Proteolysis-targeting chimeras designed to target chromatin modifiers face distinct challenges in target selectivity, cellular permeability, tissue-specific degradation, and the hook effect, according to an upcoming Article Collection from the journal Epigenomics published by Taylor & Francis.
Chemical Strategies and Therapeutic Impact in Epigenomic PROTACs
Researchers are exploring cutting-edge chemical strategies, proteomics, and functional genomics approaches to assess the specificity and efficacy of proteolysis-targeting chimeras. According to Taylor & Francis, the upcoming collection in Epigenomics aims to capture these methodologies alongside emerging evidence of therapeutic impact in nuclear chromatin complexes.
Key Design Challenges for Nuclear Chromatin Complexes
Designing effective PROTACs for nuclear targets introduces complex biophysical hurdles. According to the journal announcement, primary obstacles include achieving target selectivity, ensuring proper cellular permeability, and managing tissue-specific degradation.
Expert Leadership and Contribution Details
The Article Collection is guided by Guest Advisers Dr. Vassiliki Saloura and Dr. William J. Moore from the Center for Cancer Research at the National Cancer Institute, according to Taylor & Francis. Investigators interested in submitting their work or learning more about the collection can reach out to Commissioning Editor George Leung.
Frequently Asked Questions
What journal is hosting the Article Collection on chromatin modifiers?
The collection is hosted by the journal Epigenomics, published by Taylor & Francis.
Who are the Guest Advisers for this collection?
Dr. Vassiliki Saloura and Dr. William J. Moore from the Center for Cancer Research, National Cancer Institute, serve as the Guest Advisers, according to the publisher.
Who should interested authors contact to submit work?
Prospective contributors can contact Commissioning Editor George Leung for assistance regarding submissions.
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