Cell

Visualizing Cellular Molecular Machines with Cryo-ET

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Using cryo-electron tomography, researchers from Julia Mahamid’s European Molecular Biology Laboratory Heidelberg research group have visualized how different cellular processes are connected in 3D. Published in two papers in the journal Cell, the findings allow scientists to map protein production machinery across hundreds of individual cells and uncover previously unseen connections between transcription and translation. … Read more

USP15 Enzyme: A New Target for Ovarian Cancer Treatment

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Ovarian cancer is frequently diagnosed after the disease has already spread to other parts of the body, leaving patients with a five-year survival rate of under 30 percent, according to researchers at the University of Maryland, Baltimore County (UMBC). Standard therapies often inflict heavy damage on healthy cells alongside malignant cells. New research published September … Read more

University of Vermont Seeks to Map Full Spectrum of Biology with $19 Million Observatory

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The University of Vermont is establishing a $19 million, five-year National Science Foundation project to build a national observatory that will image life’s smallest structures in three dimensions. Led by neuroscientist Davi Bock at the University of Vermont’s Robert Larner, M.D. College of Medicine alongside co-principal investigators Doug Taatjes of UVM and Mark Ellisman of … Read more

New Blood Test Enhances Cancer Detection in Screening

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A single blood test screening for more than 50 cancers substantially increases cancer detection when added to standard screenings, according to a study published in Nature Medicine by researchers at the Oregon Health & Science University Knight Cancer Institute. GRAIL’s Galleri test was assessed in the PATHFINDER 2 study, utilizing a machine-learning algorithm to analyze … Read more

Hidden Inflammation Drives High Colon Cancer Risk, Garvan Research Reveals

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According to recent research published in Nature Communications by the Garvan Institute of Medical Research, primary sclerosing cholangitis (PSC) and ulcerative colitis are fundamentally different bowel diseases despite currently receiving identical treatments. The findings reveal why PSC patients face a colorectal cancer risk three times higher than those with ulcerative colitis alone, offering new pathways … Read more

City of Hope Develops Modular Plug-and-Play CAR T Therapy for Tumors

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City of Hope investigators have formulated an innovative plug-and-play technique that incorporates engineered molecules into chimeric antigen receptor (CAR) T cells post-treatment, based on findings shared this month in Cancer Immunology Research, an American Association for Cancer Research journal. The preclinical study offers a flexible approach to help CAR T cells keep pace with mutating … Read more

KAUST AI Tool Maps Cell Evolution

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According to research published in Nature Communications by a KAUST-led team, scientists have developed an artificial intelligence tool named Unify to compare similar cell types across distant species and assess which animal study findings apply to human health. Cells from humans, mice, fish, flies, and worms perform similar biological functions even when their underlying genes … Read more

Flatworm Genes Hold the Secret to Regrowing Brain Cells

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According to researchers at the University of Georgia, studying flatworms has revealed nearly a dozen specific genes responsible for regenerating lost brain tissue, offering a fresh perspective on why human brains struggle to heal from injury or disease. Published in Nature Communications by a team including corresponding author Rachel Roberts-Galbraith and first authors Kendall Clay … Read more

Meprin-β Protein Active Form Rises in Alzheimer’s Disease

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Researchers at the Institute for Neurosciences, a joint centre of the Miguel Hernández University of Elche and the Spanish National Research Council, have identified elevated levels of the active form of the protein meprin-β in the brain and cerebrospinal fluid of Alzheimer’s disease patients, providing new insights into beta-amyloid processing. Meprin-β Elevation in Alzheimer’s Brain … Read more

New mRNA Flu Vaccine for Older Adults: Benefits & Protection

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Adults aged 50 and older have a new option for fall immunization after the U.S. Produced by Moderna, the shot uses lipid particles to deliver mRNA sequences into human cells, instructing them to temporarily produce a harmless hemagglutinin protein to stimulate an immune response against circulating influenza strains. How the mRNA Flu Vaccine Works Compared … Read more

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