According to a statement released by University College Dublin (UCD), DNA samples obtained from the parchment pages of historic manuscripts have been used to track the sheep pox virus back more than 3,700 years. Researchers extracted samples from sheep teeth and detected the pathogen in medieval manuscripts, opening new avenues for understanding ancient animal diseases through archival preservation.
Tracking Sheep Pox Through Ancient DNA in Historic Archives
The recovery of ancient pathogen DNA from historical records is changing how scientists view past livestock epidemics. According to Louis L’Hôte of UCD, this method proves that parchment can preserve animal pathogen DNA just as it preserves human historical texts. Researchers found genetic traces of the disease inside a 1,000-year-old illuminated manuscript known as the York Gospels, as well as an early English dictionary called the Corpus Glossary. Sheep pox is a highly contagious affliction characterized by high mortality rates, wool damage, and reduced milk and meat yields. L’Hôte noted that libraries and archives worldwide likely contain similar genetic records of historical animal disease outbreaks.
Cross-Species Contamination and Parchment Production Materials
Genetic evidence of the virus was also discovered in parchment manufactured from calfskin and goatskin. According to L’Hôte, this unexpected presence likely stems from cross-species transmission or contamination that took place during the historical parchment-making process. Artisans preparing vellum and leather in medieval workshops handled animal skins under conditions that could easily transfer biological materials across different livestock populations. These findings connect directly to historical production methods documented at sites like English tanneries where animal hides were routinely processed for scribal use.
Did you know? Parchment used in medieval manuscripts was frequently made from sheep, calf, or goat skins, creating an unexpected biological archive of livestock diseases that survived for centuries in libraries.
Frequently Asked Questions
What is sheep pox?
Sheep pox is a highly contagious viral disease affecting sheep that features high mortality rates, wool damage, and reduced yields of milk and meat.

How did researchers track the sheep pox virus?
According to University College Dublin, researchers extracted DNA samples from sheep teeth and detected viral traces preserved within historic parchment manuscripts like the York Gospels and the Corpus Glossary.
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