Neural stem cells in the cerebral cortex split into two independent lineages early in development to produce different types of neurons, according to a study by Irene Varela-Martínez published in Science Advances. This finding, led by the postdoctoral researcher at the Institute of Science and Technology Austria (ISTA), challenges the long-held “inside-out” model of brain … Read more
Researchers at the Memorial Sloan Kettering Cancer Center have identified a single protein called ZFP36L2 that acts as a molecular switch linking the gut’s damage-sensing system to cellular identity shifts, according to a study published August 5 in Nature. According to physician-scientist Karuna Ganesh, senior author of the study, the protein controls how cells detect … Read more
Lactylation-driven metabolic reprogramming acts as a central driver of therapeutic resistance in cancer, according to recent findings published in the journal Genes & Diseases by researchers Wanghao Zhang, Guanglong Huang, Woheng Tang, Jiaxian Li, Jingxian Chen, Yaojiang Feng, Kaichen Li, Can Pan, Shunshen Li, Huayang Zhang, Rongxu Ye, Hao Long, and Guo-zhong Yi. This cellular … Read more
Immunosuppressed patients diagnosed with non-melanoma skin cancer are not lacking vital cancer-fighting immune cells as previously believed, but rather possess macrophages that have lost their ability to communicate effectively, according to a study published in Cell by researchers at The University of Texas MD Anderson Cancer Center. The findings reveal that macrophages in patients with … Read more
Human populations living today share a specific genetic legacy from ancient interbreeding events, according to a study led by researchers Hugo Zeberg of Karolinska Institutet and Philipp Kanis of the Max Planck Institute for Evolutionary Anthropology. Modern humans inherited a variant of the growth hormone receptor through interbreeding with Neandertals around 47,000 years ago, resulting … Read more
Researchers at the Sant Pau Research Institute in Barcelona have identified early microscopic white matter abnormalities in Alzheimer’s disease patients using a specialized neuroimaging metric called peak width of skeletonized mean diffusivity, or PSMD. According to a study published in the journal Alzheimer’s & Dementia, this advanced diffusion magnetic resonance imaging tool detects subtle structural … Read more
Insilico Medicine published a collaborative study in the journal npj Precision Oncology, detailing how artificial intelligence and multi-omic analysis identified therapeutic targets in inverted papilloma-associated sinonasal squamous cell carcinoma (IP-SNSCC), a rare head and neck cancer. Conducted with researchers from the University of Chicago and Johns Hopkins University, the peer-reviewed paper offers the first comprehensive … Read more
Cellular instructions for activating genes have remained nearly unchanged across two billion years of evolution, while the mechanisms used to switch genes off vary widely across branches of life, according to a study published in Nature Genetics by the Centre for Genomic Regulation (CRG) in Barcelona. Researchers used a new profiling method called iChIP2 to … Read more
Traditional Japanese medicine Bofutsushosan, widely used to treat obesity, may also protect aging tissues from destructive fibrosis, according to a preclinical study published in Phytomedicine. Researchers at the University of Osaka and Kobayashi Pharmaceutical Co., Ltd. found that the multi-ingredient formula reduced scar-like tissue buildup in the liver and fat tissue of mice fed a … Read more
Recent research reveals that arthropod fertilization often relies on sperm cooperation rather than individual competition, reshaping evolutionary biology understandings of reproduction. According to a study published in Nature Communications by evolutionary biologists from Syracuse University, the University of Siena, and the University of Szeged, sperm cells in numerous species form coordinated groups using sperm-associated material … Read more