Lead exposure significantly damages human nerve cells and weakens cellular waste-clearing structures when combined with amyloid-beta, according to a laboratory study published in the Journal of Applied Toxicology by researchers at the ICMR-National Institute of Nutrition (ICMR-NIN) in Hyderabad. How Lead and Amyloid-Beta Compound Nerve Damage Scientists at the Hyderabad-based institution tested lead alongside two … Read more
Researchers at the Sant Pau Research Institute in Barcelona have identified early microscopic white matter abnormalities in Alzheimer’s disease patients using a specialized neuroimaging metric called peak width of skeletonized mean diffusivity, or PSMD. According to a study published in the journal Alzheimer’s & Dementia, this advanced diffusion magnetic resonance imaging tool detects subtle structural … Read more
Hallucinations and delusions appearing for the first time in midlife or later are frequently categorized as psychiatric symptoms of unclear biological origin, but new research published in Molecular Psychiatry reveals they may be linked to dementia-related brain changes. According to the National Institutes for Quantum Science and Technology, about 65 percent of patients who develop … Read more
Artificial intelligence can now generate detailed maps highlighting differences in how distinct parts of the brain age, according to a study published in the journal Proceedings of the National Academy of Sciences. Developed by University of Southern California researchers, the deep learning model analyzes magnetic resonance imaging (MRI) scans from nearly 15,000 individuals to map … Read more
According to a study published in the journal Nature, researchers using artificial intelligence-based protein sequence redesign to stabilize enzyme starting points achieved superior outcomes in automated directed evolution, mitigating stability-activity trade-offs that traditionally constrain enzyme engineering. By combining the deep-learning model ProteinMPNN with the computational stabilization tool PROSS on botulinum neurotoxin (BoNT) protease models, scientists … Read more
A 24-year analysis of 1,712 adults from the Atherosclerosis Risk in Communities (ARIC) study reveals that the impact of sedentary behavior on brain health depends heavily on the activity performed. Research published in the journal Alzheimer’s & Dementia indicates that while television watching is associated with reduced brain volumes and increased vascular markers, occupational sitting … Read more
Regularly sleeping nine to 10 hours or more per night is linked to higher levels of p-tau181, a blood-based protein marker for Alzheimer’s disease, according to a study from UT Health San Antonio. Researchers found that the association becomes most pronounced beyond 10 hours of sleep, suggesting long sleep may be an early indicator of … Read more
Women who have used hormonal birth control or menopausal hormone therapy (MHT) show structural brain differences associated with healthier aging, according to research published in the journal NeuroImage. A study of 459 women aged 65 to 80 found that lifetime exposure to these hormones correlates with greater gray matter volume and cortical thickness in brain … Read more
Domestic cats experience age-related brain deterioration that mirrors human cognitive decline, creating a new pathway for veterinary and medical researchers to study neurodegenerative diseases. A study published in the journal Biology Open by researchers from the University of Bath, Auburn University, and the National Veterinary School of Toulouse confirms that cats and humans share comparable … Read more
Researchers at the University of Pennsylvania have identified a new class of potential antibiotics hidden within prions, the misfolded proteins typically associated with fatal neurodegenerative conditions. By using the deep-learning platform APEX 1.1 to scan 19.3 million protein fragments, the team discovered 1,179 antimicrobial candidates—dubbed “prionins”—that can kill drug-resistant bacteria, according to findings published in … Read more