Cell

Advanced AI Cell Models Transform Modern Cell Biology Research

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Researchers at Stanford Medicine have developed two artificial intelligence models of the biological cell, culminating in a second-generation algorithm called TranscriptFormer that can process gene expression data across 112 million cells and 12 distinct species. According to Stanford University bioengineering professor Stephen Quake, the technology provides a mathematical space that allows scientists to analyze massive, … Read more

How Interferon-Alpha Treats Rare Blood Cancers: New Study Findings

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Interferon-alpha treats myeloproliferative neoplasms such as essential thrombocythemia by forcing mutant blood stem cells to rapidly mature into short-lived neutrophils, according to a study published in Nature Genetics by Weill Cornell Medicine investigators. The biologic drug also balances myeloid and lymphoid cell production while depleting malignant cell pools in the bone marrow, though its broad … Read more

Brain MRI Surveillance Cuts Cognitive Risk in SCLC Without PCI

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Patients with small-cell lung cancer (SCLC) undergoing regular brain MRI surveillance without prophylactic cranial irradiation (PCI) achieved significantly better cognitive failure–free survival, according to phase III randomized trial results presented at the Presidential Symposium of the IASLC 2026 World Conference on Lung Cancer in Seoul, Republic of Korea. Researchers reported that MRI surveillance alone improved … Read more

Hot Tea and Coffee Linked to Increased Cancer Risk in Study

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Drinking tea or coffee at very hot temperatures triples the risk of developing esophageal squamous cell carcinoma, according to a study published in the International Journal of Cancer. Researchers from the University of Oxford analyzed data from nearly one million UK adults, finding that individuals who prefer their beverages very hot face a significantly higher … Read more

MD Anderson Trial Challenges NSCLC Local Consolidative Therapy Paradigm

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Adding local consolidative therapy after induction treatment with nivolumab plus ipilimumab does not improve overall survival or progression-free survival in patients with metastatic non-small cell lung cancer, including those with oligometastatic disease, according to phase III trial results presented at the International Association for the Study of Lung Cancer 2026 World Conference on Lung Cancer. … Read more

FDA Clears Trial for Dual-Targeted CAR T-Cell Cancer Therapy

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Food and Drug Administration this week to test genetically engineered CAR T-cell immune cells in adults with advanced colorectal cancer and pediatric patients with solid tumors, according to university announcements. The experimental therapy attacks two specific targets, B7-H3 and IL-8, aiming to overcome the defenses of solid tumors where standard treatments have failed. University of … Read more

Giant-Nucleus Cells Form the Foundation of Early-Stage Cancer

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Abnormally large giant-nucleus cells that survive iron-induced oxidative stress form the foundation of early-stage cancer, according to a Japanese research team at the Nagoya University Graduate School of Medicine whose findings were published in the journal Redox Biology. While excess iron damages cells and increases cancer risk, a subset of cells survives the damage by … Read more

Spleen Imaging Features Predict Coronary Artery Disease Risk

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Hidden features within the spleen detected on abdominal imaging scans can signal a person’s risk of developing coronary artery disease, according to a new study published in Science Translational Medicine. Led by investigators from Mass General Brigham, the research leverages artificial intelligence and genomic analyses to uncover how blood-forming and immune functions in the spleen … Read more

Laser-Carved Microvalves Stop Dangerous Backflow in Medical Microcatheters

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Microcatheters used to deliver targeted therapies into the brain, retina, or inner ear face a persistent risk of failure when a single cough, deep breath, or postural shift forces blood and tissue backward into the channel. According to a study published in the International Journal of Extreme Manufacturing by Prof. Zhuo-Chen Ma, Prof. Bing Han … Read more

Single-Cell Atlas Uncovers Key Macrophage Subtypes in Myocardial Infarction

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According to researchers publishing in BIO Integration, a comprehensive single-cell immune atlas of human myocardial infarction maps 44,574 cells to reveal how myeloid subtypes drive post-injury inflammation. Scientists analyzed single-cell RNA sequencing data to decode cardiac microenvironment remodeling, identifying C1 S100A4+ macrophages as a primary signaling hub orchestrating tissue repair. Mapping the Post-Infarction Immune Microenvironment … Read more

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