversed and we begin to have more infections and more infections and more infections, ”said López-Gatell.

He reiterated that the epidemic continues to decline in the country.

“Today we open with a news, I insist, encouraging, between weeks 36 and 37, the epidemic was reduced 24%, the epidemic I mean the number of confirmed cases comparing, those estimated for week 36 with those of week 37 They were 24% less in week 37. And we have 26 states that have declined for three consecutive weeks, ”commented Undersecretary López-Gatell.

He assured that as of October the need for hospitalization for acute respiratory diseases could begin to increase.

“First of all because the influenza season is coming, it is absolutely certain that we are going to have an increase in people due to COVID-19 and both will need hospitalization in a percentage that ranges from 2 to 7% of the people who have the disease may need hospital care, including critical medicine, ”said Hugo López-Gatell, undersecretary of Prevention and Health Promotion.

Due to COVID-19 there are 697 thousand 663 accumulated confirmed cases in Mexico, 79 thousand 155 suspected cases and 73 thousand 493 accumulated deaths, confirmed.

With information from Guadalupe Madrigal.


Alert! 7 New Symptoms of Covid-19 Infection that Make Doctors with Decades of Experience Amazed

kompas.com / PSBB Jakarta 14 September 2020

Corona virus (Covid-19) cases in Indonesia.

GridHype.ID – It seems the public is probably quite aware of it symptoms general from infection Covid-19.

Symptoms such as dry cough, shortness of breath, fever, chills, muscle aches, sore throat, and loss of the ability to smell.

In addition, we also get information symptoms in the form of a strange skin rash, marks from toenails, and even conjunctivist or red eyes.

Also Read: Since Sunday Night, the Citizens of the Capital City were shocked with a mysterious thud, the sound was again heard this Monday morning

However, there are a number symptoms which has only recently been revealed, based on the results of research and the experiences of the doctors who handled the case.

Doing checks and seeking professional help is indeed the most appropriate step when we feel it symptoms annoying.

But knowing symptomssymptoms what appears can also be a way to protect yourself.

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