Actor Eric Dane, best known for his roles as Dr. Mark Sloan (“McSteamy”) on Grey’s Anatomy, Cal Jacobs in Euphoria, and Tom Chandler in The Last Ship, died Thursday at the age of 53 following a battle with ALS. Tributes from fellow actors including Sam Levinson, Ashton Kutcher, Nina Dobrev, Alyssa Milano, Kevin McKidd, James Pickens Jr., Michael Grassi, Selma Blair, and Alexander Ludwig have begun to surface.
A Public Battle with ALS
Dane publicly revealed his diagnosis of amyotrophic lateral sclerosis, likewise known as Lou Gehrig’s disease, in April 2025. His representatives shared in a statement that he spent his final days surrounded by his wife, two daughters, Billie and Georgia, and close friends. The statement also noted that throughout his journey with ALS, Dane became a passionate advocate for awareness and research.
Hollywood Mourns
Sam Levinson, creator of Euphoria, described Dane as a “dear friend,” stating that working with him was an honor and being his friend a gift. The official Instagram account for Euphoria and HBO Max expressed sadness at his passing, acknowledging his talent and three seasons of operate on the show.
Fellow Grey’s Anatomy cast members also shared tributes. Kevin McKidd wrote “Rest in Peace Buddy” on his Instagram Story, while James Pickens Jr. And Sarah Drew both posted “Rest in Peace” on Instagram.
Alyssa Milano, who worked with Dane on Charmed, remembered his “spark” and sense of humor, noting his tenderness toward his family. Nina Dobrev, who starred alongside Dane in 2022’s Redeeming Love, described him as warm, generous, and kind, and expressed hope that his memory would inspire further research into ALS.
Michael Grassi, creator of Brilliant Minds, called Dane a “TV icon” and praised his bravery. Alexander Ludwig, a co-star in 2024’s Bad Boys: Ride or Die, expressed his sadness and appreciation for working with him. Selma Blair shared a video from their 2000 appearance on Zoe, Duncan, Jack & Jane, writing, “I love you. And yours.”
Frequently Asked Questions
When did Eric Dane announce his ALS diagnosis?
Eric Dane publicly announced his diagnosis of ALS in April 2025.
What roles was Eric Dane known for?
Eric Dane was known for his roles as Dr. Mark Sloan (“McSteamy”) in Grey’s Anatomy, Cal Jacobs in Euphoria, and Tom Chandler in The Last Ship.
How did Eric Dane spend his final days?
He spent his final days surrounded by dear friends, his devoted wife, and his two daughters, Billie and Georgia.
As the entertainment community mourns the loss of Eric Dane, his advocacy for ALS awareness is likely to continue to inspire efforts toward research and support for those affected by this challenging disease.
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