A new analytical method developed by researchers at the University of Campinas (Unicamp) and Embrapa significantly increases the detection accuracy of emerging water contaminants, such as pharmaceuticals and pesticides, at the nanogram-per-liter level. By integrating liquid chromatography with tandem mass spectrometry (LC-MS/MS), the protocol allows for both targeted identification and the screening of unknown substances, providing a more robust framework for environmental monitoring agencies and urban water supply systems, according to the research team.
How does the new detection method improve water safety?
Traditional water monitoring often fails to capture the full spectrum of pollutants because many chemicals exist in trace amounts. According to Bianca Ferreira, who led the research at Unicamp, the new protocol utilizes LC-MS/MS to separate complex mixtures and identify molecules with high precision. Unlike standard tests that look only for a predetermined list of heavy metals or industrial residues, this method enables “suspect screening.” This approach identifies chemicals that are not yet regulated but may still pose risks to human health and aquatic life, such as surfactants found in common household shampoos and detergents.

Many emerging contaminants, including hormones and personal care products, are present in water at concentrations as low as nanograms per liter—the equivalent of a single drop in an Olympic-sized swimming pool.
Why are emerging contaminants harder to track than traditional pollutants?
Emerging contaminants present a unique challenge because they are chemically diverse and often appear in complex mixtures. Sonia Queiroz, a researcher at Embrapa Meio Ambiente, notes that conventional techniques struggle to isolate these substances when they are diluted in water bodies influenced by combined agricultural and urban runoff. While traditional regulations focus on well-known pollutants like lead or mercury, this new method bridges the gap by detecting substances that currently escape standard regulatory oversight. This creates a higher standard of accuracy, reducing the risk of both false positives and false negatives in environmental reports.
What are the practical applications for environmental monitoring?
The transition to high-resolution mass spectrometry allows for more automated and comprehensive surveillance of water resources. Carla Bottoli, a professor at Unicamp and the study’s advisor, explains that by integrating targeted analysis with broad screening, laboratories can update their testing routines to reflect the actual chemical composition of local water sources. For regulatory agencies, this means the ability to monitor the environmental impact of new chemicals in real-time, rather than waiting for outdated legislative frameworks to catch up with industrial and agricultural trends.
Pro Tip: Improving Water Quality Data
For municipal water authorities, moving toward high-resolution mass spectrometry (LC-MS/MS) is the gold standard for reducing uncertainty. If your facility uses legacy testing, consider a phased transition toward multi-target screening to ensure compliance with future, stricter environmental guidelines.

Frequently Asked Questions
- What are emerging contaminants? These are substances like pesticides, pharmaceuticals, and endocrine-disrupting chemicals that are not currently regulated in most water quality standards but are known to be present in the environment.
- Why is LC-MS/MS more effective? It combines the separation power of liquid chromatography with the precise molecular identification of mass spectrometry, allowing for the detection of substances at extremely low concentrations.
- Can this method be used for drinking water? Yes, the research specifically aims to support the monitoring of urban water supply systems to ensure that trace contaminants are identified and managed effectively.
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