Scientists at Sao Paulo University’s DNA Longevo project are analyzing the DNA of three Brazilian sisters—Levita de Deus Nunes (109), Zoraide de Deus Mota (104), and Zulina de Deus Nunes (103)—to identify “protective genes.” These genetic markers may prevent organ decay and cognitive decline, offering a roadmap for future medical interventions in human aging.
How do “protective genes” shield the body from aging?
Researchers are investigating whether specific genetic sequences act as a biological buffer against the standard degradation of human cells. Mayana Zatz, who coordinates the Human Genome Research Center at Sao Paulo University, states that the team is searching for “protective genes” within the sisters’ DNA.
According to Zatz, these genes are suspected of protecting vital organs, including the heart and muscles, while maintaining cognitive brain function. The study focuses on identifying these markers by comparing the DNA of highly resilient centenarians against those who experience typical age-related declines, such as dementia or chronic disease.
“Melalui pengujian DNA, kami mencari gen pelindung, dan kami tahu ada beberapa di antaranya,” kata Mayana Zatz, ilmuwan yang mengkoordinasikan Pusat Penelitian Genom Manusia di universitas tersebut.
The three sisters from Rio de Janeiro hold the Guinness World Record for the oldest living siblings, with a combined age of 316 years.
Is longevity driven by DNA or daily habits?
The debate between lifestyle and genetics remains central to longevity research. Ben Meyers, CEO of LongeviQuest, notes that while the sisters’ longevity clearly points to a massive biological component, environmental factors play a supporting role. Meyers highlights that their proximity to one another provided a critical social support network, which acts as a psychological buffer in old age.
The sisters’ early lives also featured elements that modern science frequently links to health:
- Dietary simplicity: Zulina de Deus Nunes recalled a childhood without processed foods or refrigerators, relying entirely on fresh ingredients.
- Physical activity: Her upbringing included consistent movement through swimming and fishing in local rivers.
- Early development: Her sister, Zoraide, emphasized the importance of breastfeeding as a foundation for long-term health.
